experiments_tdep

# library(devtools)
# install_github("michaelyanwang/dcalasso")

library(survival)
library(dcalasso)

## Loading required package: mgcv

## Loading required package: nlme

## This is mgcv 1.9-1. For overview type 'help("mgcv-package")'.

## Loading required package: glmnet

## Loading required package: Matrix

## Loaded glmnet 4.1-8

## Loading required package: doParallel

## Loading required package: foreach

## Loading required package: iterators

## Loading required package: parallel

## Loading required package: MASS

library(profvis)
library(rms)

## Loading required package: Hmisc

## 
## Attaching package: 'Hmisc'

## The following objects are masked from 'package:base':
## 
##     format.pval, units

library(glmnet)

# Helper functions
dac_BIC <- function(cph_mod) {
  return(cph_mod$loglik / cph_mod$n + log(cph_mod$nevent) * length(cph_tv$coefficients))
}

concordance_index <- function(mod, data, time_col="stop", event_col="event", cph=TRUE) {
  time <- data[, time_col]
  status <- data[, event_col]
  
  # Survival package automatically centers the linear predictors
  if (cph) {
    x <- predict(mod, newdata=data)
  } else {
    x <- scale(predict(mod, newdata=data)$fit, scale=F)
  }
  
  n <- length(time)
  ord <- order(time, -status)
  time <- time[ord]
  status <- status[ord]
  x <- x[ord]
  
  wh <- which(status == 1)
  total <- concordant <- 0
  
  # Loop over event rows
  for (i in wh) {
    # Get indices for all subjects that have later times (time[j] > time[i])
    later_times <- which(time > time[i])
    
    # Get the predictions for those subjects
    x_later <- x[later_times]
    x_i <- x[i]
    
    # Compare predictions for concordance
    concordant <- concordant + sum(x_later < x_i) + 0.5 * sum(x_later == x_i)
    total <- total + length(later_times)
  }
  
  # Calculate concordance
  concordance <- concordant / total
  return(concordance)
}


scale_data <- function(df_train, df_test, cont_var) {
  train_means <- colMeans(df_train[, cont_var])
  train_sd <- apply(df_train[, cont_var], 2, sd)
  
  df_train[, cont_var] <- scale(df_train[, cont_var], center=train_means, scale=train_sd)
  df_test[, cont_var] <- scale(df_test[, cont_var], center=train_means, scale=train_sd)
  
  return(list(train=df_train, test=df_test))
}


load_data <- function(path_train, path_test, cont_var, tv=T) {
  df_train <- read.csv(path_train)
  df_test <- read.csv(path_test)
  
  scale_res <- scale_data(df_train, df_test, cont_var)
  df_train <- scale_res$train
  df_test <- scale_res$test
  
  df_train[df_train == "True"] <- 1
  df_train[df_train == "False"] <- 0
  
  df_test[df_test == "True"] <- 1
  df_test[df_test == "False"] <- 0
  
  if (tv) {
    df_train["event"] <- as.integer(df_train$event)
    df_test["event"] <- as.integer(df_test$event)
    
    df_train <- df_train[df_train$stop > df_train$start,]
    df_test <- df_test[df_test$stop > df_test$start,]
  } else {
    df_train[c("death", "ami", "stroke")] <- lapply(df_train[c("death", "ami", "stroke")], as.integer)
    df_test[c("death", "ami", "stroke")] <- lapply(df_test[c("death", "ami", "stroke")], as.integer)
  }
  
  return(list(train=df_train, test=df_test))
}


# fit_cox <- function(df_train, df_test, form, cont_var){
#   x_var <- all.vars(form[[3]])
#   cat_var <- setdiff(x_var, cont_var)
#   rcs_var <- paste0("rcs_", cont_var)
#   new_var <- c()
#   
#   time_col <- all.vars(form[[2]])[1]
#   event_col <- all.vars(form[[2]])[2]
#   
#   # Build X matrix with manually created rcs columns
#   X <- df_train[, cat_var]
#   X_test <- df_test[, cat_var]
#   for (var in cont_var) {
#     rcs_var <- rcspline.eval(df_train[, var], nk=5, inclx=T)
#     rcs_var_test <- rcspline.eval(df_test[, var], nk=5, inclx=T)
#     
#     colnames(rcs_var) <- paste0("rcs_", var, "_", seq_len(ncol(rcs_var)))
#     colnames(rcs_var_test) <- paste0("rcs_", var, "_", seq_len(ncol(rcs_var_test)))
#     
#     new_var <- append(new_var, colnames(rcs_var))
#     
#     X <- cbind(X, rcs_var)
#     X_test <- cbind(X_test, rcs_var_test)
#   }
#   
#   # Add interaction columns where necessary
#   term_labels <- attr(terms(form), "term.labels")
#   int_terms <- term_labels[grepl(":", term_labels)]
#   if (length(int_terms) > 0) {
#     for (int_term in int_terms) {
#       # Extract which variables are in the interaction
#       vars <- unlist(strsplit(int_term, ":"))
#       
#       if (grepl("rcs\\(", vars[1])) {
#         var1 <- gsub("rcs\\(|\\)", "", vars[1])  
#       }
#       
#       if (grepl("rcs\\(", vars[2])) {
#         var2 <- gsub("rcs\\(|\\)", "", vars[2])  
#       }
#       
#       cols1 <- new_var[grepl(var1, new_var)]
#       cols2 <- new_var[grepl(var2, new_var)]
#       
#       for (c1 in cols1) {
#         for (c2 in cols2) {
#           int_var <- as.data.frame(X[, c1] * X[, c2])
#           colnames(int_var) <- paste0(c1, "_X_", c2)
#           
#           new_var <- append(new_var, paste0(c1, "_X_", c2))
#           X <- cbind(X, int_var)
#         }
#       }
#       
#     }
#   }
#   new_var <- append(new_var, cat_var)
#   
#   y <- Surv(df_train[, time_col], df_train[, event_col])
#   cv_fit <- cv.glmnet(as.matrix(X), y, family="cox")
#   coef_cv <- coef(cv_fit, s="lambda.min")
#   
#   # Turn into CPH object
#   data <- cbind(X, df_train[, c(time_col, event_col)])
#   data_test <- cbind(X_test, df_test[, c(time_col, event_col)])
#   
#   cph <- coxph(as.formula(paste0("Surv(", time_col, ", ", event_col, ") ~ ", paste(new_var, collapse="+"))), data, x=T, init=as.numeric(coef_cv), iter.max=0)
#   
#   conc_train <- concordance(cph, newdata=data)$concordance
#   conc_test <- concordance(cph, newdata=data_test)$concordance
#   
#   return(list(cph=cph, conc_train=conc_train, conc_test=conc_test))
# }


fit_cox <- function(df_train, df_test, form, gr_i){
  # Define null model and variable scope
  null_form <- as.formula(paste0(deparse(form[[2]]), " ~ factor(cpap_treated)"))
  scope <- as.formula(paste0("~ ", paste(deparse(form[[3]]), collapse="")))
  # scope <- update(scope, . ~ . - factor(cpap_treated))
  null_mod <- coxph(null_form, df_train)
  
  # Compute and evaluate
  step_mod <- stepAIC(null_mod, scope=list(lower=as.formula("~ factor(cpap_treated)"), upper=scope), direction="both")
  
  # Save model to file
  # saveRDS(step_mod, paste0("Models/cph_", gr_i, ".rds"))
  
  conc_train <- concordance(step_mod, newdata=df_train)$concordance
  conc_test <- concordance(step_mod, newdata=df_test)$concordance
  
  return(list(cph=step_mod, conc_train=conc_train, conc_test=conc_test))
}


fit_dac <- function(df_train, form, gamma_values=seq(0.5, 2, by=0.5), K=20) {
  mods <- list()
  bics <- c()
  
  j <- 1
  for (i in seq_along(gamma_values)) {
    gamma <- gamma_values[i]
    penalties <- c(0, rep(gamma, length(attr(terms(form), "term.labels")) - 1))
    dac <- dcalasso(form, data=df_train, gamma=penalties, K=K)
    
    mods[[j]] <- dac
    bics <- c(bics, dac$BIC.opt)
    
    j <- j + 1
  }
  
  dac_opt <- mods[[which(bics == min(bics))]]
  
  return(dac_opt)
}


run_models <- function(vec_forms, df_train, df_test, time_col, event_col, cont_var, prof_out_file, gr_i, K=20, bigd=T) {
  assign("df_train", df_train, envir=.GlobalEnv)

  i <- 1
  for (form in vec_forms) {
    print(paste("### FORMULA", i, "###"))
    
    # Train models
    prof <- profvis({
      cph_list <- fit_cox(df_train, df_test, form, cont_var)
      cph <- cph_list$cph
      conc_train <- cph_list$conc_train
      conc_test <- cph_list$conc_test
      
      if (bigd) {
        try({
          dac <- fit_dac(df_train, form, K=K)
          
          print("--- DAC RESULTS ---")
          print(summary(dac))
          conc_train_dac <- concordance_index(dac, df_train, time_col, event_col, cph=F)
          conc_test_dac <- concordance_index(dac, df_test, time_col, event_col, cph=F)
        }, silent=T
        )
      }

      # Evaluations
      zph <- cox.zph(cph)

      # Print summaries and plot
      print("--- SURVIVAL RESULTS ---")
      print(summary(cph))

      plot(zph, resid=F)
      termplot(cph)
      
      # Compute concordance index
      print("--- CONCORDANCE RESULTS ---")
      cat("C-index train:", conc_train,
          "\nC-index test:", conc_test
          )

      if (bigd) {
        try({
          cat("\nC-index DAC train:", conc_train_dac,
              "\nC-index DAC test:", conc_test_dac)
      }, silent=T)
      }

    })

    # Save profiling results
    htmlwidgets::saveWidget(prof, paste0("Profiling/dac_form", i, "_", prof_out_file))
    
    i <- i + 1
  }
}

Load data

cont_var <- c("time_to_cpap_start", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk")

# Load data
tind_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_survival_times_train.csv",
                       "/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_survival_times_test.csv",
                       cont_var, tv=F)
df_survival_times_train <- tind_load$train
df_survival_times_test <- tind_load$test

# death_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/death_tv_train.csv",
#                         "/vault/marja987_amed/subsets_thesis_marijn/Data/death_tv_test.csv",
#                         setdiff(cont_var, c("time_to_cpap_start")))
# df_death_tv_train <- death_load$train
# df_death_tv_test <- death_load$test
# 
# ami_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ami_tv_train.csv",
#                       "/vault/marja987_amed/subsets_thesis_marijn/Data/ami_tv_train.csv",
#                        setdiff(cont_var, c("time_to_cpap_start")))
# df_ami_tv_train <- ami_load$train
# df_ami_tv_test <- ami_load$test
# 
# stroke_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_tv_train.csv",
#                          "/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_tv_test.csv",
#                          setdiff(cont_var, c("time_to_cpap_start")))
# df_stroke_tv_train <- stroke_load$train
# df_stroke_tv_test <- stroke_load$test

cont_var <- c("time_to_cpap_start", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk")

cont_var_sleep <- c("time_to_cpap_start", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk", "IV_AHI", "IV_ODI", "IV_AverageSaturation")

# Load data
tind_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_sesar_survival_times_train.csv",
                           "/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_sesar_survival_times_test.csv",
                           cont_var_sleep, tv=F)
df_survival_times_sub_train <- tind_sub_load$train
df_survival_times_sub_test <- tind_sub_load$test
# 
# death_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/death_sub_tv_train.csv",
#                             "/vault/marja987_amed/subsets_thesis_marijn/Data/death_sub_tv_test.csv",
#                             setdiff(cont_var_sleep, c("time_to_cpap_start")))
# df_death_sub_tv_train <- death_sub_load$train
# df_death_sub_tv_test <- death_sub_load$test
# 
# ami_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ami_sub_tv_train.csv",
#                           "/vault/marja987_amed/subsets_thesis_marijn/Data/ami_sub_tv_train.csv",
#                           setdiff(cont_var_sleep, c("time_to_cpap_start")))
# df_ami_sub_tv_train <- ami_sub_load$train
# df_ami_sub_tv_test <- ami_sub_load$test
# 
# stroke_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_sub_tv_train.csv",
#                              "/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_sub_tv_test.csv",
#                              setdiff(cont_var_sleep, c("time_to_cpap_start")))
# df_stroke_sub_tv_train <- stroke_sub_load$train
# df_stroke_sub_tv_test <- stroke_sub_load$test

Generate formulas

base_form <- . ~ factor(cpap_treated) + rcs(alder) + factor(sex) + rcs(bmi) + factor(rokare) + factor(ami_history) + factor(stroke_history) + factor(Civil) + factor(HushallsType_RTB) + factor(Sun2000niva_old) + rcs(DispInkKEHB04) + rcs(Raks_AndelArblosInk) + rcs(Raks_AndelSjukInk) + rcs(Raks_AndelEkBisInk) + factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) + factor(antihypertensive_comb) + factor(lipid_modifying_agents) + factor(cpap_treated):factor(antithrombotic_agents) + factor(cpap_treated):factor(antihypertensive_comb) + factor(cpap_treated):factor(lipid_modifying_agents) + rcs(alder):rcs(bmi) 

list_forms <- list()

for (time_setting in c("tind", "tdep")) {
    if (time_setting == "tind") {
      # In the time-independent formulas, the time and event columns are named accordingly
      for (event in c("death", "ami", "stroke")) {
        # Create both a spline and categorized instance for updating later
        list_forms[[paste0("form_", event, "_", time_setting, "_spl")]] <- update(base_form, paste0("Surv(time_to_", event, ", ", event, ") ~ . + rcs(time_to_cpap_start)"))
        list_forms[[paste0("form_", event, "_", time_setting, "_cat")]] <- update(base_form, paste0("Surv(time_to_", event, ", ", event, ") ~ . + rcs(time_to_cpap_start)"))
      } 
    } else {
      # In the time-dependent formulas, the time and event columns are start, stop, event always
      list_forms[[paste0("form_", time_setting, "_spl")]] <- update(base_form, "Surv(start, stop, event) ~ .")
  }
}

# Add spline or categorized variables, respectively
for (type in c("spline", "categorized")) {
  i <- 1
  for (form_name in names(list_forms)) {
    if (grepl("_spl", form_name)) {
      list_forms[[i]] <- update(list_forms[[i]], paste(". ~ . + rcs(hba1c) + rcs(GFR) + rcs(kolesterol) + rcs(systoliskt) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)"))
    } else if (grepl("_cat", form_name)) {
      list_forms[[i]] <- update(list_forms[[i]], paste(". ~ . + factor(hba1c_high) + factor(GFR_high) + factor(kolesterol_high) + factor(systoliskt_high) + rcs(alder):factor(GFR_high) + factor(cpap_treated):factor(GFR_high)"))
    }
    i <- i + 1
  } 
}

# Create a copy that has sleep data for Group 2
list_forms_sleep <- list_forms
i <- 1
for (form in list_forms) {
  list_forms_sleep[[i]] <- update(form, ". ~ . + rcs(IV_AHI) + rcs(IV_ODI) + rcs(IV_AverageSaturation)")
  i <- i + 1
}

Death

Time-independent

Group 1

# formula_cat_death, 
run_models(c(list_forms[["form_death_tind_spl"]], list_forms[["form_death_tind_cat"]]), df_survival_times_train, df_test=df_survival_times_test, "time_to_death", "death", cont_var, "prof_death_ind_g1.html")

## [1] "### FORMULA 1 ###"
## Start:  AIC=4042829
## Surv(time_to_death, death) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + rcs(alder)                      4 3884854
## + rcs(GFR)                        4 3997026
## + factor(antithrombotic_agents)   1 4013290
## + rcs(DispInkKEHB04)              4 4016154
## + factor(Civil)                   1 4019043
## + factor(Sun2000niva_old)         6 4020250
## + rcs(bmi)                        4 4030892
## + factor(stroke_history)          1 4034213
## + rcs(time_to_cpap_start)         4 4036876
## + factor(FodelseLand_EU27_2020)   1 4036888
## + rcs(kolesterol)                 4 4037144
## + factor(ami_history)             1 4037454
## + rcs(Raks_AndelArblosInk)        4 4038022
## + rcs(Raks_AndelEkBisInk)         4 4038478
## + factor(antihypertensive_comb)   1 4038619
## + rcs(Raks_AndelSjukInk)          4 4038730
## + rcs(hba1c)                      4 4040197
## + rcs(systoliskt)                 4 4040545
## + factor(lipid_modifying_agents)  1 4042730
## + factor(sex)                     1 4042817
## + factor(rokare)                  1 4042828
## <none>                              4042829
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3884854
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 4 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + rcs(GFR)                        4 3876165
## + rcs(hba1c)                      4 3879418
## + rcs(Raks_AndelSjukInk)          4 3879786
## + rcs(Raks_AndelEkBisInk)         4 3880643
## + factor(antithrombotic_agents)   1 3880705
## + rcs(Raks_AndelArblosInk)        4 3880877
## + factor(rokare)                  1 3881068
## + factor(sex)                     1 3881934
## + rcs(DispInkKEHB04)              4 3882139
## + factor(stroke_history)          1 3882396
## + rcs(systoliskt)                 4 3882613
## + rcs(kolesterol)                 4 3883030
## + factor(ami_history)             1 3883210
## + rcs(time_to_cpap_start)         4 3883401
## + factor(Sun2000niva_old)         6 3883547
## + rcs(bmi)                        4 3883879
## + factor(FodelseLand_EU27_2020)   1 3884723
## + factor(Civil)                   1 3884783
## + factor(antihypertensive_comb)   1 3884828
## + factor(lipid_modifying_agents)  1 3884844
## <none>                              3884854
## - rcs(alder)                      4 4042829
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3876165
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 4 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + rcs(Raks_AndelSjukInk)          4 3871203
## + rcs(hba1c)                      4 3871593
## + rcs(Raks_AndelEkBisInk)         4 3872110
## + rcs(Raks_AndelArblosInk)        4 3872244
## + factor(rokare)                  1 3872483
## + factor(antithrombotic_agents)   1 3872554
## + factor(sex)                     1 3872756
## + rcs(DispInkKEHB04)              4 3873855
## + factor(stroke_history)          1 3873924
## + rcs(alder):rcs(GFR)            16 3874033
## + rcs(systoliskt)                 4 3874312
## + rcs(kolesterol)                 4 3874315
## + factor(ami_history)             1 3874741
## + rcs(time_to_cpap_start)         4 3874955
## + factor(Sun2000niva_old)         6 3875102
## + rcs(bmi)                        4 3875271
## + factor(FodelseLand_EU27_2020)   1 3876000
## + factor(Civil)                   1 3876057
## + factor(lipid_modifying_agents)  1 3876118
## + factor(cpap_treated):rcs(GFR)   4 3876161
## <none>                              3876165
## + factor(antihypertensive_comb)   1 3876167
## - rcs(GFR)                        4 3884854
## - rcs(alder)                      4 3997026
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3871203
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + rcs(hba1c)                      4 3866659
## + factor(rokare)                  1 3867545
## + factor(antithrombotic_agents)   1 3867593
## + factor(sex)                     1 3867779
## + rcs(DispInkKEHB04)              4 3868383
## + rcs(Raks_AndelEkBisInk)         4 3868861
## + factor(stroke_history)          1 3868994
## + rcs(alder):rcs(GFR)            16 3869115
## + rcs(Raks_AndelArblosInk)        4 3869143
## + rcs(kolesterol)                 4 3869389
## + rcs(systoliskt)                 4 3869411
## + factor(ami_history)             1 3869804
## + rcs(time_to_cpap_start)         4 3869959
## + factor(Sun2000niva_old)         6 3870067
## + rcs(bmi)                        4 3870311
## + factor(FodelseLand_EU27_2020)   1 3871026
## + factor(Civil)                   1 3871120
## + factor(lipid_modifying_agents)  1 3871168
## + factor(cpap_treated):rcs(GFR)   4 3871199
## <none>                              3871203
## + factor(antihypertensive_comb)   1 3871204
## - rcs(Raks_AndelSjukInk)          4 3876165
## - rcs(GFR)                        4 3879786
## - rcs(alder)                      4 3994208
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3866659
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + factor(rokare)                  1 3863037
## + factor(antithrombotic_agents)   1 3863183
## + factor(sex)                     1 3863431
## + rcs(DispInkKEHB04)              4 3864219
## + rcs(Raks_AndelEkBisInk)         4 3864424
## + factor(stroke_history)          1 3864477
## + rcs(Raks_AndelArblosInk)        4 3864618
## + rcs(alder):rcs(GFR)            16 3864649
## + rcs(systoliskt)                 4 3864845
## + rcs(kolesterol)                 4 3864925
## + factor(ami_history)             1 3865256
## + rcs(time_to_cpap_start)         4 3865684
## + factor(Sun2000niva_old)         6 3865696
## + rcs(bmi)                        4 3865741
## + factor(FodelseLand_EU27_2020)   1 3866435
## + factor(Civil)                   1 3866559
## + factor(lipid_modifying_agents)  1 3866629
## + factor(cpap_treated):rcs(GFR)   4 3866654
## + factor(antihypertensive_comb)   1 3866655
## <none>                              3866659
## - rcs(hba1c)                      4 3871203
## - rcs(Raks_AndelSjukInk)          4 3871593
## - rcs(GFR)                        4 3874389
## - rcs(alder)                      4 3991495
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3863037
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 4 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + factor(antithrombotic_agents)   1 3859609
## + factor(sex)                     1 3859755
## + rcs(DispInkKEHB04)              4 3860876
## + factor(stroke_history)          1 3860917
## + rcs(Raks_AndelEkBisInk)         4 3860943
## + rcs(alder):rcs(GFR)            16 3861015
## + rcs(Raks_AndelArblosInk)        4 3861042
## + rcs(systoliskt)                 4 3861314
## + rcs(kolesterol)                 4 3861344
## + factor(ami_history)             1 3861645
## + rcs(time_to_cpap_start)         4 3862104
## + rcs(bmi)                        4 3862164
## + factor(Sun2000niva_old)         6 3862183
## + factor(FodelseLand_EU27_2020)   1 3862760
## + factor(Civil)                   1 3862929
## + factor(lipid_modifying_agents)  1 3863006
## + factor(antihypertensive_comb)   1 3863026
## + factor(cpap_treated):rcs(GFR)   4 3863032
## <none>                              3863037
## - factor(rokare)                  1 3866659
## - rcs(hba1c)                      4 3867545
## - rcs(Raks_AndelSjukInk)          4 3867946
## - rcs(GFR)                        4 3870701
## - rcs(alder)                      4 3991129
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3859609
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 4 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(sex)                                         1 3856986
## + rcs(Raks_AndelEkBisInk)                             4 3857429
## + rcs(DispInkKEHB04)                                  4 3857495
## + rcs(Raks_AndelArblosInk)                            4 3857502
## + rcs(alder):rcs(GFR)                                16 3857648
## + rcs(systoliskt)                                     4 3858153
## + factor(stroke_history)                              1 3858314
## + rcs(kolesterol)                                     4 3858325
## + rcs(bmi)                                            4 3858650
## + factor(Sun2000niva_old)                             6 3858819
## + rcs(time_to_cpap_start)                             4 3858861
## + factor(ami_history)                                 1 3859016
## + factor(lipid_modifying_agents)                      1 3859059
## + factor(FodelseLand_EU27_2020)                       1 3859356
## + factor(Civil)                                       1 3859528
## + factor(antihypertensive_comb)                       1 3859568
## + factor(cpap_treated):rcs(GFR)                       4 3859604
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3859606
## <none>                                                  3859609
## - factor(antithrombotic_agents)                       1 3863037
## - factor(rokare)                                      1 3863183
## - rcs(hba1c)                                          4 3863986
## - rcs(Raks_AndelSjukInk)                              4 3864531
## - rcs(GFR)                                            4 3866728
## - rcs(alder)                                          4 3974033
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3856986
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(DispInkKEHB04)                                  4 3853947
## + rcs(Raks_AndelEkBisInk)                             4 3854898
## + rcs(Raks_AndelArblosInk)                            4 3854958
## + rcs(alder):rcs(GFR)                                16 3855028
## + rcs(bmi)                                            4 3855571
## + rcs(systoliskt)                                     4 3855601
## + factor(stroke_history)                              1 3855755
## + rcs(kolesterol)                                     4 3855817
## + factor(Sun2000niva_old)                             6 3855968
## + rcs(time_to_cpap_start)                             4 3856185
## + factor(lipid_modifying_agents)                      1 3856373
## + factor(ami_history)                                 1 3856569
## + factor(FodelseLand_EU27_2020)                       1 3856793
## + factor(antihypertensive_comb)                       1 3856938
## + factor(Civil)                                       1 3856961
## + factor(cpap_treated):rcs(GFR)                       4 3856982
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3856984
## <none>                                                  3856986
## - factor(sex)                                         1 3859609
## - factor(antithrombotic_agents)                       1 3859755
## - factor(rokare)                                      1 3860619
## - rcs(hba1c)                                          4 3861206
## - rcs(Raks_AndelSjukInk)                              4 3861925
## - rcs(GFR)                                            4 3864589
## - rcs(alder)                                          4 3973965
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3853947
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(Raks_AndelArblosInk)                            4 3851787
## + rcs(Raks_AndelEkBisInk)                             4 3852071
## + rcs(alder):rcs(GFR)                                16 3852083
## + rcs(bmi)                                            4 3852596
## + rcs(systoliskt)                                     4 3852597
## + factor(stroke_history)                              1 3852717
## + rcs(kolesterol)                                     4 3852842
## + factor(lipid_modifying_agents)                      1 3853368
## + factor(FodelseLand_EU27_2020)                       1 3853467
## + factor(ami_history)                                 1 3853540
## + rcs(time_to_cpap_start)                             4 3853559
## + factor(Sun2000niva_old)                             6 3853641
## + factor(antihypertensive_comb)                       1 3853903
## + factor(cpap_treated):rcs(GFR)                       4 3853943
## + factor(Civil)                                       1 3853945
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3853945
## <none>                                                  3853947
## - factor(antithrombotic_agents)                       1 3856571
## - rcs(DispInkKEHB04)                                  4 3856986
## - factor(rokare)                                      1 3857250
## - factor(sex)                                         1 3857495
## - rcs(hba1c)                                          4 3857708
## - rcs(Raks_AndelSjukInk)                              4 3859475
## - rcs(GFR)                                            4 3861288
## - rcs(alder)                                          4 3957498
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3851787
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(alder):rcs(GFR)                                16 3849906
## + rcs(bmi)                                            4 3850432
## + rcs(systoliskt)                                     4 3850467
## + factor(stroke_history)                              1 3850557
## + rcs(kolesterol)                                     4 3850709
## + rcs(Raks_AndelEkBisInk)                             4 3850727
## + factor(FodelseLand_EU27_2020)                       1 3851200
## + factor(lipid_modifying_agents)                      1 3851247
## + factor(ami_history)                                 1 3851375
## + rcs(time_to_cpap_start)                             4 3851435
## + factor(Sun2000niva_old)                             6 3851479
## + factor(antihypertensive_comb)                       1 3851759
## + factor(Civil)                                       1 3851782
## + factor(cpap_treated):rcs(GFR)                       4 3851783
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3851785
## <none>                                                  3851787
## - rcs(Raks_AndelArblosInk)                            4 3853947
## - factor(antithrombotic_agents)                       1 3854510
## - rcs(DispInkKEHB04)                                  4 3854958
## - factor(rokare)                                      1 3855047
## - factor(sex)                                         1 3855291
## - rcs(Raks_AndelSjukInk)                              4 3855399
## - rcs(hba1c)                                          4 3855521
## - rcs(GFR)                                            4 3859017
## - rcs(alder)                                          4 3953466
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3849906
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(systoliskt)                                     4 3848596
## + rcs(bmi)                                            4 3848607
## + factor(stroke_history)                              1 3848671
## + rcs(Raks_AndelEkBisInk)                             4 3848849
## + rcs(kolesterol)                                     4 3848857
## + factor(FodelseLand_EU27_2020)                       1 3849327
## + factor(lipid_modifying_agents)                      1 3849362
## + factor(ami_history)                                 1 3849472
## + rcs(time_to_cpap_start)                             4 3849549
## + factor(Sun2000niva_old)                             6 3849594
## + factor(antihypertensive_comb)                       1 3849872
## + factor(Civil)                                       1 3849899
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3849904
## <none>                                                  3849906
## + factor(cpap_treated):rcs(GFR)                       4 3849911
## - rcs(alder):rcs(GFR)                                16 3851787
## - rcs(Raks_AndelArblosInk)                            4 3852083
## - factor(antithrombotic_agents)                       1 3852577
## - rcs(DispInkKEHB04)                                  4 3852974
## - factor(rokare)                                      1 3853199
## - factor(sex)                                         1 3853392
## - rcs(Raks_AndelSjukInk)                              4 3853460
## - rcs(hba1c)                                          4 3853600
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3848596
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(bmi)                                            4 3847327
## + factor(stroke_history)                              1 3847387
## + rcs(Raks_AndelEkBisInk)                             4 3847555
## + rcs(kolesterol)                                     4 3847601
## + factor(FodelseLand_EU27_2020)                       1 3847985
## + factor(lipid_modifying_agents)                      1 3848036
## + rcs(time_to_cpap_start)                             4 3848195
## + factor(ami_history)                                 1 3848230
## + factor(Sun2000niva_old)                             6 3848261
## + factor(antihypertensive_comb)                       1 3848579
## + factor(Civil)                                       1 3848586
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3848594
## <none>                                                  3848596
## + factor(cpap_treated):rcs(GFR)                       4 3848601
## - rcs(systoliskt)                                     4 3849906
## - rcs(alder):rcs(GFR)                                16 3850467
## - rcs(Raks_AndelArblosInk)                            4 3850744
## - factor(antithrombotic_agents)                       1 3851060
## - rcs(DispInkKEHB04)                                  4 3851630
## - factor(rokare)                                      1 3851813
## - factor(sex)                                         1 3851996
## - rcs(Raks_AndelSjukInk)                              4 3852097
## - rcs(hba1c)                                          4 3852290
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3847327
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(stroke_history)                              1 3846089
## + rcs(Raks_AndelEkBisInk)                             4 3846288
## + rcs(kolesterol)                                     4 3846307
## + factor(FodelseLand_EU27_2020)                       1 3846737
## + rcs(alder):rcs(bmi)                                16 3846740
## + factor(lipid_modifying_agents)                      1 3846798
## + rcs(time_to_cpap_start)                             4 3846915
## + factor(ami_history)                                 1 3846956
## + factor(Sun2000niva_old)                             6 3846990
## + factor(antihypertensive_comb)                       1 3847311
## + factor(Civil)                                       1 3847316
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3847325
## <none>                                                  3847327
## + factor(cpap_treated):rcs(GFR)                       4 3847332
## - rcs(bmi)                                            4 3848596
## - rcs(systoliskt)                                     4 3848607
## - rcs(alder):rcs(GFR)                                16 3849144
## - rcs(Raks_AndelArblosInk)                            4 3849478
## - factor(antithrombotic_agents)                       1 3849809
## - rcs(DispInkKEHB04)                                  4 3850298
## - factor(rokare)                                      1 3850520
## - rcs(Raks_AndelSjukInk)                              4 3850832
## - rcs(hba1c)                                          4 3850984
## - factor(sex)                                         1 3851177
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3846089
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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##                                                      Df     AIC
## + rcs(Raks_AndelEkBisInk)                             4 3845057
## + rcs(kolesterol)                                     4 3845093
## + factor(lipid_modifying_agents)                      1 3845471
## + factor(FodelseLand_EU27_2020)                       1 3845509
## + rcs(alder):rcs(bmi)                                16 3845534
## + rcs(time_to_cpap_start)                             4 3845641
## + factor(ami_history)                                 1 3845680
## + factor(Sun2000niva_old)                             6 3845754
## + factor(antihypertensive_comb)                       1 3846072
## + factor(Civil)                                       1 3846078
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3846087
## <none>                                                  3846089
## + factor(cpap_treated):rcs(GFR)                       4 3846094
## - factor(stroke_history)                              1 3847327
## - rcs(systoliskt)                                     4 3847343
## - rcs(bmi)                                            4 3847387
## - rcs(alder):rcs(GFR)                                16 3847913
## - factor(antithrombotic_agents)                       1 3847925
## - rcs(Raks_AndelArblosInk)                            4 3848239
## - rcs(DispInkKEHB04)                                  4 3849054
## - factor(rokare)                                      1 3849253
## - rcs(Raks_AndelSjukInk)                              4 3849571
## - rcs(hba1c)                                          4 3849743
## - factor(sex)                                         1 3849879
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3845057
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
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##                                                      Df     AIC
## + rcs(kolesterol)                                     4 3844069
## + factor(FodelseLand_EU27_2020)                       1 3844358
## + factor(lipid_modifying_agents)                      1 3844455
## + rcs(alder):rcs(bmi)                                16 3844518
## + rcs(time_to_cpap_start)                             4 3844639
## + factor(ami_history)                                 1 3844651
## + factor(Sun2000niva_old)                             6 3844718
## + factor(Civil)                                       1 3845037
## + factor(antihypertensive_comb)                       1 3845045
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3845055
## <none>                                                  3845057
## + factor(cpap_treated):rcs(GFR)                       4 3845062
## - rcs(Raks_AndelEkBisInk)                             4 3846089
## - factor(stroke_history)                              1 3846288
## - rcs(systoliskt)                                     4 3846295
## - rcs(bmi)                                            4 3846352
## - rcs(Raks_AndelArblosInk)                            4 3846401
## - rcs(alder):rcs(GFR)                                16 3846878
## - factor(antithrombotic_agents)                       1 3846938
## - rcs(Raks_AndelSjukInk)                              4 3847314
## - rcs(DispInkKEHB04)                                  4 3847894
## - factor(rokare)                                      1 3848151
## - rcs(hba1c)                                          4 3848681
## - factor(sex)                                         1 3848750
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3844069
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(FodelseLand_EU27_2020)                       1 3843383
## + factor(lipid_modifying_agents)                      1 3843517
## + rcs(alder):rcs(bmi)                                16 3843563
## + rcs(time_to_cpap_start)                             4 3843669
## + factor(ami_history)                                 1 3843673
## + factor(Sun2000niva_old)                             6 3843740
## + factor(Civil)                                       1 3844052
## + factor(antihypertensive_comb)                       1 3844060
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3844068
## <none>                                                  3844069
## + factor(cpap_treated):rcs(GFR)                       4 3844074
## - rcs(kolesterol)                                     4 3845057
## - rcs(Raks_AndelEkBisInk)                             4 3845093
## - rcs(systoliskt)                                     4 3845255
## - factor(stroke_history)                              1 3845277
## - rcs(bmi)                                            4 3845392
## - rcs(Raks_AndelArblosInk)                            4 3845395
## - rcs(alder):rcs(GFR)                                16 3845864
## - factor(antithrombotic_agents)                       1 3845903
## - rcs(Raks_AndelSjukInk)                              4 3846300
## - rcs(DispInkKEHB04)                                  4 3846850
## - factor(rokare)                                      1 3847109
## - rcs(hba1c)                                          4 3847591
## - factor(sex)                                         1 3847680
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3843383
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
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##                                                      Df     AIC
## + factor(lipid_modifying_agents)                      1 3842809
## + rcs(alder):rcs(bmi)                                16 3842897
## + factor(ami_history)                                 1 3842985
## + rcs(time_to_cpap_start)                             4 3843025
## + factor(Sun2000niva_old)                             6 3843114
## + factor(antihypertensive_comb)                       1 3843368
## + factor(Civil)                                       1 3843370
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3843382
## <none>                                                  3843383
## + factor(cpap_treated):rcs(GFR)                       4 3843389
## - factor(FodelseLand_EU27_2020)                       1 3844069
## - rcs(kolesterol)                                     4 3844358
## - rcs(Raks_AndelEkBisInk)                             4 3844523
## - factor(stroke_history)                              1 3844584
## - rcs(systoliskt)                                     4 3844592
## - rcs(bmi)                                            4 3844678
## - rcs(Raks_AndelArblosInk)                            4 3844751
## - rcs(alder):rcs(GFR)                                16 3845166
## - factor(antithrombotic_agents)                       1 3845181
## - rcs(Raks_AndelSjukInk)                              4 3845653
## - rcs(DispInkKEHB04)                                  4 3846416
## - factor(rokare)                                      1 3846477
## - rcs(hba1c)                                          4 3846931
## - factor(sex)                                         1 3846945
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3842809
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df     AIC
## + factor(ami_history)                                  1 3842306
## + rcs(alder):rcs(bmi)                                 16 3842328
## + rcs(time_to_cpap_start)                              4 3842445
## + factor(Sun2000niva_old)                              6 3842529
## + factor(Civil)                                        1 3842796
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3842807
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3842808
## <none>                                                   3842809
## + factor(antihypertensive_comb)                        1 3842811
## + factor(cpap_treated):rcs(GFR)                        4 3842815
## - factor(lipid_modifying_agents)                       1 3843383
## - factor(FodelseLand_EU27_2020)                        1 3843517
## - rcs(kolesterol)                                      4 3843741
## - rcs(Raks_AndelEkBisInk)                              4 3843927
## - rcs(systoliskt)                                      4 3844023
## - rcs(bmi)                                             4 3844067
## - factor(stroke_history)                               1 3844086
## - rcs(Raks_AndelArblosInk)                             4 3844150
## - rcs(alder):rcs(GFR)                                 16 3844595
## - factor(antithrombotic_agents)                        1 3845010
## - rcs(Raks_AndelSjukInk)                               4 3845042
## - rcs(DispInkKEHB04)                                   4 3845811
## - factor(rokare)                                       1 3845913
## - factor(sex)                                          1 3846312
## - rcs(hba1c)                                           4 3846348
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3842306
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
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##                                                       Df     AIC
## + rcs(alder):rcs(bmi)                                 16 3841828
## + rcs(time_to_cpap_start)                              4 3841911
## + factor(Sun2000niva_old)                              6 3842034
## + factor(Civil)                                        1 3842293
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3842304
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3842305
## <none>                                                   3842306
## + factor(antihypertensive_comb)                        1 3842307
## + factor(cpap_treated):rcs(GFR)                        4 3842311
## - factor(ami_history)                                  1 3842809
## - factor(lipid_modifying_agents)                       1 3842985
## - factor(FodelseLand_EU27_2020)                        1 3843018
## - rcs(kolesterol)                                      4 3843197
## - rcs(Raks_AndelEkBisInk)                              4 3843422
## - rcs(systoliskt)                                      4 3843453
## - rcs(bmi)                                             4 3843569
## - factor(stroke_history)                               1 3843638
## - rcs(Raks_AndelArblosInk)                             4 3843649
## - factor(antithrombotic_agents)                        1 3844100
## - rcs(alder):rcs(GFR)                                 16 3844115
## - rcs(Raks_AndelSjukInk)                               4 3844531
## - rcs(DispInkKEHB04)                                   4 3845293
## - factor(rokare)                                       1 3845405
## - factor(sex)                                          1 3845641
## - rcs(hba1c)                                           4 3845847
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841828
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(alder):rcs(GFR) + 
##     rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df     AIC
## + rcs(time_to_cpap_start)                              4 3841422
## + factor(Sun2000niva_old)                              6 3841552
## + factor(Civil)                                        1 3841812
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3841826
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3841826
## <none>                                                   3841828
## + factor(antihypertensive_comb)                        1 3841828
## + factor(cpap_treated):rcs(GFR)                        4 3841833
## - rcs(alder):rcs(bmi)                                 16 3842306
## - factor(ami_history)                                  1 3842328
## - factor(lipid_modifying_agents)                       1 3842501
## - factor(FodelseLand_EU27_2020)                        1 3842519
## - rcs(kolesterol)                                      4 3842688
## - rcs(Raks_AndelEkBisInk)                              4 3842924
## - rcs(systoliskt)                                      4 3842966
## - factor(stroke_history)                               1 3843129
## - rcs(Raks_AndelArblosInk)                             4 3843170
## - rcs(alder):rcs(GFR)                                 16 3843558
## - factor(antithrombotic_agents)                        1 3843615
## - rcs(Raks_AndelSjukInk)                               4 3844038
## - rcs(DispInkKEHB04)                                   4 3844789
## - factor(rokare)                                       1 3844867
## - factor(sex)                                          1 3845218
## - rcs(hba1c)                                           4 3845356
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841422
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     rcs(alder):rcs(GFR) + rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
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##                                                       Df     AIC
## + factor(Sun2000niva_old)                              6 3841154
## + factor(Civil)                                        1 3841409
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3841420
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3841420
## <none>                                                   3841422
## + factor(antihypertensive_comb)                        1 3841422
## + factor(cpap_treated):rcs(GFR)                        4 3841427
## - rcs(time_to_cpap_start)                              4 3841828
## - rcs(alder):rcs(bmi)                                 16 3841911
## - factor(ami_history)                                  1 3841953
## - factor(FodelseLand_EU27_2020)                        1 3842070
## - factor(lipid_modifying_agents)                       1 3842105
## - rcs(kolesterol)                                      4 3842264
## - rcs(Raks_AndelEkBisInk)                              4 3842497
## - rcs(systoliskt)                                      4 3842597
## - rcs(Raks_AndelArblosInk)                             4 3842726
## - factor(stroke_history)                               1 3842758
## - factor(antithrombotic_agents)                        1 3843105
## - rcs(alder):rcs(GFR)                                 16 3843157
## - rcs(Raks_AndelSjukInk)                               4 3843605
## - rcs(DispInkKEHB04)                                   4 3843928
## - factor(rokare)                                       1 3844461
## - factor(sex)                                          1 3844785
## - rcs(hba1c)                                           4 3844824
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841154
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(Sun2000niva_old) + rcs(alder):rcs(GFR) + rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df     AIC
## + factor(Civil)                                        1 3841144
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3841152
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3841152
## + factor(antihypertensive_comb)                        1 3841153
## <none>                                                   3841154
## + factor(cpap_treated):rcs(GFR)                        4 3841159
## - factor(Sun2000niva_old)                              6 3841422
## - rcs(time_to_cpap_start)                              4 3841552
## - rcs(alder):rcs(bmi)                                 16 3841647
## - factor(ami_history)                                  1 3841677
## - factor(FodelseLand_EU27_2020)                        1 3841745
## - factor(lipid_modifying_agents)                       1 3841848
## - rcs(kolesterol)                                      4 3841989
## - rcs(Raks_AndelEkBisInk)                              4 3842231
## - rcs(systoliskt)                                      4 3842345
## - rcs(Raks_AndelArblosInk)                             4 3842451
## - factor(stroke_history)                               1 3842490
## - factor(antithrombotic_agents)                        1 3842827
## - rcs(alder):rcs(GFR)                                 16 3842892
## - rcs(DispInkKEHB04)                                   4 3843064
## - rcs(Raks_AndelSjukInk)                               4 3843318
## - factor(rokare)                                       1 3844145
## - factor(sex)                                          1 3844512
## - rcs(hba1c)                                           4 3844519
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841144
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(Sun2000niva_old) + factor(Civil) + rcs(alder):rcs(GFR) + 
##     rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
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##                                                       Df     AIC
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3841142
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3841142
## + factor(antihypertensive_comb)                        1 3841143
## <none>                                                   3841144
## + factor(cpap_treated):rcs(GFR)                        4 3841149
## - factor(Civil)                                        1 3841154
## - factor(Sun2000niva_old)                              6 3841409
## - rcs(time_to_cpap_start)                              4 3841540
## - rcs(alder):rcs(bmi)                                 16 3841639
## - factor(ami_history)                                  1 3841667
## - factor(FodelseLand_EU27_2020)                        1 3841733
## - factor(lipid_modifying_agents)                       1 3841837
## - rcs(kolesterol)                                      4 3841978
## - rcs(Raks_AndelEkBisInk)                              4 3842226
## - rcs(systoliskt)                                      4 3842337
## - rcs(Raks_AndelArblosInk)                             4 3842444
## - factor(stroke_history)                               1 3842481
## - factor(antithrombotic_agents)                        1 3842815
## - rcs(alder):rcs(GFR)                                 16 3842883
## - rcs(DispInkKEHB04)                                   4 3843036
## - rcs(Raks_AndelSjukInk)                               4 3843311
## - factor(rokare)                                       1 3844133
## - factor(sex)                                          1 3844393
## - rcs(hba1c)                                           4 3844505
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841142
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(Sun2000niva_old) + factor(Civil) + rcs(alder):rcs(GFR) + 
##     rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df     AIC
## + factor(antihypertensive_comb)                        1 3841141
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3841142
## <none>                                                   3841142
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 3841144
## + factor(cpap_treated):rcs(GFR)                        4 3841147
## - factor(Civil)                                        1 3841152
## - factor(Sun2000niva_old)                              6 3841406
## - rcs(time_to_cpap_start)                              4 3841538
## - rcs(alder):rcs(bmi)                                 16 3841637
## - factor(ami_history)                                  1 3841665
## - factor(FodelseLand_EU27_2020)                        1 3841731
## - rcs(kolesterol)                                      4 3841976
## - rcs(Raks_AndelEkBisInk)                              4 3842224
## - rcs(systoliskt)                                      4 3842334
## - rcs(Raks_AndelArblosInk)                             4 3842442
## - factor(stroke_history)                               1 3842479
## - factor(antithrombotic_agents)                        1 3842813
## - rcs(alder):rcs(GFR)                                 16 3842881
## - rcs(DispInkKEHB04)                                   4 3843034
## - rcs(Raks_AndelSjukInk)                               4 3843309
## - factor(rokare)                                       1 3844131
## - factor(sex)                                          1 3844391
## - rcs(hba1c)                                           4 3844503
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841141
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(Sun2000niva_old) + factor(Civil) + factor(antihypertensive_comb) + 
##     rcs(alder):rcs(GFR) + rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
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##                                                       Df     AIC
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3841141
## <none>                                                   3841141
## - factor(antihypertensive_comb)                        1 3841142
## + factor(cpap_treated):factor(antihypertensive_comb)   1 3841143
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 3841143
## + factor(cpap_treated):rcs(GFR)                        4 3841146
## - factor(Civil)                                        1 3841151
## - factor(Sun2000niva_old)                              6 3841406
## - rcs(time_to_cpap_start)                              4 3841537
## - rcs(alder):rcs(bmi)                                 16 3841636
## - factor(ami_history)                                  1 3841665
## - factor(FodelseLand_EU27_2020)                        1 3841731
## - rcs(kolesterol)                                      4 3841975
## - rcs(Raks_AndelEkBisInk)                              4 3842219
## - rcs(systoliskt)                                      4 3842326
## - rcs(Raks_AndelArblosInk)                             4 3842437
## - factor(stroke_history)                               1 3842477
## - factor(antithrombotic_agents)                        1 3842803
## - rcs(alder):rcs(GFR)                                 16 3842881
## - rcs(DispInkKEHB04)                                   4 3843031
## - rcs(Raks_AndelSjukInk)                               4 3843304
## - factor(rokare)                                       1 3844126
## - factor(sex)                                          1 3844392
## - rcs(hba1c)                                           4 3844494
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3841141
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + factor(rokare) + 
##     factor(antithrombotic_agents) + factor(sex) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelArblosInk) + rcs(systoliskt) + rcs(bmi) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + rcs(kolesterol) + factor(FodelseLand_EU27_2020) + 
##     factor(lipid_modifying_agents) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(Sun2000niva_old) + factor(Civil) + factor(antihypertensive_comb) + 
##     rcs(alder):rcs(GFR) + rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df     AIC
## <none>                                                   3841141
## - factor(cpap_treated):factor(antithrombotic_agents)   1 3841141
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 3841141
## - factor(antihypertensive_comb)                        1 3841142
## + factor(cpap_treated):factor(antihypertensive_comb)   1 3841143
## + factor(cpap_treated):rcs(GFR)                        4 3841147
## - factor(Civil)                                        1 3841151
## - factor(Sun2000niva_old)                              6 3841406
## - rcs(time_to_cpap_start)                              4 3841538
## - rcs(alder):rcs(bmi)                                 16 3841636
## - factor(ami_history)                                  1 3841665
## - factor(FodelseLand_EU27_2020)                        1 3841731
## - rcs(kolesterol)                                      4 3841975
## - rcs(Raks_AndelEkBisInk)                              4 3842219
## - rcs(systoliskt)                                      4 3842326
## - rcs(Raks_AndelArblosInk)                             4 3842438
## - factor(stroke_history)                               1 3842477
## - rcs(alder):rcs(GFR)                                 16 3842881
## - rcs(DispInkKEHB04)                                   4 3843031
## - rcs(Raks_AndelSjukInk)                               4 3843304
## - factor(rokare)                                       1 3844126
## - factor(sex)                                          1 3844391
## - rcs(hba1c)                                           4 3844494
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_death, death) ~ factor(cpap_treated) + 
##     rcs(alder) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + factor(antithrombotic_agents) + factor(sex) + 
##     rcs(DispInkKEHB04) + rcs(Raks_AndelArblosInk) + rcs(systoliskt) + 
##     rcs(bmi) + factor(stroke_history) + rcs(Raks_AndelEkBisInk) + 
##     rcs(kolesterol) + factor(FodelseLand_EU27_2020) + factor(lipid_modifying_agents) + 
##     factor(ami_history) + rcs(time_to_cpap_start) + factor(Sun2000niva_old) + 
##     factor(Civil) + factor(antihypertensive_comb) + rcs(alder):rcs(GFR) + 
##     rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents) + 
##     factor(cpap_treated):factor(antithrombotic_agents), data = df_train)
## 
##   n= 562724, number of events= 159490 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                  -8.508e-01   4.271e-01
## rcs(alder)alder                                         1.024e+00   2.786e+00
## rcs(alder)alder'                                       -1.396e+00   2.477e-01
## rcs(alder)alder''                                       1.759e+01   4.376e+07
## rcs(alder)alder'''                                     -3.788e+01   3.548e-17
## rcs(GFR)GFR                                            -7.624e-01   4.665e-01
## rcs(GFR)GFR'                                            9.102e-01   2.485e+00
## rcs(GFR)GFR''                                           2.593e+00   1.337e+01
## rcs(GFR)GFR'''                                         -1.059e+01   2.508e-05
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 8.718e+00   6.110e+03
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -1.405e+04   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               1.718e+04         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             -3.165e+03   0.000e+00
## rcs(hba1c)hba1c                                        -5.452e-01   5.797e-01
## rcs(hba1c)hba1c'                                        9.931e+00   2.056e+04
## rcs(hba1c)hba1c''                                      -2.842e+01   4.529e-13
## rcs(hba1c)hba1c'''                                      1.932e+01   2.467e+08
## factor(rokare)1                                         4.014e-01   1.494e+00
## factor(antithrombotic_agents)1                          2.343e-01   1.264e+00
## factor(sex)1                                           -3.239e-01   7.233e-01
## rcs(DispInkKEHB04)DispInkKEHB04                         4.060e-02   1.041e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       -2.384e+01   4.436e-11
## rcs(DispInkKEHB04)DispInkKEHB04''                       5.786e+01   1.339e+25
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -3.710e+01   7.757e-17
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             6.126e+00   4.575e+02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -4.339e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           5.058e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         -7.351e+02  5.850e-320
## rcs(systoliskt)systoliskt                              -3.426e-01   7.099e-01
## rcs(systoliskt)systoliskt'                              1.195e+00   3.302e+00
## rcs(systoliskt)systoliskt''                            -8.224e+00   2.680e-04
## rcs(systoliskt)systoliskt'''                            1.733e+01   3.376e+07
## rcs(bmi)bmi                                            -4.791e-01   6.194e-01
## rcs(bmi)bmi'                                            6.433e-01   1.903e+00
## rcs(bmi)bmi''                                           7.518e+00   1.841e+03
## rcs(bmi)bmi'''                                         -2.001e+01   2.036e-09
## factor(stroke_history)1                                 3.546e-01   1.426e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               3.700e+00   4.044e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -9.307e+02   0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             1.021e+03         Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           -9.235e+01   7.820e-41
## rcs(kolesterol)kolesterol                              -1.964e-01   8.217e-01
## rcs(kolesterol)kolesterol'                              1.610e+00   5.003e+00
## rcs(kolesterol)kolesterol''                            -1.416e+01   7.110e-07
## rcs(kolesterol)kolesterol'''                            3.151e+01   4.825e+13
## factor(FodelseLand_EU27_2020)1                          1.791e-01   1.196e+00
## factor(lipid_modifying_agents)1                        -1.471e-01   8.632e-01
## factor(ami_history)1                                    2.016e-01   1.223e+00
## rcs(time_to_cpap_start)time_to_cpap_start              -2.149e-03   9.979e-01
## rcs(time_to_cpap_start)time_to_cpap_start'              1.233e-01   1.131e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            -2.059e-01   8.139e-01
## rcs(time_to_cpap_start)time_to_cpap_start'''           -9.683e-01   3.797e-01
## factor(Sun2000niva_old)2                                5.270e-02   1.054e+00
## factor(Sun2000niva_old)3                               -2.482e-02   9.755e-01
## factor(Sun2000niva_old)4                               -4.665e-02   9.544e-01
## factor(Sun2000niva_old)5                               -8.980e-02   9.141e-01
## factor(Sun2000niva_old)6                               -1.228e-01   8.845e-01
## factor(Sun2000niva_old)7                               -1.889e-01   8.278e-01
## factor(Civil)1                                          2.365e-02   1.024e+00
## factor(antihypertensive_comb)1                         -1.001e-02   9.900e-01
## rcs(alder)alder:rcs(GFR)GFR                             1.051e-01   1.111e+00
## rcs(alder)alder':rcs(GFR)GFR                           -5.818e-01   5.589e-01
## rcs(alder)alder'':rcs(GFR)GFR                           6.302e+00   5.458e+02
## rcs(alder)alder''':rcs(GFR)GFR                         -1.286e+01   2.588e-06
## rcs(alder)alder:rcs(GFR)GFR'                            2.289e-01   1.257e+00
## rcs(alder)alder':rcs(GFR)GFR'                           4.740e+00   1.145e+02
## rcs(alder)alder'':rcs(GFR)GFR'                         -4.041e+01   2.827e-18
## rcs(alder)alder''':rcs(GFR)GFR'                         7.344e+01   7.861e+31
## rcs(alder)alder:rcs(GFR)GFR''                           5.040e-01   1.655e+00
## rcs(alder)alder':rcs(GFR)GFR''                         -3.581e+01   2.799e-16
## rcs(alder)alder'':rcs(GFR)GFR''                         2.653e+02  1.612e+115
## rcs(alder)alder''':rcs(GFR)GFR''                       -4.536e+02  1.045e-197
## rcs(alder)alder:rcs(GFR)GFR'''                         -4.110e+00   1.641e-02
## rcs(alder)alder':rcs(GFR)GFR'''                         6.349e+01   3.755e+27
## rcs(alder)alder'':rcs(GFR)GFR'''                       -4.326e+02  1.389e-188
## rcs(alder)alder''':rcs(GFR)GFR'''                       7.085e+02  4.895e+307
## rcs(alder)alder:rcs(bmi)bmi                             2.353e-01   1.265e+00
## rcs(alder)alder':rcs(bmi)bmi                           -8.047e-01   4.472e-01
## rcs(alder)alder'':rcs(bmi)bmi                           7.625e+00   2.050e+03
## rcs(alder)alder''':rcs(bmi)bmi                         -1.631e+01   8.257e-08
## rcs(alder)alder:rcs(bmi)bmi'                           -2.452e+00   8.609e-02
## rcs(alder)alder':rcs(bmi)bmi'                           1.074e+01   4.617e+04
## rcs(alder)alder'':rcs(bmi)bmi'                         -8.737e+01   1.142e-38
## rcs(alder)alder''':rcs(bmi)bmi'                         1.788e+02   4.631e+77
## rcs(alder)alder:rcs(bmi)bmi''                           1.499e+01   3.240e+06
## rcs(alder)alder':rcs(bmi)bmi''                         -6.799e+01   2.964e-30
## rcs(alder)alder'':rcs(bmi)bmi''                         5.126e+02  4.028e+222
## rcs(alder)alder''':rcs(bmi)bmi''                       -1.030e+03   0.000e+00
## rcs(alder)alder:rcs(bmi)bmi'''                         -2.134e+01   5.390e-10
## rcs(alder)alder':rcs(bmi)bmi'''                         9.794e+01   3.410e+42
## rcs(alder)alder'':rcs(bmi)bmi'''                       -7.042e+02  1.485e-306
## rcs(alder)alder''':rcs(bmi)bmi'''                       1.397e+03         Inf
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.374e-01   1.147e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1    1.294e-01   1.138e+00
##                                                          se(coef)       z
## factor(cpap_treated)1                                   7.633e-02 -11.147
## rcs(alder)alder                                         3.033e-01   3.378
## rcs(alder)alder'                                        8.161e-01  -1.710
## rcs(alder)alder''                                       4.203e+00   4.186
## rcs(alder)alder'''                                      6.389e+00  -5.929
## rcs(GFR)GFR                                             1.507e-01  -5.061
## rcs(GFR)GFR'                                            9.622e-01   0.946
## rcs(GFR)GFR''                                           6.616e+00   0.392
## rcs(GFR)GFR'''                                          1.141e+01  -0.928
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 2.018e-01  43.206
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                3.576e+02 -39.284
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               4.390e+02  39.134
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              8.271e+01 -38.269
## rcs(hba1c)hba1c                                         2.751e-02 -19.822
## rcs(hba1c)hba1c'                                        5.136e-01  19.337
## rcs(hba1c)hba1c''                                       1.920e+00 -14.803
## rcs(hba1c)hba1c'''                                      1.850e+00  10.446
## factor(rokare)1                                         7.045e-03  56.976
## factor(antithrombotic_agents)1                          5.775e-03  40.582
## factor(sex)1                                            5.708e-03 -56.747
## rcs(DispInkKEHB04)DispInkKEHB04                         6.946e-02   0.584
## rcs(DispInkKEHB04)DispInkKEHB04'                        1.635e+00 -14.580
## rcs(DispInkKEHB04)DispInkKEHB04''                       4.885e+00  11.844
## rcs(DispInkKEHB04)DispInkKEHB04'''                      4.614e+00  -8.040
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             1.558e-01  39.329
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'            1.177e+02 -36.875
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           1.377e+02  36.737
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          2.067e+01 -35.557
## rcs(systoliskt)systoliskt                               1.144e-02 -29.945
## rcs(systoliskt)systoliskt'                              6.175e-02  19.344
## rcs(systoliskt)systoliskt''                             5.321e-01 -15.456
## rcs(systoliskt)systoliskt'''                            1.275e+00  13.591
## rcs(bmi)bmi                                             2.173e-01  -2.204
## rcs(bmi)bmi'                                            1.695e+00   0.380
## rcs(bmi)bmi''                                           9.259e+00   0.812
## rcs(bmi)bmi'''                                          1.251e+01  -1.599
## factor(stroke_history)1                                 9.282e-03  38.203
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.069e-01  34.613
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              3.006e+01 -30.961
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             3.309e+01  30.847
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''            3.166e+00 -29.172
## rcs(kolesterol)kolesterol                               1.231e-02 -15.948
## rcs(kolesterol)kolesterol'                              6.936e-02  23.214
## rcs(kolesterol)kolesterol''                             5.141e-01 -27.536
## rcs(kolesterol)kolesterol'''                            1.116e+00  28.228
## factor(FodelseLand_EU27_2020)1                          7.493e-03  23.900
## factor(lipid_modifying_agents)1                         5.674e-03 -25.928
## factor(ami_history)1                                    8.607e-03  23.421
## rcs(time_to_cpap_start)time_to_cpap_start               3.216e-02  -0.067
## rcs(time_to_cpap_start)time_to_cpap_start'              6.891e-02   1.789
## rcs(time_to_cpap_start)time_to_cpap_start''             2.428e-01  -0.848
## rcs(time_to_cpap_start)time_to_cpap_start'''            1.012e+00  -0.956
## factor(Sun2000niva_old)2                                9.528e-03   5.530
## factor(Sun2000niva_old)3                                6.418e-03  -3.867
## factor(Sun2000niva_old)4                                9.297e-03  -5.018
## factor(Sun2000niva_old)5                                1.092e-02  -8.226
## factor(Sun2000niva_old)6                                1.085e-02 -11.314
## factor(Sun2000niva_old)7                                3.765e-02  -5.019
## factor(Civil)1                                          6.793e-03   3.481
## factor(antihypertensive_comb)1                          5.765e-03  -1.736
## rcs(alder)alder:rcs(GFR)GFR                             1.291e-01   0.814
## rcs(alder)alder':rcs(GFR)GFR                            3.535e-01  -1.646
## rcs(alder)alder'':rcs(GFR)GFR                           1.833e+00   3.438
## rcs(alder)alder''':rcs(GFR)GFR                          2.786e+00  -4.618
## rcs(alder)alder:rcs(GFR)GFR'                            8.482e-01   0.270
## rcs(alder)alder':rcs(GFR)GFR'                           2.243e+00   2.114
## rcs(alder)alder'':rcs(GFR)GFR'                          1.139e+01  -3.547
## rcs(alder)alder''':rcs(GFR)GFR'                         1.714e+01   4.284
## rcs(alder)alder:rcs(GFR)GFR''                           5.762e+00   0.087
## rcs(alder)alder':rcs(GFR)GFR''                          1.553e+01  -2.306
## rcs(alder)alder'':rcs(GFR)GFR''                         8.077e+01   3.284
## rcs(alder)alder''':rcs(GFR)GFR''                        1.254e+02  -3.617
## rcs(alder)alder:rcs(GFR)GFR'''                          9.769e+00  -0.421
## rcs(alder)alder':rcs(GFR)GFR'''                         2.705e+01   2.347
## rcs(alder)alder'':rcs(GFR)GFR'''                        1.449e+02  -2.985
## rcs(alder)alder''':rcs(GFR)GFR'''                       2.329e+02   3.042
## rcs(alder)alder:rcs(bmi)bmi                             1.778e-01   1.324
## rcs(alder)alder':rcs(bmi)bmi                            5.167e-01  -1.557
## rcs(alder)alder'':rcs(bmi)bmi                           2.808e+00   2.716
## rcs(alder)alder''':rcs(bmi)bmi                          4.434e+00  -3.679
## rcs(alder)alder:rcs(bmi)bmi'                            1.415e+00  -1.733
## rcs(alder)alder':rcs(bmi)bmi'                           4.020e+00   2.672
## rcs(alder)alder'':rcs(bmi)bmi'                          2.163e+01  -4.039
## rcs(alder)alder''':rcs(bmi)bmi'                         3.424e+01   5.223
## rcs(alder)alder:rcs(bmi)bmi''                           7.738e+00   1.937
## rcs(alder)alder':rcs(bmi)bmi''                          2.197e+01  -3.095
## rcs(alder)alder'':rcs(bmi)bmi''                         1.184e+02   4.329
## rcs(alder)alder''':rcs(bmi)bmi''                        1.885e+02  -5.462
## rcs(alder)alder:rcs(bmi)bmi'''                          1.044e+01  -2.044
## rcs(alder)alder':rcs(bmi)bmi'''                         2.972e+01   3.295
## rcs(alder)alder'':rcs(bmi)bmi'''                        1.607e+02  -4.381
## rcs(alder)alder''':rcs(bmi)bmi'''                       2.574e+02   5.428
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   9.222e-02   1.490
## factor(cpap_treated)1:factor(antithrombotic_agents)1    9.080e-02   1.425
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                  < 2e-16 ***
## rcs(alder)alder                                       0.000731 ***
## rcs(alder)alder'                                      0.087214 .  
## rcs(alder)alder''                                     2.84e-05 ***
## rcs(alder)alder'''                                    3.05e-09 ***
## rcs(GFR)GFR                                           4.18e-07 ***
## rcs(GFR)GFR'                                          0.344211    
## rcs(GFR)GFR''                                         0.695115    
## rcs(GFR)GFR'''                                        0.353275    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             < 2e-16 ***
## rcs(hba1c)hba1c                                        < 2e-16 ***
## rcs(hba1c)hba1c'                                       < 2e-16 ***
## rcs(hba1c)hba1c''                                      < 2e-16 ***
## rcs(hba1c)hba1c'''                                     < 2e-16 ***
## factor(rokare)1                                        < 2e-16 ***
## factor(antithrombotic_agents)1                         < 2e-16 ***
## factor(sex)1                                           < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04                       0.558915    
## rcs(DispInkKEHB04)DispInkKEHB04'                       < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                      < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04'''                    9.00e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         < 2e-16 ***
## rcs(systoliskt)systoliskt                              < 2e-16 ***
## rcs(systoliskt)systoliskt'                             < 2e-16 ***
## rcs(systoliskt)systoliskt''                            < 2e-16 ***
## rcs(systoliskt)systoliskt'''                           < 2e-16 ***
## rcs(bmi)bmi                                           0.027512 *  
## rcs(bmi)bmi'                                          0.704276    
## rcs(bmi)bmi''                                         0.416796    
## rcs(bmi)bmi'''                                        0.109805    
## factor(stroke_history)1                                < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           < 2e-16 ***
## rcs(kolesterol)kolesterol                              < 2e-16 ***
## rcs(kolesterol)kolesterol'                             < 2e-16 ***
## rcs(kolesterol)kolesterol''                            < 2e-16 ***
## rcs(kolesterol)kolesterol'''                           < 2e-16 ***
## factor(FodelseLand_EU27_2020)1                         < 2e-16 ***
## factor(lipid_modifying_agents)1                        < 2e-16 ***
## factor(ami_history)1                                   < 2e-16 ***
## rcs(time_to_cpap_start)time_to_cpap_start             0.946728    
## rcs(time_to_cpap_start)time_to_cpap_start'            0.073544 .  
## rcs(time_to_cpap_start)time_to_cpap_start''           0.396327    
## rcs(time_to_cpap_start)time_to_cpap_start'''          0.338898    
## factor(Sun2000niva_old)2                              3.19e-08 ***
## factor(Sun2000niva_old)3                              0.000110 ***
## factor(Sun2000niva_old)4                              5.23e-07 ***
## factor(Sun2000niva_old)5                               < 2e-16 ***
## factor(Sun2000niva_old)6                               < 2e-16 ***
## factor(Sun2000niva_old)7                              5.20e-07 ***
## factor(Civil)1                                        0.000499 ***
## factor(antihypertensive_comb)1                        0.082642 .  
## rcs(alder)alder:rcs(GFR)GFR                           0.415503    
## rcs(alder)alder':rcs(GFR)GFR                          0.099836 .  
## rcs(alder)alder'':rcs(GFR)GFR                         0.000586 ***
## rcs(alder)alder''':rcs(GFR)GFR                        3.87e-06 ***
## rcs(alder)alder:rcs(GFR)GFR'                          0.787288    
## rcs(alder)alder':rcs(GFR)GFR'                         0.034527 *  
## rcs(alder)alder'':rcs(GFR)GFR'                        0.000389 ***
## rcs(alder)alder''':rcs(GFR)GFR'                       1.83e-05 ***
## rcs(alder)alder:rcs(GFR)GFR''                         0.930302    
## rcs(alder)alder':rcs(GFR)GFR''                        0.021113 *  
## rcs(alder)alder'':rcs(GFR)GFR''                       0.001023 ** 
## rcs(alder)alder''':rcs(GFR)GFR''                      0.000298 ***
## rcs(alder)alder:rcs(GFR)GFR'''                        0.673994    
## rcs(alder)alder':rcs(GFR)GFR'''                       0.018920 *  
## rcs(alder)alder'':rcs(GFR)GFR'''                      0.002840 ** 
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.002350 ** 
## rcs(alder)alder:rcs(bmi)bmi                           0.185566    
## rcs(alder)alder':rcs(bmi)bmi                          0.119400    
## rcs(alder)alder'':rcs(bmi)bmi                         0.006615 ** 
## rcs(alder)alder''':rcs(bmi)bmi                        0.000234 ***
## rcs(alder)alder:rcs(bmi)bmi'                          0.083108 .  
## rcs(alder)alder':rcs(bmi)bmi'                         0.007544 ** 
## rcs(alder)alder'':rcs(bmi)bmi'                        5.37e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi'                       1.76e-07 ***
## rcs(alder)alder:rcs(bmi)bmi''                         0.052696 .  
## rcs(alder)alder':rcs(bmi)bmi''                        0.001968 ** 
## rcs(alder)alder'':rcs(bmi)bmi''                       1.50e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi''                      4.70e-08 ***
## rcs(alder)alder:rcs(bmi)bmi'''                        0.040927 *  
## rcs(alder)alder':rcs(bmi)bmi'''                       0.000984 ***
## rcs(alder)alder'':rcs(bmi)bmi'''                      1.18e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi'''                     5.69e-08 ***
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.136351    
## factor(cpap_treated)1:factor(antithrombotic_agents)1  0.154200    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  4.271e-01  2.342e+00
## rcs(alder)alder                                        2.786e+00  3.590e-01
## rcs(alder)alder'                                       2.477e-01  4.038e+00
## rcs(alder)alder''                                      4.376e+07  2.285e-08
## rcs(alder)alder'''                                     3.548e-17  2.818e+16
## rcs(GFR)GFR                                            4.665e-01  2.143e+00
## rcs(GFR)GFR'                                           2.485e+00  4.025e-01
## rcs(GFR)GFR''                                          1.337e+01  7.479e-02
## rcs(GFR)GFR'''                                         2.508e-05  3.988e+04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                6.110e+03  1.637e-04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00        Inf
## rcs(hba1c)hba1c                                        5.797e-01  1.725e+00
## rcs(hba1c)hba1c'                                       2.056e+04  4.864e-05
## rcs(hba1c)hba1c''                                      4.529e-13  2.208e+12
## rcs(hba1c)hba1c'''                                     2.467e+08  4.054e-09
## factor(rokare)1                                        1.494e+00  6.694e-01
## factor(antithrombotic_agents)1                         1.264e+00  7.911e-01
## factor(sex)1                                           7.233e-01  1.383e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        1.041e+00  9.602e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       4.436e-11  2.254e+10
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.339e+25  7.470e-26
## rcs(DispInkKEHB04)DispInkKEHB04'''                     7.757e-17  1.289e+16
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            4.575e+02  2.186e-03
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        5.851e-320        Inf
## rcs(systoliskt)systoliskt                              7.099e-01  1.409e+00
## rcs(systoliskt)systoliskt'                             3.302e+00  3.029e-01
## rcs(systoliskt)systoliskt''                            2.680e-04  3.731e+03
## rcs(systoliskt)systoliskt'''                           3.376e+07  2.962e-08
## rcs(bmi)bmi                                            6.194e-01  1.615e+00
## rcs(bmi)bmi'                                           1.903e+00  5.255e-01
## rcs(bmi)bmi''                                          1.841e+03  5.431e-04
## rcs(bmi)bmi'''                                         2.036e-09  4.910e+08
## factor(stroke_history)1                                1.426e+00  7.015e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              4.044e+01  2.473e-02
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             0.000e+00        Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''                  Inf  0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           7.820e-41  1.279e+40
## rcs(kolesterol)kolesterol                              8.217e-01  1.217e+00
## rcs(kolesterol)kolesterol'                             5.003e+00  1.999e-01
## rcs(kolesterol)kolesterol''                            7.110e-07  1.407e+06
## rcs(kolesterol)kolesterol'''                           4.825e+13  2.073e-14
## factor(FodelseLand_EU27_2020)1                         1.196e+00  8.360e-01
## factor(lipid_modifying_agents)1                        8.632e-01  1.158e+00
## factor(ami_history)1                                   1.223e+00  8.174e-01
## rcs(time_to_cpap_start)time_to_cpap_start              9.979e-01  1.002e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             1.131e+00  8.840e-01
## rcs(time_to_cpap_start)time_to_cpap_start''            8.139e-01  1.229e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           3.797e-01  2.633e+00
## factor(Sun2000niva_old)2                               1.054e+00  9.487e-01
## factor(Sun2000niva_old)3                               9.755e-01  1.025e+00
## factor(Sun2000niva_old)4                               9.544e-01  1.048e+00
## factor(Sun2000niva_old)5                               9.141e-01  1.094e+00
## factor(Sun2000niva_old)6                               8.845e-01  1.131e+00
## factor(Sun2000niva_old)7                               8.278e-01  1.208e+00
## factor(Civil)1                                         1.024e+00  9.766e-01
## factor(antihypertensive_comb)1                         9.900e-01  1.010e+00
## rcs(alder)alder:rcs(GFR)GFR                            1.111e+00  9.002e-01
## rcs(alder)alder':rcs(GFR)GFR                           5.589e-01  1.789e+00
## rcs(alder)alder'':rcs(GFR)GFR                          5.458e+02  1.832e-03
## rcs(alder)alder''':rcs(GFR)GFR                         2.588e-06  3.864e+05
## rcs(alder)alder:rcs(GFR)GFR'                           1.257e+00  7.954e-01
## rcs(alder)alder':rcs(GFR)GFR'                          1.145e+02  8.735e-03
## rcs(alder)alder'':rcs(GFR)GFR'                         2.827e-18  3.538e+17
## rcs(alder)alder''':rcs(GFR)GFR'                        7.861e+31  1.272e-32
## rcs(alder)alder:rcs(GFR)GFR''                          1.655e+00  6.041e-01
## rcs(alder)alder':rcs(GFR)GFR''                         2.799e-16  3.573e+15
## rcs(alder)alder'':rcs(GFR)GFR''                       1.612e+115 6.205e-116
## rcs(alder)alder''':rcs(GFR)GFR''                      1.045e-197 9.568e+196
## rcs(alder)alder:rcs(GFR)GFR'''                         1.641e-02  6.092e+01
## rcs(alder)alder':rcs(GFR)GFR'''                        3.755e+27  2.663e-28
## rcs(alder)alder'':rcs(GFR)GFR'''                      1.389e-188 7.200e+187
## rcs(alder)alder''':rcs(GFR)GFR'''                     4.895e+307 2.043e-308
## rcs(alder)alder:rcs(bmi)bmi                            1.265e+00  7.903e-01
## rcs(alder)alder':rcs(bmi)bmi                           4.472e-01  2.236e+00
## rcs(alder)alder'':rcs(bmi)bmi                          2.050e+03  4.879e-04
## rcs(alder)alder''':rcs(bmi)bmi                         8.257e-08  1.211e+07
## rcs(alder)alder:rcs(bmi)bmi'                           8.609e-02  1.162e+01
## rcs(alder)alder':rcs(bmi)bmi'                          4.617e+04  2.166e-05
## rcs(alder)alder'':rcs(bmi)bmi'                         1.142e-38  8.753e+37
## rcs(alder)alder''':rcs(bmi)bmi'                        4.631e+77  2.159e-78
## rcs(alder)alder:rcs(bmi)bmi''                          3.240e+06  3.087e-07
## rcs(alder)alder':rcs(bmi)bmi''                         2.964e-30  3.374e+29
## rcs(alder)alder'':rcs(bmi)bmi''                       4.028e+222 2.483e-223
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00        Inf
## rcs(alder)alder:rcs(bmi)bmi'''                         5.390e-10  1.855e+09
## rcs(alder)alder':rcs(bmi)bmi'''                        3.410e+42  2.932e-43
## rcs(alder)alder'':rcs(bmi)bmi'''                      1.485e-306 6.735e+305
## rcs(alder)alder''':rcs(bmi)bmi'''                            Inf  0.000e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  1.147e+00  8.717e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1   1.138e+00  8.786e-01
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  3.677e-01  4.960e-01
## rcs(alder)alder                                        1.537e+00  5.048e+00
## rcs(alder)alder'                                       5.003e-02  1.226e+00
## rcs(alder)alder''                                      1.157e+04  1.656e+11
## rcs(alder)alder'''                                     1.294e-22  9.727e-12
## rcs(GFR)GFR                                            3.472e-01  6.268e-01
## rcs(GFR)GFR'                                           3.769e-01  1.638e+01
## rcs(GFR)GFR''                                          3.122e-05  5.727e+06
## rcs(GFR)GFR'''                                         4.843e-15  1.299e+05
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                4.114e+03  9.074e+03
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00  0.000e+00
## rcs(hba1c)hba1c                                        5.493e-01  6.118e-01
## rcs(hba1c)hba1c'                                       7.514e+03  5.626e+04
## rcs(hba1c)hba1c''                                      1.051e-14  1.952e-11
## rcs(hba1c)hba1c'''                                     6.569e+06  9.264e+09
## factor(rokare)1                                        1.473e+00  1.515e+00
## factor(antithrombotic_agents)1                         1.250e+00  1.278e+00
## factor(sex)1                                           7.152e-01  7.314e-01
## rcs(DispInkKEHB04)DispInkKEHB04                        9.089e-01  1.193e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       1.800e-12  1.093e-09
## rcs(DispInkKEHB04)DispInkKEHB04''                      9.302e+20  1.926e+29
## rcs(DispInkKEHB04)DispInkKEHB04'''                     9.167e-21  6.563e-13
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            3.371e+02  6.208e+02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         0.000e+00 2.312e-302
## rcs(systoliskt)systoliskt                              6.942e-01  7.260e-01
## rcs(systoliskt)systoliskt'                             2.926e+00  3.727e+00
## rcs(systoliskt)systoliskt''                            9.446e-05  7.605e-04
## rcs(systoliskt)systoliskt'''                           2.771e+06  4.112e+08
## rcs(bmi)bmi                                            4.045e-01  9.483e-01
## rcs(bmi)bmi'                                           6.865e-02  5.275e+01
## rcs(bmi)bmi''                                          2.420e-05  1.401e+11
## rcs(bmi)bmi'''                                         4.532e-20  9.152e+01
## factor(stroke_history)1                                1.400e+00  1.452e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              3.280e+01  4.987e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             0.000e+00  0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''                  Inf        Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           1.580e-43  3.871e-38
## rcs(kolesterol)kolesterol                              8.021e-01  8.418e-01
## rcs(kolesterol)kolesterol'                             4.367e+00  5.732e+00
## rcs(kolesterol)kolesterol''                            2.596e-07  1.947e-06
## rcs(kolesterol)kolesterol'''                           5.412e+12  4.301e+14
## factor(FodelseLand_EU27_2020)1                         1.179e+00  1.214e+00
## factor(lipid_modifying_agents)1                        8.536e-01  8.728e-01
## factor(ami_history)1                                   1.203e+00  1.244e+00
## rcs(time_to_cpap_start)time_to_cpap_start              9.369e-01  1.063e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             9.883e-01  1.295e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            5.057e-01  1.310e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           5.220e-02  2.762e+00
## factor(Sun2000niva_old)2                               1.035e+00  1.074e+00
## factor(Sun2000niva_old)3                               9.633e-01  9.878e-01
## factor(Sun2000niva_old)4                               9.372e-01  9.720e-01
## factor(Sun2000niva_old)5                               8.948e-01  9.339e-01
## factor(Sun2000niva_old)6                               8.659e-01  9.035e-01
## factor(Sun2000niva_old)7                               7.690e-01  8.912e-01
## factor(Civil)1                                         1.010e+00  1.038e+00
## factor(antihypertensive_comb)1                         9.789e-01  1.001e+00
## rcs(alder)alder:rcs(GFR)GFR                            8.625e-01  1.431e+00
## rcs(alder)alder':rcs(GFR)GFR                           2.795e-01  1.118e+00
## rcs(alder)alder'':rcs(GFR)GFR                          1.502e+01  1.983e+04
## rcs(alder)alder''':rcs(GFR)GFR                         1.101e-08  6.082e-04
## rcs(alder)alder:rcs(GFR)GFR'                           2.385e-01  6.628e+00
## rcs(alder)alder':rcs(GFR)GFR'                          1.412e+00  9.280e+03
## rcs(alder)alder'':rcs(GFR)GFR'                         5.696e-28  1.403e-08
## rcs(alder)alder''':rcs(GFR)GFR'                        2.012e+17  3.071e+46
## rcs(alder)alder:rcs(GFR)GFR''                          2.063e-05  1.328e+05
## rcs(alder)alder':rcs(GFR)GFR''                         1.688e-29  4.639e-03
## rcs(alder)alder'':rcs(GFR)GFR''                        2.832e+46 9.172e+183
## rcs(alder)alder''':rcs(GFR)GFR''                      1.929e-304  5.662e-91
## rcs(alder)alder:rcs(GFR)GFR'''                         7.939e-11  3.394e+06
## rcs(alder)alder':rcs(GFR)GFR'''                        3.534e+04  3.990e+50
## rcs(alder)alder'':rcs(GFR)GFR'''                      5.973e-312  3.230e-65
## rcs(alder)alder''':rcs(GFR)GFR'''                     2.775e+109        Inf
## rcs(alder)alder:rcs(bmi)bmi                            8.931e-01  1.793e+00
## rcs(alder)alder':rcs(bmi)bmi                           1.624e-01  1.231e+00
## rcs(alder)alder'':rcs(bmi)bmi                          8.347e+00  5.033e+05
## rcs(alder)alder''':rcs(bmi)bmi                         1.390e-11  4.905e-04
## rcs(alder)alder:rcs(bmi)bmi'                           5.374e-03  1.379e+00
## rcs(alder)alder':rcs(bmi)bmi'                          1.749e+01  1.219e+08
## rcs(alder)alder'':rcs(bmi)bmi'                         4.413e-57  2.958e-20
## rcs(alder)alder''':rcs(bmi)bmi'                        3.322e+48 6.455e+106
## rcs(alder)alder:rcs(bmi)bmi''                          8.398e-01  1.250e+13
## rcs(alder)alder':rcs(bmi)bmi''                         5.931e-49  1.481e-11
## rcs(alder)alder'':rcs(bmi)bmi''                       6.685e+121        Inf
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00 1.987e-287
## rcs(alder)alder:rcs(bmi)bmi'''                         7.004e-19  4.147e-01
## rcs(alder)alder':rcs(bmi)bmi'''                        1.711e+17  6.798e+67
## rcs(alder)alder'':rcs(bmi)bmi'''                       0.000e+00 9.488e-170
## rcs(alder)alder''':rcs(bmi)bmi'''                            Inf        Inf
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  9.575e-01  1.375e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1   9.526e-01  1.360e+00
## 
## Concordance= 0.8  (se = 0.001 )
## Likelihood ratio test= 203987  on 94 df,   p=<2e-16
## Wald test            = 188420  on 94 df,   p=<2e-16
## Score (logrank) test = 283989  on 94 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7996224 
## C-index test: 0.7996264[1] "### FORMULA 2 ###"
## Start:  AIC=4042829
## Surv(time_to_death, death) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + rcs(alder)                      4 3884854
## + factor(GFR_high)                1 4010125
## + factor(antithrombotic_agents)   1 4013290
## + rcs(DispInkKEHB04)              4 4016154
## + factor(Civil)                   1 4019043
## + factor(Sun2000niva_old)         6 4020250
## + rcs(bmi)                        4 4030892
## + factor(stroke_history)          1 4034213
## + rcs(time_to_cpap_start)         4 4036876
## + factor(FodelseLand_EU27_2020)   1 4036888
## + factor(ami_history)             1 4037454
## + rcs(Raks_AndelArblosInk)        4 4038022
## + factor(kolesterol_high)         1 4038416
## + rcs(Raks_AndelEkBisInk)         4 4038478
## + factor(antihypertensive_comb)   1 4038619
## + rcs(Raks_AndelSjukInk)          4 4038730
## + factor(hba1c_high)              1 4041385
## + factor(systoliskt_high)         1 4042562
## + factor(lipid_modifying_agents)  1 4042730
## + factor(sex)                     1 4042817
## + factor(rokare)                  1 4042828
## <none>                              4042829
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3884854
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 4 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + rcs(Raks_AndelSjukInk)          4 3879786
## + rcs(Raks_AndelEkBisInk)         4 3880643
## + factor(antithrombotic_agents)   1 3880705
## + rcs(Raks_AndelArblosInk)        4 3880877
## + factor(rokare)                  1 3881068
## + factor(GFR_high)                1 3881869
## + factor(sex)                     1 3881934
## + rcs(DispInkKEHB04)              4 3882139
## + factor(stroke_history)          1 3882396
## + factor(hba1c_high)              1 3883125
## + factor(ami_history)             1 3883210
## + rcs(time_to_cpap_start)         4 3883401
## + factor(Sun2000niva_old)         6 3883547
## + factor(kolesterol_high)         1 3883784
## + rcs(bmi)                        4 3883879
## + factor(systoliskt_high)         1 3884282
## + factor(FodelseLand_EU27_2020)   1 3884723
## + factor(Civil)                   1 3884783
## + factor(antihypertensive_comb)   1 3884828
## + factor(lipid_modifying_agents)  1 3884844
## <none>                              3884854
## - rcs(alder)                      4 4042829
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3879786
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df     AIC
## + factor(antithrombotic_agents)   1 3875646
## + factor(rokare)                  1 3876020
## + rcs(DispInkKEHB04)              4 3876531
## + factor(GFR_high)                1 3876817
## + factor(sex)                     1 3876837
## + rcs(Raks_AndelEkBisInk)         4 3877284
## + factor(stroke_history)          1 3877366
## + rcs(Raks_AndelArblosInk)        4 3877633
## + factor(hba1c_high)              1 3878067
## + factor(ami_history)             1 3878170
## + rcs(time_to_cpap_start)         4 3878289
## + factor(Sun2000niva_old)         6 3878408
## + factor(kolesterol_high)         1 3878713
## + rcs(bmi)                        4 3878817
## + factor(systoliskt_high)         1 3879230
## + factor(FodelseLand_EU27_2020)   1 3879642
## + factor(Civil)                   1 3879734
## + factor(antihypertensive_comb)   1 3879749
## + factor(lipid_modifying_agents)  1 3879781
## <none>                              3879786
## - rcs(Raks_AndelSjukInk)          4 3884854
## - rcs(alder)                      4 4038730
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3875646
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(rokare)                                      1 3871910
## + rcs(DispInkKEHB04)                                  4 3872475
## + rcs(Raks_AndelEkBisInk)                             4 3873044
## + factor(GFR_high)                                    1 3873091
## + factor(sex)                                         1 3873370
## + rcs(Raks_AndelArblosInk)                            4 3873374
## + factor(hba1c_high)                                  1 3874113
## + factor(stroke_history)                              1 3874214
## + factor(Sun2000niva_old)                             6 3874367
## + rcs(time_to_cpap_start)                             4 3874436
## + rcs(bmi)                                            4 3874599
## + factor(ami_history)                                 1 3874994
## + factor(kolesterol_high)                             1 3875105
## + factor(lipid_modifying_agents)                      1 3875142
## + factor(systoliskt_high)                             1 3875264
## + factor(FodelseLand_EU27_2020)                       1 3875521
## + factor(Civil)                                       1 3875613
## + factor(antihypertensive_comb)                       1 3875620
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3875644
## <none>                                                  3875646
## - factor(antithrombotic_agents)                       1 3879786
## - rcs(Raks_AndelSjukInk)                              4 3880705
## - rcs(alder)                                          4 4009732
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3871910
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(DispInkKEHB04)                                  4 3869077
## + factor(GFR_high)                                    1 3869219
## + rcs(Raks_AndelEkBisInk)                             4 3869466
## + factor(sex)                                         1 3869593
## + rcs(Raks_AndelArblosInk)                            4 3869677
## + factor(hba1c_high)                                  1 3870402
## + factor(stroke_history)                              1 3870515
## + rcs(time_to_cpap_start)                             4 3870739
## + factor(Sun2000niva_old)                             6 3870765
## + rcs(bmi)                                            4 3870873
## + factor(ami_history)                                 1 3871253
## + factor(kolesterol_high)                             1 3871374
## + factor(lipid_modifying_agents)                      1 3871414
## + factor(systoliskt_high)                             1 3871522
## + factor(FodelseLand_EU27_2020)                       1 3871740
## + factor(Civil)                                       1 3871871
## + factor(antihypertensive_comb)                       1 3871897
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3871908
## <none>                                                  3871910
## - factor(rokare)                                      1 3875646
## - factor(antithrombotic_agents)                       1 3876020
## - rcs(Raks_AndelSjukInk)                              4 3876959
## - rcs(alder)                                          4 4009706
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3869077
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(sex)                                         1 3865732
## + factor(GFR_high)                                    1 3866558
## + rcs(Raks_AndelArblosInk)                            4 3866729
## + rcs(Raks_AndelEkBisInk)                             4 3866883
## + factor(stroke_history)                              1 3867672
## + factor(hba1c_high)                                  1 3867771
## + rcs(bmi)                                            4 3868167
## + factor(ami_history)                                 1 3868397
## + rcs(time_to_cpap_start)                             4 3868415
## + factor(kolesterol_high)                             1 3868547
## + factor(lipid_modifying_agents)                      1 3868614
## + factor(FodelseLand_EU27_2020)                       1 3868639
## + factor(Sun2000niva_old)                             6 3868672
## + factor(systoliskt_high)                             1 3868682
## + factor(Civil)                                       1 3868934
## + factor(antihypertensive_comb)                       1 3869066
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3869075
## <none>                                                  3869077
## - rcs(DispInkKEHB04)                                  4 3871910
## - factor(rokare)                                      1 3872475
## - factor(antithrombotic_agents)                       1 3873107
## - rcs(Raks_AndelSjukInk)                              4 3874645
## - rcs(alder)                                          4 3987930
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3865732
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(GFR_high)                                    1 3862719
## + rcs(Raks_AndelArblosInk)                            4 3863426
## + rcs(Raks_AndelEkBisInk)                             4 3863693
## + rcs(bmi)                                            4 3864271
## + factor(stroke_history)                              1 3864401
## + factor(hba1c_high)                                  1 3864529
## + rcs(time_to_cpap_start)                             4 3865108
## + factor(lipid_modifying_agents)                      1 3865230
## + factor(ami_history)                                 1 3865257
## + factor(FodelseLand_EU27_2020)                       1 3865308
## + factor(Sun2000niva_old)                             6 3865312
## + factor(systoliskt_high)                             1 3865383
## + factor(kolesterol_high)                             1 3865440
## + factor(antihypertensive_comb)                       1 3865721
## + factor(Civil)                                       1 3865724
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3865731
## <none>                                                  3865732
## - factor(antithrombotic_agents)                       1 3868971
## - factor(sex)                                         1 3869077
## - factor(rokare)                                      1 3869111
## - rcs(DispInkKEHB04)                                  4 3869593
## - rcs(Raks_AndelSjukInk)                              4 3871462
## - rcs(alder)                                          4 3987799
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3862719
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(Raks_AndelArblosInk)                            4 3860442
## + rcs(Raks_AndelEkBisInk)                             4 3860695
## + rcs(bmi)                                            4 3861272
## + factor(stroke_history)                              1 3861439
## + rcs(alder):factor(GFR_high)                         4 3861505
## + factor(hba1c_high)                                  1 3861561
## + factor(lipid_modifying_agents)                      1 3862110
## + rcs(time_to_cpap_start)                             4 3862162
## + factor(ami_history)                                 1 3862309
## + factor(Sun2000niva_old)                             6 3862323
## + factor(FodelseLand_EU27_2020)                       1 3862334
## + factor(kolesterol_high)                             1 3862384
## + factor(systoliskt_high)                             1 3862449
## + factor(antihypertensive_comb)                       1 3862659
## + factor(Civil)                                       1 3862713
## + factor(cpap_treated):factor(GFR_high)               1 3862717
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3862718
## <none>                                                  3862719
## - factor(antithrombotic_agents)                       1 3865520
## - factor(GFR_high)                                    1 3865732
## - factor(rokare)                                      1 3866248
## - rcs(DispInkKEHB04)                                  4 3866453
## - factor(sex)                                         1 3866558
## - rcs(Raks_AndelSjukInk)                              4 3868429
## - rcs(alder)                                          4 3968328
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3860442
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(bmi)                                            4 3858991
## + factor(stroke_history)                              1 3859163
## + rcs(alder):factor(GFR_high)                         4 3859234
## + rcs(Raks_AndelEkBisInk)                             4 3859282
## + factor(hba1c_high)                                  1 3859298
## + factor(lipid_modifying_agents)                      1 3859871
## + rcs(time_to_cpap_start)                             4 3859930
## + factor(FodelseLand_EU27_2020)                       1 3859959
## + factor(ami_history)                                 1 3860026
## + factor(Sun2000niva_old)                             6 3860043
## + factor(kolesterol_high)                             1 3860117
## + factor(systoliskt_high)                             1 3860180
## + factor(antihypertensive_comb)                       1 3860400
## + factor(Civil)                                       1 3860432
## + factor(cpap_treated):factor(GFR_high)               1 3860440
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3860441
## <none>                                                  3860442
## - rcs(Raks_AndelArblosInk)                            4 3862719
## - factor(antithrombotic_agents)                       1 3863346
## - factor(GFR_high)                                    1 3863426
## - factor(rokare)                                      1 3863929
## - factor(sex)                                         1 3864234
## - rcs(Raks_AndelSjukInk)                              4 3864273
## - rcs(DispInkKEHB04)                                  4 3864319
## - rcs(alder)                                          4 3964135
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3858991
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(stroke_history)                              1 3857679
## + factor(hba1c_high)                                  1 3857808
## + rcs(alder):factor(GFR_high)                         4 3857813
## + rcs(Raks_AndelEkBisInk)                             4 3857832
## + rcs(alder):rcs(bmi)                                16 3858270
## + rcs(time_to_cpap_start)                             4 3858453
## + factor(lipid_modifying_agents)                      1 3858454
## + factor(FodelseLand_EU27_2020)                       1 3858522
## + factor(ami_history)                                 1 3858571
## + factor(Sun2000niva_old)                             6 3858597
## + factor(kolesterol_high)                             1 3858658
## + factor(systoliskt_high)                             1 3858746
## + factor(antihypertensive_comb)                       1 3858946
## + factor(Civil)                                       1 3858980
## + factor(cpap_treated):factor(GFR_high)               1 3858989
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3858990
## <none>                                                  3858991
## - rcs(bmi)                                            4 3860442
## - rcs(Raks_AndelArblosInk)                            4 3861272
## - factor(antithrombotic_agents)                       1 3861902
## - factor(GFR_high)                                    1 3861960
## - factor(rokare)                                      1 3862466
## - rcs(DispInkKEHB04)                                  4 3862768
## - rcs(Raks_AndelSjukInk)                              4 3862817
## - factor(sex)                                         1 3863322
## - rcs(alder)                                          4 3955641
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3857679
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(hba1c_high)                                  1 3856487
## + rcs(alder):factor(GFR_high)                         4 3856500
## + rcs(Raks_AndelEkBisInk)                             4 3856524
## + rcs(alder):rcs(bmi)                                16 3856991
## + factor(lipid_modifying_agents)                      1 3857047
## + rcs(time_to_cpap_start)                             4 3857100
## + factor(ami_history)                                 1 3857217
## + factor(FodelseLand_EU27_2020)                       1 3857219
## + factor(Sun2000niva_old)                             6 3857285
## + factor(kolesterol_high)                             1 3857378
## + factor(systoliskt_high)                             1 3857452
## + factor(antihypertensive_comb)                       1 3857633
## + factor(Civil)                                       1 3857667
## + factor(cpap_treated):factor(GFR_high)               1 3857677
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3857678
## <none>                                                  3857679
## - factor(stroke_history)                              1 3858991
## - rcs(bmi)                                            4 3859163
## - factor(antithrombotic_agents)                       1 3859844
## - rcs(Raks_AndelArblosInk)                            4 3859959
## - factor(GFR_high)                                    1 3860592
## - factor(rokare)                                      1 3861125
## - rcs(DispInkKEHB04)                                  4 3861451
## - rcs(Raks_AndelSjukInk)                              4 3861475
## - factor(sex)                                         1 3861942
## - rcs(alder)                                          4 3953510
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3856487
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(alder):factor(GFR_high)                         4 3855305
## + rcs(Raks_AndelEkBisInk)                             4 3855352
## + rcs(alder):rcs(bmi)                                16 3855815
## + factor(lipid_modifying_agents)                      1 3855832
## + factor(FodelseLand_EU27_2020)                       1 3856011
## + factor(ami_history)                                 1 3856013
## + rcs(time_to_cpap_start)                             4 3856034
## + factor(Sun2000niva_old)                             6 3856115
## + factor(kolesterol_high)                             1 3856199
## + factor(systoliskt_high)                             1 3856231
## + factor(antihypertensive_comb)                       1 3856446
## + factor(Civil)                                       1 3856478
## + factor(cpap_treated):factor(GFR_high)               1 3856485
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3856485
## <none>                                                  3856487
## - factor(hba1c_high)                                  1 3857679
## - factor(stroke_history)                              1 3857808
## - rcs(bmi)                                            4 3858009
## - factor(antithrombotic_agents)                       1 3858565
## - rcs(Raks_AndelArblosInk)                            4 3858752
## - factor(GFR_high)                                    1 3859365
## - factor(rokare)                                      1 3859916
## - rcs(DispInkKEHB04)                                  4 3860032
## - rcs(Raks_AndelSjukInk)                              4 3860243
## - factor(sex)                                         1 3860609
## - rcs(alder)                                          4 3952338
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3855305
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + rcs(Raks_AndelEkBisInk)                             4 3854170
## + factor(lipid_modifying_agents)                      1 3854637
## + rcs(alder):rcs(bmi)                                16 3854685
## + factor(ami_history)                                 1 3854818
## + factor(FodelseLand_EU27_2020)                       1 3854835
## + rcs(time_to_cpap_start)                             4 3854852
## + factor(Sun2000niva_old)                             6 3854928
## + factor(kolesterol_high)                             1 3855024
## + factor(systoliskt_high)                             1 3855046
## + factor(antihypertensive_comb)                       1 3855256
## + factor(Civil)                                       1 3855293
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3855303
## <none>                                                  3855305
## + factor(cpap_treated):factor(GFR_high)               1 3855307
## - rcs(alder):factor(GFR_high)                         4 3856487
## - factor(hba1c_high)                                  1 3856500
## - factor(stroke_history)                              1 3856627
## - rcs(bmi)                                            4 3856797
## - factor(antithrombotic_agents)                       1 3857333
## - rcs(Raks_AndelArblosInk)                            4 3857563
## - factor(rokare)                                      1 3858780
## - rcs(DispInkKEHB04)                                  4 3858794
## - rcs(Raks_AndelSjukInk)                              4 3859032
## - factor(sex)                                         1 3859456
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3854170
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 33 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 29 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df     AIC
## + factor(lipid_modifying_agents)                      1 3853520
## + factor(FodelseLand_EU27_2020)                       1 3853546
## + rcs(alder):rcs(bmi)                                16 3853567
## + factor(ami_history)                                 1 3853687
## + rcs(time_to_cpap_start)                             4 3853738
## + factor(Sun2000niva_old)                             6 3853783
## + factor(kolesterol_high)                             1 3853895
## + factor(systoliskt_high)                             1 3853917
## + factor(antihypertensive_comb)                       1 3854133
## + factor(Civil)                                       1 3854150
## + factor(cpap_treated):factor(antithrombotic_agents)  1 3854169
## <none>                                                  3854170
## + factor(cpap_treated):factor(GFR_high)               1 3854172
## - rcs(Raks_AndelEkBisInk)                             4 3855305
## - factor(hba1c_high)                                  1 3855346
## - rcs(alder):factor(GFR_high)                         4 3855352
## - factor(stroke_history)                              1 3855489
## - rcs(Raks_AndelArblosInk)                            4 3855573
## - rcs(bmi)                                            4 3855660
## - factor(antithrombotic_agents)                       1 3856252
## - rcs(Raks_AndelSjukInk)                              4 3856597
## - rcs(DispInkKEHB04)                                  4 3857445
## - factor(rokare)                                      1 3857564
## - factor(sex)                                         1 3858211
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## 
## Step:  AIC=3853520
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 30 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 33 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 31 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 34 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 34 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(FodelseLand_EU27_2020)                        1 3852882
## + factor(ami_history)                                  1 3852885
## + rcs(alder):rcs(bmi)                                 16 3852926
## + factor(kolesterol_high)                              1 3853078
## + rcs(time_to_cpap_start)                              4 3853086
## + factor(Sun2000niva_old)                              6 3853118
## + factor(systoliskt_high)                              1 3853245
## + factor(Civil)                                        1 3853502
## + factor(antihypertensive_comb)                        1 3853516
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3853519
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3853519
## <none>                                                   3853520
## + factor(cpap_treated):factor(GFR_high)                1 3853522
## - factor(lipid_modifying_agents)                       1 3854170
## - rcs(Raks_AndelEkBisInk)                              4 3854637
## - rcs(alder):factor(GFR_high)                          4 3854715
## - factor(hba1c_high)                                   1 3854720
## - rcs(Raks_AndelArblosInk)                             4 3854895
## - factor(stroke_history)                               1 3854936
## - rcs(bmi)                                             4 3854973
## - rcs(Raks_AndelSjukInk)                               4 3855904
## - factor(antithrombotic_agents)                        1 3856113
## - rcs(DispInkKEHB04)                                   4 3856759
## - factor(rokare)                                       1 3856908
## - factor(sex)                                          1 3857615
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## 
## Step:  AIC=3852882
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 31 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 34,35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 32 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(ami_history)                                  1 3852240
## + rcs(alder):rcs(bmi)                                 16 3852300
## + factor(kolesterol_high)                              1 3852434
## + rcs(time_to_cpap_start)                              4 3852491
## + factor(Sun2000niva_old)                              6 3852544
## + factor(systoliskt_high)                              1 3852603
## + factor(Civil)                                        1 3852866
## + factor(antihypertensive_comb)                        1 3852873
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3852880
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3852880
## <none>                                                   3852882
## + factor(cpap_treated):factor(GFR_high)                1 3852884
## - factor(FodelseLand_EU27_2020)                        1 3853520
## - factor(lipid_modifying_agents)                       1 3853546
## - rcs(alder):factor(GFR_high)                          4 3854068
## - factor(hba1c_high)                                   1 3854092
## - rcs(Raks_AndelEkBisInk)                              4 3854150
## - factor(stroke_history)                               1 3854291
## - rcs(Raks_AndelArblosInk)                             4 3854301
## - rcs(bmi)                                             4 3854311
## - rcs(Raks_AndelSjukInk)                               4 3855305
## - factor(antithrombotic_agents)                        1 3855447
## - factor(rokare)                                       1 3856326
## - rcs(DispInkKEHB04)                                   4 3856383
## - factor(sex)                                          1 3856949
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## 
## Step:  AIC=3852240
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 32 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 33 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 38 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 43 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 38 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 38 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

##                                                       Df     AIC
## + rcs(alder):rcs(bmi)                                 16 3851662
## + rcs(time_to_cpap_start)                              4 3851808
## + factor(kolesterol_high)                              1 3851833
## + factor(Sun2000niva_old)                              6 3851912
## + factor(systoliskt_high)                              1 3851996
## + factor(Civil)                                        1 3852224
## + factor(antihypertensive_comb)                        1 3852229
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3852238
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3852238
## <none>                                                   3852240
## + factor(cpap_treated):factor(GFR_high)                1 3852242
## - factor(ami_history)                                  1 3852882
## - factor(FodelseLand_EU27_2020)                        1 3852885
## - factor(lipid_modifying_agents)                       1 3853059
## - rcs(alder):factor(GFR_high)                          4 3853440
## - factor(hba1c_high)                                   1 3853467
## - rcs(Raks_AndelEkBisInk)                              4 3853504
## - rcs(Raks_AndelArblosInk)                             4 3853661
## - rcs(bmi)                                             4 3853671
## - factor(stroke_history)                               1 3853709
## - factor(antithrombotic_agents)                        1 3854276
## - rcs(Raks_AndelSjukInk)                               4 3854650
## - factor(rokare)                                       1 3855681
## - rcs(DispInkKEHB04)                                   4 3855724
## - factor(sex)                                          1 3856053
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=3851662
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(alder):factor(GFR_high) + 
##     rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 32,34 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 35 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 33 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 37 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df     AIC
## + rcs(time_to_cpap_start)                              4 3851219
## + factor(kolesterol_high)                              1 3851277
## + factor(Sun2000niva_old)                              6 3851330
## + factor(systoliskt_high)                              1 3851412
## + factor(Civil)                                        1 3851644
## + factor(antihypertensive_comb)                        1 3851652
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3851660
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3851661
## <none>                                                   3851662
## + factor(cpap_treated):factor(GFR_high)                1 3851664
## - rcs(alder):rcs(bmi)                                 16 3852240
## - factor(FodelseLand_EU27_2020)                        1 3852295
## - factor(ami_history)                                  1 3852300
## - factor(lipid_modifying_agents)                       1 3852471
## - rcs(alder):factor(GFR_high)                          4 3852814
## - factor(hba1c_high)                                   1 3852874
## - rcs(Raks_AndelEkBisInk)                              4 3852905
## - rcs(Raks_AndelArblosInk)                             4 3853086
## - factor(stroke_history)                               1 3853096
## - factor(antithrombotic_agents)                        1 3853692
## - rcs(Raks_AndelSjukInk)                               4 3854060
## - factor(rokare)                                       1 3855017
## - rcs(DispInkKEHB04)                                   4 3855108
## - factor(sex)                                          1 3855555
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## 
## Step:  AIC=3851219
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     rcs(alder):factor(GFR_high) + rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 36 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 40 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(kolesterol_high)                              1 3850865
## + factor(Sun2000niva_old)                              6 3850899
## + factor(systoliskt_high)                              1 3850950
## + factor(Civil)                                        1 3851204
## + factor(antihypertensive_comb)                        1 3851208
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3851217
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3851217
## <none>                                                   3851219
## + factor(cpap_treated):factor(GFR_high)                1 3851221
## - rcs(time_to_cpap_start)                              4 3851662
## - factor(FodelseLand_EU27_2020)                        1 3851806
## - rcs(alder):rcs(bmi)                                 16 3851808
## - factor(ami_history)                                  1 3851898
## - factor(lipid_modifying_agents)                       1 3852035
## - factor(hba1c_high)                                   1 3852301
## - rcs(alder):factor(GFR_high)                          4 3852370
## - rcs(Raks_AndelEkBisInk)                              4 3852447
## - rcs(Raks_AndelArblosInk)                             4 3852602
## - factor(stroke_history)                               1 3852690
## - factor(antithrombotic_agents)                        1 3853129
## - rcs(Raks_AndelSjukInk)                               4 3853587
## - rcs(DispInkKEHB04)                                   4 3854136
## - factor(rokare)                                       1 3854579
## - factor(sex)                                          1 3855085
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## 
## Step:  AIC=3850865
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + rcs(alder):factor(GFR_high) + rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 41 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 43 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 43 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 43 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(Sun2000niva_old)                              6 3850549
## + factor(systoliskt_high)                              1 3850615
## + factor(Civil)                                        1 3850850
## + factor(antihypertensive_comb)                        1 3850852
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3850863
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3850863
## <none>                                                   3850865
## + factor(cpap_treated):factor(GFR_high)                1 3850867
## - factor(kolesterol_high)                              1 3851219
## - rcs(time_to_cpap_start)                              4 3851277
## - rcs(alder):rcs(bmi)                                 16 3851433
## - factor(FodelseLand_EU27_2020)                        1 3851458
## - factor(ami_history)                                  1 3851502
## - factor(lipid_modifying_agents)                       1 3851837
## - factor(hba1c_high)                                   1 3851941
## - rcs(alder):factor(GFR_high)                          4 3852008
## - rcs(Raks_AndelEkBisInk)                              4 3852083
## - rcs(Raks_AndelArblosInk)                             4 3852238
## - factor(stroke_history)                               1 3852310
## - factor(antithrombotic_agents)                        1 3852657
## - rcs(Raks_AndelSjukInk)                               4 3853226
## - rcs(DispInkKEHB04)                                   4 3853761
## - factor(rokare)                                       1 3854220
## - factor(sex)                                          1 3854477
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## 
## Step:  AIC=3850549
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + rcs(alder):factor(GFR_high) + 
##     rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 47 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 42 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(systoliskt_high)                              1 3850293
## + factor(antihypertensive_comb)                        1 3850533
## + factor(Civil)                                        1 3850538
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3850547
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3850547
## <none>                                                   3850549
## + factor(cpap_treated):factor(GFR_high)                1 3850551
## - factor(Sun2000niva_old)                              6 3850865
## - factor(kolesterol_high)                              1 3850899
## - rcs(time_to_cpap_start)                              4 3850950
## - factor(FodelseLand_EU27_2020)                        1 3851084
## - rcs(alder):rcs(bmi)                                 16 3851121
## - factor(ami_history)                                  1 3851177
## - factor(lipid_modifying_agents)                       1 3851533
## - factor(hba1c_high)                                   1 3851607
## - rcs(alder):factor(GFR_high)                          4 3851696
## - rcs(Raks_AndelEkBisInk)                              4 3851773
## - rcs(Raks_AndelArblosInk)                             4 3851915
## - factor(stroke_history)                               1 3851994
## - factor(antithrombotic_agents)                        1 3852331
## - rcs(DispInkKEHB04)                                   4 3852733
## - rcs(Raks_AndelSjukInk)                               4 3852886
## - factor(rokare)                                       1 3853848
## - factor(sex)                                          1 3854155
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## 
## Step:  AIC=3850293
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(systoliskt_high) + 
##     rcs(alder):factor(GFR_high) + rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 44 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 43 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 48 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(Civil)                                        1 3850281
## + factor(antihypertensive_comb)                        1 3850286
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3850291
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3850291
## <none>                                                   3850293
## + factor(cpap_treated):factor(GFR_high)                1 3850295
## - factor(systoliskt_high)                              1 3850549
## - factor(Sun2000niva_old)                              6 3850615
## - factor(kolesterol_high)                              1 3850624
## - rcs(time_to_cpap_start)                              4 3850713
## - factor(FodelseLand_EU27_2020)                        1 3850827
## - rcs(alder):rcs(bmi)                                 16 3850872
## - factor(ami_history)                                  1 3850889
## - factor(lipid_modifying_agents)                       1 3851294
## - factor(hba1c_high)                                   1 3851376
## - rcs(alder):factor(GFR_high)                          4 3851441
## - rcs(Raks_AndelEkBisInk)                              4 3851509
## - rcs(Raks_AndelArblosInk)                             4 3851656
## - factor(stroke_history)                               1 3851720
## - factor(antithrombotic_agents)                        1 3852021
## - rcs(DispInkKEHB04)                                   4 3852470
## - rcs(Raks_AndelSjukInk)                               4 3852622
## - factor(rokare)                                       1 3853595
## - factor(sex)                                          1 3853862
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## 
## Step:  AIC=3850281
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(systoliskt_high) + 
##     factor(Civil) + rcs(alder):factor(GFR_high) + rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 45 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 44 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 49 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(antihypertensive_comb)                        1 3850274
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3850279
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3850279
## <none>                                                   3850281
## + factor(cpap_treated):factor(GFR_high)                1 3850283
## - factor(Civil)                                        1 3850293
## - factor(systoliskt_high)                              1 3850538
## - factor(Sun2000niva_old)                              6 3850599
## - factor(kolesterol_high)                              1 3850611
## - rcs(time_to_cpap_start)                              4 3850698
## - factor(FodelseLand_EU27_2020)                        1 3850813
## - rcs(alder):rcs(bmi)                                 16 3850862
## - factor(ami_history)                                  1 3850876
## - factor(lipid_modifying_agents)                       1 3851280
## - factor(hba1c_high)                                   1 3851361
## - rcs(alder):factor(GFR_high)                          4 3851431
## - rcs(Raks_AndelEkBisInk)                              4 3851503
## - rcs(Raks_AndelArblosInk)                             4 3851646
## - factor(stroke_history)                               1 3851709
## - factor(antithrombotic_agents)                        1 3852008
## - rcs(DispInkKEHB04)                                   4 3852435
## - rcs(Raks_AndelSjukInk)                               4 3852613
## - factor(rokare)                                       1 3853581
## - factor(sex)                                          1 3853736
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## 
## Step:  AIC=3850274
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(systoliskt_high) + 
##     factor(Civil) + factor(antihypertensive_comb) + rcs(alder):factor(GFR_high) + 
##     rcs(alder):rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 46 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 45 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 3850272
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3850272
## <none>                                                   3850274
## + factor(cpap_treated):factor(antihypertensive_comb)   1 3850275
## + factor(cpap_treated):factor(GFR_high)                1 3850276
## - factor(antihypertensive_comb)                        1 3850281
## - factor(Civil)                                        1 3850286
## - factor(systoliskt_high)                              1 3850522
## - factor(Sun2000niva_old)                              6 3850594
## - factor(kolesterol_high)                              1 3850605
## - rcs(time_to_cpap_start)                              4 3850692
## - factor(FodelseLand_EU27_2020)                        1 3850809
## - rcs(alder):rcs(bmi)                                 16 3850855
## - factor(ami_history)                                  1 3850871
## - factor(lipid_modifying_agents)                       1 3851227
## - factor(hba1c_high)                                   1 3851351
## - rcs(alder):factor(GFR_high)                          4 3851427
## - rcs(Raks_AndelEkBisInk)                              4 3851489
## - rcs(Raks_AndelArblosInk)                             4 3851634
## - factor(stroke_history)                               1 3851701
## - factor(antithrombotic_agents)                        1 3852005
## - rcs(DispInkKEHB04)                                   4 3852426
## - rcs(Raks_AndelSjukInk)                               4 3852600
## - factor(rokare)                                       1 3853565
## - factor(sex)                                          1 3853733
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## 
## Step:  AIC=3850272
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(systoliskt_high) + 
##     factor(Civil) + factor(antihypertensive_comb) + rcs(alder):factor(GFR_high) + 
##     rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 46 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 45 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

##                                                       Df     AIC
## + factor(cpap_treated):factor(antithrombotic_agents)   1 3850272
## <none>                                                   3850272
## + factor(cpap_treated):factor(antihypertensive_comb)   1 3850274
## + factor(cpap_treated):factor(GFR_high)                1 3850274
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 3850274
## - factor(antihypertensive_comb)                        1 3850279
## - factor(Civil)                                        1 3850284
## - factor(systoliskt_high)                              1 3850520
## - factor(Sun2000niva_old)                              6 3850592
## - factor(kolesterol_high)                              1 3850604
## - rcs(time_to_cpap_start)                              4 3850690
## - factor(FodelseLand_EU27_2020)                        1 3850807
## - rcs(alder):rcs(bmi)                                 16 3850852
## - factor(ami_history)                                  1 3850869
## - factor(hba1c_high)                                   1 3851349
## - rcs(alder):factor(GFR_high)                          4 3851425
## - rcs(Raks_AndelEkBisInk)                              4 3851487
## - rcs(Raks_AndelArblosInk)                             4 3851632
## - factor(stroke_history)                               1 3851699
## - factor(antithrombotic_agents)                        1 3852002
## - rcs(DispInkKEHB04)                                   4 3852424
## - rcs(Raks_AndelSjukInk)                               4 3852598
## - factor(rokare)                                       1 3853563
## - factor(sex)                                          1 3853730
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## 
## Step:  AIC=3850272
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(systoliskt_high) + 
##     factor(Civil) + factor(antihypertensive_comb) + rcs(alder):factor(GFR_high) + 
##     rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 46 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 45 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 50 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 51 ; coefficient may be infinite.

##                                                       Df     AIC
## <none>                                                   3850272
## - factor(cpap_treated):factor(antithrombotic_agents)   1 3850272
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 3850272
## + factor(cpap_treated):factor(antihypertensive_comb)   1 3850274
## + factor(cpap_treated):factor(GFR_high)                1 3850274
## - factor(antihypertensive_comb)                        1 3850279
## - factor(Civil)                                        1 3850284
## - factor(systoliskt_high)                              1 3850520
## - factor(Sun2000niva_old)                              6 3850592
## - factor(kolesterol_high)                              1 3850603
## - rcs(time_to_cpap_start)                              4 3850690
## - factor(FodelseLand_EU27_2020)                        1 3850806
## - rcs(alder):rcs(bmi)                                 16 3850852
## - factor(ami_history)                                  1 3850869
## - factor(hba1c_high)                                   1 3851349
## - rcs(alder):factor(GFR_high)                          4 3851425
## - rcs(Raks_AndelEkBisInk)                              4 3851487
## - rcs(Raks_AndelArblosInk)                             4 3851632
## - factor(stroke_history)                               1 3851699
## - rcs(DispInkKEHB04)                                   4 3852423
## - rcs(Raks_AndelSjukInk)                               4 3852598
## - factor(rokare)                                       1 3853563
## - factor(sex)                                          1 3853730
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_death, death) ~ factor(cpap_treated) + 
##     rcs(alder) + rcs(Raks_AndelSjukInk) + factor(antithrombotic_agents) + 
##     factor(rokare) + rcs(DispInkKEHB04) + factor(sex) + factor(GFR_high) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(stroke_history) + 
##     factor(hba1c_high) + rcs(Raks_AndelEkBisInk) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(ami_history) + rcs(time_to_cpap_start) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(systoliskt_high) + 
##     factor(Civil) + factor(antihypertensive_comb) + rcs(alder):factor(GFR_high) + 
##     rcs(alder):rcs(bmi) + factor(cpap_treated):factor(lipid_modifying_agents) + 
##     factor(cpap_treated):factor(antithrombotic_agents), data = df_train)
## 
##   n= 562724, number of events= 159490 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                  -8.629e-01   4.219e-01
## rcs(alder)alder                                         6.305e-01   1.878e+00
## rcs(alder)alder'                                       -4.928e-01   6.109e-01
## rcs(alder)alder''                                       8.975e+00   7.900e+03
## rcs(alder)alder'''                                     -2.010e+01   1.873e-09
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 8.896e+00   7.301e+03
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -1.430e+04   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               1.748e+04         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             -3.219e+03   0.000e+00
## factor(antithrombotic_agents)1                          2.384e-01   1.269e+00
## factor(rokare)1                                         4.212e-01   1.524e+00
## rcs(DispInkKEHB04)DispInkKEHB04                         1.540e-02   1.016e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       -2.580e+01   6.255e-12
## rcs(DispInkKEHB04)DispInkKEHB04''                       6.346e+01   3.620e+27
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -4.176e+01   7.289e-19
## factor(sex)1                                           -3.308e-01   7.183e-01
## factor(GFR_high)1                                      -6.172e-01   5.395e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             6.240e+00   5.128e+02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -4.438e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           5.174e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         -7.527e+02   0.000e+00
## rcs(bmi)bmi                                            -5.837e-01   5.578e-01
## rcs(bmi)bmi'                                            1.001e+00   2.721e+00
## rcs(bmi)bmi''                                           6.750e+00   8.544e+02
## rcs(bmi)bmi'''                                         -2.000e+01   2.066e-09
## factor(stroke_history)1                                 3.669e-01   1.443e+00
## factor(hba1c_high)1                                     1.814e-01   1.199e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               3.910e+00   4.989e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -9.783e+02   0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             1.073e+03         Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           -9.683e+01   8.859e-43
## factor(lipid_modifying_agents)1                        -1.719e-01   8.421e-01
## factor(FodelseLand_EU27_2020)1                          1.704e-01   1.186e+00
## factor(ami_history)1                                    2.147e-01   1.240e+00
## rcs(time_to_cpap_start)time_to_cpap_start              -9.997e-03   9.901e-01
## rcs(time_to_cpap_start)time_to_cpap_start'              1.835e-01   1.201e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            -4.652e-01   6.280e-01
## rcs(time_to_cpap_start)time_to_cpap_start'''           -3.067e-01   7.358e-01
## factor(kolesterol_high)1                               -1.138e-01   8.924e-01
## factor(Sun2000niva_old)2                                4.930e-02   1.051e+00
## factor(Sun2000niva_old)3                               -3.102e-02   9.695e-01
## factor(Sun2000niva_old)4                               -5.742e-02   9.442e-01
## factor(Sun2000niva_old)5                               -1.037e-01   9.015e-01
## factor(Sun2000niva_old)6                               -1.366e-01   8.723e-01
## factor(Sun2000niva_old)7                               -2.049e-01   8.147e-01
## factor(systoliskt_high)1                               -9.204e-02   9.121e-01
## factor(Civil)1                                          2.571e-02   1.026e+00
## factor(antihypertensive_comb)1                         -1.737e-02   9.828e-01
## rcs(alder)alder:factor(GFR_high)1                       5.639e-01   1.758e+00
## rcs(alder)alder':factor(GFR_high)1                     -7.356e-02   9.291e-01
## rcs(alder)alder'':factor(GFR_high)1                    -4.228e-02   9.586e-01
## rcs(alder)alder''':factor(GFR_high)1                   -1.081e+00   3.391e-01
## rcs(alder)alder:rcs(bmi)bmi                             2.466e-01   1.280e+00
## rcs(alder)alder':rcs(bmi)bmi                           -7.987e-01   4.499e-01
## rcs(alder)alder'':rcs(bmi)bmi                           8.165e+00   3.516e+03
## rcs(alder)alder''':rcs(bmi)bmi                         -1.805e+01   1.446e-08
## rcs(alder)alder:rcs(bmi)bmi'                           -2.543e+00   7.862e-02
## rcs(alder)alder':rcs(bmi)bmi'                           1.123e+01   7.553e+04
## rcs(alder)alder'':rcs(bmi)bmi'                         -9.341e+01   2.702e-41
## rcs(alder)alder''':rcs(bmi)bmi'                         1.936e+02   1.150e+84
## rcs(alder)alder:rcs(bmi)bmi''                           1.581e+01   7.338e+06
## rcs(alder)alder':rcs(bmi)bmi''                         -7.180e+01   6.581e-32
## rcs(alder)alder'':rcs(bmi)bmi''                         5.481e+02  1.049e+238
## rcs(alder)alder''':rcs(bmi)bmi''                       -1.110e+03   0.000e+00
## rcs(alder)alder:rcs(bmi)bmi'''                         -2.275e+01   1.323e-10
## rcs(alder)alder':rcs(bmi)bmi'''                         1.039e+02   1.274e+45
## rcs(alder)alder'':rcs(bmi)bmi'''                       -7.529e+02   0.000e+00
## rcs(alder)alder''':rcs(bmi)bmi'''                       1.502e+03         Inf
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.354e-01   1.145e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1    1.297e-01   1.138e+00
##                                                          se(coef)       z
## factor(cpap_treated)1                                   7.608e-02 -11.342
## rcs(alder)alder                                         2.335e-01   2.700
## rcs(alder)alder'                                        6.442e-01  -0.765
## rcs(alder)alder''                                       3.379e+00   2.656
## rcs(alder)alder'''                                      5.199e+00  -3.865
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 2.012e-01  44.217
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                3.572e+02 -40.024
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               4.385e+02  39.866
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              8.265e+01 -38.955
## factor(antithrombotic_agents)1                          5.758e-03  41.408
## factor(rokare)1                                         7.023e-03  59.979
## rcs(DispInkKEHB04)DispInkKEHB04                         6.089e-02   0.253
## rcs(DispInkKEHB04)DispInkKEHB04'                        1.548e+00 -16.663
## rcs(DispInkKEHB04)DispInkKEHB04''                       4.705e+00  13.486
## rcs(DispInkKEHB04)DispInkKEHB04'''                      4.511e+00  -9.257
## factor(sex)1                                            5.655e-03 -58.502
## factor(GFR_high)1                                       1.451e-01  -4.253
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             1.549e-01  40.272
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'            1.175e+02 -37.762
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           1.375e+02  37.621
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          2.067e+01 -36.422
## rcs(bmi)bmi                                             2.127e-01  -2.745
## rcs(bmi)bmi'                                            1.675e+00   0.598
## rcs(bmi)bmi''                                           9.185e+00   0.735
## rcs(bmi)bmi'''                                          1.244e+01  -1.607
## factor(stroke_history)1                                 9.279e-03  39.540
## factor(hba1c_high)1                                     5.588e-03  32.460
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.064e-01  36.736
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              2.999e+01 -32.618
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             3.302e+01  32.491
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''            3.161e+00 -30.633
## factor(lipid_modifying_agents)1                         5.550e-03 -30.965
## factor(FodelseLand_EU27_2020)1                          7.486e-03  22.768
## factor(ami_history)1                                    8.573e-03  25.049
## rcs(time_to_cpap_start)time_to_cpap_start               3.204e-02  -0.312
## rcs(time_to_cpap_start)time_to_cpap_start'              6.875e-02   2.670
## rcs(time_to_cpap_start)time_to_cpap_start''             2.424e-01  -1.920
## rcs(time_to_cpap_start)time_to_cpap_start'''            1.012e+00  -0.303
## factor(kolesterol_high)1                                6.290e-03 -18.097
## factor(Sun2000niva_old)2                                9.526e-03   5.175
## factor(Sun2000niva_old)3                                6.418e-03  -4.834
## factor(Sun2000niva_old)4                                9.294e-03  -6.178
## factor(Sun2000niva_old)5                                1.091e-02  -9.507
## factor(Sun2000niva_old)6                                1.085e-02 -12.594
## factor(Sun2000niva_old)7                                3.764e-02  -5.444
## factor(systoliskt_high)1                                5.784e-03 -15.913
## factor(Civil)1                                          6.791e-03   3.786
## factor(antihypertensive_comb)1                          5.715e-03  -3.039
## rcs(alder)alder:factor(GFR_high)1                       1.319e-01   4.276
## rcs(alder)alder':factor(GFR_high)1                      3.322e-01  -0.221
## rcs(alder)alder'':factor(GFR_high)1                     1.603e+00  -0.026
## rcs(alder)alder''':factor(GFR_high)1                    2.273e+00  -0.476
## rcs(alder)alder:rcs(bmi)bmi                             1.721e-01   1.433
## rcs(alder)alder':rcs(bmi)bmi                            5.075e-01  -1.574
## rcs(alder)alder'':rcs(bmi)bmi                           2.785e+00   2.931
## rcs(alder)alder''':rcs(bmi)bmi                          4.427e+00  -4.078
## rcs(alder)alder:rcs(bmi)bmi'                            1.391e+00  -1.828
## rcs(alder)alder':rcs(bmi)bmi'                           3.980e+00   2.822
## rcs(alder)alder'':rcs(bmi)bmi'                          2.153e+01  -4.339
## rcs(alder)alder''':rcs(bmi)bmi'                         3.419e+01   5.661
## rcs(alder)alder:rcs(bmi)bmi''                           7.650e+00   2.066
## rcs(alder)alder':rcs(bmi)bmi''                          2.182e+01  -3.290
## rcs(alder)alder'':rcs(bmi)bmi''                         1.180e+02   4.645
## rcs(alder)alder''':rcs(bmi)bmi''                        1.883e+02  -5.894
## rcs(alder)alder:rcs(bmi)bmi'''                          1.035e+01  -2.197
## rcs(alder)alder':rcs(bmi)bmi'''                         2.957e+01   3.512
## rcs(alder)alder'':rcs(bmi)bmi'''                        1.603e+02  -4.698
## rcs(alder)alder''':rcs(bmi)bmi'''                       2.570e+02   5.845
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   9.265e-02   1.461
## factor(cpap_treated)1:factor(antithrombotic_agents)1    9.122e-02   1.422
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                  < 2e-16 ***
## rcs(alder)alder                                       0.006928 ** 
## rcs(alder)alder'                                      0.444265    
## rcs(alder)alder''                                     0.007905 ** 
## rcs(alder)alder'''                                    0.000111 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             < 2e-16 ***
## factor(antithrombotic_agents)1                         < 2e-16 ***
## factor(rokare)1                                        < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04                       0.800383    
## rcs(DispInkKEHB04)DispInkKEHB04'                       < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                      < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04'''                     < 2e-16 ***
## factor(sex)1                                           < 2e-16 ***
## factor(GFR_high)1                                     2.11e-05 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         < 2e-16 ***
## rcs(bmi)bmi                                           0.006058 ** 
## rcs(bmi)bmi'                                          0.550056    
## rcs(bmi)bmi''                                         0.462402    
## rcs(bmi)bmi'''                                        0.107983    
## factor(stroke_history)1                                < 2e-16 ***
## factor(hba1c_high)1                                    < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           < 2e-16 ***
## factor(lipid_modifying_agents)1                        < 2e-16 ***
## factor(FodelseLand_EU27_2020)1                         < 2e-16 ***
## factor(ami_history)1                                   < 2e-16 ***
## rcs(time_to_cpap_start)time_to_cpap_start             0.755009    
## rcs(time_to_cpap_start)time_to_cpap_start'            0.007596 ** 
## rcs(time_to_cpap_start)time_to_cpap_start''           0.054911 .  
## rcs(time_to_cpap_start)time_to_cpap_start'''          0.761763    
## factor(kolesterol_high)1                               < 2e-16 ***
## factor(Sun2000niva_old)2                              2.28e-07 ***
## factor(Sun2000niva_old)3                              1.34e-06 ***
## factor(Sun2000niva_old)4                              6.48e-10 ***
## factor(Sun2000niva_old)5                               < 2e-16 ***
## factor(Sun2000niva_old)6                               < 2e-16 ***
## factor(Sun2000niva_old)7                              5.21e-08 ***
## factor(systoliskt_high)1                               < 2e-16 ***
## factor(Civil)1                                        0.000153 ***
## factor(antihypertensive_comb)1                        0.002372 ** 
## rcs(alder)alder:factor(GFR_high)1                     1.90e-05 ***
## rcs(alder)alder':factor(GFR_high)1                    0.824757    
## rcs(alder)alder'':factor(GFR_high)1                   0.978964    
## rcs(alder)alder''':factor(GFR_high)1                  0.634278    
## rcs(alder)alder:rcs(bmi)bmi                           0.151788    
## rcs(alder)alder':rcs(bmi)bmi                          0.115504    
## rcs(alder)alder'':rcs(bmi)bmi                         0.003374 ** 
## rcs(alder)alder''':rcs(bmi)bmi                        4.55e-05 ***
## rcs(alder)alder:rcs(bmi)bmi'                          0.067556 .  
## rcs(alder)alder':rcs(bmi)bmi'                         0.004770 ** 
## rcs(alder)alder'':rcs(bmi)bmi'                        1.43e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi'                       1.51e-08 ***
## rcs(alder)alder:rcs(bmi)bmi''                         0.038785 *  
## rcs(alder)alder':rcs(bmi)bmi''                        0.001000 ** 
## rcs(alder)alder'':rcs(bmi)bmi''                       3.40e-06 ***
## rcs(alder)alder''':rcs(bmi)bmi''                      3.78e-09 ***
## rcs(alder)alder:rcs(bmi)bmi'''                        0.028037 *  
## rcs(alder)alder':rcs(bmi)bmi'''                       0.000445 ***
## rcs(alder)alder'':rcs(bmi)bmi'''                      2.63e-06 ***
## rcs(alder)alder''':rcs(bmi)bmi'''                     5.07e-09 ***
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.143928    
## factor(cpap_treated)1:factor(antithrombotic_agents)1  0.155143    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  4.219e-01  2.370e+00
## rcs(alder)alder                                        1.878e+00  5.323e-01
## rcs(alder)alder'                                       6.109e-01  1.637e+00
## rcs(alder)alder''                                      7.900e+03  1.266e-04
## rcs(alder)alder'''                                     1.873e-09  5.339e+08
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                7.301e+03  1.370e-04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00        Inf
## factor(antithrombotic_agents)1                         1.269e+00  7.879e-01
## factor(rokare)1                                        1.524e+00  6.562e-01
## rcs(DispInkKEHB04)DispInkKEHB04                        1.016e+00  9.847e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       6.255e-12  1.599e+11
## rcs(DispInkKEHB04)DispInkKEHB04''                      3.620e+27  2.763e-28
## rcs(DispInkKEHB04)DispInkKEHB04'''                     7.289e-19  1.372e+18
## factor(sex)1                                           7.183e-01  1.392e+00
## factor(GFR_high)1                                      5.395e-01  1.854e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            5.128e+02  1.950e-03
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         0.000e+00        Inf
## rcs(bmi)bmi                                            5.578e-01  1.793e+00
## rcs(bmi)bmi'                                           2.721e+00  3.674e-01
## rcs(bmi)bmi''                                          8.544e+02  1.170e-03
## rcs(bmi)bmi'''                                         2.066e-09  4.839e+08
## factor(stroke_history)1                                1.443e+00  6.929e-01
## factor(hba1c_high)1                                    1.199e+00  8.341e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              4.989e+01  2.004e-02
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             0.000e+00        Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''                  Inf  0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           8.859e-43  1.129e+42
## factor(lipid_modifying_agents)1                        8.421e-01  1.188e+00
## factor(FodelseLand_EU27_2020)1                         1.186e+00  8.433e-01
## factor(ami_history)1                                   1.240e+00  8.068e-01
## rcs(time_to_cpap_start)time_to_cpap_start              9.901e-01  1.010e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             1.201e+00  8.323e-01
## rcs(time_to_cpap_start)time_to_cpap_start''            6.280e-01  1.592e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           7.358e-01  1.359e+00
## factor(kolesterol_high)1                               8.924e-01  1.121e+00
## factor(Sun2000niva_old)2                               1.051e+00  9.519e-01
## factor(Sun2000niva_old)3                               9.695e-01  1.032e+00
## factor(Sun2000niva_old)4                               9.442e-01  1.059e+00
## factor(Sun2000niva_old)5                               9.015e-01  1.109e+00
## factor(Sun2000niva_old)6                               8.723e-01  1.146e+00
## factor(Sun2000niva_old)7                               8.147e-01  1.227e+00
## factor(systoliskt_high)1                               9.121e-01  1.096e+00
## factor(Civil)1                                         1.026e+00  9.746e-01
## factor(antihypertensive_comb)1                         9.828e-01  1.018e+00
## rcs(alder)alder:factor(GFR_high)1                      1.758e+00  5.690e-01
## rcs(alder)alder':factor(GFR_high)1                     9.291e-01  1.076e+00
## rcs(alder)alder'':factor(GFR_high)1                    9.586e-01  1.043e+00
## rcs(alder)alder''':factor(GFR_high)1                   3.391e-01  2.949e+00
## rcs(alder)alder:rcs(bmi)bmi                            1.280e+00  7.814e-01
## rcs(alder)alder':rcs(bmi)bmi                           4.499e-01  2.223e+00
## rcs(alder)alder'':rcs(bmi)bmi                          3.516e+03  2.844e-04
## rcs(alder)alder''':rcs(bmi)bmi                         1.446e-08  6.915e+07
## rcs(alder)alder:rcs(bmi)bmi'                           7.862e-02  1.272e+01
## rcs(alder)alder':rcs(bmi)bmi'                          7.553e+04  1.324e-05
## rcs(alder)alder'':rcs(bmi)bmi'                         2.702e-41  3.701e+40
## rcs(alder)alder''':rcs(bmi)bmi'                        1.150e+84  8.692e-85
## rcs(alder)alder:rcs(bmi)bmi''                          7.338e+06  1.363e-07
## rcs(alder)alder':rcs(bmi)bmi''                         6.581e-32  1.520e+31
## rcs(alder)alder'':rcs(bmi)bmi''                       1.049e+238 9.532e-239
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00        Inf
## rcs(alder)alder:rcs(bmi)bmi'''                         1.323e-10  7.559e+09
## rcs(alder)alder':rcs(bmi)bmi'''                        1.274e+45  7.850e-46
## rcs(alder)alder'':rcs(bmi)bmi'''                       0.000e+00        Inf
## rcs(alder)alder''':rcs(bmi)bmi'''                            Inf  0.000e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  1.145e+00  8.734e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1   1.138e+00  8.784e-01
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  3.635e-01  4.898e-01
## rcs(alder)alder                                        1.189e+00  2.969e+00
## rcs(alder)alder'                                       1.728e-01  2.159e+00
## rcs(alder)alder''                                      1.051e+01  5.939e+06
## rcs(alder)alder'''                                     7.032e-14  4.989e-05
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                4.922e+03  1.083e+04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00  0.000e+00
## factor(antithrombotic_agents)1                         1.255e+00  1.284e+00
## factor(rokare)1                                        1.503e+00  1.545e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        9.013e-01  1.144e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       3.009e-13  1.300e-10
## rcs(DispInkKEHB04)DispInkKEHB04''                      3.577e+23  3.663e+31
## rcs(DispInkKEHB04)DispInkKEHB04'''                     1.053e-22  5.043e-15
## factor(sex)1                                           7.104e-01  7.263e-01
## factor(GFR_high)1                                      4.059e-01  7.170e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            3.785e+02  6.948e+02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         0.000e+00 4.776e-310
## rcs(bmi)bmi                                            3.677e-01  8.463e-01
## rcs(bmi)bmi'                                           1.021e-01  7.256e+01
## rcs(bmi)bmi''                                          1.297e-05  5.628e+10
## rcs(bmi)bmi'''                                         5.310e-20  8.042e+01
## factor(stroke_history)1                                1.417e+00  1.470e+00
## factor(hba1c_high)1                                    1.186e+00  1.212e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              4.050e+01  6.146e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             0.000e+00  0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''                  Inf        Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           1.806e-45  4.345e-40
## factor(lipid_modifying_agents)1                        8.330e-01  8.513e-01
## factor(FodelseLand_EU27_2020)1                         1.169e+00  1.203e+00
## factor(ami_history)1                                   1.219e+00  1.261e+00
## rcs(time_to_cpap_start)time_to_cpap_start              9.298e-01  1.054e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             1.050e+00  1.375e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            3.905e-01  1.010e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           1.013e-01  5.346e+00
## factor(kolesterol_high)1                               8.815e-01  9.035e-01
## factor(Sun2000niva_old)2                               1.031e+00  1.070e+00
## factor(Sun2000niva_old)3                               9.573e-01  9.817e-01
## factor(Sun2000niva_old)4                               9.272e-01  9.616e-01
## factor(Sun2000niva_old)5                               8.824e-01  9.209e-01
## factor(Sun2000niva_old)6                               8.539e-01  8.910e-01
## factor(Sun2000niva_old)7                               7.568e-01  8.771e-01
## factor(systoliskt_high)1                               9.018e-01  9.225e-01
## factor(Civil)1                                         1.012e+00  1.040e+00
## factor(antihypertensive_comb)1                         9.718e-01  9.939e-01
## rcs(alder)alder:factor(GFR_high)1                      1.357e+00  2.276e+00
## rcs(alder)alder':factor(GFR_high)1                     4.845e-01  1.782e+00
## rcs(alder)alder'':factor(GFR_high)1                    4.138e-02  2.221e+01
## rcs(alder)alder''':factor(GFR_high)1                   3.938e-03  2.920e+01
## rcs(alder)alder:rcs(bmi)bmi                            9.134e-01  1.793e+00
## rcs(alder)alder':rcs(bmi)bmi                           1.664e-01  1.216e+00
## rcs(alder)alder'':rcs(bmi)bmi                          1.497e+01  8.258e+05
## rcs(alder)alder''':rcs(bmi)bmi                         2.465e-12  8.484e-05
## rcs(alder)alder:rcs(bmi)bmi'                           5.145e-03  1.202e+00
## rcs(alder)alder':rcs(bmi)bmi'                          3.093e+01  1.845e+08
## rcs(alder)alder'':rcs(bmi)bmi'                         1.278e-59  5.712e-23
## rcs(alder)alder''':rcs(bmi)bmi'                        9.034e+54 1.465e+113
## rcs(alder)alder:rcs(bmi)bmi''                          2.259e+00  2.384e+13
## rcs(alder)alder':rcs(bmi)bmi''                         1.758e-50  2.463e-13
## rcs(alder)alder'':rcs(bmi)bmi''                       3.838e+137        Inf
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00 2.322e-322
## rcs(alder)alder:rcs(bmi)bmi'''                         2.032e-19  8.613e-02
## rcs(alder)alder':rcs(bmi)bmi'''                        8.554e+19  1.897e+70
## rcs(alder)alder'':rcs(bmi)bmi'''                       0.000e+00 2.784e-191
## rcs(alder)alder''':rcs(bmi)bmi'''                            Inf        Inf
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  9.549e-01  1.373e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1   9.521e-01  1.361e+00
## 
## Concordance= 0.793  (se = 0.001 )
## Likelihood ratio test= 194808  on 70 df,   p=<2e-16
## Wald test            = 178602  on 70 df,   p=<2e-16
## Score (logrank) test = 267027  on 70 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7934963 
## C-index test: 0.7935634

Group 2

run_models(c(list_forms_sleep[["form_death_tind_spl"]], list_forms_sleep[["form_death_tind_cat"]]), df_survival_times_sub_train, df_survival_times_sub_test, "time_to_death", "death", cont_var, "prof_death_ind_g2.html", bigd=F)

## [1] "### FORMULA 1 ###"
## Start:  AIC=12308.99
## Surv(time_to_death, death) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(alder)                      4 11842
## + rcs(time_to_cpap_start)         4 12075
## + factor(antithrombotic_agents)   1 12159
## + rcs(GFR)                        4 12184
## + rcs(IV_AverageSaturation)       4 12240
## + factor(Sun2000niva_old)         6 12247
## + factor(antihypertensive_comb)   1 12250
## + factor(ami_history)             1 12265
## + rcs(DispInkKEHB04)              4 12267
## + rcs(IV_AHI)                     4 12269
## + rcs(IV_ODI)                     4 12273
## + factor(stroke_history)          1 12274
## + factor(Civil)                   1 12281
## + factor(FodelseLand_EU27_2020)   1 12286
## + factor(sex)                     1 12292
## + rcs(systoliskt)                 4 12294
## + rcs(kolesterol)                 4 12294
## + rcs(bmi)                        4 12298
## + factor(lipid_modifying_agents)  1 12299
## + rcs(hba1c)                      4 12299
## + rcs(Raks_AndelEkBisInk)         3 12300
## + rcs(Raks_AndelSjukInk)          4 12303
## <none>                              12309
## + factor(rokare)                  1 12311
## + rcs(Raks_AndelArblosInk)        4 12314
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11842.38
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(time_to_cpap_start)         4 11653
## + rcs(IV_AverageSaturation)       4 11772
## + rcs(bmi)                        4 11794
## + rcs(GFR)                        4 11802
## + factor(antithrombotic_agents)   1 11803
## + rcs(IV_ODI)                     4 11803
## + rcs(IV_AHI)                     4 11811
## + factor(sex)                     1 11814
## + rcs(DispInkKEHB04)              4 11819
## + rcs(hba1c)                      4 11822
## + factor(ami_history)             1 11823
## + factor(antihypertensive_comb)   1 11823
## + factor(Sun2000niva_old)         6 11826
## + rcs(systoliskt)                 4 11827
## + factor(stroke_history)          1 11828
## + rcs(Raks_AndelSjukInk)          4 11837
## + factor(FodelseLand_EU27_2020)   1 11839
## + factor(rokare)                  1 11840
## + rcs(kolesterol)                 4 11841
## <none>                              11842
## + rcs(Raks_AndelEkBisInk)         3 11842
## + factor(lipid_modifying_agents)  1 11843
## + factor(Civil)                   1 11844
## + rcs(Raks_AndelArblosInk)        4 11848
## - rcs(alder)                      4 12309
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11652.69
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(IV_AverageSaturation)       4 11587
## + rcs(GFR)                        4 11612
## + rcs(DispInkKEHB04)              4 11614
## + factor(antithrombotic_agents)   1 11614
## + rcs(IV_ODI)                     4 11618
## + rcs(bmi)                        4 11620
## + rcs(hba1c)                      4 11621
## + rcs(IV_AHI)                     4 11624
## + factor(sex)                     1 11626
## + factor(Sun2000niva_old)         6 11632
## + factor(antihypertensive_comb)   1 11632
## + factor(ami_history)             1 11638
## + factor(stroke_history)          1 11639
## + rcs(systoliskt)                 4 11640
## + factor(rokare)                  1 11649
## + factor(FodelseLand_EU27_2020)   1 11651
## + rcs(kolesterol)                 4 11652
## + rcs(Raks_AndelSjukInk)          4 11652
## + rcs(Raks_AndelEkBisInk)         3 11652
## <none>                              11653
## + factor(lipid_modifying_agents)  1 11654
## + factor(Civil)                   1 11655
## + rcs(Raks_AndelArblosInk)        4 11659
## - rcs(time_to_cpap_start)         4 11842
## - rcs(alder)                      4 12075
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11587.37
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(antithrombotic_agents)   1 11552
## + rcs(GFR)                        4 11552
## + rcs(DispInkKEHB04)              4 11553
## + factor(sex)                     1 11556
## + rcs(hba1c)                      4 11560
## + factor(antihypertensive_comb)   1 11571
## + factor(Sun2000niva_old)         6 11573
## + factor(ami_history)             1 11574
## + factor(stroke_history)          1 11574
## + rcs(bmi)                        4 11574
## + rcs(systoliskt)                 4 11576
## + rcs(IV_ODI)                     4 11583
## + rcs(IV_AHI)                     4 11584
## + rcs(kolesterol)                 4 11585
## + factor(FodelseLand_EU27_2020)   1 11585
## + factor(rokare)                  1 11585
## + rcs(Raks_AndelSjukInk)          4 11586
## <none>                              11587
## + factor(lipid_modifying_agents)  1 11588
## + rcs(Raks_AndelEkBisInk)         3 11588
## + factor(Civil)                   1 11589
## + rcs(Raks_AndelArblosInk)        4 11594
## - rcs(IV_AverageSaturation)       4 11653
## - rcs(time_to_cpap_start)         4 11772
## - rcs(alder)                      4 12012
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11551.85
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(DispInkKEHB04)                                  4 11520
## + rcs(GFR)                                            4 11522
## + factor(sex)                                         1 11527
## + rcs(hba1c)                                          4 11528
## + rcs(bmi)                                            4 11538
## + factor(Sun2000niva_old)                             6 11539
## + rcs(systoliskt)                                     4 11543
## + factor(antihypertensive_comb)                       1 11544
## + factor(stroke_history)                              1 11545
## + rcs(IV_ODI)                                         4 11547
## + factor(ami_history)                                 1 11548
## + rcs(IV_AHI)                                         4 11548
## + factor(FodelseLand_EU27_2020)                       1 11549
## + factor(rokare)                                      1 11550
## + rcs(Raks_AndelEkBisInk)                             3 11552
## <none>                                                  11552
## + rcs(Raks_AndelSjukInk)                              4 11552
## + factor(lipid_modifying_agents)                      1 11553
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11554
## + factor(Civil)                                       1 11554
## + rcs(kolesterol)                                     4 11556
## + rcs(Raks_AndelArblosInk)                            4 11558
## - factor(antithrombotic_agents)                       1 11587
## - rcs(IV_AverageSaturation)                           4 11614
## - rcs(time_to_cpap_start)                             4 11736
## - rcs(alder)                                          4 11864
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11519.79
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(sex)                                         1 11484
## + rcs(GFR)                                            4 11494
## + rcs(hba1c)                                          4 11499
## + factor(FodelseLand_EU27_2020)                       1 11508
## + rcs(bmi)                                            4 11508
## + factor(antihypertensive_comb)                       1 11510
## + factor(stroke_history)                              1 11512
## + rcs(systoliskt)                                     4 11513
## + rcs(IV_AHI)                                         4 11515
## + rcs(IV_ODI)                                         4 11515
## + rcs(Raks_AndelEkBisInk)                             3 11516
## + factor(ami_history)                                 1 11516
## + factor(Sun2000niva_old)                             6 11517
## + factor(rokare)                                      1 11519
## <none>                                                  11520
## + rcs(Raks_AndelSjukInk)                              4 11520
## + factor(lipid_modifying_agents)                      1 11522
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11522
## + factor(Civil)                                       1 11522
## + rcs(kolesterol)                                     4 11524
## + rcs(Raks_AndelArblosInk)                            4 11527
## - rcs(DispInkKEHB04)                                  4 11552
## - factor(antithrombotic_agents)                       1 11553
## - rcs(IV_AverageSaturation)                           4 11577
## - rcs(time_to_cpap_start)                             4 11718
## - rcs(alder)                                          4 11814
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11484.09
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(GFR)                                            4 11454
## + rcs(bmi)                                            4 11464
## + rcs(hba1c)                                          4 11467
## + factor(FodelseLand_EU27_2020)                       1 11471
## + factor(antihypertensive_comb)                       1 11476
## + factor(stroke_history)                              1 11476
## + rcs(systoliskt)                                     4 11478
## + rcs(Raks_AndelEkBisInk)                             3 11479
## + rcs(IV_ODI)                                         4 11481
## + factor(Sun2000niva_old)                             6 11482
## + factor(ami_history)                                 1 11482
## + rcs(IV_AHI)                                         4 11482
## + factor(rokare)                                      1 11483
## + rcs(Raks_AndelSjukInk)                              4 11483
## <none>                                                  11484
## + factor(Civil)                                       1 11485
## + factor(lipid_modifying_agents)                      1 11485
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11486
## + rcs(kolesterol)                                     4 11491
## + rcs(Raks_AndelArblosInk)                            4 11492
## - factor(antithrombotic_agents)                       1 11509
## - factor(sex)                                         1 11520
## - rcs(DispInkKEHB04)                                  4 11527
## - rcs(IV_AverageSaturation)                           4 11546
## - rcs(time_to_cpap_start)                             4 11682
## - rcs(alder)                                          4 11796
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11453.63
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(bmi)                                            4 11436
## + factor(FodelseLand_EU27_2020)                       1 11438
## + rcs(hba1c)                                          4 11441
## + factor(antihypertensive_comb)                       1 11446
## + factor(stroke_history)                              1 11447
## + rcs(Raks_AndelEkBisInk)                             3 11447
## + rcs(systoliskt)                                     4 11449
## + rcs(IV_ODI)                                         4 11451
## + rcs(Raks_AndelSjukInk)                              4 11452
## + factor(Sun2000niva_old)                             6 11452
## + factor(ami_history)                                 1 11453
## + rcs(IV_AHI)                                         4 11453
## + factor(rokare)                                      1 11453
## <none>                                                  11454
## + factor(Civil)                                       1 11454
## + factor(lipid_modifying_agents)                      1 11455
## + rcs(alder):rcs(GFR)                                16 11455
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11455
## + factor(cpap_treated):rcs(GFR)                       4 11456
## + rcs(kolesterol)                                     4 11461
## + rcs(Raks_AndelArblosInk)                            4 11461
## - factor(antithrombotic_agents)                       1 11474
## - rcs(GFR)                                            4 11484
## - rcs(DispInkKEHB04)                                  4 11493
## - factor(sex)                                         1 11494
## - rcs(IV_AverageSaturation)                           4 11511
## - rcs(time_to_cpap_start)                             4 11654
## - rcs(alder)                                          4 11713
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11436.24
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(FodelseLand_EU27_2020)                       1 11422
## + rcs(hba1c)                                          4 11426
## + factor(antihypertensive_comb)                       1 11428
## + rcs(Raks_AndelEkBisInk)                             3 11430
## + factor(stroke_history)                              1 11430
## + rcs(systoliskt)                                     4 11431
## + rcs(IV_ODI)                                         4 11435
## + factor(rokare)                                      1 11435
## + rcs(Raks_AndelSjukInk)                              4 11435
## + factor(ami_history)                                 1 11435
## + factor(Sun2000niva_old)                             6 11436
## <none>                                                  11436
## + factor(Civil)                                       1 11436
## + rcs(alder):rcs(GFR)                                16 11437
## + rcs(IV_AHI)                                         4 11437
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11438
## + factor(lipid_modifying_agents)                      1 11438
## + factor(cpap_treated):rcs(GFR)                       4 11438
## + rcs(Raks_AndelArblosInk)                            4 11444
## + rcs(kolesterol)                                     4 11444
## + rcs(alder):rcs(bmi)                                16 11445
## - rcs(bmi)                                            4 11454
## - factor(antithrombotic_agents)                       1 11457
## - rcs(GFR)                                            4 11464
## - rcs(DispInkKEHB04)                                  4 11473
## - rcs(IV_AverageSaturation)                           4 11477
## - factor(sex)                                         1 11484
## - rcs(time_to_cpap_start)                             4 11626
## - rcs(alder)                                          4 11701
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11421.54
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(hba1c)                                          4 11412
## + factor(antihypertensive_comb)                       1 11414
## + factor(stroke_history)                              1 11417
## + rcs(systoliskt)                                     4 11417
## + rcs(Raks_AndelEkBisInk)                             3 11419
## + factor(rokare)                                      1 11420
## + factor(ami_history)                                 1 11420
## + rcs(IV_ODI)                                         4 11420
## + rcs(Raks_AndelSjukInk)                              4 11421
## + rcs(alder):rcs(GFR)                                16 11421
## <none>                                                  11422
## + factor(Civil)                                       1 11422
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11423
## + rcs(IV_AHI)                                         4 11423
## + factor(lipid_modifying_agents)                      1 11423
## + factor(Sun2000niva_old)                             6 11423
## + factor(cpap_treated):rcs(GFR)                       4 11424
## + rcs(kolesterol)                                     4 11428
## + rcs(Raks_AndelArblosInk)                            4 11429
## + rcs(alder):rcs(bmi)                                16 11431
## - factor(FodelseLand_EU27_2020)                       1 11436
## - rcs(bmi)                                            4 11438
## - factor(antithrombotic_agents)                       1 11443
## - rcs(GFR)                                            4 11451
## - rcs(IV_AverageSaturation)                           4 11462
## - rcs(DispInkKEHB04)                                  4 11470
## - factor(sex)                                         1 11471
## - rcs(time_to_cpap_start)                             4 11612
## - rcs(alder)                                          4 11664
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11411.69
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(antihypertensive_comb)                       1 11404
## + factor(stroke_history)                              1 11407
## + rcs(systoliskt)                                     4 11408
## + rcs(Raks_AndelEkBisInk)                             3 11409
## + factor(ami_history)                                 1 11410
## + factor(rokare)                                      1 11410
## + rcs(Raks_AndelSjukInk)                              4 11411
## + rcs(alder):rcs(GFR)                                16 11412
## <none>                                                  11412
## + rcs(IV_ODI)                                         4 11412
## + factor(Civil)                                       1 11412
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11413
## + factor(lipid_modifying_agents)                      1 11413
## + factor(cpap_treated):rcs(GFR)                       4 11414
## + factor(Sun2000niva_old)                             6 11414
## + rcs(IV_AHI)                                         4 11414
## + rcs(kolesterol)                                     4 11418
## + rcs(Raks_AndelArblosInk)                            4 11419
## + rcs(alder):rcs(bmi)                                16 11420
## - rcs(hba1c)                                          4 11422
## - factor(FodelseLand_EU27_2020)                       1 11426
## - rcs(bmi)                                            4 11426
## - factor(antithrombotic_agents)                       1 11432
## - rcs(GFR)                                            4 11437
## - rcs(IV_AverageSaturation)                           4 11451
## - rcs(DispInkKEHB04)                                  4 11456
## - factor(sex)                                         1 11458
## - rcs(time_to_cpap_start)                             4 11610
## - rcs(alder)                                          4 11653
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11404.54
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(stroke_history)                              1 11400
## + rcs(systoliskt)                                     4 11401
## + rcs(Raks_AndelEkBisInk)                             3 11402
## + factor(rokare)                                      1 11403
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11403
## + factor(ami_history)                                 1 11403
## + rcs(Raks_AndelSjukInk)                              4 11404
## <none>                                                  11404
## + rcs(IV_ODI)                                         4 11405
## + rcs(alder):rcs(GFR)                                16 11405
## + factor(Civil)                                       1 11405
## + factor(lipid_modifying_agents)                      1 11405
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11406
## + factor(cpap_treated):rcs(GFR)                       4 11407
## + factor(Sun2000niva_old)                             6 11407
## + rcs(IV_AHI)                                         4 11408
## + rcs(kolesterol)                                     4 11412
## + rcs(Raks_AndelArblosInk)                            4 11412
## - factor(antihypertensive_comb)                       1 11412
## + rcs(alder):rcs(bmi)                                16 11413
## - rcs(hba1c)                                          4 11414
## - factor(FodelseLand_EU27_2020)                       1 11418
## - factor(antithrombotic_agents)                       1 11419
## - rcs(bmi)                                            4 11420
## - rcs(GFR)                                            4 11428
## - rcs(IV_AverageSaturation)                           4 11442
## - rcs(DispInkKEHB04)                                  4 11450
## - factor(sex)                                         1 11450
## - rcs(time_to_cpap_start)                             4 11604
## - rcs(alder)                                          4 11639
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11400
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(systoliskt)                                     4 11396
## + rcs(Raks_AndelEkBisInk)                             3 11397
## + factor(ami_history)                                 1 11398
## + factor(rokare)                                      1 11398
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11398
## + rcs(Raks_AndelSjukInk)                              4 11399
## + rcs(alder):rcs(GFR)                                16 11400
## <none>                                                  11400
## + rcs(IV_ODI)                                         4 11400
## + factor(lipid_modifying_agents)                      1 11401
## + factor(Civil)                                       1 11401
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11401
## + factor(cpap_treated):rcs(GFR)                       4 11402
## + factor(Sun2000niva_old)                             6 11403
## + rcs(IV_AHI)                                         4 11403
## - factor(stroke_history)                              1 11404
## + rcs(Raks_AndelArblosInk)                            4 11407
## - factor(antihypertensive_comb)                       1 11407
## + rcs(kolesterol)                                     4 11407
## + rcs(alder):rcs(bmi)                                16 11408
## - rcs(hba1c)                                          4 11409
## - factor(antithrombotic_agents)                       1 11411
## - factor(FodelseLand_EU27_2020)                       1 11412
## - rcs(bmi)                                            4 11415
## - rcs(GFR)                                            4 11422
## - rcs(IV_AverageSaturation)                           4 11438
## - rcs(DispInkKEHB04)                                  4 11445
## - factor(sex)                                         1 11446
## - rcs(time_to_cpap_start)                             4 11598
## - rcs(alder)                                          4 11632
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11396.06
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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##                                                      Df   AIC
## + rcs(Raks_AndelEkBisInk)                             3 11393
## + factor(ami_history)                                 1 11394
## + factor(rokare)                                      1 11394
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11395
## + rcs(Raks_AndelSjukInk)                              4 11395
## + rcs(IV_ODI)                                         4 11396
## + rcs(alder):rcs(GFR)                                16 11396
## <none>                                                  11396
## + factor(Civil)                                       1 11396
## + factor(lipid_modifying_agents)                      1 11397
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11397
## + factor(cpap_treated):rcs(GFR)                       4 11398
## + factor(Sun2000niva_old)                             6 11399
## + rcs(IV_AHI)                                         4 11399
## - rcs(systoliskt)                                     4 11400
## - factor(stroke_history)                              1 11401
## - factor(antihypertensive_comb)                       1 11402
## + rcs(Raks_AndelArblosInk)                            4 11403
## + rcs(kolesterol)                                     4 11403
## + rcs(alder):rcs(bmi)                                16 11404
## - rcs(hba1c)                                          4 11405
## - factor(antithrombotic_agents)                       1 11405
## - factor(FodelseLand_EU27_2020)                       1 11408
## - rcs(bmi)                                            4 11411
## - rcs(GFR)                                            4 11417
## - rcs(IV_AverageSaturation)                           4 11434
## - rcs(DispInkKEHB04)                                  4 11440
## - factor(sex)                                         1 11442
## - rcs(time_to_cpap_start)                             4 11590
## - rcs(alder)                                          4 11632
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11392.91
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(rokare)                                      1 11391
## + factor(ami_history)                                 1 11391
## + rcs(alder):rcs(GFR)                                16 11392
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11392
## + rcs(IV_ODI)                                         4 11392
## <none>                                                  11393
## + rcs(Raks_AndelSjukInk)                              4 11393
## + factor(Civil)                                       1 11393
## + factor(lipid_modifying_agents)                      1 11394
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11394
## + factor(cpap_treated):rcs(GFR)                       4 11395
## + factor(Sun2000niva_old)                             6 11396
## - rcs(Raks_AndelEkBisInk)                             3 11396
## + rcs(IV_AHI)                                         4 11396
## - rcs(systoliskt)                                     4 11397
## - factor(stroke_history)                              1 11398
## - factor(antihypertensive_comb)                       1 11399
## + rcs(kolesterol)                                     4 11400
## + rcs(Raks_AndelArblosInk)                            4 11400
## + rcs(alder):rcs(bmi)                                16 11401
## - rcs(hba1c)                                          4 11402
## - factor(FodelseLand_EU27_2020)                       1 11402
## - factor(antithrombotic_agents)                       1 11402
## - rcs(bmi)                                            4 11409
## - rcs(GFR)                                            4 11415
## - rcs(IV_AverageSaturation)                           4 11430
## - rcs(DispInkKEHB04)                                  4 11439
## - factor(sex)                                         1 11439
## - rcs(time_to_cpap_start)                             4 11588
## - rcs(alder)                                          4 11621
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11390.86
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + 
##     factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(ami_history)                                 1 11389
## + rcs(alder):rcs(GFR)                                16 11389
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11389
## + rcs(IV_ODI)                                         4 11390
## <none>                                                  11391
## + factor(Civil)                                       1 11391
## + rcs(Raks_AndelSjukInk)                              4 11391
## + factor(lipid_modifying_agents)                      1 11392
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11392
## + factor(cpap_treated):rcs(GFR)                       4 11393
## - factor(rokare)                                      1 11393
## + rcs(IV_AHI)                                         4 11394
## + factor(Sun2000niva_old)                             6 11394
## - rcs(Raks_AndelEkBisInk)                             3 11394
## - rcs(systoliskt)                                     4 11395
## - factor(stroke_history)                              1 11396
## + rcs(alder):rcs(bmi)                                16 11398
## - factor(antihypertensive_comb)                       1 11398
## + rcs(kolesterol)                                     4 11398
## + rcs(Raks_AndelArblosInk)                            4 11398
## - rcs(hba1c)                                          4 11400
## - factor(FodelseLand_EU27_2020)                       1 11400
## - factor(antithrombotic_agents)                       1 11400
## - rcs(bmi)                                            4 11407
## - rcs(GFR)                                            4 11412
## - rcs(IV_AverageSaturation)                           4 11426
## - rcs(DispInkKEHB04)                                  4 11436
## - factor(sex)                                         1 11438
## - rcs(time_to_cpap_start)                             4 11587
## - rcs(alder)                                          4 11623
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11389.26
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + 
##     factor(rokare) + factor(ami_history)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(alder):rcs(GFR)                                16 11387
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11388
## + rcs(IV_ODI)                                         4 11388
## + factor(lipid_modifying_agents)                      1 11389
## <none>                                                  11389
## + factor(Civil)                                       1 11389
## + rcs(Raks_AndelSjukInk)                              4 11390
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11390
## - factor(ami_history)                                 1 11391
## - factor(rokare)                                      1 11391
## + factor(cpap_treated):rcs(GFR)                       4 11392
## + factor(Sun2000niva_old)                             6 11392
## - rcs(Raks_AndelEkBisInk)                             3 11392
## + rcs(IV_AHI)                                         4 11392
## - rcs(systoliskt)                                     4 11393
## - factor(antithrombotic_agents)                       1 11395
## - factor(stroke_history)                              1 11395
## - factor(antihypertensive_comb)                       1 11396
## + rcs(alder):rcs(bmi)                                16 11396
## + rcs(Raks_AndelArblosInk)                            4 11397
## + rcs(kolesterol)                                     4 11397
## - factor(FodelseLand_EU27_2020)                       1 11398
## - rcs(hba1c)                                          4 11399
## - rcs(bmi)                                            4 11405
## - rcs(GFR)                                            4 11410
## - rcs(IV_AverageSaturation)                           4 11425
## - factor(sex)                                         1 11434
## - rcs(DispInkKEHB04)                                  4 11434
## - rcs(time_to_cpap_start)                             4 11583
## - rcs(alder)                                          4 11622
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11387.35
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + 
##     factor(rokare) + factor(ami_history) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11385
## + factor(lipid_modifying_agents)                      1 11387
## + rcs(Raks_AndelSjukInk)                              4 11387
## <none>                                                  11387
## + rcs(IV_ODI)                                         4 11388
## + factor(Civil)                                       1 11388
## + factor(cpap_treated):rcs(GFR)                       4 11388
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11388
## - rcs(alder):rcs(GFR)                                16 11389
## - factor(ami_history)                                 1 11389
## + factor(Sun2000niva_old)                             6 11389
## - factor(rokare)                                      1 11390
## + rcs(IV_AHI)                                         4 11391
## - rcs(systoliskt)                                     4 11391
## - rcs(Raks_AndelEkBisInk)                             3 11392
## - factor(antithrombotic_agents)                       1 11393
## - factor(antihypertensive_comb)                       1 11394
## + rcs(alder):rcs(bmi)                                16 11394
## - factor(stroke_history)                              1 11394
## + rcs(kolesterol)                                     4 11395
## + rcs(Raks_AndelArblosInk)                            4 11395
## - factor(FodelseLand_EU27_2020)                       1 11397
## - rcs(hba1c)                                          4 11397
## - rcs(bmi)                                            4 11404
## - rcs(IV_AverageSaturation)                           4 11425
## - factor(sex)                                         1 11433
## - rcs(DispInkKEHB04)                                  4 11434
## - rcs(time_to_cpap_start)                             4 11581
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11385
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + 
##     factor(rokare) + factor(ami_history) + rcs(alder):rcs(GFR) + 
##     factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(lipid_modifying_agents)                      1 11385
## <none>                                                  11385
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11385
## + factor(Civil)                                       1 11385
## + rcs(Raks_AndelSjukInk)                              4 11385
## + rcs(IV_ODI)                                         4 11386
## + factor(cpap_treated):rcs(GFR)                       4 11386
## - factor(ami_history)                                 1 11387
## + factor(Sun2000niva_old)                             6 11387
## - factor(rokare)                                      1 11387
## - factor(cpap_treated):factor(antihypertensive_comb)  1 11387
## - rcs(alder):rcs(GFR)                                16 11388
## - rcs(systoliskt)                                     4 11388
## + rcs(IV_AHI)                                         4 11388
## - rcs(Raks_AndelEkBisInk)                             3 11390
## - factor(antithrombotic_agents)                       1 11390
## + rcs(alder):rcs(bmi)                                16 11392
## - factor(stroke_history)                              1 11392
## + rcs(kolesterol)                                     4 11392
## + rcs(Raks_AndelArblosInk)                            4 11392
## - factor(FodelseLand_EU27_2020)                       1 11394
## - rcs(hba1c)                                          4 11395
## - rcs(bmi)                                            4 11402
## - rcs(IV_AverageSaturation)                           4 11423
## - factor(sex)                                         1 11430
## - rcs(DispInkKEHB04)                                  4 11432
## - rcs(time_to_cpap_start)                             4 11578
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11384.64
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + 
##     factor(rokare) + factor(ami_history) + factor(lipid_modifying_agents) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df   AIC
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 11384
## <none>                                                   11385
## + factor(cpap_treated):factor(antithrombotic_agents)   1 11385
## + factor(Civil)                                        1 11385
## + rcs(Raks_AndelSjukInk)                               4 11385
## - factor(lipid_modifying_agents)                       1 11385
## + factor(cpap_treated):rcs(GFR)                        4 11385
## + rcs(IV_ODI)                                          4 11385
## + factor(Sun2000niva_old)                              6 11386
## - factor(cpap_treated):factor(antihypertensive_comb)   1 11387
## - factor(rokare)                                       1 11387
## - factor(ami_history)                                  1 11387
## - rcs(alder):rcs(GFR)                                 16 11388
## - rcs(systoliskt)                                      4 11388
## + rcs(IV_AHI)                                          4 11388
## - rcs(Raks_AndelEkBisInk)                              3 11389
## + rcs(alder):rcs(bmi)                                 16 11391
## + rcs(kolesterol)                                      4 11391
## - factor(antithrombotic_agents)                        1 11392
## - factor(stroke_history)                               1 11392
## + rcs(Raks_AndelArblosInk)                             4 11392
## - factor(FodelseLand_EU27_2020)                        1 11394
## - rcs(hba1c)                                           4 11395
## - rcs(bmi)                                             4 11401
## - rcs(IV_AverageSaturation)                            4 11422
## - factor(sex)                                          1 11430
## - rcs(DispInkKEHB04)                                   4 11431
## - rcs(time_to_cpap_start)                              4 11578
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11384.12
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(GFR) + rcs(bmi) + 
##     factor(FodelseLand_EU27_2020) + rcs(hba1c) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + 
##     factor(rokare) + factor(ami_history) + factor(lipid_modifying_agents) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb) + 
##     factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                       Df   AIC
## <none>                                                   11384
## + factor(Civil)                                        1 11384
## + rcs(Raks_AndelSjukInk)                               4 11384
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 11385
## + factor(cpap_treated):rcs(GFR)                        4 11385
## + rcs(IV_ODI)                                          4 11385
## + factor(cpap_treated):factor(antithrombotic_agents)   1 11385
## + factor(Sun2000niva_old)                              6 11386
## - factor(rokare)                                       1 11387
## - factor(ami_history)                                  1 11387
## - rcs(alder):rcs(GFR)                                 16 11387
## - factor(cpap_treated):factor(antihypertensive_comb)   1 11388
## - rcs(systoliskt)                                      4 11388
## + rcs(IV_AHI)                                          4 11388
## - rcs(Raks_AndelEkBisInk)                              3 11388
## + rcs(alder):rcs(bmi)                                 16 11390
## + rcs(kolesterol)                                      4 11391
## - factor(antithrombotic_agents)                        1 11391
## - factor(stroke_history)                               1 11391
## + rcs(Raks_AndelArblosInk)                             4 11392
## - factor(FodelseLand_EU27_2020)                        1 11394
## - rcs(hba1c)                                           4 11394
## - rcs(bmi)                                             4 11401
## - rcs(IV_AverageSaturation)                            4 11421
## - factor(sex)                                          1 11429
## - rcs(DispInkKEHB04)                                   4 11430
## - rcs(time_to_cpap_start)                              4 11578
## + factor(HushallsType_RTB)                                    
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_death, death) ~ factor(cpap_treated) + 
##     rcs(alder) + rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + 
##     factor(antithrombotic_agents) + rcs(DispInkKEHB04) + factor(sex) + 
##     rcs(GFR) + rcs(bmi) + factor(FodelseLand_EU27_2020) + rcs(hba1c) + 
##     factor(antihypertensive_comb) + factor(stroke_history) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(rokare) + 
##     factor(ami_history) + factor(lipid_modifying_agents) + rcs(alder):rcs(GFR) + 
##     factor(cpap_treated):factor(antihypertensive_comb) + factor(cpap_treated):factor(lipid_modifying_agents), 
##     data = df_train)
## 
##   n= 10603, number of events= 732 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                  -1.183e+00   3.063e-01
## rcs(alder)alder                                        -5.523e+00   3.993e-03
## rcs(alder)alder'                                        1.832e+01   9.064e+07
## rcs(alder)alder''                                      -8.139e+01   4.483e-36
## rcs(alder)alder'''                                      1.019e+02   1.747e+44
## rcs(time_to_cpap_start)time_to_cpap_start              -5.700e-01   5.655e-01
## rcs(time_to_cpap_start)time_to_cpap_start'             -2.288e+00   1.015e-01
## rcs(time_to_cpap_start)time_to_cpap_start''             6.854e+00   9.479e+02
## rcs(time_to_cpap_start)time_to_cpap_start'''           -5.567e+00   3.822e-03
## rcs(IV_AverageSaturation)IV_AverageSaturation          -1.491e-01   8.615e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'         -4.891e-01   6.132e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation''         3.679e+00   3.959e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation'''       -5.492e+00   4.119e-03
## factor(antithrombotic_agents)1                          2.655e-01   1.304e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        -4.984e-01   6.075e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       -1.427e+01   6.371e-07
## rcs(DispInkKEHB04)DispInkKEHB04''                       4.611e+01   1.062e+20
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -4.263e+01   3.061e-19
## factor(sex)1                                           -5.806e-01   5.596e-01
## rcs(GFR)GFR                                            -5.714e+00   3.299e-03
## rcs(GFR)GFR'                                            4.344e+01   7.362e+18
## rcs(GFR)GFR''                                          -2.636e+02  3.176e-115
## rcs(GFR)GFR'''                                          4.602e+02  7.559e+199
## rcs(bmi)bmi                                            -7.631e-01   4.662e-01
## rcs(bmi)bmi'                                            7.316e+00   1.504e+03
## rcs(bmi)bmi''                                          -3.653e+01   1.359e-16
## rcs(bmi)bmi'''                                          4.038e+01   3.428e+17
## factor(FodelseLand_EU27_2020)1                          3.465e-01   1.414e+00
## rcs(hba1c)hba1c                                        -3.773e-01   6.857e-01
## rcs(hba1c)hba1c'                                        1.510e+01   3.611e+06
## rcs(hba1c)hba1c''                                      -4.583e+01   1.244e-20
## rcs(hba1c)hba1c'''                                      3.619e+01   5.207e+15
## factor(antihypertensive_comb)1                          5.117e-01   1.668e+00
## factor(stroke_history)1                                 4.938e-01   1.639e+00
## rcs(systoliskt)systoliskt                              -4.108e-01   6.631e-01
## rcs(systoliskt)systoliskt'                              1.214e+00   3.367e+00
## rcs(systoliskt)systoliskt''                            -6.580e+00   1.388e-03
## rcs(systoliskt)systoliskt'''                            1.190e+01   1.467e+05
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              -1.463e-01   8.639e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              6.662e+01   8.532e+28
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            -7.091e+01   1.602e-31
## factor(rokare)1                                         2.288e-01   1.257e+00
## factor(ami_history)1                                    2.749e-01   1.316e+00
## factor(lipid_modifying_agents)1                        -2.527e-01   7.767e-01
## rcs(alder)alder:rcs(GFR)GFR                            -4.045e+00   1.751e-02
## rcs(alder)alder':rcs(GFR)GFR                            1.102e+01   6.115e+04
## rcs(alder)alder'':rcs(GFR)GFR                          -4.381e+01   9.363e-20
## rcs(alder)alder''':rcs(GFR)GFR                          4.663e+01   1.787e+20
## rcs(alder)alder:rcs(GFR)GFR'                            3.247e+01   1.264e+14
## rcs(alder)alder':rcs(GFR)GFR'                          -1.002e+02   3.142e-44
## rcs(alder)alder'':rcs(GFR)GFR'                          4.685e+02  2.831e+203
## rcs(alder)alder''':rcs(GFR)GFR'                        -6.077e+02  1.236e-264
## rcs(alder)alder:rcs(GFR)GFR''                          -1.983e+02   7.579e-87
## rcs(alder)alder':rcs(GFR)GFR''                          6.391e+02  3.468e+277
## rcs(alder)alder'':rcs(GFR)GFR''                        -3.114e+03   0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR''                        4.207e+03         Inf
## rcs(alder)alder:rcs(GFR)GFR'''                          3.453e+02  9.331e+149
## rcs(alder)alder':rcs(GFR)GFR'''                        -1.144e+03   0.000e+00
## rcs(alder)alder'':rcs(GFR)GFR'''                        5.706e+03         Inf
## rcs(alder)alder''':rcs(GFR)GFR'''                      -7.888e+03   0.000e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1   -4.337e-01   6.481e-01
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   2.462e-01   1.279e+00
##                                                          se(coef)      z
## factor(cpap_treated)1                                   1.923e-01 -6.152
## rcs(alder)alder                                         2.903e+00 -1.903
## rcs(alder)alder'                                        7.529e+00  2.434
## rcs(alder)alder''                                       3.428e+01 -2.374
## rcs(alder)alder'''                                      4.697e+01  2.169
## rcs(time_to_cpap_start)time_to_cpap_start               3.005e-01 -1.897
## rcs(time_to_cpap_start)time_to_cpap_start'              1.809e+00 -1.264
## rcs(time_to_cpap_start)time_to_cpap_start''             6.648e+00  1.031
## rcs(time_to_cpap_start)time_to_cpap_start'''            7.966e+00 -0.699
## rcs(IV_AverageSaturation)IV_AverageSaturation           5.621e-02 -2.653
## rcs(IV_AverageSaturation)IV_AverageSaturation'          2.827e-01 -1.730
## rcs(IV_AverageSaturation)IV_AverageSaturation''         3.125e+00  1.177
## rcs(IV_AverageSaturation)IV_AverageSaturation'''        1.261e+01 -0.435
## factor(antithrombotic_agents)1                          8.875e-02  2.992
## rcs(DispInkKEHB04)DispInkKEHB04                         3.119e-01 -1.598
## rcs(DispInkKEHB04)DispInkKEHB04'                        5.758e+00 -2.478
## rcs(DispInkKEHB04)DispInkKEHB04''                       2.154e+01  2.141
## rcs(DispInkKEHB04)DispInkKEHB04'''                      2.586e+01 -1.648
## factor(sex)1                                            8.771e-02 -6.619
## rcs(GFR)GFR                                             2.684e+00 -2.129
## rcs(GFR)GFR'                                            1.427e+01  3.045
## rcs(GFR)GFR''                                           7.809e+01 -3.376
## rcs(GFR)GFR'''                                          1.304e+02  3.529
## rcs(bmi)bmi                                             1.978e-01 -3.857
## rcs(bmi)bmi'                                            1.723e+00  4.246
## rcs(bmi)bmi''                                           9.766e+00 -3.741
## rcs(bmi)bmi'''                                          1.225e+01  3.295
## factor(FodelseLand_EU27_2020)1                          1.030e-01  3.364
## rcs(hba1c)hba1c                                         5.026e-01 -0.751
## rcs(hba1c)hba1c'                                        1.118e+01  1.350
## rcs(hba1c)hba1c''                                       3.700e+01 -1.239
## rcs(hba1c)hba1c'''                                      3.438e+01  1.053
## factor(antihypertensive_comb)1                          1.371e-01  3.731
## factor(stroke_history)1                                 1.529e-01  3.229
## rcs(systoliskt)systoliskt                               1.546e-01 -2.657
## rcs(systoliskt)systoliskt'                              8.138e-01  1.492
## rcs(systoliskt)systoliskt''                             6.376e+00 -1.032
## rcs(systoliskt)systoliskt'''                            1.390e+01  0.856
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.211e+00 -0.121
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              2.525e+02  0.264
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             2.653e+02 -0.267
## factor(rokare)1                                         1.057e-01  2.164
## factor(ami_history)1                                    1.253e-01  2.194
## factor(lipid_modifying_agents)1                         1.141e-01 -2.214
## rcs(alder)alder:rcs(GFR)GFR                             2.655e+00 -1.524
## rcs(alder)alder':rcs(GFR)GFR                            6.218e+00  1.772
## rcs(alder)alder'':rcs(GFR)GFR                           2.614e+01 -1.676
## rcs(alder)alder''':rcs(GFR)GFR                          3.335e+01  1.398
## rcs(alder)alder:rcs(GFR)GFR'                            1.273e+01  2.551
## rcs(alder)alder':rcs(GFR)GFR'                           3.407e+01 -2.940
## rcs(alder)alder'':rcs(GFR)GFR'                          1.589e+02  2.948
## rcs(alder)alder''':rcs(GFR)GFR'                         2.232e+02 -2.722
## rcs(alder)alder:rcs(GFR)GFR''                           6.697e+01 -2.961
## rcs(alder)alder':rcs(GFR)GFR''                          1.896e+02  3.371
## rcs(alder)alder'':rcs(GFR)GFR''                         9.213e+02 -3.381
## rcs(alder)alder''':rcs(GFR)GFR''                        1.349e+03  3.118
## rcs(alder)alder:rcs(GFR)GFR'''                          1.094e+02  3.157
## rcs(alder)alder':rcs(GFR)GFR'''                         3.213e+02 -3.561
## rcs(alder)alder'':rcs(GFR)GFR'''                        1.613e+03  3.537
## rcs(alder)alder''':rcs(GFR)GFR'''                       2.453e+03 -3.216
## factor(cpap_treated)1:factor(antihypertensive_comb)1    1.821e-01 -2.381
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.551e-01  1.587
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                 7.66e-10 ***
## rcs(alder)alder                                       0.057056 .  
## rcs(alder)alder'                                      0.014948 *  
## rcs(alder)alder''                                     0.017575 *  
## rcs(alder)alder'''                                    0.030100 *  
## rcs(time_to_cpap_start)time_to_cpap_start             0.057844 .  
## rcs(time_to_cpap_start)time_to_cpap_start'            0.206070    
## rcs(time_to_cpap_start)time_to_cpap_start''           0.302525    
## rcs(time_to_cpap_start)time_to_cpap_start'''          0.484666    
## rcs(IV_AverageSaturation)IV_AverageSaturation         0.007980 ** 
## rcs(IV_AverageSaturation)IV_AverageSaturation'        0.083606 .  
## rcs(IV_AverageSaturation)IV_AverageSaturation''       0.239184    
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      0.663279    
## factor(antithrombotic_agents)1                        0.002773 ** 
## rcs(DispInkKEHB04)DispInkKEHB04                       0.110118    
## rcs(DispInkKEHB04)DispInkKEHB04'                      0.013227 *  
## rcs(DispInkKEHB04)DispInkKEHB04''                     0.032290 *  
## rcs(DispInkKEHB04)DispInkKEHB04'''                    0.099312 .  
## factor(sex)1                                          3.61e-11 ***
## rcs(GFR)GFR                                           0.033244 *  
## rcs(GFR)GFR'                                          0.002329 ** 
## rcs(GFR)GFR''                                         0.000735 ***
## rcs(GFR)GFR'''                                        0.000417 ***
## rcs(bmi)bmi                                           0.000115 ***
## rcs(bmi)bmi'                                          2.18e-05 ***
## rcs(bmi)bmi''                                         0.000183 ***
## rcs(bmi)bmi'''                                        0.000983 ***
## factor(FodelseLand_EU27_2020)1                        0.000768 ***
## rcs(hba1c)hba1c                                       0.452865    
## rcs(hba1c)hba1c'                                      0.177003    
## rcs(hba1c)hba1c''                                     0.215383    
## rcs(hba1c)hba1c'''                                    0.292532    
## factor(antihypertensive_comb)1                        0.000191 ***
## factor(stroke_history)1                               0.001243 ** 
## rcs(systoliskt)systoliskt                             0.007894 ** 
## rcs(systoliskt)systoliskt'                            0.135776    
## rcs(systoliskt)systoliskt''                           0.302094    
## rcs(systoliskt)systoliskt'''                          0.392017    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             0.903837    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            0.791951    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           0.789286    
## factor(rokare)1                                       0.030475 *  
## factor(ami_history)1                                  0.028232 *  
## factor(lipid_modifying_agents)1                       0.026854 *  
## rcs(alder)alder:rcs(GFR)GFR                           0.127611    
## rcs(alder)alder':rcs(GFR)GFR                          0.076314 .  
## rcs(alder)alder'':rcs(GFR)GFR                         0.093755 .  
## rcs(alder)alder''':rcs(GFR)GFR                        0.162097    
## rcs(alder)alder:rcs(GFR)GFR'                          0.010727 *  
## rcs(alder)alder':rcs(GFR)GFR'                         0.003278 ** 
## rcs(alder)alder'':rcs(GFR)GFR'                        0.003194 ** 
## rcs(alder)alder''':rcs(GFR)GFR'                       0.006489 ** 
## rcs(alder)alder:rcs(GFR)GFR''                         0.003066 ** 
## rcs(alder)alder':rcs(GFR)GFR''                        0.000749 ***
## rcs(alder)alder'':rcs(GFR)GFR''                       0.000723 ***
## rcs(alder)alder''':rcs(GFR)GFR''                      0.001822 ** 
## rcs(alder)alder:rcs(GFR)GFR'''                        0.001593 ** 
## rcs(alder)alder':rcs(GFR)GFR'''                       0.000370 ***
## rcs(alder)alder'':rcs(GFR)GFR'''                      0.000405 ***
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.001298 ** 
## factor(cpap_treated)1:factor(antihypertensive_comb)1  0.017261 *  
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.112449    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  3.063e-01  3.265e+00
## rcs(alder)alder                                        3.993e-03  2.505e+02
## rcs(alder)alder'                                       9.064e+07  1.103e-08
## rcs(alder)alder''                                      4.483e-36  2.230e+35
## rcs(alder)alder'''                                     1.747e+44  5.724e-45
## rcs(time_to_cpap_start)time_to_cpap_start              5.655e-01  1.768e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             1.015e-01  9.855e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            9.479e+02  1.055e-03
## rcs(time_to_cpap_start)time_to_cpap_start'''           3.822e-03  2.617e+02
## rcs(IV_AverageSaturation)IV_AverageSaturation          8.615e-01  1.161e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'         6.132e-01  1.631e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''        3.959e+01  2.526e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation'''       4.119e-03  2.428e+02
## factor(antithrombotic_agents)1                         1.304e+00  7.668e-01
## rcs(DispInkKEHB04)DispInkKEHB04                        6.075e-01  1.646e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       6.371e-07  1.570e+06
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.062e+20  9.419e-21
## rcs(DispInkKEHB04)DispInkKEHB04'''                     3.061e-19  3.267e+18
## factor(sex)1                                           5.596e-01  1.787e+00
## rcs(GFR)GFR                                            3.299e-03  3.031e+02
## rcs(GFR)GFR'                                           7.362e+18  1.358e-19
## rcs(GFR)GFR''                                         3.176e-115 3.148e+114
## rcs(GFR)GFR'''                                        7.559e+199 1.323e-200
## rcs(bmi)bmi                                            4.662e-01  2.145e+00
## rcs(bmi)bmi'                                           1.504e+03  6.649e-04
## rcs(bmi)bmi''                                          1.359e-16  7.359e+15
## rcs(bmi)bmi'''                                         3.428e+17  2.917e-18
## factor(FodelseLand_EU27_2020)1                         1.414e+00  7.072e-01
## rcs(hba1c)hba1c                                        6.857e-01  1.458e+00
## rcs(hba1c)hba1c'                                       3.611e+06  2.769e-07
## rcs(hba1c)hba1c''                                      1.244e-20  8.038e+19
## rcs(hba1c)hba1c'''                                     5.207e+15  1.921e-16
## factor(antihypertensive_comb)1                         1.668e+00  5.995e-01
## factor(stroke_history)1                                1.639e+00  6.103e-01
## rcs(systoliskt)systoliskt                              6.631e-01  1.508e+00
## rcs(systoliskt)systoliskt'                             3.367e+00  2.970e-01
## rcs(systoliskt)systoliskt''                            1.388e-03  7.206e+02
## rcs(systoliskt)systoliskt'''                           1.467e+05  6.816e-06
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              8.639e-01  1.158e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             8.532e+28  1.172e-29
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            1.602e-31  6.244e+30
## factor(rokare)1                                        1.257e+00  7.955e-01
## factor(ami_history)1                                   1.316e+00  7.596e-01
## factor(lipid_modifying_agents)1                        7.767e-01  1.287e+00
## rcs(alder)alder:rcs(GFR)GFR                            1.751e-02  5.711e+01
## rcs(alder)alder':rcs(GFR)GFR                           6.115e+04  1.635e-05
## rcs(alder)alder'':rcs(GFR)GFR                          9.363e-20  1.068e+19
## rcs(alder)alder''':rcs(GFR)GFR                         1.787e+20  5.597e-21
## rcs(alder)alder:rcs(GFR)GFR'                           1.264e+14  7.913e-15
## rcs(alder)alder':rcs(GFR)GFR'                          3.142e-44  3.183e+43
## rcs(alder)alder'':rcs(GFR)GFR'                        2.831e+203 3.532e-204
## rcs(alder)alder''':rcs(GFR)GFR'                       1.236e-264 8.093e+263
## rcs(alder)alder:rcs(GFR)GFR''                          7.579e-87  1.319e+86
## rcs(alder)alder':rcs(GFR)GFR''                        3.468e+277 2.884e-278
## rcs(alder)alder'':rcs(GFR)GFR''                        0.000e+00        Inf
## rcs(alder)alder''':rcs(GFR)GFR''                             Inf  0.000e+00
## rcs(alder)alder:rcs(GFR)GFR'''                        9.331e+149 1.072e-150
## rcs(alder)alder':rcs(GFR)GFR'''                        0.000e+00        Inf
## rcs(alder)alder'':rcs(GFR)GFR'''                             Inf  0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR'''                      0.000e+00        Inf
## factor(cpap_treated)1:factor(antihypertensive_comb)1   6.481e-01  1.543e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  1.279e+00  7.818e-01
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  2.101e-01  4.465e-01
## rcs(alder)alder                                        1.351e-05  1.180e+00
## rcs(alder)alder'                                       3.538e+01  2.322e+14
## rcs(alder)alder''                                      2.976e-65  6.754e-07
## rcs(alder)alder'''                                     1.818e+04  1.679e+84
## rcs(time_to_cpap_start)time_to_cpap_start              3.138e-01  1.019e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             2.925e-03  3.520e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            2.080e-03  4.320e+08
## rcs(time_to_cpap_start)time_to_cpap_start'''           6.329e-10  2.308e+04
## rcs(IV_AverageSaturation)IV_AverageSaturation          7.716e-01  9.618e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'         3.524e-01  1.067e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''        8.656e-02  1.811e+04
## rcs(IV_AverageSaturation)IV_AverageSaturation'''       7.545e-14  2.249e+08
## factor(antithrombotic_agents)1                         1.096e+00  1.552e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        3.296e-01  1.120e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       7.995e-12  5.076e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                      4.917e+01  2.293e+38
## rcs(DispInkKEHB04)DispInkKEHB04'''                     2.949e-41  3.177e+03
## factor(sex)1                                           4.712e-01  6.645e-01
## rcs(GFR)GFR                                            1.714e-05  6.351e-01
## rcs(GFR)GFR'                                           5.273e+06  1.028e+31
## rcs(GFR)GFR''                                         1.070e-181  9.426e-49
## rcs(GFR)GFR'''                                         7.411e+88        Inf
## rcs(bmi)bmi                                            3.164e-01  6.871e-01
## rcs(bmi)bmi'                                           5.136e+01  4.404e+04
## rcs(bmi)bmi''                                          6.611e-25  2.793e-08
## rcs(bmi)bmi'''                                         1.276e+07  9.207e+27
## factor(FodelseLand_EU27_2020)1                         1.156e+00  1.730e+00
## rcs(hba1c)hba1c                                        2.560e-01  1.836e+00
## rcs(hba1c)hba1c'                                       1.090e-03  1.196e+16
## rcs(hba1c)hba1c''                                      4.023e-52  3.848e+11
## rcs(hba1c)hba1c'''                                     2.828e-14  9.586e+44
## factor(antihypertensive_comb)1                         1.275e+00  2.183e+00
## factor(stroke_history)1                                1.214e+00  2.211e+00
## rcs(systoliskt)systoliskt                              4.898e-01  8.979e-01
## rcs(systoliskt)systoliskt'                             6.831e-01  1.659e+01
## rcs(systoliskt)systoliskt''                            5.185e-09  3.714e+02
## rcs(systoliskt)systoliskt'''                           2.170e-07  9.921e+16
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              8.044e-02  9.277e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            9.195e-187 7.917e+243
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           2.218e-257 1.157e+195
## factor(rokare)1                                        1.022e+00  1.546e+00
## factor(ami_history)1                                   1.030e+00  1.683e+00
## factor(lipid_modifying_agents)1                        6.210e-01  9.715e-01
## rcs(alder)alder:rcs(GFR)GFR                            9.628e-05  3.185e+00
## rcs(alder)alder':rcs(GFR)GFR                           3.117e-01  1.200e+10
## rcs(alder)alder'':rcs(GFR)GFR                          5.220e-42  1.679e+03
## rcs(alder)alder''':rcs(GFR)GFR                         7.248e-09  4.404e+48
## rcs(alder)alder:rcs(GFR)GFR'                           1.858e+03  8.593e+24
## rcs(alder)alder':rcs(GFR)GFR'                          3.161e-73  3.124e-15
## rcs(alder)alder'':rcs(GFR)GFR'                         1.609e+68        Inf
## rcs(alder)alder''':rcs(GFR)GFR'                        0.000e+00  1.310e-74
## rcs(alder)alder:rcs(GFR)GFR''                         7.514e-144  7.644e-30
## rcs(alder)alder':rcs(GFR)GFR''                        1.479e+116        Inf
## rcs(alder)alder'':rcs(GFR)GFR''                        0.000e+00  0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR''                             Inf        Inf
## rcs(alder)alder:rcs(GFR)GFR'''                         7.403e+56 1.176e+243
## rcs(alder)alder':rcs(GFR)GFR'''                        0.000e+00 4.358e-224
## rcs(alder)alder'':rcs(GFR)GFR'''                             Inf        Inf
## rcs(alder)alder''':rcs(GFR)GFR'''                      0.000e+00  0.000e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1   4.536e-01  9.262e-01
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  9.438e-01  1.734e+00
## 
## Concordance= 0.823  (se = 0.008 )
## Likelihood ratio test= 1053  on 62 df,   p=<2e-16
## Wald test            = 1049  on 62 df,   p=<2e-16
## Score (logrank) test = 1379  on 62 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.8234875 
## C-index test: 0.8193051[1] "### FORMULA 2 ###"
## Start:  AIC=12308.99
## Surv(time_to_death, death) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(alder)                      4 11842
## + rcs(time_to_cpap_start)         4 12075
## + factor(antithrombotic_agents)   1 12159
## + factor(GFR_high)                1 12218
## + rcs(IV_AverageSaturation)       4 12240
## + factor(Sun2000niva_old)         6 12247
## + factor(antihypertensive_comb)   1 12250
## + factor(ami_history)             1 12265
## + rcs(DispInkKEHB04)              4 12267
## + rcs(IV_AHI)                     4 12269
## + rcs(IV_ODI)                     4 12273
## + factor(stroke_history)          1 12274
## + factor(Civil)                   1 12281
## + factor(FodelseLand_EU27_2020)   1 12286
## + factor(sex)                     1 12292
## + factor(hba1c_high)              1 12296
## + factor(kolesterol_high)         1 12298
## + rcs(bmi)                        4 12298
## + factor(lipid_modifying_agents)  1 12299
## + rcs(Raks_AndelEkBisInk)         3 12300
## + rcs(Raks_AndelSjukInk)          4 12303
## <none>                              12309
## + factor(rokare)                  1 12311
## + factor(systoliskt_high)         1 12311
## + rcs(Raks_AndelArblosInk)        4 12314
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11842.38
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(time_to_cpap_start)         4 11653
## + rcs(IV_AverageSaturation)       4 11772
## + rcs(bmi)                        4 11794
## + factor(antithrombotic_agents)   1 11803
## + rcs(IV_ODI)                     4 11803
## + rcs(IV_AHI)                     4 11811
## + factor(sex)                     1 11814
## + rcs(DispInkKEHB04)              4 11819
## + factor(ami_history)             1 11823
## + factor(antihypertensive_comb)   1 11823
## + factor(GFR_high)                1 11825
## + factor(Sun2000niva_old)         6 11826
## + factor(hba1c_high)              1 11827
## + factor(stroke_history)          1 11828
## + rcs(Raks_AndelSjukInk)          4 11837
## + factor(FodelseLand_EU27_2020)   1 11839
## + factor(kolesterol_high)         1 11840
## + factor(rokare)                  1 11840
## <none>                              11842
## + rcs(Raks_AndelEkBisInk)         3 11842
## + factor(lipid_modifying_agents)  1 11843
## + factor(systoliskt_high)         1 11844
## + factor(Civil)                   1 11844
## + rcs(Raks_AndelArblosInk)        4 11848
## - rcs(alder)                      4 12309
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11652.69
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(IV_AverageSaturation)       4 11587
## + rcs(DispInkKEHB04)              4 11614
## + factor(antithrombotic_agents)   1 11614
## + rcs(IV_ODI)                     4 11618
## + rcs(bmi)                        4 11620
## + rcs(IV_AHI)                     4 11624
## + factor(sex)                     1 11626
## + factor(hba1c_high)              1 11629
## + factor(Sun2000niva_old)         6 11632
## + factor(antihypertensive_comb)   1 11632
## + factor(GFR_high)                1 11636
## + factor(ami_history)             1 11638
## + factor(stroke_history)          1 11639
## + factor(kolesterol_high)         1 11648
## + factor(rokare)                  1 11649
## + factor(FodelseLand_EU27_2020)   1 11651
## + rcs(Raks_AndelSjukInk)          4 11652
## + rcs(Raks_AndelEkBisInk)         3 11652
## <none>                              11653
## + factor(lipid_modifying_agents)  1 11654
## + factor(systoliskt_high)         1 11655
## + factor(Civil)                   1 11655
## + rcs(Raks_AndelArblosInk)        4 11659
## - rcs(time_to_cpap_start)         4 11842
## - rcs(alder)                      4 12075
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11587.37
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(antithrombotic_agents)   1 11552
## + rcs(DispInkKEHB04)              4 11553
## + factor(sex)                     1 11556
## + factor(hba1c_high)              1 11566
## + factor(antihypertensive_comb)   1 11571
## + factor(GFR_high)                1 11573
## + factor(Sun2000niva_old)         6 11573
## + factor(ami_history)             1 11574
## + factor(stroke_history)          1 11574
## + rcs(bmi)                        4 11574
## + factor(kolesterol_high)         1 11581
## + rcs(IV_ODI)                     4 11583
## + rcs(IV_AHI)                     4 11584
## + factor(FodelseLand_EU27_2020)   1 11585
## + factor(rokare)                  1 11585
## + rcs(Raks_AndelSjukInk)          4 11586
## <none>                              11587
## + factor(lipid_modifying_agents)  1 11588
## + rcs(Raks_AndelEkBisInk)         3 11588
## + factor(systoliskt_high)         1 11589
## + factor(Civil)                   1 11589
## + rcs(Raks_AndelArblosInk)        4 11594
## - rcs(IV_AverageSaturation)       4 11653
## - rcs(time_to_cpap_start)         4 11772
## - rcs(alder)                      4 12012
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11551.85
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(DispInkKEHB04)                                  4 11520
## + factor(sex)                                         1 11527
## + factor(hba1c_high)                                  1 11533
## + rcs(bmi)                                            4 11538
## + factor(Sun2000niva_old)                             6 11539
## + factor(GFR_high)                                    1 11539
## + factor(antihypertensive_comb)                       1 11544
## + factor(stroke_history)                              1 11545
## + rcs(IV_ODI)                                         4 11547
## + factor(ami_history)                                 1 11548
## + rcs(IV_AHI)                                         4 11548
## + factor(FodelseLand_EU27_2020)                       1 11549
## + factor(rokare)                                      1 11550
## + factor(kolesterol_high)                             1 11550
## + rcs(Raks_AndelEkBisInk)                             3 11552
## <none>                                                  11552
## + rcs(Raks_AndelSjukInk)                              4 11552
## + factor(lipid_modifying_agents)                      1 11553
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11554
## + factor(Civil)                                       1 11554
## + factor(systoliskt_high)                             1 11554
## + rcs(Raks_AndelArblosInk)                            4 11558
## - factor(antithrombotic_agents)                       1 11587
## - rcs(IV_AverageSaturation)                           4 11614
## - rcs(time_to_cpap_start)                             4 11736
## - rcs(alder)                                          4 11864
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11519.79
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(sex)                                         1 11484
## + factor(hba1c_high)                                  1 11503
## + factor(FodelseLand_EU27_2020)                       1 11508
## + rcs(bmi)                                            4 11508
## + factor(GFR_high)                                    1 11509
## + factor(antihypertensive_comb)                       1 11510
## + factor(stroke_history)                              1 11512
## + rcs(IV_AHI)                                         4 11515
## + rcs(IV_ODI)                                         4 11515
## + rcs(Raks_AndelEkBisInk)                             3 11516
## + factor(ami_history)                                 1 11516
## + factor(Sun2000niva_old)                             6 11517
## + factor(rokare)                                      1 11519
## + factor(kolesterol_high)                             1 11519
## <none>                                                  11520
## + rcs(Raks_AndelSjukInk)                              4 11520
## + factor(lipid_modifying_agents)                      1 11522
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11522
## + factor(Civil)                                       1 11522
## + factor(systoliskt_high)                             1 11522
## + rcs(Raks_AndelArblosInk)                            4 11527
## - rcs(DispInkKEHB04)                                  4 11552
## - factor(antithrombotic_agents)                       1 11553
## - rcs(IV_AverageSaturation)                           4 11577
## - rcs(time_to_cpap_start)                             4 11718
## - rcs(alder)                                          4 11814
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11484.09
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(bmi)                                            4 11464
## + factor(hba1c_high)                                  1 11470
## + factor(FodelseLand_EU27_2020)                       1 11471
## + factor(GFR_high)                                    1 11471
## + factor(antihypertensive_comb)                       1 11476
## + factor(stroke_history)                              1 11476
## + rcs(Raks_AndelEkBisInk)                             3 11479
## + rcs(IV_ODI)                                         4 11481
## + factor(Sun2000niva_old)                             6 11482
## + factor(ami_history)                                 1 11482
## + rcs(IV_AHI)                                         4 11482
## + factor(rokare)                                      1 11483
## + rcs(Raks_AndelSjukInk)                              4 11483
## <none>                                                  11484
## + factor(kolesterol_high)                             1 11485
## + factor(Civil)                                       1 11485
## + factor(lipid_modifying_agents)                      1 11485
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11486
## + factor(systoliskt_high)                             1 11486
## + rcs(Raks_AndelArblosInk)                            4 11492
## - factor(antithrombotic_agents)                       1 11509
## - factor(sex)                                         1 11520
## - rcs(DispInkKEHB04)                                  4 11527
## - rcs(IV_AverageSaturation)                           4 11546
## - rcs(time_to_cpap_start)                             4 11682
## - rcs(alder)                                          4 11796
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11464.1
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(FodelseLand_EU27_2020)                       1 11451
## + factor(GFR_high)                                    1 11452
## + factor(hba1c_high)                                  1 11452
## + factor(antihypertensive_comb)                       1 11455
## + factor(stroke_history)                              1 11456
## + rcs(Raks_AndelEkBisInk)                             3 11459
## + factor(ami_history)                                 1 11462
## + factor(rokare)                                      1 11463
## + rcs(IV_ODI)                                         4 11463
## + factor(Sun2000niva_old)                             6 11463
## + rcs(Raks_AndelSjukInk)                              4 11464
## <none>                                                  11464
## + rcs(IV_AHI)                                         4 11464
## + factor(Civil)                                       1 11464
## + factor(kolesterol_high)                             1 11465
## + factor(lipid_modifying_agents)                      1 11466
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11466
## + factor(systoliskt_high)                             1 11466
## + rcs(Raks_AndelArblosInk)                            4 11472
## + rcs(alder):rcs(bmi)                                16 11474
## - rcs(bmi)                                            4 11484
## - factor(antithrombotic_agents)                       1 11490
## - rcs(DispInkKEHB04)                                  4 11505
## - rcs(IV_AverageSaturation)                           4 11508
## - factor(sex)                                         1 11508
## - rcs(time_to_cpap_start)                             4 11652
## - rcs(alder)                                          4 11780
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11451.4
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(GFR_high)                                    1 11438
## + factor(hba1c_high)                                  1 11439
## + factor(antihypertensive_comb)                       1 11443
## + factor(stroke_history)                              1 11445
## + factor(ami_history)                                 1 11450
## + rcs(Raks_AndelEkBisInk)                             3 11450
## + factor(rokare)                                      1 11450
## + rcs(IV_ODI)                                         4 11450
## <none>                                                  11451
## + rcs(Raks_AndelSjukInk)                              4 11452
## + factor(kolesterol_high)                             1 11452
## + factor(Civil)                                       1 11452
## + rcs(IV_AHI)                                         4 11452
## + factor(Sun2000niva_old)                             6 11452
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11453
## + factor(lipid_modifying_agents)                      1 11453
## + factor(systoliskt_high)                             1 11453
## + rcs(Raks_AndelArblosInk)                            4 11459
## + rcs(alder):rcs(bmi)                                16 11461
## - factor(FodelseLand_EU27_2020)                       1 11464
## - rcs(bmi)                                            4 11471
## - factor(antithrombotic_agents)                       1 11477
## - rcs(IV_AverageSaturation)                           4 11495
## - factor(sex)                                         1 11497
## - rcs(DispInkKEHB04)                                  4 11503
## - rcs(time_to_cpap_start)                             4 11640
## - rcs(alder)                                          4 11739
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11438.31
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(hba1c_high)                                  1 11426
## + factor(antihypertensive_comb)                       1 11431
## + factor(stroke_history)                              1 11432
## + rcs(Raks_AndelEkBisInk)                             3 11436
## + factor(rokare)                                      1 11436
## + factor(ami_history)                                 1 11437
## + rcs(IV_ODI)                                         4 11438
## + rcs(Raks_AndelSjukInk)                              4 11438
## <none>                                                  11438
## + factor(kolesterol_high)                             1 11439
## + factor(cpap_treated):factor(GFR_high)               1 11439
## + factor(Civil)                                       1 11439
## + factor(Sun2000niva_old)                             6 11439
## + rcs(IV_AHI)                                         4 11440
## + factor(lipid_modifying_agents)                      1 11440
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11440
## + factor(systoliskt_high)                             1 11440
## + rcs(alder):factor(GFR_high)                         4 11440
## + rcs(Raks_AndelArblosInk)                            4 11446
## + rcs(alder):rcs(bmi)                                16 11447
## - factor(GFR_high)                                    1 11451
## - factor(FodelseLand_EU27_2020)                       1 11452
## - rcs(bmi)                                            4 11458
## - factor(antithrombotic_agents)                       1 11462
## - rcs(IV_AverageSaturation)                           4 11481
## - factor(sex)                                         1 11486
## - rcs(DispInkKEHB04)                                  4 11489
## - rcs(time_to_cpap_start)                             4 11627
## - rcs(alder)                                          4 11683
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11426.01
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(antihypertensive_comb)                       1 11419
## + factor(stroke_history)                              1 11420
## + rcs(Raks_AndelEkBisInk)                             3 11424
## + factor(ami_history)                                 1 11424
## + factor(rokare)                                      1 11424
## + rcs(Raks_AndelSjukInk)                              4 11426
## <none>                                                  11426
## + rcs(IV_ODI)                                         4 11426
## + factor(kolesterol_high)                             1 11427
## + factor(Civil)                                       1 11427
## + factor(cpap_treated):factor(GFR_high)               1 11427
## + factor(Sun2000niva_old)                             6 11427
## + factor(lipid_modifying_agents)                      1 11428
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11428
## + rcs(alder):factor(GFR_high)                         4 11428
## + factor(systoliskt_high)                             1 11428
## + rcs(IV_AHI)                                         4 11429
## + rcs(Raks_AndelArblosInk)                            4 11433
## + rcs(alder):rcs(bmi)                                16 11434
## - factor(hba1c_high)                                  1 11438
## - factor(GFR_high)                                    1 11439
## - factor(FodelseLand_EU27_2020)                       1 11439
## - rcs(bmi)                                            4 11443
## - factor(antithrombotic_agents)                       1 11449
## - rcs(IV_AverageSaturation)                           4 11468
## - factor(sex)                                         1 11472
## - rcs(DispInkKEHB04)                                  4 11474
## - rcs(time_to_cpap_start)                             4 11621
## - rcs(alder)                                          4 11670
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11418.79
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(stroke_history)                              1 11413
## + rcs(Raks_AndelEkBisInk)                             3 11416
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11417
## + factor(rokare)                                      1 11417
## + factor(ami_history)                                 1 11417
## + rcs(Raks_AndelSjukInk)                              4 11419
## <none>                                                  11419
## + rcs(IV_ODI)                                         4 11419
## + factor(lipid_modifying_agents)                      1 11419
## + factor(kolesterol_high)                             1 11420
## + factor(Civil)                                       1 11420
## + factor(cpap_treated):factor(GFR_high)               1 11420
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11420
## + factor(systoliskt_high)                             1 11420
## + factor(Sun2000niva_old)                             6 11420
## + rcs(alder):factor(GFR_high)                         4 11421
## + rcs(IV_AHI)                                         4 11422
## + rcs(Raks_AndelArblosInk)                            4 11426
## - factor(antihypertensive_comb)                       1 11426
## + rcs(alder):rcs(bmi)                                16 11427
## - factor(GFR_high)                                    1 11430
## - factor(FodelseLand_EU27_2020)                       1 11431
## - factor(hba1c_high)                                  1 11431
## - factor(antithrombotic_agents)                       1 11435
## - rcs(bmi)                                            4 11437
## - rcs(IV_AverageSaturation)                           4 11459
## - factor(sex)                                         1 11463
## - rcs(DispInkKEHB04)                                  4 11468
## - rcs(time_to_cpap_start)                             4 11616
## - rcs(alder)                                          4 11654
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11413.13
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb) + 
##     factor(stroke_history)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(Raks_AndelEkBisInk)                             3 11411
## + factor(rokare)                                      1 11411
## + factor(ami_history)                                 1 11411
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11411
## + rcs(Raks_AndelSjukInk)                              4 11413
## <none>                                                  11413
## + factor(lipid_modifying_agents)                      1 11413
## + rcs(IV_ODI)                                         4 11414
## + factor(Civil)                                       1 11414
## + factor(kolesterol_high)                             1 11414
## + factor(cpap_treated):factor(GFR_high)               1 11414
## + factor(systoliskt_high)                             1 11414
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11415
## + factor(Sun2000niva_old)                             6 11415
## + rcs(alder):factor(GFR_high)                         4 11415
## + rcs(IV_AHI)                                         4 11416
## - factor(stroke_history)                              1 11419
## + rcs(Raks_AndelArblosInk)                            4 11420
## - factor(antihypertensive_comb)                       1 11420
## + rcs(alder):rcs(bmi)                                16 11421
## - factor(GFR_high)                                    1 11424
## - factor(FodelseLand_EU27_2020)                       1 11424
## - factor(hba1c_high)                                  1 11425
## - factor(antithrombotic_agents)                       1 11425
## - rcs(bmi)                                            4 11431
## - rcs(IV_AverageSaturation)                           4 11454
## - factor(sex)                                         1 11458
## - rcs(DispInkKEHB04)                                  4 11462
## - rcs(time_to_cpap_start)                             4 11608
## - rcs(alder)                                          4 11647
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11410.55
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(Raks_AndelEkBisInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(rokare)                                      1 11408
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11409
## + factor(ami_history)                                 1 11409
## <none>                                                  11411
## + rcs(IV_ODI)                                         4 11411
## + rcs(Raks_AndelSjukInk)                              4 11411
## + factor(lipid_modifying_agents)                      1 11411
## + factor(Civil)                                       1 11411
## + factor(cpap_treated):factor(GFR_high)               1 11412
## + factor(kolesterol_high)                             1 11412
## + factor(systoliskt_high)                             1 11412
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11412
## + rcs(alder):factor(GFR_high)                         4 11412
## + factor(Sun2000niva_old)                             6 11413
## - rcs(Raks_AndelEkBisInk)                             3 11413
## + rcs(IV_AHI)                                         4 11414
## - factor(stroke_history)                              1 11416
## - factor(antihypertensive_comb)                       1 11418
## + rcs(Raks_AndelArblosInk)                            4 11418
## + rcs(alder):rcs(bmi)                                16 11418
## - factor(FodelseLand_EU27_2020)                       1 11418
## - factor(GFR_high)                                    1 11422
## - factor(hba1c_high)                                  1 11423
## - factor(antithrombotic_agents)                       1 11424
## - rcs(bmi)                                            4 11429
## - rcs(IV_AverageSaturation)                           4 11450
## - factor(sex)                                         1 11456
## - rcs(DispInkKEHB04)                                  4 11462
## - rcs(time_to_cpap_start)                             4 11606
## - rcs(alder)                                          4 11636
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11408.1
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(Raks_AndelEkBisInk) + factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(cpap_treated):factor(antihypertensive_comb)  1 11406
## + factor(ami_history)                                 1 11406
## + rcs(IV_ODI)                                         4 11408
## <none>                                                  11408
## + factor(lipid_modifying_agents)                      1 11408
## + rcs(Raks_AndelSjukInk)                              4 11408
## + factor(Civil)                                       1 11409
## + factor(cpap_treated):factor(GFR_high)               1 11409
## + factor(kolesterol_high)                             1 11409
## + rcs(alder):factor(GFR_high)                         4 11410
## + factor(systoliskt_high)                             1 11410
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11410
## - factor(rokare)                                      1 11411
## + factor(Sun2000niva_old)                             6 11411
## - rcs(Raks_AndelEkBisInk)                             3 11411
## + rcs(IV_AHI)                                         4 11411
## - factor(stroke_history)                              1 11414
## + rcs(alder):rcs(bmi)                                16 11415
## + rcs(Raks_AndelArblosInk)                            4 11416
## - factor(antihypertensive_comb)                       1 11416
## - factor(FodelseLand_EU27_2020)                       1 11416
## - factor(GFR_high)                                    1 11420
## - factor(hba1c_high)                                  1 11420
## - factor(antithrombotic_agents)                       1 11421
## - rcs(bmi)                                            4 11427
## - rcs(IV_AverageSaturation)                           4 11446
## - factor(sex)                                         1 11454
## - rcs(DispInkKEHB04)                                  4 11459
## - rcs(time_to_cpap_start)                             4 11605
## - rcs(alder)                                          4 11638
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11406.16
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(Raks_AndelEkBisInk) + factor(rokare) + 
##     factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(ami_history)                                 1 11404
## <none>                                                  11406
## + rcs(IV_ODI)                                         4 11406
## + factor(lipid_modifying_agents)                      1 11406
## + factor(Civil)                                       1 11407
## + rcs(Raks_AndelSjukInk)                              4 11407
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11407
## + factor(kolesterol_high)                             1 11407
## + rcs(alder):factor(GFR_high)                         4 11407
## + factor(cpap_treated):factor(GFR_high)               1 11407
## + factor(systoliskt_high)                             1 11407
## - factor(cpap_treated):factor(antihypertensive_comb)  1 11408
## + factor(Sun2000niva_old)                             6 11409
## - factor(rokare)                                      1 11409
## - rcs(Raks_AndelEkBisInk)                             3 11409
## + rcs(IV_AHI)                                         4 11409
## - factor(stroke_history)                              1 11412
## + rcs(alder):rcs(bmi)                                16 11413
## + rcs(Raks_AndelArblosInk)                            4 11414
## - factor(FodelseLand_EU27_2020)                       1 11414
## - factor(GFR_high)                                    1 11418
## - factor(hba1c_high)                                  1 11419
## - factor(antithrombotic_agents)                       1 11419
## - rcs(bmi)                                            4 11425
## - rcs(IV_AverageSaturation)                           4 11445
## - factor(sex)                                         1 11451
## - rcs(DispInkKEHB04)                                  4 11456
## - rcs(time_to_cpap_start)                             4 11602
## - rcs(alder)                                          4 11634
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11404.47
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(Raks_AndelEkBisInk) + factor(rokare) + 
##     factor(ami_history) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(lipid_modifying_agents)                      1 11404
## <none>                                                  11404
## + rcs(IV_ODI)                                         4 11405
## + factor(Civil)                                       1 11405
## + rcs(alder):factor(GFR_high)                         4 11405
## + factor(cpap_treated):factor(antithrombotic_agents)  1 11405
## + rcs(Raks_AndelSjukInk)                              4 11405
## + factor(kolesterol_high)                             1 11406
## + factor(cpap_treated):factor(GFR_high)               1 11406
## + factor(systoliskt_high)                             1 11406
## - factor(ami_history)                                 1 11406
## - factor(cpap_treated):factor(antihypertensive_comb)  1 11406
## + factor(Sun2000niva_old)                             6 11407
## - rcs(Raks_AndelEkBisInk)                             3 11407
## - factor(rokare)                                      1 11407
## + rcs(IV_AHI)                                         4 11408
## - factor(stroke_history)                              1 11410
## + rcs(alder):rcs(bmi)                                16 11411
## + rcs(Raks_AndelArblosInk)                            4 11412
## - factor(antithrombotic_agents)                       1 11413
## - factor(FodelseLand_EU27_2020)                       1 11413
## - factor(GFR_high)                                    1 11415
## - factor(hba1c_high)                                  1 11417
## - rcs(bmi)                                            4 11423
## - rcs(IV_AverageSaturation)                           4 11443
## - factor(sex)                                         1 11447
## - rcs(DispInkKEHB04)                                  4 11454
## - rcs(time_to_cpap_start)                             4 11598
## - rcs(alder)                                          4 11632
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=11403.96
## Surv(time_to_death, death) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(sex) + rcs(bmi) + factor(FodelseLand_EU27_2020) + 
##     factor(GFR_high) + factor(hba1c_high) + factor(antihypertensive_comb) + 
##     factor(stroke_history) + rcs(Raks_AndelEkBisInk) + factor(rokare) + 
##     factor(ami_history) + factor(lipid_modifying_agents) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
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##                                                       Df   AIC
## <none>                                                   11404
## + factor(Civil)                                        1 11404
## + rcs(alder):factor(GFR_high)                          4 11404
## - factor(lipid_modifying_agents)                       1 11404
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 11404
## + rcs(IV_ODI)                                          4 11405
## + factor(cpap_treated):factor(antithrombotic_agents)   1 11405
## + rcs(Raks_AndelSjukInk)                               4 11405
## + factor(kolesterol_high)                              1 11405
## + factor(systoliskt_high)                              1 11405
## + factor(cpap_treated):factor(GFR_high)                1 11405
## - factor(cpap_treated):factor(antihypertensive_comb)   1 11406
## + factor(Sun2000niva_old)                              6 11406
## - rcs(Raks_AndelEkBisInk)                              3 11406
## - factor(ami_history)                                  1 11406
## - factor(rokare)                                       1 11407
## + rcs(IV_AHI)                                          4 11407
## - factor(stroke_history)                               1 11410
## + rcs(alder):rcs(bmi)                                 16 11411
## + rcs(Raks_AndelArblosInk)                             4 11411
## - factor(FodelseLand_EU27_2020)                        1 11412
## - factor(antithrombotic_agents)                        1 11414
## - factor(GFR_high)                                     1 11415
## - factor(hba1c_high)                                   1 11417
## - rcs(bmi)                                             4 11422
## - rcs(IV_AverageSaturation)                            4 11442
## - factor(sex)                                          1 11447
## - rcs(DispInkKEHB04)                                   4 11453
## - rcs(time_to_cpap_start)                              4 11598
## - rcs(alder)                                           4 11630
## + factor(HushallsType_RTB)                                    
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_death, death) ~ factor(cpap_treated) + 
##     rcs(alder) + rcs(time_to_cpap_start) + rcs(IV_AverageSaturation) + 
##     factor(antithrombotic_agents) + rcs(DispInkKEHB04) + factor(sex) + 
##     rcs(bmi) + factor(FodelseLand_EU27_2020) + factor(GFR_high) + 
##     factor(hba1c_high) + factor(antihypertensive_comb) + factor(stroke_history) + 
##     rcs(Raks_AndelEkBisInk) + factor(rokare) + factor(ami_history) + 
##     factor(lipid_modifying_agents) + factor(cpap_treated):factor(antihypertensive_comb), 
##     data = df_train)
## 
##   n= 10603, number of events= 732 
## 
##                                                            coef  exp(coef)
## factor(cpap_treated)1                                -1.088e+00  3.368e-01
## rcs(alder)alder                                       2.753e-01  1.317e+00
## rcs(alder)alder'                                      1.235e+00  3.439e+00
## rcs(alder)alder''                                    -6.249e+00  1.932e-03
## rcs(alder)alder'''                                    1.033e+01  3.060e+04
## rcs(time_to_cpap_start)time_to_cpap_start            -5.659e-01  5.679e-01
## rcs(time_to_cpap_start)time_to_cpap_start'           -2.179e+00  1.131e-01
## rcs(time_to_cpap_start)time_to_cpap_start''           6.361e+00  5.790e+02
## rcs(time_to_cpap_start)time_to_cpap_start'''         -4.875e+00  7.636e-03
## rcs(IV_AverageSaturation)IV_AverageSaturation        -1.456e-01  8.645e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'       -5.252e-01  5.915e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation''       4.026e+00  5.605e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation'''     -6.209e+00  2.011e-03
## factor(antithrombotic_agents)1                        3.075e-01  1.360e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      -4.862e-01  6.150e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                     -1.452e+01  4.932e-07
## rcs(DispInkKEHB04)DispInkKEHB04''                     4.645e+01  1.491e+20
## rcs(DispInkKEHB04)DispInkKEHB04'''                   -4.233e+01  4.132e-19
## factor(sex)1                                         -5.647e-01  5.686e-01
## rcs(bmi)bmi                                          -8.303e-01  4.359e-01
## rcs(bmi)bmi'                                          7.538e+00  1.878e+03
## rcs(bmi)bmi''                                        -3.723e+01  6.759e-17
## rcs(bmi)bmi'''                                        4.095e+01  6.112e+17
## factor(FodelseLand_EU27_2020)1                        3.220e-01  1.380e+00
## factor(GFR_high)1                                    -3.859e-01  6.798e-01
## factor(hba1c_high)1                                   3.264e-01  1.386e+00
## factor(antihypertensive_comb)1                        4.802e-01  1.616e+00
## factor(stroke_history)1                               4.644e-01  1.591e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             3.883e-02  1.040e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            3.175e+01  6.154e+13
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          -3.429e+01  1.285e-15
## factor(rokare)1                                       2.348e-01  1.265e+00
## factor(ami_history)1                                  2.697e-01  1.310e+00
## factor(lipid_modifying_agents)1                      -1.312e-01  8.771e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1 -3.459e-01  7.076e-01
##                                                        se(coef)      z Pr(>|z|)
## factor(cpap_treated)1                                 1.818e-01 -5.985 2.17e-09
## rcs(alder)alder                                       2.805e-01  0.982 0.326311
## rcs(alder)alder'                                      9.675e-01  1.276 0.201792
## rcs(alder)alder''                                     5.259e+00 -1.188 0.234674
## rcs(alder)alder'''                                    8.307e+00  1.243 0.213760
## rcs(time_to_cpap_start)time_to_cpap_start             3.018e-01 -1.875 0.060775
## rcs(time_to_cpap_start)time_to_cpap_start'            1.813e+00 -1.202 0.229418
## rcs(time_to_cpap_start)time_to_cpap_start''           6.644e+00  0.957 0.338348
## rcs(time_to_cpap_start)time_to_cpap_start'''          7.940e+00 -0.614 0.539233
## rcs(IV_AverageSaturation)IV_AverageSaturation         5.556e-02 -2.621 0.008773
## rcs(IV_AverageSaturation)IV_AverageSaturation'        2.803e-01 -1.874 0.060947
## rcs(IV_AverageSaturation)IV_AverageSaturation''       3.107e+00  1.296 0.195017
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      1.258e+01 -0.494 0.621479
## factor(antithrombotic_agents)1                        8.787e-02  3.499 0.000467
## rcs(DispInkKEHB04)DispInkKEHB04                       2.978e-01 -1.632 0.102583
## rcs(DispInkKEHB04)DispInkKEHB04'                      5.664e+00 -2.564 0.010353
## rcs(DispInkKEHB04)DispInkKEHB04''                     2.129e+01  2.182 0.029114
## rcs(DispInkKEHB04)DispInkKEHB04'''                    2.564e+01 -1.651 0.098713
## factor(sex)1                                          8.702e-02 -6.489 8.65e-11
## rcs(bmi)bmi                                           1.973e-01 -4.208 2.58e-05
## rcs(bmi)bmi'                                          1.722e+00  4.378 1.20e-05
## rcs(bmi)bmi''                                         9.744e+00 -3.821 0.000133
## rcs(bmi)bmi'''                                        1.221e+01  3.355 0.000794
## factor(FodelseLand_EU27_2020)1                        1.027e-01  3.136 0.001713
## factor(GFR_high)1                                     1.048e-01 -3.681 0.000232
## factor(hba1c_high)1                                   8.535e-02  3.825 0.000131
## factor(antihypertensive_comb)1                        1.336e-01  3.593 0.000327
## factor(stroke_history)1                               1.518e-01  3.059 0.002218
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             1.194e+00  0.033 0.974063
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            2.493e+02  0.127 0.898675
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           2.620e+02 -0.131 0.895872
## factor(rokare)1                                       1.048e-01  2.240 0.025108
## factor(ami_history)1                                  1.239e-01  2.177 0.029452
## factor(lipid_modifying_agents)1                       8.264e-02 -1.587 0.112470
## factor(cpap_treated)1:factor(antihypertensive_comb)1  1.761e-01 -1.964 0.049520
##                                                         
## factor(cpap_treated)1                                ***
## rcs(alder)alder                                         
## rcs(alder)alder'                                        
## rcs(alder)alder''                                       
## rcs(alder)alder'''                                      
## rcs(time_to_cpap_start)time_to_cpap_start            .  
## rcs(time_to_cpap_start)time_to_cpap_start'              
## rcs(time_to_cpap_start)time_to_cpap_start''             
## rcs(time_to_cpap_start)time_to_cpap_start'''            
## rcs(IV_AverageSaturation)IV_AverageSaturation        ** 
## rcs(IV_AverageSaturation)IV_AverageSaturation'       .  
## rcs(IV_AverageSaturation)IV_AverageSaturation''         
## rcs(IV_AverageSaturation)IV_AverageSaturation'''        
## factor(antithrombotic_agents)1                       ***
## rcs(DispInkKEHB04)DispInkKEHB04                         
## rcs(DispInkKEHB04)DispInkKEHB04'                     *  
## rcs(DispInkKEHB04)DispInkKEHB04''                    *  
## rcs(DispInkKEHB04)DispInkKEHB04'''                   .  
## factor(sex)1                                         ***
## rcs(bmi)bmi                                          ***
## rcs(bmi)bmi'                                         ***
## rcs(bmi)bmi''                                        ***
## rcs(bmi)bmi'''                                       ***
## factor(FodelseLand_EU27_2020)1                       ** 
## factor(GFR_high)1                                    ***
## factor(hba1c_high)1                                  ***
## factor(antihypertensive_comb)1                       ***
## factor(stroke_history)1                              ** 
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             
## factor(rokare)1                                      *  
## factor(ami_history)1                                 *  
## factor(lipid_modifying_agents)1                         
## factor(cpap_treated)1:factor(antihypertensive_comb)1 *  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                      exp(coef) exp(-coef)
## factor(cpap_treated)1                                3.368e-01  2.969e+00
## rcs(alder)alder                                      1.317e+00  7.593e-01
## rcs(alder)alder'                                     3.439e+00  2.908e-01
## rcs(alder)alder''                                    1.932e-03  5.176e+02
## rcs(alder)alder'''                                   3.060e+04  3.268e-05
## rcs(time_to_cpap_start)time_to_cpap_start            5.679e-01  1.761e+00
## rcs(time_to_cpap_start)time_to_cpap_start'           1.131e-01  8.842e+00
## rcs(time_to_cpap_start)time_to_cpap_start''          5.790e+02  1.727e-03
## rcs(time_to_cpap_start)time_to_cpap_start'''         7.636e-03  1.310e+02
## rcs(IV_AverageSaturation)IV_AverageSaturation        8.645e-01  1.157e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'       5.915e-01  1.691e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''      5.605e+01  1.784e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation'''     2.011e-03  4.974e+02
## factor(antithrombotic_agents)1                       1.360e+00  7.353e-01
## rcs(DispInkKEHB04)DispInkKEHB04                      6.150e-01  1.626e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     4.932e-07  2.028e+06
## rcs(DispInkKEHB04)DispInkKEHB04''                    1.491e+20  6.709e-21
## rcs(DispInkKEHB04)DispInkKEHB04'''                   4.132e-19  2.420e+18
## factor(sex)1                                         5.686e-01  1.759e+00
## rcs(bmi)bmi                                          4.359e-01  2.294e+00
## rcs(bmi)bmi'                                         1.878e+03  5.323e-04
## rcs(bmi)bmi''                                        6.759e-17  1.480e+16
## rcs(bmi)bmi'''                                       6.112e+17  1.636e-18
## factor(FodelseLand_EU27_2020)1                       1.380e+00  7.247e-01
## factor(GFR_high)1                                    6.798e-01  1.471e+00
## factor(hba1c_high)1                                  1.386e+00  7.215e-01
## factor(antihypertensive_comb)1                       1.616e+00  6.187e-01
## factor(stroke_history)1                              1.591e+00  6.285e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk            1.040e+00  9.619e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           6.154e+13  1.625e-14
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          1.285e-15  7.780e+14
## factor(rokare)1                                      1.265e+00  7.907e-01
## factor(ami_history)1                                 1.310e+00  7.636e-01
## factor(lipid_modifying_agents)1                      8.771e-01  1.140e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 7.076e-01  1.413e+00
##                                                       lower .95  upper .95
## factor(cpap_treated)1                                 2.358e-01  4.810e-01
## rcs(alder)alder                                       7.600e-01  2.282e+00
## rcs(alder)alder'                                      5.162e-01  2.291e+01
## rcs(alder)alder''                                     6.455e-08  5.782e+01
## rcs(alder)alder'''                                    2.596e-03  3.606e+11
## rcs(time_to_cpap_start)time_to_cpap_start             3.143e-01  1.026e+00
## rcs(time_to_cpap_start)time_to_cpap_start'            3.235e-03  3.954e+00
## rcs(time_to_cpap_start)time_to_cpap_start''           1.280e-03  2.619e+08
## rcs(time_to_cpap_start)time_to_cpap_start'''          1.332e-09  4.378e+04
## rcs(IV_AverageSaturation)IV_AverageSaturation         7.753e-01  9.639e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'        3.415e-01  1.024e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''       1.270e-01  2.473e+04
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      3.971e-14  1.018e+08
## factor(antithrombotic_agents)1                        1.145e+00  1.616e+00
## rcs(DispInkKEHB04)DispInkKEHB04                       3.431e-01  1.102e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      7.437e-12  3.270e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                     1.128e+02  1.970e+38
## rcs(DispInkKEHB04)DispInkKEHB04'''                    6.218e-41  2.746e+03
## factor(sex)1                                          4.794e-01  6.743e-01
## rcs(bmi)bmi                                           2.961e-01  6.418e-01
## rcs(bmi)bmi'                                          6.431e+01  5.487e+04
## rcs(bmi)bmi''                                         3.432e-25  1.331e-08
## rcs(bmi)bmi'''                                        2.484e+07  1.504e+28
## factor(FodelseLand_EU27_2020)1                        1.128e+00  1.687e+00
## factor(GFR_high)1                                     5.536e-01  8.349e-01
## factor(hba1c_high)1                                   1.173e+00  1.638e+00
## factor(antihypertensive_comb)1                        1.244e+00  2.100e+00
## factor(stroke_history)1                               1.182e+00  2.142e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             1.001e-01  1.080e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           3.512e-199 1.078e+226
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          1.283e-238 1.288e+208
## factor(rokare)1                                       1.030e+00  1.553e+00
## factor(ami_history)1                                  1.027e+00  1.670e+00
## factor(lipid_modifying_agents)1                       7.459e-01  1.031e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1  5.011e-01  9.993e-01
## 
## Concordance= 0.817  (se = 0.008 )
## Likelihood ratio test= 979  on 35 df,   p=<2e-16
## Wald test            = 1005  on 35 df,   p=<2e-16
## Score (logrank) test = 1267  on 35 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.8172964 
## C-index test: 0.8119803

AMI

Time-independent

Group 1

run_models(c(list_forms[["form_ami_tind_spl"]], list_forms[["form_ami_tind_cat"]]), df_survival_times_train, df_survival_times_test, "time_to_ami", "ami", cont_var, "prof_ami_ind_g1.html")

## [1] "### FORMULA 1 ###"
## Start:  AIC=957466.2
## Surv(time_to_ami, ami) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 946570
## + factor(antithrombotic_agents)   1 949558
## + rcs(GFR)                        4 952408
## + factor(ami_history)             1 952692
## + rcs(time_to_cpap_start)         4 954689
## + factor(Sun2000niva_old)         6 955082
## + rcs(DispInkKEHB04)              4 955217
## + rcs(hba1c)                      4 955467
## + factor(antihypertensive_comb)   1 955756
## + factor(Civil)                   1 956134
## + rcs(bmi)                        4 956275
## + factor(sex)                     1 956563
## + rcs(systoliskt)                 4 956645
## + factor(lipid_modifying_agents)  1 956757
## + factor(stroke_history)          1 956780
## + rcs(Raks_AndelSjukInk)          4 957237
## + rcs(kolesterol)                 4 957243
## + rcs(Raks_AndelArblosInk)        4 957288
## + factor(FodelseLand_EU27_2020)   1 957359
## + factor(rokare)                  1 957397
## + rcs(Raks_AndelEkBisInk)         4 957410
## <none>                              957466
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=946569.6
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6,8,9 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(ami_history)             1 940733
## + factor(antithrombotic_agents)   1 943063
## + rcs(hba1c)                      4 943991
## + factor(sex)                     1 944758
## + rcs(time_to_cpap_start)         4 944868
## + rcs(GFR)                        4 945269
## + rcs(DispInkKEHB04)              4 945968
## + factor(rokare)                  1 945985
## + factor(antihypertensive_comb)   1 946112
## + factor(Sun2000niva_old)         6 946194
## + factor(lipid_modifying_agents)  1 946258
## + rcs(systoliskt)                 4 946290
## + rcs(Raks_AndelEkBisInk)         4 946303
## + factor(stroke_history)          1 946372
## + rcs(kolesterol)                 4 946397
## + rcs(Raks_AndelSjukInk)          4 946422
## + factor(FodelseLand_EU27_2020)   1 946471
## + rcs(Raks_AndelArblosInk)        4 946490
## + rcs(bmi)                        4 946519
## + factor(Civil)                   1 946561
## <none>                              946570
## - rcs(alder)                      4 957466
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=940732.7
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 935254
## + rcs(hba1c)                      4 938137
## + factor(sex)                     1 938439
## + rcs(time_to_cpap_start)         4 939126
## + rcs(GFR)                        4 939255
## + factor(lipid_modifying_agents)  1 939990
## + factor(antihypertensive_comb)   1 940079
## + factor(rokare)                  1 940138
## + rcs(DispInkKEHB04)              4 940139
## + factor(Sun2000niva_old)         6 940318
## + rcs(kolesterol)                 4 940419
## + rcs(Raks_AndelEkBisInk)         4 940472
## + factor(stroke_history)          1 940497
## + rcs(systoliskt)                 4 940503
## + rcs(Raks_AndelSjukInk)          4 940564
## + factor(FodelseLand_EU27_2020)   1 940638
## + rcs(Raks_AndelArblosInk)        4 940652
## + rcs(bmi)                        4 940667
## + factor(Civil)                   1 940714
## <none>                              940733
## - factor(ami_history)             1 946570
## - rcs(alder)                      4 952692
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=935253.8
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(hba1c)                                          4 932943
## + factor(sex)                                         1 933531
## + rcs(GFR)                                            4 934116
## + rcs(time_to_cpap_start)                             4 934157
## + factor(rokare)                                      1 934701
## + rcs(DispInkKEHB04)                                  4 934751
## + factor(Sun2000niva_old)                             6 934923
## + rcs(systoliskt)                                     4 934937
## + rcs(Raks_AndelEkBisInk)                             4 934994
## + rcs(kolesterol)                                     4 934997
## + factor(antihypertensive_comb)                       1 935081
## + rcs(Raks_AndelSjukInk)                              4 935113
## + factor(FodelseLand_EU27_2020)                       1 935148
## + rcs(Raks_AndelArblosInk)                            4 935167
## + rcs(bmi)                                            4 935190
## + factor(lipid_modifying_agents)                      1 935196
## + factor(Civil)                                       1 935244
## + factor(cpap_treated):factor(antithrombotic_agents)  1 935252
## <none>                                                  935254
## + factor(stroke_history)                              1 935255
## - factor(antithrombotic_agents)                       1 940733
## - rcs(alder)                                          4 941719
## - factor(ami_history)                                 1 943063
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=932943
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(sex)                                         1 931320
## + rcs(GFR)                                            4 931941
## + rcs(time_to_cpap_start)                             4 932093
## + factor(rokare)                                      1 932412
## + rcs(DispInkKEHB04)                                  4 932591
## + factor(Sun2000niva_old)                             6 932700
## + rcs(systoliskt)                                     4 932706
## + rcs(Raks_AndelEkBisInk)                             4 932734
## + rcs(kolesterol)                                     4 932748
## + factor(antihypertensive_comb)                       1 932753
## + rcs(Raks_AndelSjukInk)                              4 932797
## + rcs(bmi)                                            4 932850
## + rcs(Raks_AndelArblosInk)                            4 932856
## + factor(FodelseLand_EU27_2020)                       1 932866
## + factor(lipid_modifying_agents)                      1 932888
## + factor(Civil)                                       1 932927
## + factor(cpap_treated):factor(antithrombotic_agents)  1 932942
## + factor(stroke_history)                              1 932942
## <none>                                                  932943
## - rcs(hba1c)                                          4 935254
## - factor(antithrombotic_agents)                       1 938137
## - rcs(alder)                                          4 939993
## - factor(ami_history)                                 1 940685
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=931320.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(GFR)                                            4 930116
## + rcs(time_to_cpap_start)                             4 930423
## + rcs(DispInkKEHB04)                                  4 930679
## + factor(rokare)                                      1 930777
## + factor(Sun2000niva_old)                             6 931028
## + rcs(kolesterol)                                     4 931043
## + rcs(systoliskt)                                     4 931063
## + rcs(Raks_AndelEkBisInk)                             4 931082
## + factor(antihypertensive_comb)                       1 931146
## + rcs(Raks_AndelSjukInk)                              4 931157
## + factor(FodelseLand_EU27_2020)                       1 931205
## + rcs(Raks_AndelArblosInk)                            4 931242
## + factor(lipid_modifying_agents)                      1 931273
## + factor(Civil)                                       1 931288
## + rcs(bmi)                                            4 931293
## + factor(cpap_treated):factor(antithrombotic_agents)  1 931318
## <none>                                                  931320
## + factor(stroke_history)                              1 931321
## - factor(sex)                                         1 932943
## - rcs(hba1c)                                          4 933531
## - factor(antithrombotic_agents)                       1 936003
## - rcs(alder)                                          4 939233
## - factor(ami_history)                                 1 939442
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=930116
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(time_to_cpap_start)                             4 929306
## + rcs(DispInkKEHB04)                                  4 929514
## + factor(rokare)                                      1 929531
## + factor(Sun2000niva_old)                             6 929844
## + rcs(kolesterol)                                     4 929851
## + rcs(systoliskt)                                     4 929862
## + rcs(Raks_AndelEkBisInk)                             4 929875
## + rcs(Raks_AndelSjukInk)                              4 929956
## + factor(FodelseLand_EU27_2020)                       1 929993
## + factor(antihypertensive_comb)                       1 930004
## + rcs(Raks_AndelArblosInk)                            4 930039
## + rcs(alder):rcs(GFR)                                16 930056
## + rcs(bmi)                                            4 930075
## + factor(lipid_modifying_agents)                      1 930086
## + factor(Civil)                                       1 930086
## + factor(cpap_treated):factor(antithrombotic_agents)  1 930115
## <none>                                                  930116
## + factor(cpap_treated):rcs(GFR)                       4 930116
## + factor(stroke_history)                              1 930118
## - rcs(GFR)                                            4 931320
## - factor(sex)                                         1 931941
## - rcs(hba1c)                                          4 932198
## - factor(antithrombotic_agents)                       1 934409
## - rcs(alder)                                          4 935505
## - factor(ami_history)                                 1 938371
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929306.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 928742
## + rcs(DispInkKEHB04)                                  4 928906
## + rcs(kolesterol)                                     4 929004
## + rcs(Raks_AndelEkBisInk)                             4 929043
## + rcs(systoliskt)                                     4 929053
## + factor(Sun2000niva_old)                             6 929105
## + rcs(Raks_AndelSjukInk)                              4 929128
## + factor(FodelseLand_EU27_2020)                       1 929160
## + factor(antihypertensive_comb)                       1 929201
## + rcs(Raks_AndelArblosInk)                            4 929231
## + rcs(alder):rcs(GFR)                                16 929246
## + rcs(bmi)                                            4 929275
## + factor(lipid_modifying_agents)                      1 929281
## + factor(Civil)                                       1 929285
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929306
## <none>                                                  929306
## + factor(stroke_history)                              1 929306
## + factor(cpap_treated):rcs(GFR)                       4 929309
## - rcs(time_to_cpap_start)                             4 930116
## - rcs(GFR)                                            4 930423
## - rcs(hba1c)                                          4 931153
## - factor(sex)                                         1 931170
## - factor(antithrombotic_agents)                       1 933242
## - rcs(alder)                                          4 934539
## - factor(ami_history)                                 1 937359
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928742.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 928402
## + rcs(kolesterol)                                     4 928452
## + rcs(systoliskt)                                     4 928493
## + rcs(Raks_AndelEkBisInk)                             4 928507
## + rcs(Raks_AndelSjukInk)                              4 928564
## + factor(Sun2000niva_old)                             6 928567
## + factor(FodelseLand_EU27_2020)                       1 928617
## + factor(antihypertensive_comb)                       1 928626
## + rcs(Raks_AndelArblosInk)                            4 928668
## + rcs(alder):rcs(GFR)                                16 928682
## + factor(lipid_modifying_agents)                      1 928718
## + factor(Civil)                                       1 928722
## + rcs(bmi)                                            4 928724
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928742
## <none>                                                  928742
## + factor(stroke_history)                              1 928743
## + factor(cpap_treated):rcs(GFR)                       4 928745
## - factor(rokare)                                      1 929306
## - rcs(time_to_cpap_start)                             4 929531
## - rcs(GFR)                                            4 929898
## - rcs(hba1c)                                          4 930584
## - factor(sex)                                         1 930628
## - factor(antithrombotic_agents)                       1 932646
## - rcs(alder)                                          4 934296
## - factor(ami_history)                                 1 936808
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928402.2
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(kolesterol)                                     4 928111
## + rcs(systoliskt)                                     4 928160
## + rcs(Raks_AndelSjukInk)                              4 928180
## + rcs(Raks_AndelEkBisInk)                             4 928258
## + factor(antihypertensive_comb)                       1 928276
## + rcs(Raks_AndelArblosInk)                            4 928321
## + factor(Sun2000niva_old)                             6 928329
## + factor(FodelseLand_EU27_2020)                       1 928344
## + rcs(alder):rcs(GFR)                                16 928350
## + factor(lipid_modifying_agents)                      1 928375
## + rcs(bmi)                                            4 928379
## + factor(Civil)                                       1 928390
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928402
## <none>                                                  928402
## + factor(stroke_history)                              1 928403
## + factor(cpap_treated):rcs(GFR)                       4 928405
## - rcs(DispInkKEHB04)                                  4 928742
## - factor(rokare)                                      1 928906
## - rcs(time_to_cpap_start)                             4 929008
## - rcs(GFR)                                            4 929538
## - rcs(hba1c)                                          4 930138
## - factor(sex)                                         1 930492
## - factor(antithrombotic_agents)                       1 932263
## - rcs(alder)                                          4 933255
## - factor(ami_history)                                 1 936494
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928110.5
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelSjukInk)                              4 927894
## + rcs(systoliskt)                                     4 927896
## + rcs(Raks_AndelEkBisInk)                             4 927962
## + factor(antihypertensive_comb)                       1 927969
## + rcs(Raks_AndelArblosInk)                            4 928030
## + factor(Sun2000niva_old)                             6 928037
## + factor(FodelseLand_EU27_2020)                       1 928048
## + factor(lipid_modifying_agents)                      1 928052
## + rcs(alder):rcs(GFR)                                16 928059
## + rcs(bmi)                                            4 928091
## + factor(Civil)                                       1 928099
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928110
## <none>                                                  928111
## + factor(stroke_history)                              1 928111
## + factor(cpap_treated):rcs(GFR)                       4 928113
## - rcs(kolesterol)                                     4 928402
## - rcs(DispInkKEHB04)                                  4 928452
## - factor(rokare)                                      1 928603
## - rcs(time_to_cpap_start)                             4 928748
## - rcs(GFR)                                            4 929227
## - rcs(hba1c)                                          4 929769
## - factor(sex)                                         1 930294
## - factor(antithrombotic_agents)                       1 932081
## - rcs(alder)                                          4 932987
## - factor(ami_history)                                 1 936072
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927894.5
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(systoliskt)                                     4 927679
## + factor(antihypertensive_comb)                       1 927753
## + rcs(Raks_AndelEkBisInk)                             4 927766
## + factor(Sun2000niva_old)                             6 927824
## + factor(FodelseLand_EU27_2020)                       1 927830
## + factor(lipid_modifying_agents)                      1 927834
## + rcs(alder):rcs(GFR)                                16 927844
## + rcs(Raks_AndelArblosInk)                            4 927847
## + rcs(bmi)                                            4 927873
## + factor(Civil)                                       1 927883
## + factor(cpap_treated):factor(antithrombotic_agents)  1 927894
## <none>                                                  927894
## + factor(stroke_history)                              1 927895
## + factor(cpap_treated):rcs(GFR)                       4 927897
## - rcs(Raks_AndelSjukInk)                              4 928111
## - rcs(kolesterol)                                     4 928180
## - rcs(DispInkKEHB04)                                  4 928279
## - factor(rokare)                                      1 928385
## - rcs(time_to_cpap_start)                             4 928537
## - rcs(GFR)                                            4 929007
## - rcs(hba1c)                                          4 929549
## - factor(sex)                                         1 930117
## - factor(antithrombotic_agents)                       1 931830
## - rcs(alder)                                          4 932938
## - factor(ami_history)                                 1 935882
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927679.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelEkBisInk)                             4 927549
## + factor(antihypertensive_comb)                       1 927579
## + factor(Sun2000niva_old)                             6 927613
## + factor(lipid_modifying_agents)                      1 927614
## + factor(FodelseLand_EU27_2020)                       1 927616
## + rcs(alder):rcs(GFR)                                16 927632
## + rcs(Raks_AndelArblosInk)                            4 927632
## + rcs(bmi)                                            4 927656
## + factor(Civil)                                       1 927668
## + factor(cpap_treated):factor(antithrombotic_agents)  1 927679
## <none>                                                  927679
## + factor(stroke_history)                              1 927680
## + factor(cpap_treated):rcs(GFR)                       4 927682
## - rcs(systoliskt)                                     4 927894
## - rcs(Raks_AndelSjukInk)                              4 927896
## - rcs(kolesterol)                                     4 927938
## - rcs(DispInkKEHB04)                                  4 928055
## - factor(rokare)                                      1 928168
## - rcs(time_to_cpap_start)                             4 928320
## - rcs(GFR)                                            4 928787
## - rcs(hba1c)                                          4 929282
## - factor(sex)                                         1 929908
## - factor(antithrombotic_agents)                       1 931658
## - rcs(alder)                                          4 932466
## - factor(ami_history)                                 1 935602
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927549.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(antihypertensive_comb)                       1 927442
## + factor(Sun2000niva_old)                             6 927474
## + factor(lipid_modifying_agents)                      1 927481
## + rcs(alder):rcs(GFR)                                16 927502
## + rcs(Raks_AndelArblosInk)                            4 927518
## + factor(FodelseLand_EU27_2020)                       1 927519
## + rcs(bmi)                                            4 927527
## + factor(Civil)                                       1 927537
## + factor(cpap_treated):factor(antithrombotic_agents)  1 927549
## <none>                                                  927549
## + factor(stroke_history)                              1 927550
## + factor(cpap_treated):rcs(GFR)                       4 927552
## - rcs(Raks_AndelEkBisInk)                             4 927679
## - rcs(Raks_AndelSjukInk)                              4 927746
## - rcs(systoliskt)                                     4 927766
## - rcs(kolesterol)                                     4 927812
## - rcs(DispInkKEHB04)                                  4 927824
## - factor(rokare)                                      1 928025
## - rcs(time_to_cpap_start)                             4 928223
## - rcs(GFR)                                            4 928661
## - rcs(hba1c)                                          4 929130
## - factor(sex)                                         1 929772
## - factor(antithrombotic_agents)                       1 931535
## - rcs(alder)                                          4 932434
## - factor(ami_history)                                 1 935461
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927441.6
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(Sun2000niva_old)                             6 927372
## + factor(lipid_modifying_agents)                      1 927394
## + rcs(alder):rcs(GFR)                                16 927397
## + factor(FodelseLand_EU27_2020)                       1 927407
## + rcs(Raks_AndelArblosInk)                            4 927409
## + rcs(bmi)                                            4 927414
## + factor(Civil)                                       1 927430
## + factor(cpap_treated):factor(antithrombotic_agents)  1 927441
## <none>                                                  927442
## + factor(stroke_history)                              1 927442
## + factor(cpap_treated):factor(antihypertensive_comb)  1 927443
## + factor(cpap_treated):rcs(GFR)                       4 927445
## - factor(antihypertensive_comb)                       1 927549
## - rcs(Raks_AndelEkBisInk)                             4 927579
## - rcs(systoliskt)                                     4 927615
## - rcs(Raks_AndelSjukInk)                              4 927639
## - rcs(kolesterol)                                     4 927719
## - rcs(DispInkKEHB04)                                  4 927722
## - factor(rokare)                                      1 927927
## - rcs(time_to_cpap_start)                             4 928110
## - rcs(GFR)                                            4 928491
## - rcs(hba1c)                                          4 929034
## - factor(sex)                                         1 929651
## - factor(antithrombotic_agents)                       1 931098
## - rcs(alder)                                          4 932265
## - factor(ami_history)                                 1 935393
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927371.8
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(lipid_modifying_agents)                      1 927326
## + rcs(alder):rcs(GFR)                                16 927326
## + factor(FodelseLand_EU27_2020)                       1 927329
## + rcs(Raks_AndelArblosInk)                            4 927339
## + rcs(bmi)                                            4 927341
## + factor(Civil)                                       1 927362
## + factor(cpap_treated):factor(antithrombotic_agents)  1 927371
## <none>                                                  927372
## + factor(stroke_history)                              1 927372
## + factor(cpap_treated):factor(antihypertensive_comb)  1 927374
## + factor(cpap_treated):rcs(GFR)                       4 927375
## - factor(Sun2000niva_old)                             6 927442
## - factor(antihypertensive_comb)                       1 927474
## - rcs(Raks_AndelEkBisInk)                             4 927518
## - rcs(systoliskt)                                     4 927543
## - rcs(DispInkKEHB04)                                  4 927560
## - rcs(Raks_AndelSjukInk)                              4 927566
## - rcs(kolesterol)                                     4 927650
## - factor(rokare)                                      1 927848
## - rcs(time_to_cpap_start)                             4 928024
## - rcs(GFR)                                            4 928418
## - rcs(hba1c)                                          4 928941
## - factor(sex)                                         1 929567
## - factor(antithrombotic_agents)                       1 931018
## - rcs(alder)                                          4 931846
## - factor(ami_history)                                 1 935341
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927325.7
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + rcs(alder):rcs(GFR)                                 16 927280
## + factor(FodelseLand_EU27_2020)                        1 927282
## + rcs(Raks_AndelArblosInk)                             4 927292
## + rcs(bmi)                                             4 927296
## + factor(Civil)                                        1 927316
## + factor(cpap_treated):factor(antithrombotic_agents)   1 927325
## <none>                                                   927326
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927327
## + factor(stroke_history)                               1 927327
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927328
## + factor(cpap_treated):rcs(GFR)                        4 927329
## - factor(lipid_modifying_agents)                       1 927372
## - factor(Sun2000niva_old)                              6 927394
## - factor(antihypertensive_comb)                        1 927408
## - rcs(Raks_AndelEkBisInk)                              4 927474
## - rcs(systoliskt)                                      4 927503
## - rcs(DispInkKEHB04)                                   4 927517
## - rcs(Raks_AndelSjukInk)                               4 927522
## - rcs(kolesterol)                                      4 927629
## - factor(rokare)                                       1 927798
## - rcs(time_to_cpap_start)                              4 927972
## - rcs(GFR)                                             4 928360
## - rcs(hba1c)                                           4 928882
## - factor(sex)                                          1 929532
## - factor(antithrombotic_agents)                        1 930655
## - rcs(alder)                                           4 931841
## - factor(ami_history)                                  1 935342
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927280.2
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(FodelseLand_EU27_2020)                        1 927235
## + rcs(Raks_AndelArblosInk)                             4 927246
## + rcs(bmi)                                             4 927249
## + factor(Civil)                                        1 927270
## + factor(cpap_treated):factor(antithrombotic_agents)   1 927280
## <none>                                                   927280
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927281
## + factor(stroke_history)                               1 927281
## + factor(cpap_treated):rcs(GFR)                        4 927282
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927282
## - rcs(alder):rcs(GFR)                                 16 927326
## - factor(lipid_modifying_agents)                       1 927326
## - factor(Sun2000niva_old)                              6 927349
## - factor(antihypertensive_comb)                        1 927360
## - rcs(Raks_AndelEkBisInk)                              4 927428
## - rcs(systoliskt)                                      4 927456
## - rcs(DispInkKEHB04)                                   4 927466
## - rcs(Raks_AndelSjukInk)                               4 927475
## - rcs(kolesterol)                                      4 927583
## - factor(rokare)                                       1 927754
## - rcs(time_to_cpap_start)                              4 927929
## - rcs(hba1c)                                           4 928833
## - factor(sex)                                          1 929482
## - factor(antithrombotic_agents)                        1 930595
## - factor(ami_history)                                  1 935279
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927235.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + rcs(Raks_AndelArblosInk)                             4 927202
## + rcs(bmi)                                             4 927206
## + factor(Civil)                                        1 927225
## + factor(cpap_treated):factor(antithrombotic_agents)   1 927235
## <none>                                                   927235
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927236
## + factor(stroke_history)                               1 927236
## + factor(cpap_treated):rcs(GFR)                        4 927237
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927237
## - factor(FodelseLand_EU27_2020)                        1 927280
## - rcs(alder):rcs(GFR)                                 16 927282
## - factor(lipid_modifying_agents)                       1 927282
## - factor(Sun2000niva_old)                              6 927313
## - factor(antihypertensive_comb)                        1 927319
## - rcs(Raks_AndelEkBisInk)                              4 927341
## - rcs(DispInkKEHB04)                                   4 927391
## - rcs(systoliskt)                                      4 927409
## - rcs(Raks_AndelSjukInk)                               4 927431
## - rcs(kolesterol)                                      4 927542
## - factor(rokare)                                       1 927703
## - rcs(time_to_cpap_start)                              4 927900
## - rcs(hba1c)                                           4 928780
## - factor(sex)                                          1 929453
## - factor(antithrombotic_agents)                        1 930549
## - factor(ami_history)                                  1 935237
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927202.2
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(Raks_AndelArblosInk) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + rcs(bmi)                                             4 927173
## + factor(Civil)                                        1 927192
## + factor(cpap_treated):factor(antithrombotic_agents)   1 927202
## <none>                                                   927202
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927203
## + factor(stroke_history)                               1 927203
## + factor(cpap_treated):rcs(GFR)                        4 927204
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927204
## - rcs(Raks_AndelArblosInk)                             4 927235
## - factor(FodelseLand_EU27_2020)                        1 927246
## - rcs(alder):rcs(GFR)                                 16 927249
## - factor(lipid_modifying_agents)                       1 927250
## - factor(Sun2000niva_old)                              6 927280
## - factor(antihypertensive_comb)                        1 927287
## - rcs(Raks_AndelEkBisInk)                              4 927293
## - rcs(DispInkKEHB04)                                   4 927362
## - rcs(Raks_AndelSjukInk)                               4 927368
## - rcs(systoliskt)                                      4 927376
## - rcs(kolesterol)                                      4 927509
## - factor(rokare)                                       1 927669
## - rcs(time_to_cpap_start)                              4 927863
## - rcs(hba1c)                                           4 928747
## - factor(sex)                                          1 929415
## - factor(antithrombotic_agents)                        1 930519
## - factor(ami_history)                                  1 935205
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927172.7
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(Civil)                                        1 927163
## + factor(cpap_treated):factor(antithrombotic_agents)   1 927172
## <none>                                                   927173
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927174
## + factor(stroke_history)                               1 927174
## + factor(cpap_treated):rcs(GFR)                        4 927174
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927175
## + rcs(alder):rcs(bmi)                                 16 927177
## - rcs(bmi)                                             4 927202
## - rcs(Raks_AndelArblosInk)                             4 927206
## - factor(FodelseLand_EU27_2020)                        1 927215
## - factor(lipid_modifying_agents)                       1 927220
## - rcs(alder):rcs(GFR)                                 16 927221
## - factor(Sun2000niva_old)                              6 927253
## - rcs(Raks_AndelEkBisInk)                              4 927263
## - factor(antihypertensive_comb)                        1 927263
## - rcs(DispInkKEHB04)                                   4 927337
## - rcs(Raks_AndelSjukInk)                               4 927341
## - rcs(systoliskt)                                      4 927347
## - rcs(kolesterol)                                      4 927475
## - factor(rokare)                                       1 927623
## - rcs(time_to_cpap_start)                              4 927820
## - rcs(hba1c)                                           4 928730
## - factor(sex)                                          1 929295
## - factor(antithrombotic_agents)                        1 930501
## - factor(ami_history)                                  1 935182
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927162.5
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(cpap_treated):factor(antithrombotic_agents)   1 927162
## <none>                                                   927163
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927163
## + factor(stroke_history)                               1 927164
## + factor(cpap_treated):rcs(GFR)                        4 927164
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927164
## + rcs(alder):rcs(bmi)                                 16 927166
## - factor(Civil)                                        1 927173
## - rcs(bmi)                                             4 927192
## - rcs(Raks_AndelArblosInk)                             4 927196
## - factor(FodelseLand_EU27_2020)                        1 927205
## - factor(lipid_modifying_agents)                       1 927210
## - rcs(alder):rcs(GFR)                                 16 927211
## - factor(Sun2000niva_old)                              6 927241
## - factor(antihypertensive_comb)                        1 927252
## - rcs(Raks_AndelEkBisInk)                              4 927253
## - rcs(DispInkKEHB04)                                   4 927323
## - rcs(Raks_AndelSjukInk)                               4 927330
## - rcs(systoliskt)                                      4 927337
## - rcs(kolesterol)                                      4 927464
## - factor(rokare)                                       1 927613
## - rcs(time_to_cpap_start)                              4 927807
## - rcs(hba1c)                                           4 928717
## - factor(sex)                                          1 929246
## - factor(antithrombotic_agents)                        1 930489
## - factor(ami_history)                                  1 935172
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=927161.9
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + rcs(hba1c) + 
##     factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + factor(rokare) + 
##     rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):rcs(GFR) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## <none>                                                   927162
## - factor(cpap_treated):factor(antithrombotic_agents)   1 927163
## + factor(stroke_history)                               1 927163
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 927163
## + factor(cpap_treated):factor(antihypertensive_comb)   1 927164
## + factor(cpap_treated):rcs(GFR)                        4 927164
## + rcs(alder):rcs(bmi)                                 16 927165
## - factor(Civil)                                        1 927172
## - rcs(bmi)                                             4 927191
## - rcs(Raks_AndelArblosInk)                             4 927195
## - factor(FodelseLand_EU27_2020)                        1 927205
## - factor(lipid_modifying_agents)                       1 927209
## - rcs(alder):rcs(GFR)                                 16 927210
## - factor(Sun2000niva_old)                              6 927240
## - factor(antihypertensive_comb)                        1 927252
## - rcs(Raks_AndelEkBisInk)                              4 927253
## - rcs(DispInkKEHB04)                                   4 927322
## - rcs(Raks_AndelSjukInk)                               4 927330
## - rcs(systoliskt)                                      4 927336
## - rcs(kolesterol)                                      4 927464
## - factor(rokare)                                       1 927612
## - rcs(time_to_cpap_start)                              4 927805
## - rcs(hba1c)                                           4 928716
## - factor(sex)                                          1 929246
## - factor(ami_history)                                  1 935172
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_ami, ami) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(ami_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + factor(sex) + rcs(GFR) + rcs(time_to_cpap_start) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(kolesterol) + rcs(Raks_AndelSjukInk) + 
##     rcs(systoliskt) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):rcs(GFR) + factor(cpap_treated):factor(antithrombotic_agents), 
##     data = df_train)
## 
##   n= 562724, number of events= 37469 
## 
##                                                             coef   exp(coef)
## factor(cpap_treated)1                                  5.722e-01   1.772e+00
## rcs(alder)alder                                        6.865e-01   1.987e+00
## rcs(alder)alder'                                      -6.918e-01   5.007e-01
## rcs(alder)alder''                                      4.177e+00   6.515e+01
## rcs(alder)alder'''                                    -5.675e+00   3.432e-03
## factor(ami_history)1                                  -1.681e+01   5.020e-08
## factor(antithrombotic_agents)1                         6.715e-01   1.957e+00
## rcs(hba1c)hba1c                                        3.976e-01   1.488e+00
## rcs(hba1c)hba1c'                                      -1.109e+00   3.298e-01
## rcs(hba1c)hba1c''                                      5.796e+00   3.289e+02
## rcs(hba1c)hba1c'''                                    -7.947e+00   3.537e-04
## factor(sex)1                                          -5.331e-01   5.868e-01
## rcs(GFR)GFR                                           -5.426e-01   5.812e-01
## rcs(GFR)GFR'                                           1.634e+00   5.123e+00
## rcs(GFR)GFR''                                         -8.501e+00   2.033e-04
## rcs(GFR)GFR'''                                         1.204e+01   1.692e+05
## rcs(time_to_cpap_start)time_to_cpap_start              2.823e-01   1.326e+00
## rcs(time_to_cpap_start)time_to_cpap_start'            -1.371e-01   8.718e-01
## rcs(time_to_cpap_start)time_to_cpap_start''            4.749e-01   1.608e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''          -1.715e+00   1.799e-01
## factor(rokare)1                                        3.064e-01   1.359e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        2.285e-01   1.257e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      -1.636e+01   7.863e-08
## rcs(DispInkKEHB04)DispInkKEHB04''                      3.926e+01   1.122e+17
## rcs(DispInkKEHB04)DispInkKEHB04'''                    -2.504e+01   1.329e-11
## rcs(kolesterol)kolesterol                             -1.325e-01   8.759e-01
## rcs(kolesterol)kolesterol'                             1.078e+00   2.938e+00
## rcs(kolesterol)kolesterol''                           -6.805e+00   1.108e-03
## rcs(kolesterol)kolesterol'''                           1.249e+01   2.664e+05
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                3.933e+00   5.107e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              -5.684e+03   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              6.922e+03         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            -1.245e+03   0.000e+00
## rcs(systoliskt)systoliskt                             -1.189e-01   8.879e-01
## rcs(systoliskt)systoliskt'                             5.478e-01   1.729e+00
## rcs(systoliskt)systoliskt''                           -2.505e+00   8.168e-02
## rcs(systoliskt)systoliskt'''                           3.334e+00   2.804e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              1.560e+00   4.760e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            -3.268e+02  1.148e-142
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            3.568e+02  8.957e+154
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          -3.021e+01   7.618e-14
## factor(antihypertensive_comb)1                         1.167e-01   1.124e+00
## factor(Sun2000niva_old)2                              -3.450e-02   9.661e-01
## factor(Sun2000niva_old)3                              -3.229e-02   9.682e-01
## factor(Sun2000niva_old)4                              -7.480e-02   9.279e-01
## factor(Sun2000niva_old)5                              -1.033e-01   9.019e-01
## factor(Sun2000niva_old)6                              -1.854e-01   8.308e-01
## factor(Sun2000niva_old)7                              -1.945e-01   8.232e-01
## factor(lipid_modifying_agents)1                        8.021e-02   1.084e+00
## factor(FodelseLand_EU27_2020)1                        -9.425e-02   9.101e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            2.149e+00   8.580e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          -1.404e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          1.632e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        -2.321e+02  1.655e-101
## rcs(bmi)bmi                                           -7.771e-02   9.252e-01
## rcs(bmi)bmi'                                           7.021e-01   2.018e+00
## rcs(bmi)bmi''                                         -4.596e+00   1.010e-02
## rcs(bmi)bmi'''                                         6.748e+00   8.523e+02
## factor(Civil)1                                         5.525e-02   1.057e+00
## rcs(alder)alder:rcs(GFR)GFR                            8.421e-02   1.088e+00
## rcs(alder)alder':rcs(GFR)GFR                          -1.884e-01   8.282e-01
## rcs(alder)alder'':rcs(GFR)GFR                          1.785e+00   5.962e+00
## rcs(alder)alder''':rcs(GFR)GFR                        -3.491e+00   3.046e-02
## rcs(alder)alder:rcs(GFR)GFR'                           1.310e-01   1.140e+00
## rcs(alder)alder':rcs(GFR)GFR'                          5.037e-02   1.052e+00
## rcs(alder)alder'':rcs(GFR)GFR'                        -2.726e+00   6.545e-02
## rcs(alder)alder''':rcs(GFR)GFR'                        8.585e+00   5.351e+03
## rcs(alder)alder:rcs(GFR)GFR''                         -1.643e+00   1.934e-01
## rcs(alder)alder':rcs(GFR)GFR''                        -3.874e-02   9.620e-01
## rcs(alder)alder'':rcs(GFR)GFR''                        2.641e+01   2.960e+11
## rcs(alder)alder''':rcs(GFR)GFR''                      -1.093e+02   3.467e-48
## rcs(alder)alder:rcs(GFR)GFR'''                         2.806e+00   1.654e+01
## rcs(alder)alder':rcs(GFR)GFR'''                        2.073e+00   7.950e+00
## rcs(alder)alder'':rcs(GFR)GFR'''                      -6.986e+01   4.591e-31
## rcs(alder)alder''':rcs(GFR)GFR'''                      2.699e+02  1.675e+117
## factor(cpap_treated)1:factor(antithrombotic_agents)1  -1.441e-01   8.658e-01
##                                                         se(coef)       z
## factor(cpap_treated)1                                  6.368e-02   8.986
## rcs(alder)alder                                        3.658e-01   1.876
## rcs(alder)alder'                                       9.933e-01  -0.697
## rcs(alder)alder''                                      5.221e+00   0.800
## rcs(alder)alder'''                                     8.215e+00  -0.691
## factor(ami_history)1                                   6.686e+01  -0.251
## factor(antithrombotic_agents)1                         1.180e-02  56.885
## rcs(hba1c)hba1c                                        6.758e-02   5.883
## rcs(hba1c)hba1c'                                       1.182e+00  -0.938
## rcs(hba1c)hba1c''                                      4.299e+00   1.348
## rcs(hba1c)hba1c'''                                     4.040e+00  -1.967
## factor(sex)1                                           1.188e-02 -44.862
## rcs(GFR)GFR                                            2.745e-01  -1.977
## rcs(GFR)GFR'                                           1.549e+00   1.055
## rcs(GFR)GFR''                                          1.017e+01  -0.836
## rcs(GFR)GFR'''                                         1.704e+01   0.706
## rcs(time_to_cpap_start)time_to_cpap_start              5.630e-02   5.014
## rcs(time_to_cpap_start)time_to_cpap_start'             1.259e-01  -1.089
## rcs(time_to_cpap_start)time_to_cpap_start''            4.582e-01   1.036
## rcs(time_to_cpap_start)time_to_cpap_start'''           2.032e+00  -0.844
## factor(rokare)1                                        1.398e-02  21.921
## rcs(DispInkKEHB04)DispInkKEHB04                        1.701e-01   1.344
## rcs(DispInkKEHB04)DispInkKEHB04'                       3.638e+00  -4.496
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.051e+01   3.737
## rcs(DispInkKEHB04)DispInkKEHB04'''                     9.573e+00  -2.616
## rcs(kolesterol)kolesterol                              2.638e-02  -5.022
## rcs(kolesterol)kolesterol'                             1.462e-01   7.373
## rcs(kolesterol)kolesterol''                            1.056e+00  -6.445
## rcs(kolesterol)kolesterol'''                           2.221e+00   5.625
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                3.889e-01  10.112
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               6.650e+02  -8.548
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              8.151e+02   8.493
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             1.522e+02  -8.183
## rcs(systoliskt)systoliskt                              2.767e-02  -4.297
## rcs(systoliskt)systoliskt'                             1.387e-01   3.950
## rcs(systoliskt)systoliskt''                            1.145e+00  -2.188
## rcs(systoliskt)systoliskt'''                           2.681e+00   1.243
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              2.214e-01   7.049
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             5.825e+01  -5.610
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            6.401e+01   5.574
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           5.976e+00  -5.054
## factor(antihypertensive_comb)1                         1.226e-02   9.524
## factor(Sun2000niva_old)2                               1.930e-02  -1.788
## factor(Sun2000niva_old)3                               1.365e-02  -2.365
## factor(Sun2000niva_old)4                               1.861e-02  -4.019
## factor(Sun2000niva_old)5                               2.143e-02  -4.820
## factor(Sun2000niva_old)6                               2.196e-02  -8.442
## factor(Sun2000niva_old)7                               7.167e-02  -2.714
## factor(lipid_modifying_agents)1                        1.147e-02   6.995
## factor(FodelseLand_EU27_2020)1                         1.397e-02  -6.746
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            3.234e-01   6.646
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           2.230e+02  -6.296
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          2.600e+02   6.278
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         3.790e+01  -6.122
## rcs(bmi)bmi                                            3.377e-02  -2.301
## rcs(bmi)bmi'                                           2.455e-01   2.860
## rcs(bmi)bmi''                                          1.353e+00  -3.396
## rcs(bmi)bmi'''                                         1.876e+00   3.596
## factor(Civil)1                                         1.576e-02   3.505
## rcs(alder)alder:rcs(GFR)GFR                            2.323e-01   0.363
## rcs(alder)alder':rcs(GFR)GFR                           6.549e-01  -0.288
## rcs(alder)alder'':rcs(GFR)GFR                          3.520e+00   0.507
## rcs(alder)alder''':rcs(GFR)GFR                         5.597e+00  -0.624
## rcs(alder)alder:rcs(GFR)GFR'                           1.337e+00   0.098
## rcs(alder)alder':rcs(GFR)GFR'                          3.695e+00   0.014
## rcs(alder)alder'':rcs(GFR)GFR'                         1.985e+01  -0.137
## rcs(alder)alder''':rcs(GFR)GFR'                        3.205e+01   0.268
## rcs(alder)alder:rcs(GFR)GFR''                          8.657e+00  -0.190
## rcs(alder)alder':rcs(GFR)GFR''                         2.455e+01  -0.002
## rcs(alder)alder'':rcs(GFR)GFR''                        1.370e+02   0.193
## rcs(alder)alder''':rcs(GFR)GFR''                       2.327e+02  -0.470
## rcs(alder)alder:rcs(GFR)GFR'''                         1.420e+01   0.198
## rcs(alder)alder':rcs(GFR)GFR'''                        4.184e+01   0.050
## rcs(alder)alder'':rcs(GFR)GFR'''                       2.447e+02  -0.285
## rcs(alder)alder''':rcs(GFR)GFR'''                      4.384e+02   0.616
## factor(cpap_treated)1:factor(antithrombotic_agents)1   8.989e-02  -1.604
##                                                      Pr(>|z|)    
## factor(cpap_treated)1                                 < 2e-16 ***
## rcs(alder)alder                                      0.060610 .  
## rcs(alder)alder'                                     0.486091    
## rcs(alder)alder''                                    0.423764    
## rcs(alder)alder'''                                   0.489681    
## factor(ami_history)1                                 0.801507    
## factor(antithrombotic_agents)1                        < 2e-16 ***
## rcs(hba1c)hba1c                                      4.02e-09 ***
## rcs(hba1c)hba1c'                                     0.348151    
## rcs(hba1c)hba1c''                                    0.177566    
## rcs(hba1c)hba1c'''                                   0.049191 *  
## factor(sex)1                                          < 2e-16 ***
## rcs(GFR)GFR                                          0.048094 *  
## rcs(GFR)GFR'                                         0.291507    
## rcs(GFR)GFR''                                        0.403053    
## rcs(GFR)GFR'''                                       0.479883    
## rcs(time_to_cpap_start)time_to_cpap_start            5.32e-07 ***
## rcs(time_to_cpap_start)time_to_cpap_start'           0.276037    
## rcs(time_to_cpap_start)time_to_cpap_start''          0.299985    
## rcs(time_to_cpap_start)time_to_cpap_start'''         0.398521    
## factor(rokare)1                                       < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04                      0.179013    
## rcs(DispInkKEHB04)DispInkKEHB04'                     6.91e-06 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                    0.000187 ***
## rcs(DispInkKEHB04)DispInkKEHB04'''                   0.008892 ** 
## rcs(kolesterol)kolesterol                            5.12e-07 ***
## rcs(kolesterol)kolesterol'                           1.66e-13 ***
## rcs(kolesterol)kolesterol''                          1.16e-10 ***
## rcs(kolesterol)kolesterol'''                         1.85e-08 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''           2.77e-16 ***
## rcs(systoliskt)systoliskt                            1.73e-05 ***
## rcs(systoliskt)systoliskt'                           7.83e-05 ***
## rcs(systoliskt)systoliskt''                          0.028666 *  
## rcs(systoliskt)systoliskt'''                         0.213719    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk            1.81e-12 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           2.02e-08 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          2.49e-08 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''         4.32e-07 ***
## factor(antihypertensive_comb)1                        < 2e-16 ***
## factor(Sun2000niva_old)2                             0.073845 .  
## factor(Sun2000niva_old)3                             0.018036 *  
## factor(Sun2000niva_old)4                             5.84e-05 ***
## factor(Sun2000niva_old)5                             1.44e-06 ***
## factor(Sun2000niva_old)6                              < 2e-16 ***
## factor(Sun2000niva_old)7                             0.006647 ** 
## factor(lipid_modifying_agents)1                      2.66e-12 ***
## factor(FodelseLand_EU27_2020)1                       1.52e-11 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk          3.01e-11 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'         3.05e-10 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''        3.43e-10 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''       9.22e-10 ***
## rcs(bmi)bmi                                          0.021384 *  
## rcs(bmi)bmi'                                         0.004230 ** 
## rcs(bmi)bmi''                                        0.000683 ***
## rcs(bmi)bmi'''                                       0.000323 ***
## factor(Civil)1                                       0.000456 ***
## rcs(alder)alder:rcs(GFR)GFR                          0.716948    
## rcs(alder)alder':rcs(GFR)GFR                         0.773546    
## rcs(alder)alder'':rcs(GFR)GFR                        0.611998    
## rcs(alder)alder''':rcs(GFR)GFR                       0.532753    
## rcs(alder)alder:rcs(GFR)GFR'                         0.921984    
## rcs(alder)alder':rcs(GFR)GFR'                        0.989122    
## rcs(alder)alder'':rcs(GFR)GFR'                       0.890725    
## rcs(alder)alder''':rcs(GFR)GFR'                      0.788811    
## rcs(alder)alder:rcs(GFR)GFR''                        0.849458    
## rcs(alder)alder':rcs(GFR)GFR''                       0.998741    
## rcs(alder)alder'':rcs(GFR)GFR''                      0.847093    
## rcs(alder)alder''':rcs(GFR)GFR''                     0.638589    
## rcs(alder)alder:rcs(GFR)GFR'''                       0.843409    
## rcs(alder)alder':rcs(GFR)GFR'''                      0.960484    
## rcs(alder)alder'':rcs(GFR)GFR'''                     0.775268    
## rcs(alder)alder''':rcs(GFR)GFR'''                    0.538106    
## factor(cpap_treated)1:factor(antithrombotic_agents)1 0.108801    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                       exp(coef) exp(-coef)
## factor(cpap_treated)1                                 1.772e+00  5.643e-01
## rcs(alder)alder                                       1.987e+00  5.034e-01
## rcs(alder)alder'                                      5.007e-01  1.997e+00
## rcs(alder)alder''                                     6.515e+01  1.535e-02
## rcs(alder)alder'''                                    3.432e-03  2.914e+02
## factor(ami_history)1                                  5.020e-08  1.992e+07
## factor(antithrombotic_agents)1                        1.957e+00  5.109e-01
## rcs(hba1c)hba1c                                       1.488e+00  6.719e-01
## rcs(hba1c)hba1c'                                      3.298e-01  3.033e+00
## rcs(hba1c)hba1c''                                     3.289e+02  3.040e-03
## rcs(hba1c)hba1c'''                                    3.537e-04  2.828e+03
## factor(sex)1                                          5.868e-01  1.704e+00
## rcs(GFR)GFR                                           5.812e-01  1.720e+00
## rcs(GFR)GFR'                                          5.123e+00  1.952e-01
## rcs(GFR)GFR''                                         2.033e-04  4.919e+03
## rcs(GFR)GFR'''                                        1.692e+05  5.911e-06
## rcs(time_to_cpap_start)time_to_cpap_start             1.326e+00  7.540e-01
## rcs(time_to_cpap_start)time_to_cpap_start'            8.718e-01  1.147e+00
## rcs(time_to_cpap_start)time_to_cpap_start''           1.608e+00  6.219e-01
## rcs(time_to_cpap_start)time_to_cpap_start'''          1.799e-01  5.558e+00
## factor(rokare)1                                       1.359e+00  7.361e-01
## rcs(DispInkKEHB04)DispInkKEHB04                       1.257e+00  7.957e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                      7.863e-08  1.272e+07
## rcs(DispInkKEHB04)DispInkKEHB04''                     1.122e+17  8.916e-18
## rcs(DispInkKEHB04)DispInkKEHB04'''                    1.329e-11  7.522e+10
## rcs(kolesterol)kolesterol                             8.759e-01  1.142e+00
## rcs(kolesterol)kolesterol'                            2.938e+00  3.403e-01
## rcs(kolesterol)kolesterol''                           1.108e-03  9.022e+02
## rcs(kolesterol)kolesterol'''                          2.664e+05  3.753e-06
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               5.107e+01  1.958e-02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                   Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            0.000e+00        Inf
## rcs(systoliskt)systoliskt                             8.879e-01  1.126e+00
## rcs(systoliskt)systoliskt'                            1.729e+00  5.782e-01
## rcs(systoliskt)systoliskt''                           8.168e-02  1.224e+01
## rcs(systoliskt)systoliskt'''                          2.804e+01  3.567e-02
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             4.760e+00  2.101e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           1.148e-142 8.712e+141
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          8.957e+154 1.116e-155
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          7.618e-14  1.313e+13
## factor(antihypertensive_comb)1                        1.124e+00  8.898e-01
## factor(Sun2000niva_old)2                              9.661e-01  1.035e+00
## factor(Sun2000niva_old)3                              9.682e-01  1.033e+00
## factor(Sun2000niva_old)4                              9.279e-01  1.078e+00
## factor(Sun2000niva_old)5                              9.019e-01  1.109e+00
## factor(Sun2000niva_old)6                              8.308e-01  1.204e+00
## factor(Sun2000niva_old)7                              8.232e-01  1.215e+00
## factor(lipid_modifying_agents)1                       1.084e+00  9.229e-01
## factor(FodelseLand_EU27_2020)1                        9.101e-01  1.099e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           8.580e+00  1.165e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''               Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''       1.655e-101 6.043e+100
## rcs(bmi)bmi                                           9.252e-01  1.081e+00
## rcs(bmi)bmi'                                          2.018e+00  4.955e-01
## rcs(bmi)bmi''                                         1.010e-02  9.905e+01
## rcs(bmi)bmi'''                                        8.523e+02  1.173e-03
## factor(Civil)1                                        1.057e+00  9.462e-01
## rcs(alder)alder:rcs(GFR)GFR                           1.088e+00  9.192e-01
## rcs(alder)alder':rcs(GFR)GFR                          8.282e-01  1.207e+00
## rcs(alder)alder'':rcs(GFR)GFR                         5.962e+00  1.677e-01
## rcs(alder)alder''':rcs(GFR)GFR                        3.046e-02  3.283e+01
## rcs(alder)alder:rcs(GFR)GFR'                          1.140e+00  8.772e-01
## rcs(alder)alder':rcs(GFR)GFR'                         1.052e+00  9.509e-01
## rcs(alder)alder'':rcs(GFR)GFR'                        6.545e-02  1.528e+01
## rcs(alder)alder''':rcs(GFR)GFR'                       5.351e+03  1.869e-04
## rcs(alder)alder:rcs(GFR)GFR''                         1.934e-01  5.172e+00
## rcs(alder)alder':rcs(GFR)GFR''                        9.620e-01  1.040e+00
## rcs(alder)alder'':rcs(GFR)GFR''                       2.960e+11  3.378e-12
## rcs(alder)alder''':rcs(GFR)GFR''                      3.467e-48  2.884e+47
## rcs(alder)alder:rcs(GFR)GFR'''                        1.654e+01  6.047e-02
## rcs(alder)alder':rcs(GFR)GFR'''                       7.950e+00  1.258e-01
## rcs(alder)alder'':rcs(GFR)GFR'''                      4.591e-31  2.178e+30
## rcs(alder)alder''':rcs(GFR)GFR'''                    1.675e+117 5.970e-118
## factor(cpap_treated)1:factor(antithrombotic_agents)1  8.658e-01  1.155e+00
##                                                       lower .95  upper .95
## factor(cpap_treated)1                                 1.564e+00  2.008e+00
## rcs(alder)alder                                       9.699e-01  4.069e+00
## rcs(alder)alder'                                      7.146e-02  3.507e+00
## rcs(alder)alder''                                     2.341e-03  1.813e+06
## rcs(alder)alder'''                                    3.493e-10  3.371e+04
## factor(ami_history)1                                  6.211e-65  4.057e+49
## factor(antithrombotic_agents)1                        1.912e+00  2.003e+00
## rcs(hba1c)hba1c                                       1.304e+00  1.699e+00
## rcs(hba1c)hba1c'                                      3.248e-02  3.348e+00
## rcs(hba1c)hba1c''                                     7.212e-02  1.500e+06
## rcs(hba1c)hba1c'''                                    1.286e-07  9.722e-01
## factor(sex)1                                          5.733e-01  6.006e-01
## rcs(GFR)GFR                                           3.394e-01  9.955e-01
## rcs(GFR)GFR'                                          2.461e-01  1.066e+02
## rcs(GFR)GFR''                                         4.514e-13  9.156e+04
## rcs(GFR)GFR'''                                        5.295e-10  5.405e+19
## rcs(time_to_cpap_start)time_to_cpap_start             1.188e+00  1.481e+00
## rcs(time_to_cpap_start)time_to_cpap_start'            6.812e-01  1.116e+00
## rcs(time_to_cpap_start)time_to_cpap_start''           6.550e-01  3.947e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''          3.356e-03  9.647e+00
## factor(rokare)1                                       1.322e+00  1.396e+00
## rcs(DispInkKEHB04)DispInkKEHB04                       9.005e-01  1.754e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      6.292e-11  9.826e-05
## rcs(DispInkKEHB04)DispInkKEHB04''                     1.278e+08  9.843e+25
## rcs(DispInkKEHB04)DispInkKEHB04'''                    9.452e-20  1.870e-03
## rcs(kolesterol)kolesterol                             8.318e-01  9.224e-01
## rcs(kolesterol)kolesterol'                            2.206e+00  3.913e+00
## rcs(kolesterol)kolesterol''                           1.399e-04  8.780e-03
## rcs(kolesterol)kolesterol'''                          3.430e+03  2.070e+07
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               2.383e+01  1.094e+02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                   Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            0.000e+00  0.000e+00
## rcs(systoliskt)systoliskt                             8.410e-01  9.374e-01
## rcs(systoliskt)systoliskt'                            1.318e+00  2.270e+00
## rcs(systoliskt)systoliskt''                           8.662e-03  7.702e-01
## rcs(systoliskt)systoliskt'''                          1.464e-01  5.368e+03
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             3.085e+00  7.346e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           2.977e-192  4.425e-93
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          2.932e+100 2.737e+209
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          6.234e-19  9.310e-09
## factor(antihypertensive_comb)1                        1.097e+00  1.151e+00
## factor(Sun2000niva_old)2                              9.302e-01  1.003e+00
## factor(Sun2000niva_old)3                              9.427e-01  9.945e-01
## factor(Sun2000niva_old)4                              8.947e-01  9.624e-01
## factor(Sun2000niva_old)5                              8.648e-01  9.406e-01
## factor(Sun2000niva_old)6                              7.958e-01  8.673e-01
## factor(Sun2000niva_old)7                              7.154e-01  9.474e-01
## factor(lipid_modifying_agents)1                       1.059e+00  1.108e+00
## factor(FodelseLand_EU27_2020)1                        8.855e-01  9.353e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           4.552e+00  1.617e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''               Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''       9.027e-134  3.034e-69
## rcs(bmi)bmi                                           8.660e-01  9.885e-01
## rcs(bmi)bmi'                                          1.247e+00  3.265e+00
## rcs(bmi)bmi''                                         7.118e-04  1.432e-01
## rcs(bmi)bmi'''                                        2.155e+01  3.371e+04
## factor(Civil)1                                        1.025e+00  1.090e+00
## rcs(alder)alder:rcs(GFR)GFR                           6.900e-01  1.715e+00
## rcs(alder)alder':rcs(GFR)GFR                          2.295e-01  2.990e+00
## rcs(alder)alder'':rcs(GFR)GFR                         6.013e-03  5.912e+03
## rcs(alder)alder''':rcs(GFR)GFR                        5.243e-07  1.769e+03
## rcs(alder)alder:rcs(GFR)GFR'                          8.288e-02  1.568e+01
## rcs(alder)alder':rcs(GFR)GFR'                         7.530e-04  1.469e+03
## rcs(alder)alder'':rcs(GFR)GFR'                        8.388e-19  5.107e+15
## rcs(alder)alder''':rcs(GFR)GFR'                       2.795e-24  1.025e+31
## rcs(alder)alder:rcs(GFR)GFR''                         8.267e-09  4.522e+06
## rcs(alder)alder':rcs(GFR)GFR''                        1.213e-21  7.631e+20
## rcs(alder)alder'':rcs(GFR)GFR''                      7.481e-106 1.171e+128
## rcs(alder)alder''':rcs(GFR)GFR''                     3.074e-246 3.912e+150
## rcs(alder)alder:rcs(GFR)GFR'''                        1.345e-11  2.034e+13
## rcs(alder)alder':rcs(GFR)GFR'''                       1.916e-35  3.300e+36
## rcs(alder)alder'':rcs(GFR)GFR'''                     2.421e-239 8.705e+177
## rcs(alder)alder''':rcs(GFR)GFR'''                    1.126e-256        Inf
## factor(cpap_treated)1:factor(antithrombotic_agents)1  7.259e-01  1.033e+00
## 
## Concordance= 0.751  (se = 0.001 )
## Likelihood ratio test= 30462  on 76 df,   p=<2e-16
## Wald test            = 24307  on 76 df,   p=<2e-16
## Score (logrank) test = 30806  on 76 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7508489 
## C-index test: 0.7515804[1] "### FORMULA 2 ###"
## Start:  AIC=957466.2
## Surv(time_to_ami, ami) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 946570
## + factor(antithrombotic_agents)   1 949558
## + factor(ami_history)             1 952692
## + factor(GFR_high)                1 954076
## + rcs(time_to_cpap_start)         4 954689
## + factor(Sun2000niva_old)         6 955082
## + rcs(DispInkKEHB04)              4 955217
## + factor(antihypertensive_comb)   1 955756
## + factor(hba1c_high)              1 956132
## + factor(Civil)                   1 956134
## + rcs(bmi)                        4 956275
## + factor(sex)                     1 956563
## + factor(lipid_modifying_agents)  1 956757
## + factor(stroke_history)          1 956780
## + factor(systoliskt_high)         1 957076
## + rcs(Raks_AndelSjukInk)          4 957237
## + rcs(Raks_AndelArblosInk)        4 957288
## + factor(kolesterol_high)         1 957357
## + factor(FodelseLand_EU27_2020)   1 957359
## + factor(rokare)                  1 957397
## + rcs(Raks_AndelEkBisInk)         4 957410
## <none>                              957466
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=946569.6
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6,8,9 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(ami_history)             1 940733
## + factor(antithrombotic_agents)   1 943063
## + factor(sex)                     1 944758
## + rcs(time_to_cpap_start)         4 944868
## + factor(hba1c_high)              1 945090
## + factor(GFR_high)                1 945884
## + rcs(DispInkKEHB04)              4 945968
## + factor(rokare)                  1 945985
## + factor(antihypertensive_comb)   1 946112
## + factor(Sun2000niva_old)         6 946194
## + factor(lipid_modifying_agents)  1 946258
## + rcs(Raks_AndelEkBisInk)         4 946303
## + factor(stroke_history)          1 946372
## + rcs(Raks_AndelSjukInk)          4 946422
## + factor(FodelseLand_EU27_2020)   1 946471
## + rcs(Raks_AndelArblosInk)        4 946490
## + factor(systoliskt_high)         1 946508
## + rcs(bmi)                        4 946519
## + factor(Civil)                   1 946561
## <none>                              946570
## + factor(kolesterol_high)         1 946570
## - rcs(alder)                      4 957466
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=940732.7
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 935254
## + factor(sex)                     1 938439
## + rcs(time_to_cpap_start)         4 939126
## + factor(hba1c_high)              1 939244
## + factor(GFR_high)                1 939931
## + factor(lipid_modifying_agents)  1 939990
## + factor(antihypertensive_comb)   1 940079
## + factor(rokare)                  1 940138
## + rcs(DispInkKEHB04)              4 940139
## + factor(Sun2000niva_old)         6 940318
## + rcs(Raks_AndelEkBisInk)         4 940472
## + factor(stroke_history)          1 940497
## + rcs(Raks_AndelSjukInk)          4 940564
## + factor(FodelseLand_EU27_2020)   1 940638
## + rcs(Raks_AndelArblosInk)        4 940652
## + rcs(bmi)                        4 940667
## + factor(kolesterol_high)         1 940691
## + factor(systoliskt_high)         1 940713
## + factor(Civil)                   1 940714
## <none>                              940733
## - factor(ami_history)             1 946570
## - rcs(alder)                      4 952692
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=935253.8
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(sex)                                         1 933531
## + factor(hba1c_high)                                  1 933983
## + rcs(time_to_cpap_start)                             4 934157
## + factor(GFR_high)                                    1 934690
## + factor(rokare)                                      1 934701
## + rcs(DispInkKEHB04)                                  4 934751
## + factor(Sun2000niva_old)                             6 934923
## + rcs(Raks_AndelEkBisInk)                             4 934994
## + factor(antihypertensive_comb)                       1 935081
## + rcs(Raks_AndelSjukInk)                              4 935113
## + factor(FodelseLand_EU27_2020)                       1 935148
## + rcs(Raks_AndelArblosInk)                            4 935167
## + factor(systoliskt_high)                             1 935188
## + rcs(bmi)                                            4 935190
## + factor(lipid_modifying_agents)                      1 935196
## + factor(kolesterol_high)                             1 935237
## + factor(Civil)                                       1 935244
## + factor(cpap_treated):factor(antithrombotic_agents)  1 935252
## <none>                                                  935254
## + factor(stroke_history)                              1 935255
## - factor(antithrombotic_agents)                       1 940733
## - rcs(alder)                                          4 941719
## - factor(ami_history)                                 1 943063
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=933531.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(hba1c_high)                                  1 932308
## + rcs(time_to_cpap_start)                             4 932390
## + rcs(DispInkKEHB04)                                  4 932680
## + factor(GFR_high)                                    1 932803
## + factor(rokare)                                      1 932962
## + factor(Sun2000niva_old)                             6 933137
## + rcs(Raks_AndelEkBisInk)                             4 933237
## + rcs(Raks_AndelSjukInk)                              4 933373
## + factor(antihypertensive_comb)                       1 933376
## + factor(FodelseLand_EU27_2020)                       1 933381
## + rcs(Raks_AndelArblosInk)                            4 933453
## + factor(systoliskt_high)                             1 933464
## + factor(kolesterol_high)                             1 933465
## + factor(lipid_modifying_agents)                      1 933481
## + factor(Civil)                                       1 933485
## + rcs(bmi)                                            4 933504
## + factor(cpap_treated):factor(antithrombotic_agents)  1 933529
## <none>                                                  933531
## + factor(stroke_history)                              1 933533
## - factor(sex)                                         1 935254
## - factor(antithrombotic_agents)                       1 938439
## - rcs(alder)                                          4 940872
## - factor(ami_history)                                 1 941733
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=932307.9
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(time_to_cpap_start)                             4 931366
## + rcs(DispInkKEHB04)                                  4 931576
## + factor(GFR_high)                                    1 931607
## + factor(rokare)                                      1 931754
## + factor(Sun2000niva_old)                             6 931975
## + rcs(Raks_AndelEkBisInk)                             4 932043
## + factor(antihypertensive_comb)                       1 932147
## + rcs(Raks_AndelSjukInk)                              4 932147
## + factor(FodelseLand_EU27_2020)                       1 932179
## + rcs(Raks_AndelArblosInk)                            4 932229
## + factor(kolesterol_high)                             1 932239
## + factor(systoliskt_high)                             1 932258
## + factor(lipid_modifying_agents)                      1 932264
## + factor(Civil)                                       1 932270
## + rcs(bmi)                                            4 932287
## + factor(cpap_treated):factor(antithrombotic_agents)  1 932306
## <none>                                                  932308
## + factor(stroke_history)                              1 932309
## - factor(hba1c_high)                                  1 933531
## - factor(sex)                                         1 933983
## - factor(antithrombotic_agents)                       1 937037
## - rcs(alder)                                          4 939794
## - factor(ami_history)                                 1 940450
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=931366.5
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(GFR_high)                                    1 930711
## + factor(rokare)                                      1 930831
## + rcs(DispInkKEHB04)                                  4 930875
## + rcs(Raks_AndelEkBisInk)                             4 931075
## + factor(Sun2000niva_old)                             6 931119
## + rcs(Raks_AndelSjukInk)                              4 931185
## + factor(FodelseLand_EU27_2020)                       1 931211
## + factor(antihypertensive_comb)                       1 931216
## + factor(kolesterol_high)                             1 931265
## + rcs(Raks_AndelArblosInk)                            4 931289
## + factor(systoliskt_high)                             1 931327
## + factor(lipid_modifying_agents)                      1 931330
## + factor(Civil)                                       1 931340
## + rcs(bmi)                                            4 931348
## + factor(stroke_history)                              1 931365
## + factor(cpap_treated):factor(antithrombotic_agents)  1 931366
## <none>                                                  931366
## - rcs(time_to_cpap_start)                             4 932308
## - factor(hba1c_high)                                  1 932390
## - factor(sex)                                         1 933086
## - factor(antithrombotic_agents)                       1 935663
## - rcs(alder)                                          4 938527
## - factor(ami_history)                                 1 939282
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=930710.8
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 930148
## + rcs(DispInkKEHB04)                                  4 930238
## + rcs(Raks_AndelEkBisInk)                             4 930413
## + factor(Sun2000niva_old)                             6 930474
## + rcs(Raks_AndelSjukInk)                              4 930531
## + factor(FodelseLand_EU27_2020)                       1 930547
## + factor(antihypertensive_comb)                       1 930605
## + factor(kolesterol_high)                             1 930620
## + rcs(Raks_AndelArblosInk)                            4 930634
## + factor(systoliskt_high)                             1 930658
## + rcs(alder):factor(GFR_high)                         4 930658
## + factor(lipid_modifying_agents)                      1 930685
## + factor(Civil)                                       1 930686
## + rcs(bmi)                                            4 930688
## + factor(cpap_treated):factor(GFR_high)               1 930709
## + factor(stroke_history)                              1 930710
## + factor(cpap_treated):factor(antithrombotic_agents)  1 930711
## <none>                                                  930711
## - factor(GFR_high)                                    1 931366
## - rcs(time_to_cpap_start)                             4 931607
## - factor(hba1c_high)                                  1 931713
## - factor(sex)                                         1 932581
## - factor(antithrombotic_agents)                       1 934775
## - rcs(alder)                                          4 936279
## - factor(ami_history)                                 1 938720
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=930147.9
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 929743
## + rcs(Raks_AndelEkBisInk)                             4 929882
## + factor(Sun2000niva_old)                             6 929941
## + rcs(Raks_AndelSjukInk)                              4 929968
## + factor(FodelseLand_EU27_2020)                       1 930008
## + factor(antihypertensive_comb)                       1 930029
## + factor(kolesterol_high)                             1 930058
## + rcs(Raks_AndelArblosInk)                            4 930072
## + rcs(alder):factor(GFR_high)                         4 930091
## + factor(systoliskt_high)                             1 930095
## + factor(lipid_modifying_agents)                      1 930122
## + factor(Civil)                                       1 930125
## + rcs(bmi)                                            4 930132
## + factor(cpap_treated):factor(GFR_high)               1 930147
## + factor(cpap_treated):factor(antithrombotic_agents)  1 930147
## <none>                                                  930148
## + factor(stroke_history)                              1 930148
## - factor(rokare)                                      1 930711
## - factor(GFR_high)                                    1 930831
## - rcs(time_to_cpap_start)                             4 931025
## - factor(hba1c_high)                                  1 931141
## - factor(sex)                                         1 932036
## - factor(antithrombotic_agents)                       1 934185
## - rcs(alder)                                          4 936102
## - factor(ami_history)                                 1 938164
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929743.1
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelSjukInk)                              4 929515
## + rcs(Raks_AndelEkBisInk)                             4 929587
## + factor(antihypertensive_comb)                       1 929613
## + factor(kolesterol_high)                             1 929648
## + factor(Sun2000niva_old)                             6 929658
## + rcs(Raks_AndelArblosInk)                            4 929660
## + factor(FodelseLand_EU27_2020)                       1 929681
## + factor(systoliskt_high)                             1 929686
## + rcs(alder):factor(GFR_high)                         4 929692
## + factor(lipid_modifying_agents)                      1 929713
## + rcs(bmi)                                            4 929726
## + factor(Civil)                                       1 929730
## + factor(cpap_treated):factor(GFR_high)               1 929742
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929743
## <none>                                                  929743
## + factor(stroke_history)                              1 929744
## - rcs(DispInkKEHB04)                                  4 930148
## - factor(rokare)                                      1 930238
## - factor(GFR_high)                                    1 930407
## - rcs(time_to_cpap_start)                             4 930410
## - factor(hba1c_high)                                  1 930681
## - factor(sex)                                         1 931859
## - factor(antithrombotic_agents)                       1 933737
## - rcs(alder)                                          4 934971
## - factor(ami_history)                                 1 937787
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929515.5
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 15 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelEkBisInk)                             4 929379
## + factor(antihypertensive_comb)                       1 929385
## + factor(kolesterol_high)                             1 929421
## + factor(Sun2000niva_old)                             6 929435
## + factor(FodelseLand_EU27_2020)                       1 929452
## + factor(systoliskt_high)                             1 929458
## + rcs(alder):factor(GFR_high)                         4 929465
## + rcs(Raks_AndelArblosInk)                            4 929466
## + factor(lipid_modifying_agents)                      1 929483
## + rcs(bmi)                                            4 929498
## + factor(Civil)                                       1 929502
## + factor(cpap_treated):factor(GFR_high)               1 929514
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929515
## <none>                                                  929515
## + factor(stroke_history)                              1 929517
## - rcs(Raks_AndelSjukInk)                              4 929743
## - rcs(DispInkKEHB04)                                  4 929968
## - factor(rokare)                                      1 930008
## - factor(GFR_high)                                    1 930178
## - rcs(time_to_cpap_start)                             4 930189
## - factor(hba1c_high)                                  1 930449
## - factor(sex)                                         1 931672
## - factor(antithrombotic_agents)                       1 933473
## - rcs(alder)                                          4 934921
## - factor(ami_history)                                 1 937586
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929378.6
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(antihypertensive_comb)                       1 929239
## + factor(kolesterol_high)                             1 929281
## + factor(Sun2000niva_old)                             6 929288
## + factor(systoliskt_high)                             1 929318
## + rcs(alder):factor(GFR_high)                         4 929329
## + factor(lipid_modifying_agents)                      1 929344
## + rcs(Raks_AndelArblosInk)                            4 929345
## + factor(FodelseLand_EU27_2020)                       1 929350
## + rcs(bmi)                                            4 929361
## + factor(Civil)                                       1 929364
## + factor(cpap_treated):factor(GFR_high)               1 929377
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929378
## <none>                                                  929379
## + factor(stroke_history)                              1 929379
## - rcs(Raks_AndelEkBisInk)                             4 929515
## - rcs(Raks_AndelSjukInk)                              4 929587
## - rcs(DispInkKEHB04)                                  4 929711
## - factor(rokare)                                      1 929857
## - factor(GFR_high)                                    1 930046
## - rcs(time_to_cpap_start)                             4 930088
## - factor(hba1c_high)                                  1 930299
## - factor(sex)                                         1 931522
## - factor(antithrombotic_agents)                       1 933336
## - rcs(alder)                                          4 934879
## - factor(ami_history)                                 1 937442
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929238.7
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(kolesterol_high)                             1 929132
## + factor(Sun2000niva_old)                             6 929155
## + rcs(alder):factor(GFR_high)                         4 929192
## + factor(systoliskt_high)                             1 929194
## + rcs(Raks_AndelArblosInk)                            4 929204
## + factor(FodelseLand_EU27_2020)                       1 929205
## + rcs(bmi)                                            4 929218
## + factor(lipid_modifying_agents)                      1 929221
## + factor(Civil)                                       1 929225
## + factor(cpap_treated):factor(GFR_high)               1 929237
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929238
## <none>                                                  929239
## + factor(stroke_history)                              1 929240
## + factor(cpap_treated):factor(antihypertensive_comb)  1 929241
## - factor(antihypertensive_comb)                       1 929379
## - rcs(Raks_AndelEkBisInk)                             4 929385
## - rcs(Raks_AndelSjukInk)                              4 929448
## - rcs(DispInkKEHB04)                                  4 929578
## - factor(rokare)                                      1 929730
## - factor(GFR_high)                                    1 929857
## - rcs(time_to_cpap_start)                             4 929940
## - factor(hba1c_high)                                  1 930162
## - factor(sex)                                         1 931364
## - factor(antithrombotic_agents)                       1 932828
## - rcs(alder)                                          4 934567
## - factor(ami_history)                                 1 937348
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929132.5
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(Sun2000niva_old)                             6 929047
## + rcs(alder):factor(GFR_high)                         4 929085
## + factor(systoliskt_high)                             1 929093
## + rcs(Raks_AndelArblosInk)                            4 929097
## + factor(FodelseLand_EU27_2020)                       1 929097
## + factor(lipid_modifying_agents)                      1 929099
## + rcs(bmi)                                            4 929111
## + factor(Civil)                                       1 929119
## + factor(cpap_treated):factor(GFR_high)               1 929131
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929132
## <none>                                                  929132
## + factor(stroke_history)                              1 929133
## + factor(cpap_treated):factor(antihypertensive_comb)  1 929134
## - factor(kolesterol_high)                             1 929239
## - factor(antihypertensive_comb)                       1 929281
## - rcs(Raks_AndelEkBisInk)                             4 929282
## - rcs(Raks_AndelSjukInk)                              4 929341
## - rcs(DispInkKEHB04)                                  4 929475
## - factor(rokare)                                      1 929622
## - factor(GFR_high)                                    1 929738
## - rcs(time_to_cpap_start)                             4 929860
## - factor(hba1c_high)                                  1 930057
## - factor(sex)                                         1 931329
## - factor(antithrombotic_agents)                       1 932820
## - rcs(alder)                                          4 934517
## - factor(ami_history)                                 1 937142
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=929047.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(alder):factor(GFR_high)                         4 928999
## + factor(FodelseLand_EU27_2020)                       1 929002
## + factor(systoliskt_high)                             1 929009
## + rcs(Raks_AndelArblosInk)                            4 929012
## + factor(lipid_modifying_agents)                      1 929015
## + rcs(bmi)                                            4 929024
## + factor(Civil)                                       1 929036
## + factor(cpap_treated):factor(GFR_high)               1 929046
## + factor(cpap_treated):factor(antithrombotic_agents)  1 929047
## <none>                                                  929047
## + factor(stroke_history)                              1 929048
## + factor(cpap_treated):factor(antihypertensive_comb)  1 929049
## - factor(Sun2000niva_old)                             6 929132
## - factor(kolesterol_high)                             1 929155
## - factor(antihypertensive_comb)                       1 929189
## - rcs(Raks_AndelEkBisInk)                             4 929207
## - rcs(Raks_AndelSjukInk)                              4 929252
## - rcs(DispInkKEHB04)                                  4 929278
## - factor(rokare)                                      1 929526
## - factor(GFR_high)                                    1 929650
## - rcs(time_to_cpap_start)                             4 929756
## - factor(hba1c_high)                                  1 929955
## - factor(sex)                                         1 931231
## - factor(antithrombotic_agents)                       1 932726
## - rcs(alder)                                          4 934027
## - factor(ami_history)                                 1 937075
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928999
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(FodelseLand_EU27_2020)                       1 928953
## + factor(systoliskt_high)                             1 928961
## + rcs(Raks_AndelArblosInk)                            4 928964
## + factor(lipid_modifying_agents)                      1 928967
## + rcs(bmi)                                            4 928975
## + factor(Civil)                                       1 928988
## + factor(cpap_treated):factor(GFR_high)               1 928995
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928999
## <none>                                                  928999
## + factor(stroke_history)                              1 928999
## + factor(cpap_treated):factor(antihypertensive_comb)  1 929001
## - rcs(alder):factor(GFR_high)                         4 929047
## - factor(Sun2000niva_old)                             6 929085
## - factor(kolesterol_high)                             1 929108
## - factor(antihypertensive_comb)                       1 929137
## - rcs(Raks_AndelEkBisInk)                             4 929158
## - rcs(Raks_AndelSjukInk)                              4 929203
## - rcs(DispInkKEHB04)                                  4 929225
## - factor(rokare)                                      1 929481
## - rcs(time_to_cpap_start)                             4 929708
## - factor(hba1c_high)                                  1 929908
## - factor(sex)                                         1 931185
## - factor(antithrombotic_agents)                       1 932664
## - factor(ami_history)                                 1 937016
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928953.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(systoliskt_high)                             1 928915
## + rcs(Raks_AndelArblosInk)                            4 928919
## + factor(lipid_modifying_agents)                      1 928921
## + rcs(bmi)                                            4 928931
## + factor(Civil)                                       1 928942
## + factor(cpap_treated):factor(GFR_high)               1 928949
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928953
## <none>                                                  928953
## + factor(stroke_history)                              1 928953
## + factor(cpap_treated):factor(antihypertensive_comb)  1 928955
## - factor(FodelseLand_EU27_2020)                       1 928999
## - rcs(alder):factor(GFR_high)                         4 929002
## - factor(Sun2000niva_old)                             6 929049
## - factor(kolesterol_high)                             1 929063
## - rcs(Raks_AndelEkBisInk)                             4 929068
## - factor(antihypertensive_comb)                       1 929096
## - rcs(DispInkKEHB04)                                  4 929144
## - rcs(Raks_AndelSjukInk)                              4 929157
## - factor(rokare)                                      1 929428
## - rcs(time_to_cpap_start)                             4 929681
## - factor(hba1c_high)                                  1 929855
## - factor(sex)                                         1 931153
## - factor(antithrombotic_agents)                       1 932617
## - factor(ami_history)                                 1 936974
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928915
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelArblosInk)                            4 928880
## + factor(lipid_modifying_agents)                      1 928880
## + rcs(bmi)                                            4 928893
## + factor(Civil)                                       1 928904
## + factor(cpap_treated):factor(GFR_high)               1 928911
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928915
## + factor(stroke_history)                              1 928915
## <none>                                                  928915
## + factor(cpap_treated):factor(antihypertensive_comb)  1 928917
## - factor(systoliskt_high)                             1 928953
## - factor(FodelseLand_EU27_2020)                       1 928961
## - rcs(alder):factor(GFR_high)                         4 928964
## - factor(Sun2000niva_old)                             6 929010
## - factor(kolesterol_high)                             1 929019
## - rcs(Raks_AndelEkBisInk)                             4 929031
## - factor(antihypertensive_comb)                       1 929043
## - rcs(DispInkKEHB04)                                  4 929107
## - rcs(Raks_AndelSjukInk)                              4 929120
## - factor(rokare)                                      1 929390
## - rcs(time_to_cpap_start)                             4 929632
## - factor(hba1c_high)                                  1 929804
## - factor(sex)                                         1 931118
## - factor(antithrombotic_agents)                       1 932612
## - factor(ami_history)                                 1 936884
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928880.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(lipid_modifying_agents)                      1 928845
## + rcs(bmi)                                            4 928859
## + factor(Civil)                                       1 928869
## + factor(cpap_treated):factor(GFR_high)               1 928876
## + factor(cpap_treated):factor(antithrombotic_agents)  1 928880
## + factor(stroke_history)                              1 928880
## <none>                                                  928880
## + factor(cpap_treated):factor(antihypertensive_comb)  1 928882
## - rcs(Raks_AndelArblosInk)                            4 928915
## - factor(systoliskt_high)                             1 928919
## - factor(FodelseLand_EU27_2020)                       1 928925
## - rcs(alder):factor(GFR_high)                         4 928930
## - factor(Sun2000niva_old)                             6 928975
## - rcs(Raks_AndelEkBisInk)                             4 928980
## - factor(kolesterol_high)                             1 928985
## - factor(antihypertensive_comb)                       1 929010
## - rcs(Raks_AndelSjukInk)                              4 929056
## - rcs(DispInkKEHB04)                                  4 929077
## - factor(rokare)                                      1 929355
## - rcs(time_to_cpap_start)                             4 929594
## - factor(hba1c_high)                                  1 929770
## - factor(sex)                                         1 931079
## - factor(antithrombotic_agents)                       1 932582
## - factor(ami_history)                                 1 936850
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928845.2
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + factor(lipid_modifying_agents) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + rcs(bmi)                                             4 928824
## + factor(Civil)                                        1 928834
## + factor(cpap_treated):factor(GFR_high)                1 928841
## + factor(cpap_treated):factor(antithrombotic_agents)   1 928845
## <none>                                                   928845
## + factor(stroke_history)                               1 928846
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 928846
## + factor(cpap_treated):factor(antihypertensive_comb)   1 928847
## - factor(lipid_modifying_agents)                       1 928880
## - rcs(Raks_AndelArblosInk)                             4 928880
## - factor(systoliskt_high)                              1 928886
## - factor(FodelseLand_EU27_2020)                        1 928891
## - rcs(alder):factor(GFR_high)                          4 928894
## - factor(Sun2000niva_old)                              6 928939
## - rcs(Raks_AndelEkBisInk)                              4 928946
## - factor(antihypertensive_comb)                        1 928954
## - factor(kolesterol_high)                              1 928966
## - rcs(Raks_AndelSjukInk)                               4 929022
## - rcs(DispInkKEHB04)                                   4 929045
## - factor(rokare)                                       1 929318
## - rcs(time_to_cpap_start)                              4 929556
## - factor(hba1c_high)                                   1 929729
## - factor(sex)                                          1 931047
## - factor(antithrombotic_agents)                        1 932206
## - factor(ami_history)                                  1 936851
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928823.7
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + factor(lipid_modifying_agents) + 
##     rcs(bmi) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 5 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(Civil)                                        1 928812
## + factor(cpap_treated):factor(GFR_high)                1 928820
## + factor(cpap_treated):factor(antithrombotic_agents)   1 928823
## <none>                                                   928824
## + factor(stroke_history)                               1 928825
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 928825
## + factor(cpap_treated):factor(antihypertensive_comb)   1 928826
## + rcs(alder):rcs(bmi)                                 16 928828
## - rcs(bmi)                                             4 928845
## - factor(lipid_modifying_agents)                       1 928859
## - rcs(Raks_AndelArblosInk)                             4 928859
## - factor(systoliskt_high)                              1 928864
## - factor(FodelseLand_EU27_2020)                        1 928868
## - rcs(alder):factor(GFR_high)                          4 928873
## - factor(Sun2000niva_old)                              6 928919
## - rcs(Raks_AndelEkBisInk)                              4 928925
## - factor(antihypertensive_comb)                        1 928936
## - factor(kolesterol_high)                              1 928945
## - rcs(Raks_AndelSjukInk)                               4 929002
## - rcs(DispInkKEHB04)                                   4 929027
## - factor(rokare)                                       1 929284
## - rcs(time_to_cpap_start)                              4 929524
## - factor(hba1c_high)                                   1 929708
## - factor(sex)                                          1 930954
## - factor(antithrombotic_agents)                        1 932189
## - factor(ami_history)                                  1 936837
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928812.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + factor(lipid_modifying_agents) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(cpap_treated):factor(GFR_high)                1 928808
## + factor(cpap_treated):factor(antithrombotic_agents)   1 928812
## <none>                                                   928812
## + factor(stroke_history)                               1 928813
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 928813
## + factor(cpap_treated):factor(antihypertensive_comb)   1 928814
## + rcs(alder):rcs(bmi)                                 16 928817
## - factor(Civil)                                        1 928824
## - rcs(bmi)                                             4 928834
## - rcs(Raks_AndelArblosInk)                             4 928847
## - factor(lipid_modifying_agents)                       1 928848
## - factor(systoliskt_high)                              1 928852
## - factor(FodelseLand_EU27_2020)                        1 928857
## - rcs(alder):factor(GFR_high)                          4 928863
## - factor(Sun2000niva_old)                              6 928905
## - rcs(Raks_AndelEkBisInk)                              4 928914
## - factor(antihypertensive_comb)                        1 928924
## - factor(kolesterol_high)                              1 928934
## - rcs(Raks_AndelSjukInk)                               4 928991
## - rcs(DispInkKEHB04)                                   4 929010
## - factor(rokare)                                       1 929272
## - rcs(time_to_cpap_start)                              4 929509
## - factor(hba1c_high)                                   1 929695
## - factor(sex)                                          1 930906
## - factor(antithrombotic_agents)                        1 932176
## - factor(ami_history)                                  1 936825
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928808.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + factor(lipid_modifying_agents) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):factor(GFR_high) + 
##     factor(cpap_treated):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(cpap_treated):factor(antithrombotic_agents)   1 928808
## <none>                                                   928808
## + factor(stroke_history)                               1 928809
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 928809
## + factor(cpap_treated):factor(antihypertensive_comb)   1 928810
## - factor(cpap_treated):factor(GFR_high)                1 928812
## + rcs(alder):rcs(bmi)                                 16 928813
## - factor(Civil)                                        1 928820
## - rcs(bmi)                                             4 928829
## - factor(lipid_modifying_agents)                       1 928843
## - rcs(Raks_AndelArblosInk)                             4 928843
## - factor(systoliskt_high)                              1 928848
## - factor(FodelseLand_EU27_2020)                        1 928853
## - rcs(alder):factor(GFR_high)                          4 928861
## - factor(Sun2000niva_old)                              6 928901
## - rcs(Raks_AndelEkBisInk)                              4 928910
## - factor(antihypertensive_comb)                        1 928920
## - factor(kolesterol_high)                              1 928930
## - rcs(Raks_AndelSjukInk)                               4 928986
## - rcs(DispInkKEHB04)                                   4 929006
## - factor(rokare)                                       1 929268
## - rcs(time_to_cpap_start)                              4 929504
## - factor(hba1c_high)                                   1 929691
## - factor(sex)                                          1 930902
## - factor(antithrombotic_agents)                        1 932171
## - factor(ami_history)                                  1 936820
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=928808.3
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(ami_history) + factor(antithrombotic_agents) + factor(sex) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(GFR_high) + 
##     factor(rokare) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + factor(lipid_modifying_agents) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):factor(GFR_high) + 
##     factor(cpap_treated):factor(GFR_high) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## <none>                                                   928808
## - factor(cpap_treated):factor(antithrombotic_agents)   1 928808
## + factor(stroke_history)                               1 928809
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 928810
## + factor(cpap_treated):factor(antihypertensive_comb)   1 928810
## - factor(cpap_treated):factor(GFR_high)                1 928812
## + rcs(alder):rcs(bmi)                                 16 928813
## - factor(Civil)                                        1 928820
## - rcs(bmi)                                             4 928830
## - factor(lipid_modifying_agents)                       1 928843
## - rcs(Raks_AndelArblosInk)                             4 928843
## - factor(systoliskt_high)                              1 928848
## - factor(FodelseLand_EU27_2020)                        1 928853
## - rcs(alder):factor(GFR_high)                          4 928861
## - factor(Sun2000niva_old)                              6 928901
## - rcs(Raks_AndelEkBisInk)                              4 928910
## - factor(antihypertensive_comb)                        1 928920
## - factor(kolesterol_high)                              1 928930
## - rcs(Raks_AndelSjukInk)                               4 928986
## - rcs(DispInkKEHB04)                                   4 929006
## - factor(rokare)                                       1 929268
## - rcs(time_to_cpap_start)                              4 929503
## - factor(hba1c_high)                                   1 929691
## - factor(sex)                                          1 930903
## - factor(ami_history)                                  1 936820
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_ami, ami) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(ami_history) + factor(antithrombotic_agents) + 
##     factor(sex) + factor(hba1c_high) + rcs(time_to_cpap_start) + 
##     factor(GFR_high) + factor(rokare) + rcs(DispInkKEHB04) + 
##     rcs(Raks_AndelSjukInk) + rcs(Raks_AndelEkBisInk) + factor(antihypertensive_comb) + 
##     factor(kolesterol_high) + factor(Sun2000niva_old) + factor(FodelseLand_EU27_2020) + 
##     factor(systoliskt_high) + rcs(Raks_AndelArblosInk) + factor(lipid_modifying_agents) + 
##     rcs(bmi) + factor(Civil) + rcs(alder):factor(GFR_high) + 
##     factor(cpap_treated):factor(GFR_high) + factor(cpap_treated):factor(antithrombotic_agents), 
##     data = df_train)
## 
##   n= 562724, number of events= 37469 
## 
##                                                             coef   exp(coef)
## factor(cpap_treated)1                                  2.362e-01   1.266e+00
## rcs(alder)alder                                        3.224e-01   1.380e+00
## rcs(alder)alder'                                      -1.631e-01   8.495e-01
## rcs(alder)alder''                                      7.572e-01   2.132e+00
## rcs(alder)alder'''                                     8.600e-01   2.363e+00
## factor(ami_history)1                                  -1.683e+01   4.914e-08
## factor(antithrombotic_agents)1                         6.717e-01   1.958e+00
## factor(sex)1                                          -5.299e-01   5.887e-01
## factor(hba1c_high)1                                    3.486e-01   1.417e+00
## rcs(time_to_cpap_start)time_to_cpap_start              2.863e-01   1.331e+00
## rcs(time_to_cpap_start)time_to_cpap_start'            -9.366e-02   9.106e-01
## rcs(time_to_cpap_start)time_to_cpap_start''            2.754e-01   1.317e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''          -1.409e+00   2.445e-01
## factor(GFR_high)1                                     -2.858e-01   7.514e-01
## factor(rokare)1                                        3.088e-01   1.362e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        1.940e-01   1.214e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      -1.848e+01   9.438e-09
## rcs(DispInkKEHB04)DispInkKEHB04''                      4.564e+01   6.604e+19
## rcs(DispInkKEHB04)DispInkKEHB04'''                    -3.071e+01   4.591e-14
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                4.055e+00   5.770e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              -5.870e+03   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              7.149e+03         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            -1.287e+03   0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              1.638e+00   5.147e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            -3.446e+02  2.096e-150
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            3.763e+02  2.563e+163
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          -3.187e+01   1.443e-14
## factor(antihypertensive_comb)1                         1.283e-01   1.137e+00
## factor(kolesterol_high)1                               1.355e-01   1.145e+00
## factor(Sun2000niva_old)2                              -3.662e-02   9.640e-01
## factor(Sun2000niva_old)3                              -3.447e-02   9.661e-01
## factor(Sun2000niva_old)4                              -8.414e-02   9.193e-01
## factor(Sun2000niva_old)5                              -1.135e-01   8.927e-01
## factor(Sun2000niva_old)6                              -1.975e-01   8.208e-01
## factor(Sun2000niva_old)7                              -2.039e-01   8.156e-01
## factor(FodelseLand_EU27_2020)1                        -9.601e-02   9.085e-01
## factor(systoliskt_high)1                               7.891e-02   1.082e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            2.196e+00   8.985e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          -1.436e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          1.670e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        -2.375e+02  7.269e-104
## factor(lipid_modifying_agents)1                        6.838e-02   1.071e+00
## rcs(bmi)bmi                                           -7.605e-02   9.268e-01
## rcs(bmi)bmi'                                           7.760e-01   2.173e+00
## rcs(bmi)bmi''                                         -4.868e+00   7.687e-03
## rcs(bmi)bmi'''                                         6.928e+00   1.021e+03
## factor(Civil)1                                         5.782e-02   1.060e+00
## rcs(alder)alder:factor(GFR_high)1                      3.572e-01   1.429e+00
## rcs(alder)alder':factor(GFR_high)1                    -4.562e-01   6.337e-01
## rcs(alder)alder'':factor(GFR_high)1                    2.561e+00   1.294e+01
## rcs(alder)alder''':factor(GFR_high)1                  -4.754e+00   8.614e-03
## factor(cpap_treated)1:factor(GFR_high)1                3.577e-01   1.430e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1  -1.274e-01   8.804e-01
##                                                         se(coef)       z
## factor(cpap_treated)1                                  1.613e-01   1.464
## rcs(alder)alder                                        2.217e-01   1.454
## rcs(alder)alder'                                       5.697e-01  -0.286
## rcs(alder)alder''                                      2.810e+00   0.269
## rcs(alder)alder'''                                     4.094e+00   0.210
## factor(ami_history)1                                   6.772e+01  -0.249
## factor(antithrombotic_agents)1                         1.175e-02  57.161
## factor(sex)1                                           1.179e-02 -44.944
## factor(hba1c_high)1                                    1.203e-02  28.974
## rcs(time_to_cpap_start)time_to_cpap_start              5.621e-02   5.093
## rcs(time_to_cpap_start)time_to_cpap_start'             1.258e-01  -0.745
## rcs(time_to_cpap_start)time_to_cpap_start''            4.579e-01   0.602
## rcs(time_to_cpap_start)time_to_cpap_start'''           2.031e+00  -0.694
## factor(GFR_high)1                                      2.518e-01  -1.135
## factor(rokare)1                                        1.394e-02  22.152
## rcs(DispInkKEHB04)DispInkKEHB04                        1.670e-01   1.162
## rcs(DispInkKEHB04)DispInkKEHB04'                       3.605e+00  -5.126
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.044e+01   4.373
## rcs(DispInkKEHB04)DispInkKEHB04'''                     9.531e+00  -3.222
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                3.884e-01  10.440
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               6.644e+02  -8.836
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              8.144e+02   8.779
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             1.521e+02  -8.461
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              2.209e-01   7.416
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             5.819e+01  -5.923
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            6.394e+01   5.885
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           5.972e+00  -5.337
## factor(antihypertensive_comb)1                         1.213e-02  10.575
## factor(kolesterol_high)1                               1.208e-02  11.219
## factor(Sun2000niva_old)2                               1.929e-02  -1.898
## factor(Sun2000niva_old)3                               1.365e-02  -2.526
## factor(Sun2000niva_old)4                               1.860e-02  -4.524
## factor(Sun2000niva_old)5                               2.142e-02  -5.297
## factor(Sun2000niva_old)6                               2.195e-02  -8.996
## factor(Sun2000niva_old)7                               7.167e-02  -2.844
## factor(FodelseLand_EU27_2020)1                         1.397e-02  -6.874
## factor(systoliskt_high)1                               1.231e-02   6.409
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            3.221e-01   6.817
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           2.223e+02  -6.461
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          2.592e+02   6.443
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         3.779e+01  -6.284
## factor(lipid_modifying_agents)1                        1.125e-02   6.076
## rcs(bmi)bmi                                            3.379e-02  -2.251
## rcs(bmi)bmi'                                           2.454e-01   3.162
## rcs(bmi)bmi''                                          1.351e+00  -3.603
## rcs(bmi)bmi'''                                         1.871e+00   3.703
## factor(Civil)1                                         1.576e-02   3.669
## rcs(alder)alder:factor(GFR_high)1                      2.252e-01   1.586
## rcs(alder)alder':factor(GFR_high)1                     5.841e-01  -0.781
## rcs(alder)alder'':factor(GFR_high)1                    2.922e+00   0.876
## rcs(alder)alder''':factor(GFR_high)1                   4.351e+00  -1.093
## factor(cpap_treated)1:factor(GFR_high)1                1.593e-01   2.246
## factor(cpap_treated)1:factor(antithrombotic_agents)1   9.008e-02  -1.414
##                                                      Pr(>|z|)    
## factor(cpap_treated)1                                0.143232    
## rcs(alder)alder                                      0.145901    
## rcs(alder)alder'                                     0.774667    
## rcs(alder)alder''                                    0.787593    
## rcs(alder)alder'''                                   0.833625    
## factor(ami_history)1                                 0.803742    
## factor(antithrombotic_agents)1                        < 2e-16 ***
## factor(sex)1                                          < 2e-16 ***
## factor(hba1c_high)1                                   < 2e-16 ***
## rcs(time_to_cpap_start)time_to_cpap_start            3.53e-07 ***
## rcs(time_to_cpap_start)time_to_cpap_start'           0.456562    
## rcs(time_to_cpap_start)time_to_cpap_start''          0.547504    
## rcs(time_to_cpap_start)time_to_cpap_start'''         0.487883    
## factor(GFR_high)1                                    0.256236    
## factor(rokare)1                                       < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04                      0.245127    
## rcs(DispInkKEHB04)DispInkKEHB04'                     2.96e-07 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                    1.23e-05 ***
## rcs(DispInkKEHB04)DispInkKEHB04'''                   0.001272 ** 
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk            1.21e-13 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           3.16e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          3.98e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''         9.46e-08 ***
## factor(antihypertensive_comb)1                        < 2e-16 ***
## factor(kolesterol_high)1                              < 2e-16 ***
## factor(Sun2000niva_old)2                             0.057673 .  
## factor(Sun2000niva_old)3                             0.011549 *  
## factor(Sun2000niva_old)4                             6.06e-06 ***
## factor(Sun2000niva_old)5                             1.17e-07 ***
## factor(Sun2000niva_old)6                              < 2e-16 ***
## factor(Sun2000niva_old)7                             0.004448 ** 
## factor(FodelseLand_EU27_2020)1                       6.23e-12 ***
## factor(systoliskt_high)1                             1.46e-10 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk          9.30e-12 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'         1.04e-10 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''        1.17e-10 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''       3.31e-10 ***
## factor(lipid_modifying_agents)1                      1.23e-09 ***
## rcs(bmi)bmi                                          0.024411 *  
## rcs(bmi)bmi'                                         0.001565 ** 
## rcs(bmi)bmi''                                        0.000314 ***
## rcs(bmi)bmi'''                                       0.000213 ***
## factor(Civil)1                                       0.000243 ***
## rcs(alder)alder:factor(GFR_high)1                    0.112767    
## rcs(alder)alder':factor(GFR_high)1                   0.434791    
## rcs(alder)alder'':factor(GFR_high)1                  0.380812    
## rcs(alder)alder''':factor(GFR_high)1                 0.274571    
## factor(cpap_treated)1:factor(GFR_high)1              0.024735 *  
## factor(cpap_treated)1:factor(antithrombotic_agents)1 0.157374    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                       exp(coef) exp(-coef)
## factor(cpap_treated)1                                 1.266e+00  7.897e-01
## rcs(alder)alder                                       1.380e+00  7.244e-01
## rcs(alder)alder'                                      8.495e-01  1.177e+00
## rcs(alder)alder''                                     2.132e+00  4.690e-01
## rcs(alder)alder'''                                    2.363e+00  4.232e-01
## factor(ami_history)1                                  4.914e-08  2.035e+07
## factor(antithrombotic_agents)1                        1.958e+00  5.108e-01
## factor(sex)1                                          5.887e-01  1.699e+00
## factor(hba1c_high)1                                   1.417e+00  7.057e-01
## rcs(time_to_cpap_start)time_to_cpap_start             1.331e+00  7.511e-01
## rcs(time_to_cpap_start)time_to_cpap_start'            9.106e-01  1.098e+00
## rcs(time_to_cpap_start)time_to_cpap_start''           1.317e+00  7.593e-01
## rcs(time_to_cpap_start)time_to_cpap_start'''          2.445e-01  4.090e+00
## factor(GFR_high)1                                     7.514e-01  1.331e+00
## factor(rokare)1                                       1.362e+00  7.343e-01
## rcs(DispInkKEHB04)DispInkKEHB04                       1.214e+00  8.236e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                      9.438e-09  1.059e+08
## rcs(DispInkKEHB04)DispInkKEHB04''                     6.604e+19  1.514e-20
## rcs(DispInkKEHB04)DispInkKEHB04'''                    4.591e-14  2.178e+13
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               5.770e+01  1.733e-02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                   Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            0.000e+00        Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             5.147e+00  1.943e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           2.096e-150 4.772e+149
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          2.563e+163 3.902e-164
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          1.443e-14  6.930e+13
## factor(antihypertensive_comb)1                        1.137e+00  8.796e-01
## factor(kolesterol_high)1                              1.145e+00  8.732e-01
## factor(Sun2000niva_old)2                              9.640e-01  1.037e+00
## factor(Sun2000niva_old)3                              9.661e-01  1.035e+00
## factor(Sun2000niva_old)4                              9.193e-01  1.088e+00
## factor(Sun2000niva_old)5                              8.927e-01  1.120e+00
## factor(Sun2000niva_old)6                              8.208e-01  1.218e+00
## factor(Sun2000niva_old)7                              8.156e-01  1.226e+00
## factor(FodelseLand_EU27_2020)1                        9.085e-01  1.101e+00
## factor(systoliskt_high)1                              1.082e+00  9.241e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           8.985e+00  1.113e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''               Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''       7.269e-104 1.376e+103
## factor(lipid_modifying_agents)1                       1.071e+00  9.339e-01
## rcs(bmi)bmi                                           9.268e-01  1.079e+00
## rcs(bmi)bmi'                                          2.173e+00  4.602e-01
## rcs(bmi)bmi''                                         7.687e-03  1.301e+02
## rcs(bmi)bmi'''                                        1.021e+03  9.798e-04
## factor(Civil)1                                        1.060e+00  9.438e-01
## rcs(alder)alder:factor(GFR_high)1                     1.429e+00  6.996e-01
## rcs(alder)alder':factor(GFR_high)1                    6.337e-01  1.578e+00
## rcs(alder)alder'':factor(GFR_high)1                   1.294e+01  7.726e-02
## rcs(alder)alder''':factor(GFR_high)1                  8.614e-03  1.161e+02
## factor(cpap_treated)1:factor(GFR_high)1               1.430e+00  6.993e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1  8.804e-01  1.136e+00
##                                                       lower .95  upper .95
## factor(cpap_treated)1                                 9.231e-01  1.737e+00
## rcs(alder)alder                                       8.939e-01  2.131e+00
## rcs(alder)alder'                                      2.781e-01  2.595e+00
## rcs(alder)alder''                                     8.642e-03  5.261e+02
## rcs(alder)alder'''                                    7.736e-04  7.219e+03
## factor(ami_history)1                                  1.120e-65  2.155e+50
## factor(antithrombotic_agents)1                        1.913e+00  2.003e+00
## factor(sex)1                                          5.752e-01  6.024e-01
## factor(hba1c_high)1                                   1.384e+00  1.451e+00
## rcs(time_to_cpap_start)time_to_cpap_start             1.193e+00  1.487e+00
## rcs(time_to_cpap_start)time_to_cpap_start'            7.116e-01  1.165e+00
## rcs(time_to_cpap_start)time_to_cpap_start''           5.369e-01  3.231e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''          4.568e-03  1.308e+01
## factor(GFR_high)1                                     4.587e-01  1.231e+00
## factor(rokare)1                                       1.325e+00  1.399e+00
## rcs(DispInkKEHB04)DispInkKEHB04                       8.753e-01  1.684e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      8.065e-12  1.105e-05
## rcs(DispInkKEHB04)DispInkKEHB04''                     8.642e+10  5.047e+28
## rcs(DispInkKEHB04)DispInkKEHB04'''                    3.538e-22  5.958e-06
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               2.695e+01  1.235e+02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                   Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            0.000e+00  0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             3.338e+00  7.936e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           6.223e-200 7.058e-101
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          9.701e+108 6.771e+217
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          1.192e-19  1.747e-09
## factor(antihypertensive_comb)1                        1.110e+00  1.164e+00
## factor(kolesterol_high)1                              1.118e+00  1.173e+00
## factor(Sun2000niva_old)2                              9.283e-01  1.001e+00
## factor(Sun2000niva_old)3                              9.406e-01  9.923e-01
## factor(Sun2000niva_old)4                              8.864e-01  9.534e-01
## factor(Sun2000niva_old)5                              8.561e-01  9.310e-01
## factor(Sun2000niva_old)6                              7.863e-01  8.569e-01
## factor(Sun2000niva_old)7                              7.087e-01  9.386e-01
## factor(FodelseLand_EU27_2020)1                        8.839e-01  9.337e-01
## factor(systoliskt_high)1                              1.056e+00  1.109e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           4.779e+00  1.689e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''               Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''       4.911e-136  1.076e-71
## factor(lipid_modifying_agents)1                       1.047e+00  1.095e+00
## rcs(bmi)bmi                                           8.674e-01  9.902e-01
## rcs(bmi)bmi'                                          1.343e+00  3.515e+00
## rcs(bmi)bmi''                                         5.443e-04  1.086e-01
## rcs(bmi)bmi'''                                        2.607e+01  3.996e+04
## factor(Civil)1                                        1.027e+00  1.093e+00
## rcs(alder)alder:factor(GFR_high)1                     9.192e-01  2.223e+00
## rcs(alder)alder':factor(GFR_high)1                    2.017e-01  1.991e+00
## rcs(alder)alder'':factor(GFR_high)1                   4.218e-02  3.972e+03
## rcs(alder)alder''':factor(GFR_high)1                  1.703e-06  4.357e+01
## factor(cpap_treated)1:factor(GFR_high)1               1.047e+00  1.954e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1  7.379e-01  1.050e+00
## 
## Concordance= 0.745  (se = 0.001 )
## Likelihood ratio test= 28770  on 53 df,   p=<2e-16
## Wald test            = 22298  on 53 df,   p=<2e-16
## Score (logrank) test = 28520  on 53 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7449234 
## C-index test: 0.7462108

Group 2

run_models(c(list_forms_sleep[["form_ami_tind_spl"]], list_forms_sleep[["form_ami_tind_cat"]]), df_survival_times_sub_train, df_survival_times_sub_test, "time_to_ami", "ami", cont_var, "prof_ami_ind_g2.html", bigd=F)

## [1] "### FORMULA 1 ###"
## Start:  AIC=10377.15
## Surv(time_to_ami, ami) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(antithrombotic_agents)   1 10263
## + rcs(alder)                      4 10285
## + factor(ami_history)             1 10308
## + factor(lipid_modifying_agents)  1 10344
## + factor(sex)                     1 10344
## + factor(antihypertensive_comb)   1 10348
## + rcs(hba1c)                      4 10350
## + rcs(time_to_cpap_start)         4 10359
## + rcs(bmi)                        4 10360
## + factor(Sun2000niva_old)         6 10361
## + rcs(GFR)                        4 10366
## + factor(rokare)                  1 10368
## + rcs(IV_ODI)                     4 10373
## + factor(stroke_history)          1 10374
## + rcs(IV_AHI)                     4 10375
## + rcs(systoliskt)                 4 10375
## + rcs(Raks_AndelSjukInk)          4 10376
## <none>                              10377
## + rcs(DispInkKEHB04)              4 10378
## + factor(FodelseLand_EU27_2020)   1 10379
## + factor(Civil)                   1 10379
## + rcs(kolesterol)                 4 10379
## + rcs(Raks_AndelEkBisInk)         3 10381
## + rcs(IV_AverageSaturation)       4 10382
## + rcs(Raks_AndelArblosInk)        4 10382
## + factor(HushallsType_RTB)               
## 
## Step:  AIC=10263.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(ami_history)                                 1 10141
## + rcs(alder)                                          4 10221
## + rcs(hba1c)                                          4 10237
## + factor(sex)                                         1 10240
## + rcs(time_to_cpap_start)                             4 10248
## + factor(rokare)                                      1 10253
## + rcs(bmi)                                            4 10254
## + factor(antihypertensive_comb)                       1 10255
## + factor(Sun2000niva_old)                             6 10257
## + rcs(systoliskt)                                     4 10259
## + factor(lipid_modifying_agents)                      1 10259
## + rcs(IV_ODI)                                         4 10263
## + rcs(GFR)                                            4 10263
## <none>                                                  10263
## + rcs(Raks_AndelSjukInk)                              4 10264
## + rcs(IV_AHI)                                         4 10265
## + factor(FodelseLand_EU27_2020)                       1 10265
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10265
## + factor(Civil)                                       1 10265
## + factor(stroke_history)                              1 10265
## + rcs(IV_AverageSaturation)                           4 10266
## + rcs(DispInkKEHB04)                                  4 10266
## + rcs(Raks_AndelEkBisInk)                             3 10267
## + rcs(kolesterol)                                     4 10268
## + rcs(Raks_AndelArblosInk)                            4 10269
## - factor(antithrombotic_agents)                       1 10377
## + factor(HushallsType_RTB)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10141.27
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + rcs(alder)                                          4 10100
## + factor(sex)                                         1 10112
## + rcs(hba1c)                                          4 10119
## + rcs(time_to_cpap_start)                             4 10129
## + factor(lipid_modifying_agents)                      1 10130
## + rcs(bmi)                                            4 10131
## + factor(antihypertensive_comb)                       1 10131
## + factor(rokare)                                      1 10132
## + factor(Sun2000niva_old)                             6 10135
## + rcs(systoliskt)                                     4 10139
## + rcs(GFR)                                            4 10140
## + rcs(IV_ODI)                                         4 10141
## <none>                                                  10141
## + rcs(Raks_AndelSjukInk)                              4 10142
## + rcs(IV_AHI)                                         4 10143
## + rcs(IV_AverageSaturation)                           4 10143
## + factor(stroke_history)                              1 10143
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10143
## + factor(FodelseLand_EU27_2020)                       1 10143
## + factor(Civil)                                       1 10143
## + rcs(DispInkKEHB04)                                  4 10144
## + rcs(Raks_AndelEkBisInk)                             3 10146
## + rcs(kolesterol)                                     4 10146
## + rcs(Raks_AndelArblosInk)                            4 10146
## - factor(ami_history)                                 1 10263
## - factor(antithrombotic_agents)                       1 10308
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10099.99
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(sex)                                         1 10068
## + rcs(hba1c)                                          4 10070
## + factor(rokare)                                      1 10084
## + rcs(time_to_cpap_start)                             4 10089
## + factor(lipid_modifying_agents)                      1 10094
## + factor(antihypertensive_comb)                       1 10097
## + rcs(GFR)                                            4 10097
## + rcs(DispInkKEHB04)                                  4 10098
## + rcs(IV_AverageSaturation)                           4 10098
## + rcs(bmi)                                            4 10100
## <none>                                                  10100
## + factor(Sun2000niva_old)                             6 10100
## + factor(Civil)                                       1 10101
## + factor(FodelseLand_EU27_2020)                       1 10101
## + rcs(Raks_AndelEkBisInk)                             3 10102
## + factor(stroke_history)                              1 10102
## + rcs(systoliskt)                                     4 10102
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10102
## + rcs(Raks_AndelSjukInk)                              4 10102
## + rcs(IV_ODI)                                         4 10103
## + rcs(kolesterol)                                     4 10104
## + rcs(IV_AHI)                                         4 10105
## + rcs(Raks_AndelArblosInk)                            4 10106
## - rcs(alder)                                          4 10141
## - factor(antithrombotic_agents)                       1 10204
## - factor(ami_history)                                 1 10221
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10068.08
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + rcs(hba1c)                                          4 10042
## + factor(rokare)                                      1 10051
## + rcs(time_to_cpap_start)                             4 10057
## + rcs(DispInkKEHB04)                                  4 10060
## + factor(lipid_modifying_agents)                      1 10063
## + rcs(GFR)                                            4 10064
## + factor(antihypertensive_comb)                       1 10066
## + rcs(IV_AverageSaturation)                           4 10066
## + factor(Sun2000niva_old)                             6 10067
## <none>                                                  10068
## + factor(FodelseLand_EU27_2020)                       1 10069
## + rcs(Raks_AndelEkBisInk)                             3 10070
## + factor(stroke_history)                              1 10070
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10070
## + factor(Civil)                                       1 10070
## + rcs(Raks_AndelSjukInk)                              4 10070
## + rcs(systoliskt)                                     4 10071
## + rcs(bmi)                                            4 10071
## + rcs(kolesterol)                                     4 10072
## + rcs(IV_ODI)                                         4 10073
## + rcs(Raks_AndelArblosInk)                            4 10074
## + rcs(IV_AHI)                                         4 10074
## - factor(sex)                                         1 10100
## - rcs(alder)                                          4 10112
## - factor(antithrombotic_agents)                       1 10162
## - factor(ami_history)                                 1 10194
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10041.58
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(rokare)                                      1 10026
## + rcs(time_to_cpap_start)                             4 10035
## + rcs(DispInkKEHB04)                                  4 10037
## + factor(lipid_modifying_agents)                      1 10037
## + rcs(IV_AverageSaturation)                           4 10040
## + factor(antihypertensive_comb)                       1 10040
## + rcs(GFR)                                            4 10040
## <none>                                                  10042
## + factor(FodelseLand_EU27_2020)                       1 10042
## + factor(Sun2000niva_old)                             6 10043
## + rcs(Raks_AndelEkBisInk)                             3 10043
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10043
## + factor(stroke_history)                              1 10044
## + factor(Civil)                                       1 10044
## + rcs(Raks_AndelSjukInk)                              4 10044
## + rcs(bmi)                                            4 10045
## + rcs(systoliskt)                                     4 10045
## + rcs(kolesterol)                                     4 10046
## + rcs(IV_ODI)                                         4 10047
## + rcs(Raks_AndelArblosInk)                            4 10047
## + rcs(IV_AHI)                                         4 10048
## - rcs(hba1c)                                          4 10068
## - factor(sex)                                         1 10070
## - rcs(alder)                                          4 10094
## - factor(antithrombotic_agents)                       1 10129
## - factor(ami_history)                                 1 10162
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10026.05
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + rcs(time_to_cpap_start)                             4 10019
## + factor(lipid_modifying_agents)                      1 10022
## + rcs(IV_AverageSaturation)                           4 10023
## + rcs(DispInkKEHB04)                                  4 10024
## + factor(antihypertensive_comb)                       1 10024
## + rcs(GFR)                                            4 10025
## <none>                                                  10026
## + factor(FodelseLand_EU27_2020)                       1 10027
## + factor(stroke_history)                              1 10028
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10028
## + factor(Civil)                                       1 10028
## + rcs(Raks_AndelSjukInk)                              4 10028
## + factor(Sun2000niva_old)                             6 10028
## + rcs(Raks_AndelEkBisInk)                             3 10029
## + rcs(bmi)                                            4 10029
## + rcs(systoliskt)                                     4 10030
## + rcs(kolesterol)                                     4 10030
## + rcs(IV_ODI)                                         4 10031
## + rcs(Raks_AndelArblosInk)                            4 10032
## + rcs(IV_AHI)                                         4 10032
## - factor(rokare)                                      1 10042
## - rcs(hba1c)                                          4 10051
## - factor(sex)                                         1 10056
## - rcs(alder)                                          4 10085
## - factor(antithrombotic_agents)                       1 10111
## - factor(ami_history)                                 1 10146
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10019.21
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     factor(rokare) + rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(lipid_modifying_agents)                      1 10015
## + rcs(IV_AverageSaturation)                           4 10015
## + factor(antihypertensive_comb)                       1 10017
## + rcs(DispInkKEHB04)                                  4 10018
## + rcs(GFR)                                            4 10019
## <none>                                                  10019
## + factor(FodelseLand_EU27_2020)                       1 10021
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10021
## + factor(stroke_history)                              1 10021
## + factor(Civil)                                       1 10021
## + rcs(Raks_AndelSjukInk)                              4 10021
## + rcs(systoliskt)                                     4 10022
## + factor(Sun2000niva_old)                             6 10022
## + rcs(Raks_AndelEkBisInk)                             3 10022
## + rcs(kolesterol)                                     4 10023
## + rcs(bmi)                                            4 10023
## + rcs(IV_ODI)                                         4 10024
## + rcs(Raks_AndelArblosInk)                            4 10025
## + rcs(IV_AHI)                                         4 10026
## - rcs(time_to_cpap_start)                             4 10026
## - factor(rokare)                                      1 10035
## - rcs(hba1c)                                          4 10041
## - factor(sex)                                         1 10049
## - rcs(alder)                                          4 10076
## - factor(antithrombotic_agents)                       1 10102
## - factor(ami_history)                                 1 10136
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10014.98
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     factor(rokare) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + rcs(IV_AverageSaturation)                            4 10010
## + factor(antihypertensive_comb)                        1 10014
## + rcs(DispInkKEHB04)                                   4 10014
## + rcs(GFR)                                             4 10015
## <none>                                                   10015
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10016
## + factor(FodelseLand_EU27_2020)                        1 10016
## + factor(stroke_history)                               1 10017
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10017
## + factor(Civil)                                        1 10017
## + rcs(Raks_AndelSjukInk)                               4 10017
## + rcs(systoliskt)                                      4 10018
## + rcs(Raks_AndelEkBisInk)                              3 10018
## + factor(Sun2000niva_old)                              6 10018
## + rcs(bmi)                                             4 10019
## - factor(lipid_modifying_agents)                       1 10019
## + rcs(kolesterol)                                      4 10020
## + rcs(IV_ODI)                                          4 10020
## + rcs(Raks_AndelArblosInk)                             4 10020
## + rcs(IV_AHI)                                          4 10022
## - rcs(time_to_cpap_start)                              4 10022
## - factor(rokare)                                       1 10030
## - rcs(hba1c)                                           4 10036
## - factor(sex)                                          1 10044
## - rcs(alder)                                           4 10068
## - factor(antithrombotic_agents)                        1 10082
## - factor(ami_history)                                  1 10136
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10010.28
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     factor(rokare) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + factor(antihypertensive_comb)                        1 10008
## + rcs(DispInkKEHB04)                                   4 10010
## + rcs(GFR)                                             4 10010
## <none>                                                   10010
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10011
## + factor(FodelseLand_EU27_2020)                        1 10012
## + factor(stroke_history)                               1 10012
## + rcs(Raks_AndelSjukInk)                               4 10012
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10012
## + factor(Civil)                                        1 10012
## + rcs(systoliskt)                                      4 10013
## + factor(Sun2000niva_old)                              6 10013
## + rcs(bmi)                                             4 10014
## + rcs(IV_ODI)                                          4 10014
## + rcs(Raks_AndelEkBisInk)                              3 10014
## + rcs(kolesterol)                                      4 10014
## - rcs(IV_AverageSaturation)                            4 10015
## + rcs(IV_AHI)                                          4 10015
## - factor(lipid_modifying_agents)                       1 10015
## + rcs(Raks_AndelArblosInk)                             4 10016
## - rcs(time_to_cpap_start)                              4 10017
## - factor(rokare)                                       1 10027
## - rcs(hba1c)                                           4 10032
## - factor(sex)                                          1 10039
## - rcs(alder)                                           4 10067
## - factor(antithrombotic_agents)                        1 10078
## - factor(ami_history)                                  1 10133
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10008.44
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     factor(rokare) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + rcs(DispInkKEHB04)                                   4 10007
## + rcs(GFR)                                             4 10008
## <none>                                                   10008
## + factor(cpap_treated):factor(antihypertensive_comb)   1 10009
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10010
## + factor(FodelseLand_EU27_2020)                        1 10010
## + rcs(Raks_AndelSjukInk)                               4 10010
## - factor(antihypertensive_comb)                        1 10010
## + factor(stroke_history)                               1 10010
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10010
## + factor(Civil)                                        1 10010
## + factor(Sun2000niva_old)                              6 10012
## - factor(lipid_modifying_agents)                       1 10012
## + rcs(IV_ODI)                                          4 10012
## + rcs(Raks_AndelEkBisInk)                              3 10012
## + rcs(bmi)                                             4 10012
## + rcs(systoliskt)                                      4 10012
## + rcs(kolesterol)                                      4 10012
## + rcs(IV_AHI)                                          4 10014
## + rcs(Raks_AndelArblosInk)                             4 10014
## - rcs(IV_AverageSaturation)                            4 10014
## - rcs(time_to_cpap_start)                              4 10015
## - factor(rokare)                                       1 10026
## - rcs(hba1c)                                           4 10030
## - factor(sex)                                          1 10036
## - rcs(alder)                                           4 10060
## - factor(antithrombotic_agents)                        1 10070
## - factor(ami_history)                                  1 10132
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10007.17
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     factor(rokare) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + factor(antihypertensive_comb) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## <none>                                                   10007
## + rcs(GFR)                                             4 10007
## + factor(cpap_treated):factor(antihypertensive_comb)   1 10008
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10008
## + rcs(Raks_AndelSjukInk)                               4 10008
## - rcs(DispInkKEHB04)                                   4 10008
## + factor(stroke_history)                               1 10009
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10009
## + factor(Civil)                                        1 10009
## + factor(FodelseLand_EU27_2020)                        1 10009
## - factor(antihypertensive_comb)                        1 10010
## - factor(lipid_modifying_agents)                       1 10010
## + rcs(IV_ODI)                                          4 10010
## + rcs(systoliskt)                                      4 10011
## + rcs(kolesterol)                                      4 10011
## + rcs(bmi)                                             4 10011
## + rcs(IV_AHI)                                          4 10012
## + rcs(Raks_AndelEkBisInk)                              3 10012
## - rcs(time_to_cpap_start)                              4 10012
## + rcs(Raks_AndelArblosInk)                             4 10013
## - rcs(IV_AverageSaturation)                            4 10013
## + factor(Sun2000niva_old)                              6 10013
## - factor(rokare)                                       1 10023
## - rcs(hba1c)                                           4 10026
## - factor(sex)                                          1 10039
## - rcs(alder)                                           4 10061
## - factor(antithrombotic_agents)                        1 10066
## - factor(ami_history)                                  1 10132
## + factor(HushallsType_RTB)                                    
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_ami, ami) ~ factor(cpap_treated) + 
##     factor(antithrombotic_agents) + factor(ami_history) + rcs(alder) + 
##     factor(sex) + rcs(hba1c) + factor(rokare) + rcs(time_to_cpap_start) + 
##     factor(lipid_modifying_agents) + rcs(IV_AverageSaturation) + 
##     factor(antihypertensive_comb) + rcs(DispInkKEHB04), data = df_train)
## 
##   n= 10603, number of events= 594 
## 
##                                                        coef  exp(coef)
## factor(cpap_treated)1                             1.624e-01  1.176e+00
## factor(antithrombotic_agents)1                    7.138e-01  2.042e+00
## factor(ami_history)1                             -1.796e+01  1.583e-08
## rcs(alder)alder                                   9.771e-01  2.657e+00
## rcs(alder)alder'                                 -1.426e+00  2.403e-01
## rcs(alder)alder''                                 6.270e+00  5.287e+02
## rcs(alder)alder'''                               -9.382e+00  8.426e-05
## factor(sex)1                                     -5.572e-01  5.728e-01
## rcs(hba1c)hba1c                                   7.965e-01  2.218e+00
## rcs(hba1c)hba1c'                                 -9.520e+00  7.338e-05
## rcs(hba1c)hba1c''                                 3.205e+01  8.284e+13
## rcs(hba1c)hba1c'''                               -3.108e+01  3.170e-14
## factor(rokare)1                                   4.536e-01  1.574e+00
## rcs(time_to_cpap_start)time_to_cpap_start         5.849e-01  1.795e+00
## rcs(time_to_cpap_start)time_to_cpap_start'       -1.086e-01  8.971e-01
## rcs(time_to_cpap_start)time_to_cpap_start''      -5.478e+00  4.178e-03
## rcs(time_to_cpap_start)time_to_cpap_start'''      1.372e+01  9.111e+05
## factor(lipid_modifying_agents)1                   2.030e-01  1.225e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation    -1.921e-01  8.252e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'    7.010e-01  2.016e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''  -3.464e+00  3.130e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation'''  7.080e+00  1.187e+03
## factor(antihypertensive_comb)1                    2.021e-01  1.224e+00
## rcs(DispInkKEHB04)DispInkKEHB04                   1.515e-01  1.164e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                 -7.659e+00  4.717e-04
## rcs(DispInkKEHB04)DispInkKEHB04''                 2.083e+01  1.114e+09
## rcs(DispInkKEHB04)DispInkKEHB04'''               -1.505e+01  2.901e-07
##                                                    se(coef)      z Pr(>|z|)    
## factor(cpap_treated)1                             1.156e-01  1.405  0.16010    
## factor(antithrombotic_agents)1                    9.109e-02  7.836 4.65e-15 ***
## factor(ami_history)1                              9.389e+02 -0.019  0.98474    
## rcs(alder)alder                                   3.425e-01  2.853  0.00433 ** 
## rcs(alder)alder'                                  1.071e+00 -1.332  0.18302    
## rcs(alder)alder''                                 5.670e+00  1.106  0.26879    
## rcs(alder)alder'''                                9.120e+00 -1.029  0.30361    
## factor(sex)1                                      9.968e-02 -5.590 2.27e-08 ***
## rcs(hba1c)hba1c                                   6.024e-01  1.322  0.18608    
## rcs(hba1c)hba1c'                                  1.292e+01 -0.737  0.46121    
## rcs(hba1c)hba1c''                                 4.216e+01  0.760  0.44716    
## rcs(hba1c)hba1c'''                                3.865e+01 -0.804  0.42129    
## factor(rokare)1                                   1.039e-01  4.364 1.28e-05 ***
## rcs(time_to_cpap_start)time_to_cpap_start         4.597e-01  1.272  0.20321    
## rcs(time_to_cpap_start)time_to_cpap_start'        2.458e+00 -0.044  0.96476    
## rcs(time_to_cpap_start)time_to_cpap_start''       8.437e+00 -0.649  0.51614    
## rcs(time_to_cpap_start)time_to_cpap_start'''      9.417e+00  1.457  0.14506    
## factor(lipid_modifying_agents)1                   8.935e-02  2.272  0.02308 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation     7.746e-02 -2.480  0.01312 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation'    3.488e-01  2.009  0.04449 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation''   3.512e+00 -0.986  0.32401    
## rcs(IV_AverageSaturation)IV_AverageSaturation'''  1.324e+01  0.535  0.59273    
## factor(antihypertensive_comb)1                    9.800e-02  2.062  0.03922 *  
## rcs(DispInkKEHB04)DispInkKEHB04                   6.308e-01  0.240  0.81020    
## rcs(DispInkKEHB04)DispInkKEHB04'                  8.158e+00 -0.939  0.34781    
## rcs(DispInkKEHB04)DispInkKEHB04''                 2.738e+01  0.761  0.44668    
## rcs(DispInkKEHB04)DispInkKEHB04'''                3.006e+01 -0.501  0.61653    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                  exp(coef) exp(-coef) lower .95
## factor(cpap_treated)1                            1.176e+00  8.501e-01 9.378e-01
## factor(antithrombotic_agents)1                   2.042e+00  4.898e-01 1.708e+00
## factor(ami_history)1                             1.583e-08  6.316e+07 0.000e+00
## rcs(alder)alder                                  2.657e+00  3.764e-01 1.358e+00
## rcs(alder)alder'                                 2.403e-01  4.161e+00 2.947e-02
## rcs(alder)alder''                                5.287e+02  1.891e-03 7.884e-03
## rcs(alder)alder'''                               8.426e-05  1.187e+04 1.456e-12
## factor(sex)1                                     5.728e-01  1.746e+00 4.712e-01
## rcs(hba1c)hba1c                                  2.218e+00  4.509e-01 6.810e-01
## rcs(hba1c)hba1c'                                 7.338e-05  1.363e+04 7.389e-16
## rcs(hba1c)hba1c''                                8.284e+13  1.207e-14 1.077e-22
## rcs(hba1c)hba1c'''                               3.170e-14  3.154e+13 3.995e-47
## factor(rokare)1                                  1.574e+00  6.353e-01 1.284e+00
## rcs(time_to_cpap_start)time_to_cpap_start        1.795e+00  5.571e-01 7.290e-01
## rcs(time_to_cpap_start)time_to_cpap_start'       8.971e-01  1.115e+00 7.259e-03
## rcs(time_to_cpap_start)time_to_cpap_start''      4.178e-03  2.394e+02 2.752e-10
## rcs(time_to_cpap_start)time_to_cpap_start'''     9.111e+05  1.098e-06 8.788e-03
## factor(lipid_modifying_agents)1                  1.225e+00  8.163e-01 1.028e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation    8.252e-01  1.212e+00 7.090e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'   2.016e+00  4.961e-01 1.017e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''  3.130e-02  3.195e+01 3.204e-05
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 1.187e+03  8.422e-04 6.432e-09
## factor(antihypertensive_comb)1                   1.224e+00  8.170e-01 1.010e+00
## rcs(DispInkKEHB04)DispInkKEHB04                  1.164e+00  8.594e-01 3.379e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                 4.717e-04  2.120e+03 5.363e-11
## rcs(DispInkKEHB04)DispInkKEHB04''                1.114e+09  8.977e-10 5.561e-15
## rcs(DispInkKEHB04)DispInkKEHB04'''               2.901e-07  3.447e+06 7.512e-33
##                                                  upper .95
## factor(cpap_treated)1                            1.475e+00
## factor(antithrombotic_agents)1                   2.441e+00
## factor(ami_history)1                                   Inf
## rcs(alder)alder                                  5.198e+00
## rcs(alder)alder'                                 1.960e+00
## rcs(alder)alder''                                3.546e+07
## rcs(alder)alder'''                               4.878e+03
## factor(sex)1                                     6.964e-01
## rcs(hba1c)hba1c                                  7.222e+00
## rcs(hba1c)hba1c'                                 7.289e+06
## rcs(hba1c)hba1c''                                6.371e+49
## rcs(hba1c)hba1c'''                               2.516e+19
## factor(rokare)1                                  1.930e+00
## rcs(time_to_cpap_start)time_to_cpap_start        4.419e+00
## rcs(time_to_cpap_start)time_to_cpap_start'       1.109e+02
## rcs(time_to_cpap_start)time_to_cpap_start''      6.343e+04
## rcs(time_to_cpap_start)time_to_cpap_start'''     9.446e+13
## factor(lipid_modifying_agents)1                  1.460e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation    9.605e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'   3.994e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''  3.057e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 2.192e+14
## factor(antihypertensive_comb)1                   1.483e+00
## rcs(DispInkKEHB04)DispInkKEHB04                  4.006e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                 4.148e+03
## rcs(DispInkKEHB04)DispInkKEHB04''                2.231e+32
## rcs(DispInkKEHB04)DispInkKEHB04'''               1.120e+19
## 
## Concordance= 0.733  (se = 0.01 )
## Likelihood ratio test= 422  on 27 df,   p=<2e-16
## Wald test            = 327.4  on 27 df,   p=<2e-16
## Score (logrank) test = 406.3  on 27 df,   p=<2e-16

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7327787 
## C-index test: 0.7262936[1] "### FORMULA 2 ###"
## Start:  AIC=10377.15
## Surv(time_to_ami, ami) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(antithrombotic_agents)   1 10263
## + rcs(alder)                      4 10285
## + factor(ami_history)             1 10308
## + factor(lipid_modifying_agents)  1 10344
## + factor(sex)                     1 10344
## + factor(antihypertensive_comb)   1 10348
## + factor(hba1c_high)              1 10358
## + rcs(time_to_cpap_start)         4 10359
## + rcs(bmi)                        4 10360
## + factor(Sun2000niva_old)         6 10361
## + factor(rokare)                  1 10368
## + factor(GFR_high)                1 10369
## + factor(systoliskt_high)         1 10372
## + rcs(IV_ODI)                     4 10373
## + factor(stroke_history)          1 10374
## + rcs(IV_AHI)                     4 10375
## + rcs(Raks_AndelSjukInk)          4 10376
## + factor(kolesterol_high)         1 10377
## <none>                              10377
## + rcs(DispInkKEHB04)              4 10378
## + factor(FodelseLand_EU27_2020)   1 10379
## + factor(Civil)                   1 10379
## + rcs(Raks_AndelEkBisInk)         3 10381
## + rcs(IV_AverageSaturation)       4 10382
## + rcs(Raks_AndelArblosInk)        4 10382
## + factor(HushallsType_RTB)               
## 
## Step:  AIC=10263.4
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(ami_history)                                 1 10141
## + rcs(alder)                                          4 10221
## + factor(sex)                                         1 10240
## + factor(hba1c_high)                                  1 10246
## + rcs(time_to_cpap_start)                             4 10248
## + factor(rokare)                                      1 10253
## + rcs(bmi)                                            4 10254
## + factor(antihypertensive_comb)                       1 10255
## + factor(systoliskt_high)                             1 10256
## + factor(Sun2000niva_old)                             6 10257
## + factor(lipid_modifying_agents)                      1 10259
## + factor(GFR_high)                                    1 10262
## + rcs(IV_ODI)                                         4 10263
## <none>                                                  10263
## + rcs(Raks_AndelSjukInk)                              4 10264
## + rcs(IV_AHI)                                         4 10265
## + factor(kolesterol_high)                             1 10265
## + factor(FodelseLand_EU27_2020)                       1 10265
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10265
## + factor(Civil)                                       1 10265
## + factor(stroke_history)                              1 10265
## + rcs(IV_AverageSaturation)                           4 10266
## + rcs(DispInkKEHB04)                                  4 10266
## + rcs(Raks_AndelEkBisInk)                             3 10267
## + rcs(Raks_AndelArblosInk)                            4 10269
## - factor(antithrombotic_agents)                       1 10377
## + factor(HushallsType_RTB)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10141.27
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.
## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + rcs(alder)                                          4 10100
## + factor(sex)                                         1 10112
## + factor(hba1c_high)                                  1 10126
## + rcs(time_to_cpap_start)                             4 10129
## + factor(lipid_modifying_agents)                      1 10130
## + rcs(bmi)                                            4 10131
## + factor(antihypertensive_comb)                       1 10131
## + factor(rokare)                                      1 10132
## + factor(Sun2000niva_old)                             6 10135
## + factor(systoliskt_high)                             1 10136
## + factor(GFR_high)                                    1 10140
## + rcs(IV_ODI)                                         4 10141
## <none>                                                  10141
## + rcs(Raks_AndelSjukInk)                              4 10142
## + rcs(IV_AHI)                                         4 10143
## + rcs(IV_AverageSaturation)                           4 10143
## + factor(stroke_history)                              1 10143
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10143
## + factor(kolesterol_high)                             1 10143
## + factor(FodelseLand_EU27_2020)                       1 10143
## + factor(Civil)                                       1 10143
## + rcs(DispInkKEHB04)                                  4 10144
## + rcs(Raks_AndelEkBisInk)                             3 10146
## + rcs(Raks_AndelArblosInk)                            4 10146
## - factor(ami_history)                                 1 10263
## - factor(antithrombotic_agents)                       1 10308
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10099.99
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(sex)                                         1 10068
## + factor(hba1c_high)                                  1 10081
## + factor(rokare)                                      1 10084
## + rcs(time_to_cpap_start)                             4 10089
## + factor(lipid_modifying_agents)                      1 10094
## + factor(antihypertensive_comb)                       1 10097
## + factor(systoliskt_high)                             1 10097
## + rcs(DispInkKEHB04)                                  4 10098
## + rcs(IV_AverageSaturation)                           4 10098
## + rcs(bmi)                                            4 10100
## <none>                                                  10100
## + factor(Sun2000niva_old)                             6 10100
## + factor(Civil)                                       1 10101
## + factor(GFR_high)                                    1 10101
## + factor(FodelseLand_EU27_2020)                       1 10101
## + rcs(Raks_AndelEkBisInk)                             3 10102
## + factor(stroke_history)                              1 10102
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10102
## + factor(kolesterol_high)                             1 10102
## + rcs(Raks_AndelSjukInk)                              4 10102
## + rcs(IV_ODI)                                         4 10103
## + rcs(IV_AHI)                                         4 10105
## + rcs(Raks_AndelArblosInk)                            4 10106
## - rcs(alder)                                          4 10141
## - factor(antithrombotic_agents)                       1 10204
## - factor(ami_history)                                 1 10221
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10068.08
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(rokare)                                      1 10051
## + factor(hba1c_high)                                  1 10051
## + rcs(time_to_cpap_start)                             4 10057
## + rcs(DispInkKEHB04)                                  4 10060
## + factor(lipid_modifying_agents)                      1 10063
## + factor(systoliskt_high)                             1 10066
## + factor(antihypertensive_comb)                       1 10066
## + rcs(IV_AverageSaturation)                           4 10066
## + factor(Sun2000niva_old)                             6 10067
## <none>                                                  10068
## + factor(GFR_high)                                    1 10068
## + factor(FodelseLand_EU27_2020)                       1 10069
## + rcs(Raks_AndelEkBisInk)                             3 10070
## + factor(stroke_history)                              1 10070
## + factor(kolesterol_high)                             1 10070
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10070
## + factor(Civil)                                       1 10070
## + rcs(Raks_AndelSjukInk)                              4 10070
## + rcs(bmi)                                            4 10071
## + rcs(IV_ODI)                                         4 10073
## + rcs(Raks_AndelArblosInk)                            4 10074
## + rcs(IV_AHI)                                         4 10074
## - factor(sex)                                         1 10100
## - rcs(alder)                                          4 10112
## - factor(antithrombotic_agents)                       1 10162
## - factor(ami_history)                                 1 10194
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10051.07
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(hba1c_high)                                  1 10035
## + rcs(time_to_cpap_start)                             4 10041
## + rcs(DispInkKEHB04)                                  4 10046
## + factor(lipid_modifying_agents)                      1 10046
## + rcs(IV_AverageSaturation)                           4 10048
## + factor(antihypertensive_comb)                       1 10049
## + factor(systoliskt_high)                             1 10049
## + factor(GFR_high)                                    1 10051
## <none>                                                  10051
## + factor(Sun2000niva_old)                             6 10051
## + factor(FodelseLand_EU27_2020)                       1 10052
## + factor(stroke_history)                              1 10053
## + factor(kolesterol_high)                             1 10053
## + factor(Civil)                                       1 10053
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10053
## + rcs(Raks_AndelSjukInk)                              4 10054
## + rcs(bmi)                                            4 10054
## + rcs(Raks_AndelEkBisInk)                             3 10054
## + rcs(IV_ODI)                                         4 10056
## + rcs(Raks_AndelArblosInk)                            4 10056
## + rcs(IV_AHI)                                         4 10057
## - factor(rokare)                                      1 10068
## - factor(sex)                                         1 10084
## - rcs(alder)                                          4 10102
## - factor(antithrombotic_agents)                       1 10141
## - factor(ami_history)                                 1 10177
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10035.21
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + rcs(time_to_cpap_start)                             4 10027
## + factor(lipid_modifying_agents)                      1 10031
## + rcs(DispInkKEHB04)                                  4 10031
## + rcs(IV_AverageSaturation)                           4 10032
## + factor(antihypertensive_comb)                       1 10033
## + factor(systoliskt_high)                             1 10034
## + factor(GFR_high)                                    1 10035
## <none>                                                  10035
## + factor(FodelseLand_EU27_2020)                       1 10037
## + factor(Sun2000niva_old)                             6 10037
## + factor(stroke_history)                              1 10037
## + factor(kolesterol_high)                             1 10037
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10037
## + factor(Civil)                                       1 10037
## + rcs(Raks_AndelSjukInk)                              4 10037
## + rcs(Raks_AndelEkBisInk)                             3 10038
## + rcs(bmi)                                            4 10039
## + rcs(IV_ODI)                                         4 10040
## + rcs(Raks_AndelArblosInk)                            4 10041
## + rcs(IV_AHI)                                         4 10042
## - factor(hba1c_high)                                  1 10051
## - factor(rokare)                                      1 10051
## - factor(sex)                                         1 10066
## - rcs(alder)                                          4 10090
## - factor(antithrombotic_agents)                       1 10122
## - factor(ami_history)                                 1 10158
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10027.09
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                      Df   AIC
## + factor(lipid_modifying_agents)                      1 10023
## + rcs(IV_AverageSaturation)                           4 10024
## + factor(antihypertensive_comb)                       1 10025
## + factor(systoliskt_high)                             1 10025
## + rcs(DispInkKEHB04)                                  4 10025
## + factor(GFR_high)                                    1 10027
## <none>                                                  10027
## + factor(FodelseLand_EU27_2020)                       1 10029
## + factor(kolesterol_high)                             1 10029
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10029
## + factor(stroke_history)                              1 10029
## + factor(Civil)                                       1 10029
## + rcs(Raks_AndelSjukInk)                              4 10029
## + factor(Sun2000niva_old)                             6 10029
## + rcs(Raks_AndelEkBisInk)                             3 10030
## + rcs(bmi)                                            4 10031
## + rcs(IV_ODI)                                         4 10032
## + rcs(Raks_AndelArblosInk)                            4 10032
## + rcs(IV_AHI)                                         4 10034
## - rcs(time_to_cpap_start)                             4 10035
## - factor(hba1c_high)                                  1 10041
## - factor(rokare)                                      1 10043
## - factor(sex)                                         1 10058
## - rcs(alder)                                          4 10080
## - factor(antithrombotic_agents)                       1 10112
## - factor(ami_history)                                 1 10147
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10023.21
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + rcs(IV_AverageSaturation)                            4 10019
## + factor(systoliskt_high)                              1 10021
## + rcs(DispInkKEHB04)                                   4 10022
## + factor(antihypertensive_comb)                        1 10022
## <none>                                                   10023
## + factor(GFR_high)                                     1 10023
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10024
## + factor(FodelseLand_EU27_2020)                        1 10025
## + factor(kolesterol_high)                              1 10025
## + factor(stroke_history)                               1 10025
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10025
## + factor(Civil)                                        1 10025
## + rcs(Raks_AndelSjukInk)                               4 10025
## + factor(Sun2000niva_old)                              6 10026
## + rcs(Raks_AndelEkBisInk)                              3 10027
## - factor(lipid_modifying_agents)                       1 10027
## + rcs(bmi)                                             4 10027
## + rcs(IV_ODI)                                          4 10028
## + rcs(Raks_AndelArblosInk)                             4 10029
## + rcs(IV_AHI)                                          4 10030
## - rcs(time_to_cpap_start)                              4 10031
## - factor(hba1c_high)                                   1 10036
## - factor(rokare)                                       1 10039
## - factor(sex)                                          1 10054
## - rcs(alder)                                           4 10072
## - factor(antithrombotic_agents)                        1 10092
## - factor(ami_history)                                  1 10147
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10018.88
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + factor(systoliskt_high)                              1 10017
## + factor(antihypertensive_comb)                        1 10017
## + rcs(DispInkKEHB04)                                   4 10017
## <none>                                                   10019
## + factor(GFR_high)                                     1 10019
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10020
## + factor(kolesterol_high)                              1 10020
## + factor(FodelseLand_EU27_2020)                        1 10021
## + factor(stroke_history)                               1 10021
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10021
## + rcs(Raks_AndelSjukInk)                               4 10021
## + factor(Civil)                                        1 10021
## + factor(Sun2000niva_old)                              6 10021
## + rcs(IV_ODI)                                          4 10022
## + rcs(bmi)                                             4 10022
## + rcs(Raks_AndelEkBisInk)                              3 10023
## - rcs(IV_AverageSaturation)                            4 10023
## + rcs(IV_AHI)                                          4 10023
## - factor(lipid_modifying_agents)                       1 10024
## + rcs(Raks_AndelArblosInk)                             4 10024
## - rcs(time_to_cpap_start)                              4 10027
## - factor(hba1c_high)                                   1 10032
## - factor(rokare)                                       1 10036
## - factor(sex)                                          1 10049
## - rcs(alder)                                           4 10071
## - factor(antithrombotic_agents)                        1 10088
## - factor(ami_history)                                  1 10144
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10016.91
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + factor(systoliskt_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + rcs(DispInkKEHB04)                                   4 10015
## + factor(antihypertensive_comb)                        1 10016
## + factor(GFR_high)                                     1 10017
## <none>                                                   10017
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10018
## + factor(kolesterol_high)                              1 10019
## + factor(FodelseLand_EU27_2020)                        1 10019
## + factor(stroke_history)                               1 10019
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10019
## - factor(systoliskt_high)                              1 10019
## + factor(Civil)                                        1 10019
## + rcs(Raks_AndelSjukInk)                               4 10019
## + factor(Sun2000niva_old)                              6 10019
## + rcs(IV_ODI)                                          4 10020
## + rcs(bmi)                                             4 10020
## + rcs(Raks_AndelEkBisInk)                              3 10021
## - rcs(IV_AverageSaturation)                            4 10021
## + rcs(IV_AHI)                                          4 10021
## - factor(lipid_modifying_agents)                       1 10022
## + rcs(Raks_AndelArblosInk)                             4 10022
## - rcs(time_to_cpap_start)                              4 10025
## - factor(hba1c_high)                                   1 10029
## - factor(rokare)                                       1 10034
## - factor(sex)                                          1 10046
## - rcs(alder)                                           4 10066
## - factor(antithrombotic_agents)                        1 10088
## - factor(ami_history)                                  1 10141
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10014.83
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + factor(systoliskt_high) + rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## + factor(antihypertensive_comb)                        1 10013
## <none>                                                   10015
## + factor(GFR_high)                                     1 10015
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10016
## + factor(kolesterol_high)                              1 10016
## + rcs(Raks_AndelSjukInk)                               4 10016
## + factor(stroke_history)                               1 10017
## + factor(FodelseLand_EU27_2020)                        1 10017
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10017
## + factor(Civil)                                        1 10017
## - rcs(DispInkKEHB04)                                   4 10017
## - factor(systoliskt_high)                              1 10017
## + rcs(IV_ODI)                                          4 10017
## + rcs(bmi)                                             4 10018
## - rcs(IV_AverageSaturation)                            4 10019
## + rcs(IV_AHI)                                          4 10019
## - factor(lipid_modifying_agents)                       1 10019
## + factor(Sun2000niva_old)                              6 10020
## + rcs(Raks_AndelEkBisInk)                              3 10020
## + rcs(Raks_AndelArblosInk)                             4 10020
## - rcs(time_to_cpap_start)                              4 10022
## - factor(hba1c_high)                                   1 10026
## - factor(rokare)                                       1 10030
## - factor(sex)                                          1 10048
## - rcs(alder)                                           4 10067
## - factor(antithrombotic_agents)                        1 10083
## - factor(ami_history)                                  1 10141
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## 
## Step:  AIC=10013.33
## Surv(time_to_ami, ami) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + factor(rokare) + 
##     factor(hba1c_high) + rcs(time_to_cpap_start) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + factor(systoliskt_high) + rcs(DispInkKEHB04) + 
##     factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; coefficient may be infinite.

##                                                       Df   AIC
## <none>                                                   10013
## + factor(cpap_treated):factor(antihypertensive_comb)   1 10014
## + factor(GFR_high)                                     1 10014
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10014
## + factor(kolesterol_high)                              1 10015
## + rcs(Raks_AndelSjukInk)                               4 10015
## - factor(antihypertensive_comb)                        1 10015
## - factor(systoliskt_high)                              1 10015
## + factor(stroke_history)                               1 10015
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10015
## + factor(FodelseLand_EU27_2020)                        1 10015
## + factor(Civil)                                        1 10015
## - rcs(DispInkKEHB04)                                   4 10016
## + rcs(IV_ODI)                                          4 10016
## - factor(lipid_modifying_agents)                       1 10016
## + rcs(bmi)                                             4 10017
## + rcs(IV_AHI)                                          4 10018
## - rcs(IV_AverageSaturation)                            4 10018
## + rcs(Raks_AndelEkBisInk)                              3 10019
## + factor(Sun2000niva_old)                              6 10019
## + rcs(Raks_AndelArblosInk)                             4 10019
## - rcs(time_to_cpap_start)                              4 10020
## - factor(hba1c_high)                                   1 10024
## - factor(rokare)                                       1 10029
## - factor(sex)                                          1 10046
## - rcs(alder)                                           4 10061
## - factor(antithrombotic_agents)                        1 10076
## - factor(ami_history)                                  1 10140
## + factor(HushallsType_RTB)                                    
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_ami, ami) ~ factor(cpap_treated) + 
##     factor(antithrombotic_agents) + factor(ami_history) + rcs(alder) + 
##     factor(sex) + factor(rokare) + factor(hba1c_high) + rcs(time_to_cpap_start) + 
##     factor(lipid_modifying_agents) + rcs(IV_AverageSaturation) + 
##     factor(systoliskt_high) + rcs(DispInkKEHB04) + factor(antihypertensive_comb), 
##     data = df_train)
## 
##   n= 10603, number of events= 594 
## 
##                                                        coef  exp(coef)
## factor(cpap_treated)1                             1.667e-01  1.181e+00
## factor(antithrombotic_agents)1                    7.345e-01  2.084e+00
## factor(ami_history)1                             -1.797e+01  1.576e-08
## rcs(alder)alder                                   9.513e-01  2.589e+00
## rcs(alder)alder'                                 -1.429e+00  2.397e-01
## rcs(alder)alder''                                 6.230e+00  5.075e+02
## rcs(alder)alder'''                               -9.179e+00  1.031e-04
## factor(sex)1                                     -5.645e-01  5.687e-01
## factor(rokare)1                                   4.611e-01  1.586e+00
## factor(hba1c_high)1                               3.335e-01  1.396e+00
## rcs(time_to_cpap_start)time_to_cpap_start         5.756e-01  1.778e+00
## rcs(time_to_cpap_start)time_to_cpap_start'        1.242e-01  1.132e+00
## rcs(time_to_cpap_start)time_to_cpap_start''      -6.523e+00  1.469e-03
## rcs(time_to_cpap_start)time_to_cpap_start'''      1.512e+01  3.682e+06
## factor(lipid_modifying_agents)1                   2.015e-01  1.223e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation    -1.952e-01  8.226e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'    7.265e-01  2.068e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''  -3.908e+00  2.007e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation'''  9.014e+00  8.217e+03
## factor(systoliskt_high)1                          1.783e-01  1.195e+00
## rcs(DispInkKEHB04)DispInkKEHB04                   1.124e-01  1.119e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                 -7.943e+00  3.550e-04
## rcs(DispInkKEHB04)DispInkKEHB04''                 2.194e+01  3.389e+09
## rcs(DispInkKEHB04)DispInkKEHB04'''               -1.626e+01  8.661e-08
## factor(antihypertensive_comb)1                    1.815e-01  1.199e+00
##                                                    se(coef)      z Pr(>|z|)    
## factor(cpap_treated)1                             1.151e-01  1.448 0.147483    
## factor(antithrombotic_agents)1                    9.121e-02  8.054 8.04e-16 ***
## factor(ami_history)1                              9.369e+02 -0.019 0.984701    
## rcs(alder)alder                                   3.408e-01  2.792 0.005240 ** 
## rcs(alder)alder'                                  1.067e+00 -1.338 0.180826    
## rcs(alder)alder''                                 5.660e+00  1.101 0.271085    
## rcs(alder)alder'''                                9.109e+00 -1.008 0.313578    
## factor(sex)1                                      9.957e-02 -5.669 1.44e-08 ***
## factor(rokare)1                                   1.038e-01  4.440 9.01e-06 ***
## factor(hba1c_high)1                               9.433e-02  3.536 0.000407 ***
## rcs(time_to_cpap_start)time_to_cpap_start         4.585e-01  1.255 0.209390    
## rcs(time_to_cpap_start)time_to_cpap_start'        2.454e+00  0.051 0.959627    
## rcs(time_to_cpap_start)time_to_cpap_start''       8.428e+00 -0.774 0.438953    
## rcs(time_to_cpap_start)time_to_cpap_start'''      9.414e+00  1.606 0.108264    
## factor(lipid_modifying_agents)1                   8.945e-02  2.252 0.024297 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation     7.787e-02 -2.507 0.012170 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation'    3.499e-01  2.076 0.037858 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation''   3.518e+00 -1.111 0.266605    
## rcs(IV_AverageSaturation)IV_AverageSaturation'''  1.326e+01  0.680 0.496645    
## factor(systoliskt_high)1                          9.620e-02  1.853 0.063878 .  
## rcs(DispInkKEHB04)DispInkKEHB04                   6.221e-01  0.181 0.856589    
## rcs(DispInkKEHB04)DispInkKEHB04'                  8.089e+00 -0.982 0.326092    
## rcs(DispInkKEHB04)DispInkKEHB04''                 2.720e+01  0.807 0.419757    
## rcs(DispInkKEHB04)DispInkKEHB04'''                2.992e+01 -0.544 0.586774    
## factor(antihypertensive_comb)1                    9.819e-02  1.848 0.064544 .  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                  exp(coef) exp(-coef) lower .95
## factor(cpap_treated)1                            1.181e+00  8.465e-01 9.428e-01
## factor(antithrombotic_agents)1                   2.084e+00  4.797e-01 1.743e+00
## factor(ami_history)1                             1.576e-08  6.347e+07 0.000e+00
## rcs(alder)alder                                  2.589e+00  3.862e-01 1.328e+00
## rcs(alder)alder'                                 2.397e-01  4.173e+00 2.958e-02
## rcs(alder)alder''                                5.075e+02  1.970e-03 7.716e-03
## rcs(alder)alder'''                               1.031e-04  9.695e+03 1.820e-12
## factor(sex)1                                     5.687e-01  1.758e+00 4.679e-01
## factor(rokare)1                                  1.586e+00  6.306e-01 1.294e+00
## factor(hba1c_high)1                              1.396e+00  7.164e-01 1.160e+00
## rcs(time_to_cpap_start)time_to_cpap_start        1.778e+00  5.624e-01 7.239e-01
## rcs(time_to_cpap_start)time_to_cpap_start'       1.132e+00  8.832e-01 9.231e-03
## rcs(time_to_cpap_start)time_to_cpap_start''      1.469e-03  6.808e+02 9.835e-11
## rcs(time_to_cpap_start)time_to_cpap_start'''     3.682e+06  2.716e-07 3.573e-02
## factor(lipid_modifying_agents)1                  1.223e+00  8.175e-01 1.027e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation    8.226e-01  1.216e+00 7.062e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'   2.068e+00  4.836e-01 1.042e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''  2.007e-02  4.982e+01 2.032e-05
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 8.217e+03  1.217e-04 4.243e-08
## factor(systoliskt_high)1                         1.195e+00  8.367e-01 9.898e-01
## rcs(DispInkKEHB04)DispInkKEHB04                  1.119e+00  8.937e-01 3.306e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                 3.550e-04  2.817e+03 4.624e-11
## rcs(DispInkKEHB04)DispInkKEHB04''                3.389e+09  2.950e-10 2.398e-14
## rcs(DispInkKEHB04)DispInkKEHB04'''               8.661e-08  1.155e+07 2.950e-33
## factor(antihypertensive_comb)1                   1.199e+00  8.340e-01 9.891e-01
##                                                  upper .95
## factor(cpap_treated)1                            1.480e+00
## factor(antithrombotic_agents)1                   2.492e+00
## factor(ami_history)1                                   Inf
## rcs(alder)alder                                  5.049e+00
## rcs(alder)alder'                                 1.942e+00
## rcs(alder)alder''                                3.338e+07
## rcs(alder)alder'''                               5.847e+03
## factor(sex)1                                     6.912e-01
## factor(rokare)1                                  1.944e+00
## factor(hba1c_high)1                              1.679e+00
## rcs(time_to_cpap_start)time_to_cpap_start        4.368e+00
## rcs(time_to_cpap_start)time_to_cpap_start'       1.389e+02
## rcs(time_to_cpap_start)time_to_cpap_start''      2.194e+04
## rcs(time_to_cpap_start)time_to_cpap_start'''     3.795e+14
## factor(lipid_modifying_agents)1                  1.458e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation    9.583e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'   4.105e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''  1.983e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 1.591e+15
## factor(systoliskt_high)1                         1.443e+00
## rcs(DispInkKEHB04)DispInkKEHB04                  3.788e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                 2.726e+03
## rcs(DispInkKEHB04)DispInkKEHB04''                4.791e+32
## rcs(DispInkKEHB04)DispInkKEHB04'''               2.543e+18
## factor(antihypertensive_comb)1                   1.453e+00
## 
## Concordance= 0.732  (se = 0.01 )
## Likelihood ratio test= 411.8  on 25 df,   p=<2e-16
## Wald test            = 317.9  on 25 df,   p=<2e-16
## Score (logrank) test = 395.8  on 25 df,   p=<2e-16

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7320863 
## C-index test: 0.7288487

Stroke

Time-independent

Group 1

run_models(c(list_forms[["form_stroke_tind_spl"]], list_forms[["form_stroke_tind_cat"]]), df_survival_times_train, df_survival_times_test, "time_to_stroke", "stroke", cont_var, "prof_stroke_ind_g1.html")

## [1] "### FORMULA 1 ###"
## Start:  AIC=920014.9
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 902501
## + factor(antithrombotic_agents)   1 913464
## + rcs(GFR)                        4 915245
## + rcs(DispInkKEHB04)              4 917107
## + factor(stroke_history)          1 917278
## + factor(Civil)                   1 917705
## + factor(Sun2000niva_old)         6 917719
## + rcs(time_to_cpap_start)         4 917786
## + rcs(bmi)                        4 918174
## + factor(antihypertensive_comb)   1 918591
## + rcs(systoliskt)                 4 918911
## + rcs(hba1c)                      4 919088
## + factor(FodelseLand_EU27_2020)   1 919427
## + factor(ami_history)             1 919451
## + rcs(Raks_AndelSjukInk)          4 919481
## + rcs(Raks_AndelArblosInk)        4 919646
## + factor(lipid_modifying_agents)  1 919678
## + rcs(kolesterol)                 4 919732
## + rcs(Raks_AndelEkBisInk)         4 919770
## + factor(sex)                     1 919985
## <none>                              920015
## + factor(rokare)                  1 920016
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=902501
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(stroke_history)          1 898540
## + factor(antithrombotic_agents)   1 900743
## + rcs(hba1c)                      4 901029
## + rcs(time_to_cpap_start)         4 901415
## + factor(rokare)                  1 902038
## + factor(sex)                     1 902039
## + rcs(DispInkKEHB04)              4 902048
## + rcs(GFR)                        4 902078
## + rcs(systoliskt)                 4 902158
## + rcs(Raks_AndelSjukInk)          4 902308
## + factor(antihypertensive_comb)   1 902348
## + rcs(Raks_AndelEkBisInk)         4 902348
## + factor(ami_history)             1 902371
## + rcs(Raks_AndelArblosInk)        4 902414
## + factor(Sun2000niva_old)         6 902424
## + rcs(kolesterol)                 4 902441
## + factor(lipid_modifying_agents)  1 902455
## + rcs(bmi)                        4 902471
## <none>                              902501
## + factor(FodelseLand_EU27_2020)   1 902502
## + factor(Civil)                   1 902502
## - rcs(alder)                      4 920015
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=898539.8
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 895992
## + rcs(hba1c)                      4 897050
## + rcs(time_to_cpap_start)         4 897478
## + factor(sex)                     1 898003
## + factor(rokare)                  1 898055
## + rcs(GFR)                        4 898061
## + rcs(DispInkKEHB04)              4 898076
## + rcs(systoliskt)                 4 898227
## + rcs(Raks_AndelSjukInk)          4 898326
## + factor(antihypertensive_comb)   1 898342
## + factor(ami_history)             1 898385
## + rcs(Raks_AndelEkBisInk)         4 898388
## + factor(lipid_modifying_agents)  1 898412
## + rcs(kolesterol)                 4 898446
## + rcs(Raks_AndelArblosInk)        4 898453
## + factor(Sun2000niva_old)         6 898457
## + rcs(bmi)                        4 898503
## + factor(Civil)                   1 898539
## <none>                              898540
## + factor(FodelseLand_EU27_2020)   1 898541
## - factor(stroke_history)          1 902501
## - rcs(alder)                      4 917278
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=895992
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(hba1c)                                          4 894623
## + rcs(time_to_cpap_start)                             4 895183
## + factor(rokare)                                      1 895524
## + rcs(DispInkKEHB04)                                  4 895572
## + rcs(systoliskt)                                     4 895590
## + rcs(GFR)                                            4 895630
## + factor(sex)                                         1 895674
## + rcs(Raks_AndelSjukInk)                              4 895803
## + rcs(Raks_AndelEkBisInk)                             4 895838
## + rcs(Raks_AndelArblosInk)                            4 895900
## + rcs(kolesterol)                                     4 895903
## + factor(Sun2000niva_old)                             6 895934
## + rcs(bmi)                                            4 895945
## + factor(antihypertensive_comb)                       1 895968
## + factor(lipid_modifying_agents)                      1 895983
## + factor(cpap_treated):factor(antithrombotic_agents)  1 895992
## <none>                                                  895992
## + factor(FodelseLand_EU27_2020)                       1 895993
## + factor(Civil)                                       1 895994
## + factor(ami_history)                                 1 895994
## - factor(antithrombotic_agents)                       1 898540
## - factor(stroke_history)                              1 900743
## - rcs(alder)                                          4 909264
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=894622.9
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(time_to_cpap_start)                             4 893969
## + factor(rokare)                                      1 894169
## + rcs(systoliskt)                                     4 894291
## + rcs(DispInkKEHB04)                                  4 894311
## + factor(sex)                                         1 894338
## + rcs(GFR)                                            4 894351
## + rcs(Raks_AndelSjukInk)                              4 894429
## + rcs(Raks_AndelEkBisInk)                             4 894495
## + rcs(Raks_AndelArblosInk)                            4 894531
## + rcs(bmi)                                            4 894551
## + rcs(kolesterol)                                     4 894566
## + factor(antihypertensive_comb)                       1 894590
## + factor(Sun2000niva_old)                             6 894591
## + factor(lipid_modifying_agents)                      1 894615
## + factor(cpap_treated):factor(antithrombotic_agents)  1 894623
## <none>                                                  894623
## + factor(Civil)                                       1 894623
## + factor(ami_history)                                 1 894625
## + factor(FodelseLand_EU27_2020)                       1 894625
## - rcs(hba1c)                                          4 895992
## - factor(antithrombotic_agents)                       1 897050
## - factor(stroke_history)                              1 899366
## - rcs(alder)                                          4 908527
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893968.5
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 893527
## + rcs(systoliskt)                                     4 893641
## + factor(sex)                                         1 893660
## + rcs(GFR)                                            4 893724
## + rcs(Raks_AndelSjukInk)                              4 893756
## + rcs(DispInkKEHB04)                                  4 893790
## + rcs(Raks_AndelEkBisInk)                             4 893835
## + rcs(Raks_AndelArblosInk)                            4 893879
## + rcs(kolesterol)                                     4 893903
## + rcs(bmi)                                            4 893907
## + factor(antihypertensive_comb)                       1 893939
## + factor(Sun2000niva_old)                             6 893949
## + factor(lipid_modifying_agents)                      1 893958
## + factor(Civil)                                       1 893966
## + factor(ami_history)                                 1 893968
## <none>                                                  893969
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893969
## + factor(FodelseLand_EU27_2020)                       1 893970
## - rcs(time_to_cpap_start)                             4 894623
## - rcs(hba1c)                                          4 895183
## - factor(antithrombotic_agents)                       1 896179
## - factor(stroke_history)                              1 898641
## - rcs(alder)                                          4 907437
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893527.2
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(systoliskt)                                     4 893204
## + factor(sex)                                         1 893214
## + rcs(GFR)                                            4 893280
## + rcs(Raks_AndelSjukInk)                              4 893317
## + rcs(DispInkKEHB04)                                  4 893383
## + rcs(Raks_AndelEkBisInk)                             4 893408
## + rcs(Raks_AndelArblosInk)                            4 893439
## + rcs(kolesterol)                                     4 893468
## + rcs(bmi)                                            4 893484
## + factor(antihypertensive_comb)                       1 893491
## + factor(Sun2000niva_old)                             6 893515
## + factor(lipid_modifying_agents)                      1 893516
## + factor(Civil)                                       1 893524
## + factor(ami_history)                                 1 893527
## <none>                                                  893527
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893528
## + factor(FodelseLand_EU27_2020)                       1 893529
## - factor(rokare)                                      1 893969
## - rcs(time_to_cpap_start)                             4 894169
## - rcs(hba1c)                                          4 894730
## - factor(antithrombotic_agents)                       1 895727
## - factor(stroke_history)                              1 898221
## - rcs(alder)                                          4 907432
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893203.7
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(sex)                                         1 892873
## + rcs(GFR)                                            4 892958
## + rcs(Raks_AndelSjukInk)                              4 892992
## + rcs(DispInkKEHB04)                                  4 893066
## + rcs(Raks_AndelEkBisInk)                             4 893084
## + rcs(Raks_AndelArblosInk)                            4 893114
## + rcs(kolesterol)                                     4 893155
## + rcs(bmi)                                            4 893158
## + factor(antihypertensive_comb)                       1 893189
## + factor(Sun2000niva_old)                             6 893193
## + factor(lipid_modifying_agents)                      1 893197
## + factor(Civil)                                       1 893199
## + factor(ami_history)                                 1 893202
## <none>                                                  893204
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893204
## + factor(FodelseLand_EU27_2020)                       1 893206
## - rcs(systoliskt)                                     4 893527
## - factor(rokare)                                      1 893641
## - rcs(time_to_cpap_start)                             4 893842
## - rcs(hba1c)                                          4 894345
## - factor(antithrombotic_agents)                       1 895471
## - factor(stroke_history)                              1 897874
## - rcs(alder)                                          4 906409
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892872.6
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(GFR)                                            4 892581
## + rcs(Raks_AndelSjukInk)                              4 892652
## + rcs(DispInkKEHB04)                                  4 892657
## + rcs(Raks_AndelEkBisInk)                             4 892750
## + rcs(Raks_AndelArblosInk)                            4 892786
## + rcs(kolesterol)                                     4 892800
## + rcs(bmi)                                            4 892843
## + factor(Sun2000niva_old)                             6 892853
## + factor(antihypertensive_comb)                       1 892860
## + factor(lipid_modifying_agents)                      1 892864
## + factor(Civil)                                       1 892870
## <none>                                                  892873
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892873
## + factor(ami_history)                                 1 892874
## + factor(FodelseLand_EU27_2020)                       1 892874
## - factor(sex)                                         1 893204
## - rcs(systoliskt)                                     4 893214
## - factor(rokare)                                      1 893315
## - rcs(time_to_cpap_start)                             4 893534
## - rcs(hba1c)                                          4 893978
## - factor(antithrombotic_agents)                       1 894946
## - factor(stroke_history)                              1 897571
## - rcs(alder)                                          4 906410
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892581.3
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelSjukInk)                              4 892365
## + rcs(DispInkKEHB04)                                  4 892377
## + rcs(Raks_AndelEkBisInk)                             4 892462
## + rcs(alder):rcs(GFR)                                16 892491
## + rcs(Raks_AndelArblosInk)                            4 892496
## + rcs(kolesterol)                                     4 892503
## + rcs(bmi)                                            4 892545
## + factor(Sun2000niva_old)                             6 892564
## + factor(lipid_modifying_agents)                      1 892569
## + factor(antihypertensive_comb)                       1 892577
## + factor(Civil)                                       1 892579
## <none>                                                  892581
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892582
## + factor(FodelseLand_EU27_2020)                       1 892583
## + factor(ami_history)                                 1 892583
## + factor(cpap_treated):rcs(GFR)                       4 892588
## - rcs(GFR)                                            4 892873
## - rcs(systoliskt)                                     4 892923
## - factor(sex)                                         1 892958
## - factor(rokare)                                      1 893030
## - rcs(time_to_cpap_start)                             4 893208
## - rcs(hba1c)                                          4 893616
## - factor(antithrombotic_agents)                       1 894539
## - factor(stroke_history)                              1 897313
## - rcs(alder)                                          4 903449
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892365.1
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 892142
## + rcs(Raks_AndelEkBisInk)                             4 892261
## + rcs(alder):rcs(GFR)                                16 892280
## + rcs(kolesterol)                                     4 892292
## + rcs(Raks_AndelArblosInk)                            4 892306
## + rcs(bmi)                                            4 892326
## + factor(Sun2000niva_old)                             6 892349
## + factor(lipid_modifying_agents)                      1 892353
## + factor(antihypertensive_comb)                       1 892361
## + factor(Civil)                                       1 892363
## <none>                                                  892365
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892365
## + factor(FodelseLand_EU27_2020)                       1 892366
## + factor(ami_history)                                 1 892367
## + factor(cpap_treated):rcs(GFR)                       4 892371
## - rcs(Raks_AndelSjukInk)                              4 892581
## - rcs(GFR)                                            4 892652
## - rcs(systoliskt)                                     4 892708
## - factor(sex)                                         1 892751
## - factor(rokare)                                      1 892812
## - rcs(time_to_cpap_start)                             4 893010
## - rcs(hba1c)                                          4 893402
## - factor(antithrombotic_agents)                       1 894296
## - factor(stroke_history)                              1 897117
## - rcs(alder)                                          4 903303
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892142.1
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 29,30,31,32 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(alder):rcs(GFR)                                16 892064
## + rcs(kolesterol)                                     4 892069
## + rcs(Raks_AndelEkBisInk)                             4 892076
## + rcs(Raks_AndelArblosInk)                            4 892079
## + rcs(bmi)                                            4 892096
## + factor(lipid_modifying_agents)                      1 892132
## + factor(Sun2000niva_old)                             6 892134
## + factor(antihypertensive_comb)                       1 892137
## + factor(FodelseLand_EU27_2020)                       1 892141
## <none>                                                  892142
## + factor(Civil)                                       1 892142
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892142
## + factor(ami_history)                                 1 892144
## + factor(cpap_treated):rcs(GFR)                       4 892148
## - rcs(DispInkKEHB04)                                  4 892365
## - rcs(Raks_AndelSjukInk)                              4 892377
## - rcs(GFR)                                            4 892418
## - rcs(systoliskt)                                     4 892478
## - factor(rokare)                                      1 892549
## - factor(sex)                                         1 892614
## - rcs(time_to_cpap_start)                             4 892640
## - rcs(hba1c)                                          4 893114
## - factor(antithrombotic_agents)                       1 894048
## - factor(stroke_history)                              1 896906
## - rcs(alder)                                          4 901971
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892064.1
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(kolesterol)                                     4 891992
## + rcs(Raks_AndelEkBisInk)                             4 891999
## + rcs(Raks_AndelArblosInk)                            4 892000
## + rcs(bmi)                                            4 892017
## + factor(lipid_modifying_agents)                      1 892054
## + factor(Sun2000niva_old)                             6 892056
## + factor(antihypertensive_comb)                       1 892059
## + factor(FodelseLand_EU27_2020)                       1 892063
## <none>                                                  892064
## + factor(Civil)                                       1 892064
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892064
## + factor(ami_history)                                 1 892066
## + factor(cpap_treated):rcs(GFR)                       4 892069
## - rcs(alder):rcs(GFR)                                16 892142
## - rcs(DispInkKEHB04)                                  4 892280
## - rcs(Raks_AndelSjukInk)                              4 892294
## - rcs(systoliskt)                                     4 892397
## - factor(rokare)                                      1 892472
## - factor(sex)                                         1 892534
## - rcs(time_to_cpap_start)                             4 892564
## - rcs(hba1c)                                          4 893031
## - factor(antithrombotic_agents)                       1 893958
## - factor(stroke_history)                              1 896826
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891992.3
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelEkBisInk)                             4 891926
## + rcs(Raks_AndelArblosInk)                            4 891929
## + rcs(bmi)                                            4 891949
## + factor(Sun2000niva_old)                             6 891985
## + factor(antihypertensive_comb)                       1 891985
## + factor(lipid_modifying_agents)                      1 891990
## + factor(FodelseLand_EU27_2020)                       1 891992
## <none>                                                  891992
## + factor(Civil)                                       1 891992
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891993
## + factor(ami_history)                                 1 891994
## + factor(cpap_treated):rcs(GFR)                       4 891997
## - rcs(kolesterol)                                     4 892064
## - rcs(alder):rcs(GFR)                                16 892069
## - rcs(DispInkKEHB04)                                  4 892208
## - rcs(Raks_AndelSjukInk)                              4 892218
## - rcs(systoliskt)                                     4 892307
## - factor(rokare)                                      1 892394
## - factor(sex)                                         1 892493
## - rcs(time_to_cpap_start)                             4 892497
## - rcs(hba1c)                                          4 892928
## - factor(antithrombotic_agents)                       1 893920
## - factor(stroke_history)                              1 896741
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891925.8
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelArblosInk)                            4 891878
## + rcs(bmi)                                            4 891883
## + factor(antihypertensive_comb)                       1 891917
## + factor(FodelseLand_EU27_2020)                       1 891918
## + factor(Sun2000niva_old)                             6 891919
## + factor(lipid_modifying_agents)                      1 891924
## + factor(Civil)                                       1 891925
## <none>                                                  891926
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891926
## + factor(ami_history)                                 1 891927
## + factor(cpap_treated):rcs(GFR)                       4 891930
## - rcs(Raks_AndelEkBisInk)                             4 891992
## - rcs(kolesterol)                                     4 891999
## - rcs(alder):rcs(GFR)                                16 892002
## - rcs(DispInkKEHB04)                                  4 892104
## - rcs(Raks_AndelSjukInk)                              4 892131
## - rcs(systoliskt)                                     4 892242
## - factor(rokare)                                      1 892320
## - factor(sex)                                         1 892420
## - rcs(time_to_cpap_start)                             4 892440
## - rcs(hba1c)                                          4 892852
## - factor(antithrombotic_agents)                       1 893859
## - factor(stroke_history)                              1 896672
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891878
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(bmi)                                            4 891836
## + factor(antihypertensive_comb)                       1 891869
## + factor(FodelseLand_EU27_2020)                       1 891870
## + factor(Sun2000niva_old)                             6 891872
## + factor(lipid_modifying_agents)                      1 891877
## + factor(Civil)                                       1 891878
## <none>                                                  891878
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891878
## + factor(ami_history)                                 1 891880
## + factor(cpap_treated):rcs(GFR)                       4 891883
## - rcs(Raks_AndelArblosInk)                            4 891926
## - rcs(Raks_AndelEkBisInk)                             4 891929
## - rcs(kolesterol)                                     4 891950
## - rcs(alder):rcs(GFR)                                16 891955
## - rcs(Raks_AndelSjukInk)                              4 892060
## - rcs(DispInkKEHB04)                                  4 892062
## - rcs(systoliskt)                                     4 892194
## - factor(rokare)                                      1 892272
## - factor(sex)                                         1 892372
## - rcs(time_to_cpap_start)                             4 892387
## - rcs(hba1c)                                          4 892805
## - factor(antithrombotic_agents)                       1 893816
## - factor(stroke_history)                              1 896627
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891835.6
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(antihypertensive_comb)                       1 891824
## + factor(FodelseLand_EU27_2020)                       1 891827
## + factor(Sun2000niva_old)                             6 891830
## + factor(lipid_modifying_agents)                      1 891834
## + factor(Civil)                                       1 891835
## <none>                                                  891836
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891836
## + factor(ami_history)                                 1 891837
## + factor(cpap_treated):rcs(GFR)                       4 891840
## + rcs(alder):rcs(bmi)                                16 891850
## - rcs(bmi)                                            4 891878
## - rcs(Raks_AndelArblosInk)                            4 891883
## - rcs(Raks_AndelEkBisInk)                             4 891886
## - rcs(kolesterol)                                     4 891904
## - rcs(alder):rcs(GFR)                                16 891914
## - rcs(Raks_AndelSjukInk)                              4 892020
## - rcs(DispInkKEHB04)                                  4 892026
## - rcs(systoliskt)                                     4 892154
## - factor(rokare)                                      1 892212
## - factor(sex)                                         1 892300
## - rcs(time_to_cpap_start)                             4 892334
## - rcs(hba1c)                                          4 892777
## - factor(antithrombotic_agents)                       1 893788
## - factor(stroke_history)                              1 896596
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891823.7
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(FodelseLand_EU27_2020)                       1 891816
## + factor(Sun2000niva_old)                             6 891818
## + factor(lipid_modifying_agents)                      1 891820
## + factor(Civil)                                       1 891823
## <none>                                                  891824
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891824
## + factor(ami_history)                                 1 891825
## + factor(cpap_treated):factor(antihypertensive_comb)  1 891826
## + factor(cpap_treated):rcs(GFR)                       4 891828
## - factor(antihypertensive_comb)                       1 891836
## + rcs(alder):rcs(bmi)                                16 891839
## - rcs(bmi)                                            4 891869
## - rcs(Raks_AndelArblosInk)                            4 891872
## - rcs(Raks_AndelEkBisInk)                             4 891875
## - rcs(kolesterol)                                     4 891896
## - rcs(alder):rcs(GFR)                                16 891901
## - rcs(Raks_AndelSjukInk)                              4 892008
## - rcs(DispInkKEHB04)                                  4 892015
## - rcs(systoliskt)                                     4 892120
## - factor(rokare)                                      1 892202
## - factor(sex)                                         1 892285
## - rcs(time_to_cpap_start)                             4 892320
## - rcs(hba1c)                                          4 892771
## - factor(antithrombotic_agents)                       1 893667
## - factor(stroke_history)                              1 896585
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891815.9
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + factor(FodelseLand_EU27_2020) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(Sun2000niva_old)                             6 891810
## + factor(lipid_modifying_agents)                      1 891812
## + factor(Civil)                                       1 891816
## <none>                                                  891816
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891816
## + factor(ami_history)                                 1 891818
## + factor(cpap_treated):factor(antihypertensive_comb)  1 891818
## + factor(cpap_treated):rcs(GFR)                       4 891820
## - factor(FodelseLand_EU27_2020)                       1 891824
## - factor(antihypertensive_comb)                       1 891827
## + rcs(alder):rcs(bmi)                                16 891831
## - rcs(bmi)                                            4 891861
## - rcs(Raks_AndelArblosInk)                            4 891864
## - rcs(Raks_AndelEkBisInk)                             4 891874
## - rcs(kolesterol)                                     4 891887
## - rcs(alder):rcs(GFR)                                16 891893
## - rcs(Raks_AndelSjukInk)                              4 892000
## - rcs(DispInkKEHB04)                                  4 892016
## - rcs(systoliskt)                                     4 892113
## - factor(rokare)                                      1 892196
## - factor(sex)                                         1 892275
## - rcs(time_to_cpap_start)                             4 892305
## - rcs(hba1c)                                          4 892765
## - factor(antithrombotic_agents)                       1 893659
## - factor(stroke_history)                              1 896579
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891809.8
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + factor(FodelseLand_EU27_2020) + 
##     factor(Sun2000niva_old) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(lipid_modifying_agents)                      1 891806
## + factor(Civil)                                       1 891809
## <none>                                                  891810
## + factor(cpap_treated):factor(antithrombotic_agents)  1 891810
## + factor(ami_history)                                 1 891812
## + factor(cpap_treated):factor(antihypertensive_comb)  1 891812
## + factor(cpap_treated):rcs(GFR)                       4 891814
## - factor(Sun2000niva_old)                             6 891816
## - factor(FodelseLand_EU27_2020)                       1 891818
## - factor(antihypertensive_comb)                       1 891821
## + rcs(alder):rcs(bmi)                                16 891825
## - rcs(bmi)                                            4 891855
## - rcs(Raks_AndelArblosInk)                            4 891858
## - rcs(Raks_AndelEkBisInk)                             4 891867
## - rcs(kolesterol)                                     4 891880
## - rcs(alder):rcs(GFR)                                16 891886
## - rcs(Raks_AndelSjukInk)                              4 891993
## - rcs(DispInkKEHB04)                                  4 892000
## - rcs(systoliskt)                                     4 892107
## - factor(rokare)                                      1 892187
## - factor(sex)                                         1 892267
## - rcs(time_to_cpap_start)                             4 892308
## - rcs(hba1c)                                          4 892761
## - factor(antithrombotic_agents)                       1 893653
## - factor(stroke_history)                              1 896573
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891806.3
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + factor(FodelseLand_EU27_2020) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 891804
## + factor(Civil)                                        1 891806
## <none>                                                   891806
## + factor(cpap_treated):factor(antithrombotic_agents)   1 891806
## + factor(ami_history)                                  1 891808
## + factor(cpap_treated):factor(antihypertensive_comb)   1 891808
## - factor(lipid_modifying_agents)                       1 891810
## + factor(cpap_treated):rcs(GFR)                        4 891811
## - factor(Sun2000niva_old)                              6 891812
## - factor(FodelseLand_EU27_2020)                        1 891814
## - factor(antihypertensive_comb)                        1 891820
## + rcs(alder):rcs(bmi)                                 16 891822
## - rcs(bmi)                                             4 891852
## - rcs(Raks_AndelArblosInk)                             4 891854
## - rcs(Raks_AndelEkBisInk)                              4 891863
## - rcs(kolesterol)                                      4 891868
## - rcs(alder):rcs(GFR)                                 16 891883
## - rcs(Raks_AndelSjukInk)                               4 891989
## - rcs(DispInkKEHB04)                                   4 891996
## - rcs(systoliskt)                                      4 892100
## - factor(rokare)                                       1 892184
## - factor(sex)                                          1 892261
## - rcs(time_to_cpap_start)                              4 892306
## - rcs(hba1c)                                           4 892759
## - factor(antithrombotic_agents)                        1 893606
## - factor(stroke_history)                               1 896556
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891803.8
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + factor(FodelseLand_EU27_2020) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(Civil)                                        1 891803
## <none>                                                   891804
## + factor(cpap_treated):factor(antithrombotic_agents)   1 891805
## + factor(ami_history)                                  1 891805
## + factor(cpap_treated):factor(antihypertensive_comb)   1 891806
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 891806
## + factor(cpap_treated):rcs(GFR)                        4 891808
## - factor(Sun2000niva_old)                              6 891810
## - factor(FodelseLand_EU27_2020)                        1 891812
## - factor(antihypertensive_comb)                        1 891817
## + rcs(alder):rcs(bmi)                                 16 891819
## - rcs(bmi)                                             4 891849
## - rcs(Raks_AndelArblosInk)                             4 891852
## - rcs(Raks_AndelEkBisInk)                              4 891861
## - rcs(kolesterol)                                      4 891865
## - rcs(alder):rcs(GFR)                                 16 891880
## - rcs(Raks_AndelSjukInk)                               4 891987
## - rcs(DispInkKEHB04)                                   4 891993
## - rcs(systoliskt)                                      4 892098
## - factor(rokare)                                       1 892182
## - factor(sex)                                          1 892259
## - rcs(time_to_cpap_start)                              4 892303
## - rcs(hba1c)                                           4 892757
## - factor(antithrombotic_agents)                        1 893603
## - factor(stroke_history)                               1 896554
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=891803.3
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + factor(FodelseLand_EU27_2020) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(Civil) + rcs(alder):rcs(GFR) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## <none>                                                   891803
## - factor(Civil)                                        1 891804
## + factor(cpap_treated):factor(antithrombotic_agents)   1 891805
## + factor(ami_history)                                  1 891805
## + factor(cpap_treated):factor(antihypertensive_comb)   1 891805
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 891806
## + factor(cpap_treated):rcs(GFR)                        4 891808
## - factor(Sun2000niva_old)                              6 891810
## - factor(FodelseLand_EU27_2020)                        1 891811
## - factor(antihypertensive_comb)                        1 891817
## + rcs(alder):rcs(bmi)                                 16 891819
## - rcs(bmi)                                             4 891849
## - rcs(Raks_AndelArblosInk)                             4 891851
## - rcs(Raks_AndelEkBisInk)                              4 891860
## - rcs(kolesterol)                                      4 891865
## - rcs(alder):rcs(GFR)                                 16 891880
## - rcs(Raks_AndelSjukInk)                               4 891986
## - rcs(DispInkKEHB04)                                   4 891991
## - rcs(systoliskt)                                      4 892097
## - factor(rokare)                                       1 892181
## - factor(sex)                                          1 892249
## - rcs(time_to_cpap_start)                              4 892301
## - rcs(hba1c)                                           4 892755
## - factor(antithrombotic_agents)                        1 893602
## - factor(stroke_history)                               1 896552
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(hba1c) + rcs(time_to_cpap_start) + factor(rokare) + rcs(systoliskt) + 
##     factor(sex) + rcs(GFR) + rcs(Raks_AndelSjukInk) + rcs(DispInkKEHB04) + 
##     rcs(kolesterol) + rcs(Raks_AndelEkBisInk) + rcs(Raks_AndelArblosInk) + 
##     rcs(bmi) + factor(antihypertensive_comb) + factor(FodelseLand_EU27_2020) + 
##     factor(Sun2000niva_old) + factor(lipid_modifying_agents) + 
##     factor(Civil) + rcs(alder):rcs(GFR) + factor(cpap_treated):factor(lipid_modifying_agents), 
##     data = df_train)
## 
##   n= 562724, number of events= 36038 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                   4.576e-01   1.580e+00
## rcs(alder)alder                                         6.671e-01   1.949e+00
## rcs(alder)alder'                                        5.724e-02   1.059e+00
## rcs(alder)alder''                                       2.267e+00   9.655e+00
## rcs(alder)alder'''                                     -6.816e+00   1.096e-03
## factor(stroke_history)1                                -1.674e+01   5.393e-08
## factor(antithrombotic_agents)1                          4.985e-01   1.646e+00
## rcs(hba1c)hba1c                                         7.405e-02   1.077e+00
## rcs(hba1c)hba1c'                                        2.226e+00   9.265e+00
## rcs(hba1c)hba1c''                                      -4.931e+00   7.222e-03
## rcs(hba1c)hba1c'''                                      1.196e+00   3.308e+00
## rcs(time_to_cpap_start)time_to_cpap_start               1.776e-01   1.194e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             -2.250e-02   9.778e-01
## rcs(time_to_cpap_start)time_to_cpap_start''             1.675e-01   1.182e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           -8.652e-02   9.171e-01
## factor(rokare)1                                         2.953e-01   1.343e+00
## rcs(systoliskt)systoliskt                              -1.366e-01   8.723e-01
## rcs(systoliskt)systoliskt'                              8.152e-01   2.260e+00
## rcs(systoliskt)systoliskt''                            -5.057e+00   6.365e-03
## rcs(systoliskt)systoliskt'''                            9.559e+00   1.418e+04
## factor(sex)1                                           -2.497e-01   7.790e-01
## rcs(GFR)GFR                                            -5.379e-01   5.840e-01
## rcs(GFR)GFR'                                            7.383e-03   1.007e+00
## rcs(GFR)GFR''                                           1.019e+01   2.665e+04
## rcs(GFR)GFR'''                                         -2.647e+01   3.184e-12
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 2.614e+00   1.365e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -3.739e+03   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               4.563e+03         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             -8.312e+02   0.000e+00
## rcs(DispInkKEHB04)DispInkKEHB04                         5.812e-02   1.060e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       -1.267e+01   3.149e-06
## rcs(DispInkKEHB04)DispInkKEHB04''                       2.746e+01   8.464e+11
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -1.326e+01   1.746e-06
## rcs(kolesterol)kolesterol                              -6.634e-02   9.358e-01
## rcs(kolesterol)kolesterol'                              7.256e-01   2.066e+00
## rcs(kolesterol)kolesterol''                            -5.688e+00   3.386e-03
## rcs(kolesterol)kolesterol'''                            1.195e+01   1.548e+05
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.678e+00   5.356e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -3.754e+02  8.959e-164
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             4.102e+02  1.464e+178
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           -3.516e+01   5.394e-16
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             2.653e+00   1.420e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -1.709e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           1.985e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         -2.799e+02  2.654e-122
## rcs(bmi)bmi                                            -1.105e-01   8.954e-01
## rcs(bmi)bmi'                                            9.971e-01   2.710e+00
## rcs(bmi)bmi''                                          -6.656e+00   1.286e-03
## rcs(bmi)bmi'''                                          1.001e+01   2.229e+04
## factor(antihypertensive_comb)1                          4.816e-02   1.049e+00
## factor(FodelseLand_EU27_2020)1                          4.670e-02   1.048e+00
## factor(Sun2000niva_old)2                                7.535e-02   1.078e+00
## factor(Sun2000niva_old)3                                3.473e-02   1.035e+00
## factor(Sun2000niva_old)4                                2.759e-02   1.028e+00
## factor(Sun2000niva_old)5                                4.627e-02   1.047e+00
## factor(Sun2000niva_old)6                                6.897e-03   1.007e+00
## factor(Sun2000niva_old)7                                7.077e-02   1.073e+00
## factor(lipid_modifying_agents)1                        -2.502e-02   9.753e-01
## factor(Civil)1                                          2.401e-02   1.024e+00
## rcs(alder)alder:rcs(GFR)GFR                            -3.561e-02   9.650e-01
## rcs(alder)alder':rcs(GFR)GFR                            1.270e-01   1.135e+00
## rcs(alder)alder'':rcs(GFR)GFR                           9.448e-01   2.572e+00
## rcs(alder)alder''':rcs(GFR)GFR                         -3.135e+00   4.348e-02
## rcs(alder)alder:rcs(GFR)GFR'                           -2.797e-01   7.560e-01
## rcs(alder)alder':rcs(GFR)GFR'                           2.902e+00   1.821e+01
## rcs(alder)alder'':rcs(GFR)GFR'                         -2.108e+01   7.010e-10
## rcs(alder)alder''':rcs(GFR)GFR'                         3.381e+01   4.811e+14
## rcs(alder)alder:rcs(GFR)GFR''                           7.431e+00   1.688e+03
## rcs(alder)alder':rcs(GFR)GFR''                         -3.589e+01   2.580e-16
## rcs(alder)alder'':rcs(GFR)GFR''                         2.089e+02   5.415e+90
## rcs(alder)alder''':rcs(GFR)GFR''                       -3.088e+02  7.949e-135
## rcs(alder)alder:rcs(GFR)GFR'''                         -1.911e+01   5.016e-09
## rcs(alder)alder':rcs(GFR)GFR'''                         7.636e+01   1.454e+33
## rcs(alder)alder'':rcs(GFR)GFR'''                       -4.104e+02  5.681e-179
## rcs(alder)alder''':rcs(GFR)GFR'''                       5.887e+02  4.593e+255
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  -2.207e-01   8.020e-01
##                                                          se(coef)       z
## factor(cpap_treated)1                                   7.683e-02   5.956
## rcs(alder)alder                                         4.726e-01   1.411
## rcs(alder)alder'                                        1.234e+00   0.046
## rcs(alder)alder''                                       6.236e+00   0.364
## rcs(alder)alder'''                                      9.412e+00  -0.724
## factor(stroke_history)1                                 8.586e+01  -0.195
## factor(antithrombotic_agents)1                          1.183e-02  42.153
## rcs(hba1c)hba1c                                         6.384e-02   1.160
## rcs(hba1c)hba1c'                                        1.146e+00   1.943
## rcs(hba1c)hba1c''                                       4.217e+00  -1.169
## rcs(hba1c)hba1c'''                                      4.008e+00   0.299
## rcs(time_to_cpap_start)time_to_cpap_start               5.696e-02   3.118
## rcs(time_to_cpap_start)time_to_cpap_start'              1.280e-01  -0.176
## rcs(time_to_cpap_start)time_to_cpap_start''             4.665e-01   0.359
## rcs(time_to_cpap_start)time_to_cpap_start'''            2.073e+00  -0.042
## factor(rokare)1                                         1.470e-02  20.089
## rcs(systoliskt)systoliskt                               2.823e-02  -4.839
## rcs(systoliskt)systoliskt'                              1.419e-01   5.745
## rcs(systoliskt)systoliskt''                             1.168e+00  -4.329
## rcs(systoliskt)systoliskt'''                            2.726e+00   3.507
## factor(sex)1                                            1.186e-02 -21.045
## rcs(GFR)GFR                                             3.713e-01  -1.449
## rcs(GFR)GFR'                                            1.940e+00   0.004
## rcs(GFR)GFR''                                           1.251e+01   0.815
## rcs(GFR)GFR'''                                          2.084e+01  -1.270
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 4.598e-01   5.685
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                7.805e+02  -4.791
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               9.564e+02   4.771
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              1.782e+02  -4.664
## rcs(DispInkKEHB04)DispInkKEHB04                         1.605e-01   0.362
## rcs(DispInkKEHB04)DispInkKEHB04'                        3.550e+00  -3.568
## rcs(DispInkKEHB04)DispInkKEHB04''                       1.038e+01   2.647
## rcs(DispInkKEHB04)DispInkKEHB04'''                      9.576e+00  -1.384
## rcs(kolesterol)kolesterol                               2.696e-02  -2.461
## rcs(kolesterol)kolesterol'                              1.489e-01   4.872
## rcs(kolesterol)kolesterol''                             1.088e+00  -5.226
## rcs(kolesterol)kolesterol'''                            2.330e+00   5.128
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               2.435e-01   6.892
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              6.492e+01  -5.783
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             7.135e+01   5.749
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''            6.697e+00  -5.249
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             3.589e-01   7.393
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'            2.498e+02  -6.842
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           2.913e+02   6.814
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          4.260e+01  -6.571
## rcs(bmi)bmi                                             3.282e-02  -3.365
## rcs(bmi)bmi'                                            2.437e-01   4.091
## rcs(bmi)bmi''                                           1.348e+00  -4.936
## rcs(bmi)bmi'''                                          1.864e+00   5.371
## factor(antihypertensive_comb)1                          1.233e-02   3.907
## factor(FodelseLand_EU27_2020)1                          1.491e-02   3.132
## factor(Sun2000niva_old)2                                1.983e-02   3.800
## factor(Sun2000niva_old)3                                1.385e-02   2.507
## factor(Sun2000niva_old)4                                1.920e-02   1.437
## factor(Sun2000niva_old)5                                2.163e-02   2.139
## factor(Sun2000niva_old)6                                2.173e-02   0.317
## factor(Sun2000niva_old)7                                6.916e-02   1.023
## factor(lipid_modifying_agents)1                         1.180e-02  -2.120
## factor(Civil)1                                          1.532e-02   1.567
## rcs(alder)alder:rcs(GFR)GFR                             3.264e-01  -0.109
## rcs(alder)alder':rcs(GFR)GFR                            8.694e-01   0.146
## rcs(alder)alder'':rcs(GFR)GFR                           4.448e+00   0.212
## rcs(alder)alder''':rcs(GFR)GFR                          6.745e+00  -0.465
## rcs(alder)alder:rcs(GFR)GFR'                            1.716e+00  -0.163
## rcs(alder)alder':rcs(GFR)GFR'                           4.551e+00   0.638
## rcs(alder)alder'':rcs(GFR)GFR'                          2.345e+01  -0.899
## rcs(alder)alder''':rcs(GFR)GFR'                         3.623e+01   0.933
## rcs(alder)alder:rcs(GFR)GFR''                           1.090e+01   0.682
## rcs(alder)alder':rcs(GFR)GFR''                          2.964e+01  -1.211
## rcs(alder)alder'':rcs(GFR)GFR''                         1.579e+02   1.323
## rcs(alder)alder''':rcs(GFR)GFR''                        2.550e+02  -1.211
## rcs(alder)alder:rcs(GFR)GFR'''                          1.780e+01  -1.073
## rcs(alder)alder':rcs(GFR)GFR'''                         5.006e+01   1.525
## rcs(alder)alder'':rcs(GFR)GFR'''                        2.776e+02  -1.479
## rcs(alder)alder''':rcs(GFR)GFR'''                       4.698e+02   1.253
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.034e-01  -2.135
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                 2.58e-09 ***
## rcs(alder)alder                                       0.158137    
## rcs(alder)alder'                                      0.962993    
## rcs(alder)alder''                                     0.716163    
## rcs(alder)alder'''                                    0.468917    
## factor(stroke_history)1                               0.845459    
## factor(antithrombotic_agents)1                         < 2e-16 ***
## rcs(hba1c)hba1c                                       0.246028    
## rcs(hba1c)hba1c'                                      0.052042 .  
## rcs(hba1c)hba1c''                                     0.242289    
## rcs(hba1c)hba1c'''                                    0.765310    
## rcs(time_to_cpap_start)time_to_cpap_start             0.001819 ** 
## rcs(time_to_cpap_start)time_to_cpap_start'            0.860445    
## rcs(time_to_cpap_start)time_to_cpap_start''           0.719558    
## rcs(time_to_cpap_start)time_to_cpap_start'''          0.966716    
## factor(rokare)1                                        < 2e-16 ***
## rcs(systoliskt)systoliskt                             1.30e-06 ***
## rcs(systoliskt)systoliskt'                            9.21e-09 ***
## rcs(systoliskt)systoliskt''                           1.50e-05 ***
## rcs(systoliskt)systoliskt'''                          0.000453 ***
## factor(sex)1                                           < 2e-16 ***
## rcs(GFR)GFR                                           0.147385    
## rcs(GFR)GFR'                                          0.996963    
## rcs(GFR)GFR''                                         0.415220    
## rcs(GFR)GFR'''                                        0.204066    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               1.31e-08 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              1.66e-06 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             1.83e-06 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            3.11e-06 ***
## rcs(DispInkKEHB04)DispInkKEHB04                       0.717237    
## rcs(DispInkKEHB04)DispInkKEHB04'                      0.000359 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                     0.008133 ** 
## rcs(DispInkKEHB04)DispInkKEHB04'''                    0.166212    
## rcs(kolesterol)kolesterol                             0.013863 *  
## rcs(kolesterol)kolesterol'                            1.10e-06 ***
## rcs(kolesterol)kolesterol''                           1.73e-07 ***
## rcs(kolesterol)kolesterol'''                          2.94e-07 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             5.51e-12 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            7.32e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           8.96e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          1.53e-07 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           1.44e-13 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          7.79e-12 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''         9.51e-12 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        5.00e-11 ***
## rcs(bmi)bmi                                           0.000765 ***
## rcs(bmi)bmi'                                          4.30e-05 ***
## rcs(bmi)bmi''                                         7.96e-07 ***
## rcs(bmi)bmi'''                                        7.82e-08 ***
## factor(antihypertensive_comb)1                        9.34e-05 ***
## factor(FodelseLand_EU27_2020)1                        0.001737 ** 
## factor(Sun2000niva_old)2                              0.000145 ***
## factor(Sun2000niva_old)3                              0.012164 *  
## factor(Sun2000niva_old)4                              0.150704    
## factor(Sun2000niva_old)5                              0.032458 *  
## factor(Sun2000niva_old)6                              0.750941    
## factor(Sun2000niva_old)7                              0.306156    
## factor(lipid_modifying_agents)1                       0.033971 *  
## factor(Civil)1                                        0.117025    
## rcs(alder)alder:rcs(GFR)GFR                           0.913115    
## rcs(alder)alder':rcs(GFR)GFR                          0.883868    
## rcs(alder)alder'':rcs(GFR)GFR                         0.831790    
## rcs(alder)alder''':rcs(GFR)GFR                        0.642041    
## rcs(alder)alder:rcs(GFR)GFR'                          0.870535    
## rcs(alder)alder':rcs(GFR)GFR'                         0.523676    
## rcs(alder)alder'':rcs(GFR)GFR'                        0.368656    
## rcs(alder)alder''':rcs(GFR)GFR'                       0.350714    
## rcs(alder)alder:rcs(GFR)GFR''                         0.495514    
## rcs(alder)alder':rcs(GFR)GFR''                        0.225950    
## rcs(alder)alder'':rcs(GFR)GFR''                       0.185726    
## rcs(alder)alder''':rcs(GFR)GFR''                      0.225911    
## rcs(alder)alder:rcs(GFR)GFR'''                        0.283082    
## rcs(alder)alder':rcs(GFR)GFR'''                       0.127195    
## rcs(alder)alder'':rcs(GFR)GFR'''                      0.139227    
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.210196    
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.032772 *  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  1.580e+00  6.328e-01
## rcs(alder)alder                                        1.949e+00  5.132e-01
## rcs(alder)alder'                                       1.059e+00  9.444e-01
## rcs(alder)alder''                                      9.655e+00  1.036e-01
## rcs(alder)alder'''                                     1.096e-03  9.128e+02
## factor(stroke_history)1                                5.393e-08  1.854e+07
## factor(antithrombotic_agents)1                         1.646e+00  6.074e-01
## rcs(hba1c)hba1c                                        1.077e+00  9.286e-01
## rcs(hba1c)hba1c'                                       9.265e+00  1.079e-01
## rcs(hba1c)hba1c''                                      7.222e-03  1.385e+02
## rcs(hba1c)hba1c'''                                     3.308e+00  3.023e-01
## rcs(time_to_cpap_start)time_to_cpap_start              1.194e+00  8.373e-01
## rcs(time_to_cpap_start)time_to_cpap_start'             9.778e-01  1.023e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            1.182e+00  8.458e-01
## rcs(time_to_cpap_start)time_to_cpap_start'''           9.171e-01  1.090e+00
## factor(rokare)1                                        1.343e+00  7.443e-01
## rcs(systoliskt)systoliskt                              8.723e-01  1.146e+00
## rcs(systoliskt)systoliskt'                             2.260e+00  4.425e-01
## rcs(systoliskt)systoliskt''                            6.365e-03  1.571e+02
## rcs(systoliskt)systoliskt'''                           1.418e+04  7.054e-05
## factor(sex)1                                           7.790e-01  1.284e+00
## rcs(GFR)GFR                                            5.840e-01  1.712e+00
## rcs(GFR)GFR'                                           1.007e+00  9.926e-01
## rcs(GFR)GFR''                                          2.665e+04  3.753e-05
## rcs(GFR)GFR'''                                         3.184e-12  3.141e+11
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                1.365e+01  7.327e-02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00        Inf
## rcs(DispInkKEHB04)DispInkKEHB04                        1.060e+00  9.435e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       3.149e-06  3.175e+05
## rcs(DispInkKEHB04)DispInkKEHB04''                      8.464e+11  1.181e-12
## rcs(DispInkKEHB04)DispInkKEHB04'''                     1.746e-06  5.727e+05
## rcs(kolesterol)kolesterol                              9.358e-01  1.069e+00
## rcs(kolesterol)kolesterol'                             2.066e+00  4.840e-01
## rcs(kolesterol)kolesterol''                            3.386e-03  2.953e+02
## rcs(kolesterol)kolesterol'''                           1.548e+05  6.461e-06
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              5.356e+00  1.867e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            8.959e-164 1.116e+163
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           1.464e+178 6.832e-179
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           5.394e-16  1.854e+15
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            1.420e+01  7.041e-02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        2.654e-122 3.767e+121
## rcs(bmi)bmi                                            8.954e-01  1.117e+00
## rcs(bmi)bmi'                                           2.710e+00  3.690e-01
## rcs(bmi)bmi''                                          1.286e-03  7.774e+02
## rcs(bmi)bmi'''                                         2.229e+04  4.485e-05
## factor(antihypertensive_comb)1                         1.049e+00  9.530e-01
## factor(FodelseLand_EU27_2020)1                         1.048e+00  9.544e-01
## factor(Sun2000niva_old)2                               1.078e+00  9.274e-01
## factor(Sun2000niva_old)3                               1.035e+00  9.659e-01
## factor(Sun2000niva_old)4                               1.028e+00  9.728e-01
## factor(Sun2000niva_old)5                               1.047e+00  9.548e-01
## factor(Sun2000niva_old)6                               1.007e+00  9.931e-01
## factor(Sun2000niva_old)7                               1.073e+00  9.317e-01
## factor(lipid_modifying_agents)1                        9.753e-01  1.025e+00
## factor(Civil)1                                         1.024e+00  9.763e-01
## rcs(alder)alder:rcs(GFR)GFR                            9.650e-01  1.036e+00
## rcs(alder)alder':rcs(GFR)GFR                           1.135e+00  8.807e-01
## rcs(alder)alder'':rcs(GFR)GFR                          2.572e+00  3.888e-01
## rcs(alder)alder''':rcs(GFR)GFR                         4.348e-02  2.300e+01
## rcs(alder)alder:rcs(GFR)GFR'                           7.560e-01  1.323e+00
## rcs(alder)alder':rcs(GFR)GFR'                          1.821e+01  5.490e-02
## rcs(alder)alder'':rcs(GFR)GFR'                         7.010e-10  1.427e+09
## rcs(alder)alder''':rcs(GFR)GFR'                        4.811e+14  2.079e-15
## rcs(alder)alder:rcs(GFR)GFR''                          1.688e+03  5.925e-04
## rcs(alder)alder':rcs(GFR)GFR''                         2.580e-16  3.876e+15
## rcs(alder)alder'':rcs(GFR)GFR''                        5.415e+90  1.847e-91
## rcs(alder)alder''':rcs(GFR)GFR''                      7.949e-135 1.258e+134
## rcs(alder)alder:rcs(GFR)GFR'''                         5.016e-09  1.994e+08
## rcs(alder)alder':rcs(GFR)GFR'''                        1.454e+33  6.878e-34
## rcs(alder)alder'':rcs(GFR)GFR'''                      5.681e-179 1.760e+178
## rcs(alder)alder''':rcs(GFR)GFR'''                     4.593e+255 2.177e-256
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  8.020e-01  1.247e+00
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  1.359e+00  1.837e+00
## rcs(alder)alder                                        7.716e-01  4.921e+00
## rcs(alder)alder'                                       9.437e-02  1.188e+01
## rcs(alder)alder''                                      4.747e-05  1.964e+06
## rcs(alder)alder'''                                     1.067e-11  1.125e+05
## factor(stroke_history)1                                4.442e-81  6.548e+65
## factor(antithrombotic_agents)1                         1.609e+00  1.685e+00
## rcs(hba1c)hba1c                                        9.502e-01  1.220e+00
## rcs(hba1c)hba1c'                                       9.805e-01  8.754e+01
## rcs(hba1c)hba1c''                                      1.859e-06  2.805e+01
## rcs(hba1c)hba1c'''                                     1.283e-03  8.528e+03
## rcs(time_to_cpap_start)time_to_cpap_start              1.068e+00  1.335e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             7.609e-01  1.256e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            4.739e-01  2.950e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           1.576e-02  5.337e+01
## factor(rokare)1                                        1.305e+00  1.383e+00
## rcs(systoliskt)systoliskt                              8.253e-01  9.219e-01
## rcs(systoliskt)systoliskt'                             1.711e+00  2.984e+00
## rcs(systoliskt)systoliskt''                            6.450e-04  6.281e-02
## rcs(systoliskt)systoliskt'''                           6.782e+01  2.963e+06
## factor(sex)1                                           7.611e-01  7.974e-01
## rcs(GFR)GFR                                            2.821e-01  1.209e+00
## rcs(GFR)GFR'                                           2.250e-02  4.510e+01
## rcs(GFR)GFR''                                          6.014e-07  1.181e+15
## rcs(GFR)GFR'''                                         5.760e-30  1.760e+06
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                5.543e+00  3.361e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00 5.380e-210
## rcs(DispInkKEHB04)DispInkKEHB04                        7.738e-01  1.452e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       2.994e-09  3.313e-03
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.242e+03  5.768e+20
## rcs(DispInkKEHB04)DispInkKEHB04'''                     1.232e-14  2.474e+02
## rcs(kolesterol)kolesterol                              8.876e-01  9.866e-01
## rcs(kolesterol)kolesterol'                             1.543e+00  2.766e+00
## rcs(kolesterol)kolesterol''                            4.011e-04  2.858e-02
## rcs(kolesterol)kolesterol'''                           1.607e+03  1.491e+07
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              3.323e+00  8.633e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            4.969e-219 1.615e-108
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           2.679e+117 7.997e+238
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           1.075e-21  2.707e-10
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            7.029e+00  2.870e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        1.446e-158  4.871e-86
## rcs(bmi)bmi                                            8.396e-01  9.549e-01
## rcs(bmi)bmi'                                           1.681e+00  4.370e+00
## rcs(bmi)bmi''                                          9.154e-05  1.808e-02
## rcs(bmi)bmi'''                                         5.775e+02  8.607e+05
## factor(antihypertensive_comb)1                         1.024e+00  1.075e+00
## factor(FodelseLand_EU27_2020)1                         1.018e+00  1.079e+00
## factor(Sun2000niva_old)2                               1.037e+00  1.121e+00
## factor(Sun2000niva_old)3                               1.008e+00  1.064e+00
## factor(Sun2000niva_old)4                               9.900e-01  1.067e+00
## factor(Sun2000niva_old)5                               1.004e+00  1.093e+00
## factor(Sun2000niva_old)6                               9.649e-01  1.051e+00
## factor(Sun2000niva_old)7                               9.373e-01  1.229e+00
## factor(lipid_modifying_agents)1                        9.530e-01  9.981e-01
## factor(Civil)1                                         9.940e-01  1.056e+00
## rcs(alder)alder:rcs(GFR)GFR                            5.090e-01  1.830e+00
## rcs(alder)alder':rcs(GFR)GFR                           2.066e-01  6.239e+00
## rcs(alder)alder'':rcs(GFR)GFR                          4.209e-04  1.572e+04
## rcs(alder)alder''':rcs(GFR)GFR                         7.890e-08  2.397e+04
## rcs(alder)alder:rcs(GFR)GFR'                           2.617e-02  2.184e+01
## rcs(alder)alder':rcs(GFR)GFR'                          2.435e-03  1.363e+05
## rcs(alder)alder'':rcs(GFR)GFR'                         7.722e-30  6.363e+10
## rcs(alder)alder''':rcs(GFR)GFR'                        7.013e-17  3.300e+45
## rcs(alder)alder:rcs(GFR)GFR''                          8.843e-07  3.221e+12
## rcs(alder)alder':rcs(GFR)GFR''                         1.511e-41  4.404e+09
## rcs(alder)alder'':rcs(GFR)GFR''                        2.236e-44 1.311e+225
## rcs(alder)alder''':rcs(GFR)GFR''                       0.000e+00  8.779e+82
## rcs(alder)alder:rcs(GFR)GFR'''                         3.515e-24  7.157e+06
## rcs(alder)alder':rcs(GFR)GFR'''                        3.536e-10  5.978e+75
## rcs(alder)alder'':rcs(GFR)GFR'''                       0.000e+00  1.038e+58
## rcs(alder)alder''':rcs(GFR)GFR'''                     5.751e-145        Inf
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  6.549e-01  9.821e-01
## 
## Concordance= 0.753  (se = 0.001 )
## Likelihood ratio test= 28422  on 76 df,   p=<2e-16
## Wald test            = 22126  on 76 df,   p=<2e-16
## Score (logrank) test = 28869  on 76 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7528039 
## C-index test: 0.7536988[1] "### FORMULA 2 ###"
## Start:  AIC=920014.9
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 902501
## + factor(antithrombotic_agents)   1 913464
## + factor(GFR_high)                1 917027
## + rcs(DispInkKEHB04)              4 917107
## + factor(stroke_history)          1 917278
## + factor(Civil)                   1 917705
## + factor(Sun2000niva_old)         6 917719
## + rcs(time_to_cpap_start)         4 917786
## + rcs(bmi)                        4 918174
## + factor(antihypertensive_comb)   1 918591
## + factor(hba1c_high)              1 919392
## + factor(FodelseLand_EU27_2020)   1 919427
## + factor(ami_history)             1 919451
## + rcs(Raks_AndelSjukInk)          4 919481
## + factor(systoliskt_high)         1 919495
## + rcs(Raks_AndelArblosInk)        4 919646
## + factor(lipid_modifying_agents)  1 919678
## + factor(kolesterol_high)         1 919760
## + rcs(Raks_AndelEkBisInk)         4 919770
## + factor(sex)                     1 919985
## <none>                              920015
## + factor(rokare)                  1 920016
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=902501
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(stroke_history)          1 898540
## + factor(antithrombotic_agents)   1 900743
## + rcs(time_to_cpap_start)         4 901415
## + factor(hba1c_high)              1 901730
## + factor(rokare)                  1 902038
## + factor(sex)                     1 902039
## + rcs(DispInkKEHB04)              4 902048
## + factor(GFR_high)                1 902303
## + rcs(Raks_AndelSjukInk)          4 902308
## + factor(antihypertensive_comb)   1 902348
## + rcs(Raks_AndelEkBisInk)         4 902348
## + factor(ami_history)             1 902371
## + rcs(Raks_AndelArblosInk)        4 902414
## + factor(Sun2000niva_old)         6 902424
## + factor(systoliskt_high)         1 902436
## + factor(lipid_modifying_agents)  1 902455
## + rcs(bmi)                        4 902471
## + factor(kolesterol_high)         1 902488
## <none>                              902501
## + factor(FodelseLand_EU27_2020)   1 902502
## + factor(Civil)                   1 902502
## - rcs(alder)                      4 920015
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=898539.8
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 895992
## + rcs(time_to_cpap_start)         4 897478
## + factor(hba1c_high)              1 897759
## + factor(sex)                     1 898003
## + factor(rokare)                  1 898055
## + rcs(DispInkKEHB04)              4 898076
## + factor(GFR_high)                1 898308
## + rcs(Raks_AndelSjukInk)          4 898326
## + factor(antihypertensive_comb)   1 898342
## + factor(ami_history)             1 898385
## + rcs(Raks_AndelEkBisInk)         4 898388
## + factor(lipid_modifying_agents)  1 898412
## + rcs(Raks_AndelArblosInk)        4 898453
## + factor(Sun2000niva_old)         6 898457
## + factor(systoliskt_high)         1 898493
## + factor(kolesterol_high)         1 898501
## + rcs(bmi)                        4 898503
## + factor(Civil)                   1 898539
## <none>                              898540
## + factor(FodelseLand_EU27_2020)   1 898541
## - factor(stroke_history)          1 902501
## - rcs(alder)                      4 917278
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=895992
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(time_to_cpap_start)                             4 895183
## + factor(hba1c_high)                                  1 895318
## + factor(rokare)                                      1 895524
## + rcs(DispInkKEHB04)                                  4 895572
## + factor(sex)                                         1 895674
## + rcs(Raks_AndelSjukInk)                              4 895803
## + rcs(Raks_AndelEkBisInk)                             4 895838
## + factor(GFR_high)                                    1 895848
## + factor(systoliskt_high)                             1 895892
## + rcs(Raks_AndelArblosInk)                            4 895900
## + factor(Sun2000niva_old)                             6 895934
## + rcs(bmi)                                            4 895945
## + factor(antihypertensive_comb)                       1 895968
## + factor(lipid_modifying_agents)                      1 895983
## + factor(kolesterol_high)                             1 895991
## + factor(cpap_treated):factor(antithrombotic_agents)  1 895992
## <none>                                                  895992
## + factor(FodelseLand_EU27_2020)                       1 895993
## + factor(Civil)                                       1 895994
## + factor(ami_history)                                 1 895994
## - factor(antithrombotic_agents)                       1 898540
## - factor(stroke_history)                              1 900743
## - rcs(alder)                                          4 909264
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=895183.2
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(hba1c_high)                                  1 894642
## + factor(rokare)                                      1 894730
## + factor(sex)                                         1 894841
## + rcs(DispInkKEHB04)                                  4 894944
## + rcs(Raks_AndelSjukInk)                              4 894972
## + rcs(Raks_AndelEkBisInk)                             4 895022
## + factor(GFR_high)                                    1 895061
## + rcs(Raks_AndelArblosInk)                            4 895094
## + factor(systoliskt_high)                             1 895100
## + rcs(bmi)                                            4 895144
## + factor(Sun2000niva_old)                             6 895151
## + factor(antihypertensive_comb)                       1 895161
## + factor(lipid_modifying_agents)                      1 895171
## + factor(kolesterol_high)                             1 895176
## + factor(FodelseLand_EU27_2020)                       1 895181
## + factor(Civil)                                       1 895182
## <none>                                                  895183
## + factor(ami_history)                                 1 895184
## + factor(cpap_treated):factor(antithrombotic_agents)  1 895184
## - rcs(time_to_cpap_start)                             4 895992
## - factor(antithrombotic_agents)                       1 897478
## - factor(stroke_history)                              1 899855
## - rcs(alder)                                          4 907991
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=894642.5
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 894195
## + factor(sex)                                         1 894315
## + rcs(DispInkKEHB04)                                  4 894431
## + rcs(Raks_AndelSjukInk)                              4 894431
## + rcs(Raks_AndelEkBisInk)                             4 894493
## + factor(GFR_high)                                    1 894526
## + rcs(Raks_AndelArblosInk)                            4 894553
## + factor(systoliskt_high)                             1 894572
## + rcs(bmi)                                            4 894596
## + factor(Sun2000niva_old)                             6 894616
## + factor(antihypertensive_comb)                       1 894619
## + factor(lipid_modifying_agents)                      1 894628
## + factor(kolesterol_high)                             1 894635
## + factor(Civil)                                       1 894640
## + factor(ami_history)                                 1 894642
## <none>                                                  894642
## + factor(FodelseLand_EU27_2020)                       1 894643
## + factor(cpap_treated):factor(antithrombotic_agents)  1 894643
## - factor(hba1c_high)                                  1 895183
## - rcs(time_to_cpap_start)                             4 895318
## - factor(antithrombotic_agents)                       1 896861
## - factor(stroke_history)                              1 899310
## - rcs(alder)                                          4 907612
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=894194.7
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(sex)                                         1 893861
## + rcs(Raks_AndelSjukInk)                              4 893986
## + rcs(DispInkKEHB04)                                  4 894020
## + rcs(Raks_AndelEkBisInk)                             4 894061
## + factor(GFR_high)                                    1 894067
## + rcs(Raks_AndelArblosInk)                            4 894107
## + factor(systoliskt_high)                             1 894125
## + rcs(bmi)                                            4 894164
## + factor(antihypertensive_comb)                       1 894166
## + factor(Sun2000niva_old)                             6 894177
## + factor(lipid_modifying_agents)                      1 894181
## + factor(kolesterol_high)                             1 894187
## + factor(Civil)                                       1 894192
## <none>                                                  894195
## + factor(ami_history)                                 1 894195
## + factor(cpap_treated):factor(antithrombotic_agents)  1 894195
## + factor(FodelseLand_EU27_2020)                       1 894196
## - factor(rokare)                                      1 894642
## - factor(hba1c_high)                                  1 894730
## - rcs(time_to_cpap_start)                             4 894858
## - factor(antithrombotic_agents)                       1 896403
## - factor(stroke_history)                              1 898883
## - rcs(alder)                                          4 907606
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893861.3
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 893596
## + rcs(Raks_AndelSjukInk)                              4 893643
## + factor(GFR_high)                                    1 893699
## + rcs(Raks_AndelEkBisInk)                             4 893724
## + rcs(Raks_AndelArblosInk)                            4 893776
## + factor(systoliskt_high)                             1 893787
## + factor(Sun2000niva_old)                             6 893832
## + factor(antihypertensive_comb)                       1 893835
## + factor(kolesterol_high)                             1 893838
## + rcs(bmi)                                            4 893839
## + factor(lipid_modifying_agents)                      1 893845
## + factor(Civil)                                       1 893857
## <none>                                                  893861
## + factor(FodelseLand_EU27_2020)                       1 893861
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893862
## + factor(ami_history)                                 1 893863
## - factor(sex)                                         1 894195
## - factor(rokare)                                      1 894315
## - factor(hba1c_high)                                  1 894381
## - rcs(time_to_cpap_start)                             4 894547
## - factor(antithrombotic_agents)                       1 895871
## - factor(stroke_history)                              1 898578
## - rcs(alder)                                          4 907607
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893596.2
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 14,15,16,17 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelSjukInk)                              4 893357
## + factor(GFR_high)                                    1 893441
## + rcs(Raks_AndelEkBisInk)                             4 893502
## + rcs(Raks_AndelArblosInk)                            4 893503
## + factor(systoliskt_high)                             1 893518
## + factor(antihypertensive_comb)                       1 893567
## + rcs(bmi)                                            4 893571
## + factor(kolesterol_high)                             1 893571
## + factor(lipid_modifying_agents)                      1 893582
## + factor(Sun2000niva_old)                             6 893588
## + factor(Civil)                                       1 893595
## + factor(FodelseLand_EU27_2020)                       1 893596
## <none>                                                  893596
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893596
## + factor(ami_history)                                 1 893598
## - rcs(DispInkKEHB04)                                  4 893861
## - factor(rokare)                                      1 894004
## - factor(sex)                                         1 894020
## - factor(hba1c_high)                                  1 894084
## - rcs(time_to_cpap_start)                             4 894118
## - factor(antithrombotic_agents)                       1 895577
## - factor(stroke_history)                              1 898329
## - rcs(alder)                                          4 905744
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893357.1
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 14 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(GFR_high)                                    1 893203
## + factor(systoliskt_high)                             1 893278
## + rcs(Raks_AndelEkBisInk)                             4 893283
## + rcs(Raks_AndelArblosInk)                            4 893293
## + factor(antihypertensive_comb)                       1 893328
## + rcs(bmi)                                            4 893330
## + factor(kolesterol_high)                             1 893333
## + factor(lipid_modifying_agents)                      1 893344
## + factor(Sun2000niva_old)                             6 893350
## + factor(Civil)                                       1 893356
## + factor(FodelseLand_EU27_2020)                       1 893357
## <none>                                                  893357
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893357
## + factor(ami_history)                                 1 893359
## - rcs(Raks_AndelSjukInk)                              4 893596
## - rcs(DispInkKEHB04)                                  4 893643
## - factor(rokare)                                      1 893763
## - factor(sex)                                         1 893797
## - factor(hba1c_high)                                  1 893843
## - rcs(time_to_cpap_start)                             4 893889
## - factor(antithrombotic_agents)                       1 895309
## - factor(stroke_history)                              1 898111
## - rcs(alder)                                          4 905561
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893203.5
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 14 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(systoliskt_high)                             1 893115
## + rcs(Raks_AndelEkBisInk)                             4 893129
## + rcs(Raks_AndelArblosInk)                            4 893140
## + rcs(alder):factor(GFR_high)                         4 893147
## + rcs(bmi)                                            4 893170
## + factor(kolesterol_high)                             1 893181
## + factor(antihypertensive_comb)                       1 893184
## + factor(lipid_modifying_agents)                      1 893187
## + factor(Sun2000niva_old)                             6 893196
## + factor(Civil)                                       1 893203
## <none>                                                  893203
## + factor(FodelseLand_EU27_2020)                       1 893204
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893204
## + factor(cpap_treated):factor(GFR_high)               1 893205
## + factor(ami_history)                                 1 893205
## - factor(GFR_high)                                    1 893357
## - rcs(Raks_AndelSjukInk)                              4 893441
## - rcs(DispInkKEHB04)                                  4 893483
## - factor(rokare)                                      1 893621
## - factor(sex)                                         1 893679
## - factor(hba1c_high)                                  1 893683
## - rcs(time_to_cpap_start)                             4 893720
## - factor(antithrombotic_agents)                       1 895072
## - factor(stroke_history)                              1 897975
## - rcs(alder)                                          4 904119
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893115
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 10,14,16,17 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelEkBisInk)                             4 893039
## + rcs(Raks_AndelArblosInk)                            4 893050
## + rcs(alder):factor(GFR_high)                         4 893059
## + rcs(bmi)                                            4 893082
## + factor(kolesterol_high)                             1 893096
## + factor(lipid_modifying_agents)                      1 893100
## + factor(antihypertensive_comb)                       1 893102
## + factor(Sun2000niva_old)                             6 893108
## + factor(Civil)                                       1 893115
## <none>                                                  893115
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893115
## + factor(FodelseLand_EU27_2020)                       1 893115
## + factor(cpap_treated):factor(GFR_high)               1 893117
## + factor(ami_history)                                 1 893117
## - factor(systoliskt_high)                             1 893203
## - factor(GFR_high)                                    1 893278
## - rcs(Raks_AndelSjukInk)                              4 893354
## - rcs(DispInkKEHB04)                                  4 893397
## - factor(rokare)                                      1 893533
## - factor(hba1c_high)                                  1 893581
## - factor(sex)                                         1 893597
## - rcs(time_to_cpap_start)                             4 893618
## - factor(antithrombotic_agents)                       1 895026
## - factor(stroke_history)                              1 897873
## - rcs(alder)                                          4 903677
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=893038.6
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(alder):factor(GFR_high)                         4 892983
## + rcs(Raks_AndelArblosInk)                            4 892991
## + rcs(bmi)                                            4 893006
## + factor(kolesterol_high)                             1 893019
## + factor(antihypertensive_comb)                       1 893024
## + factor(lipid_modifying_agents)                      1 893025
## + factor(FodelseLand_EU27_2020)                       1 893032
## + factor(Sun2000niva_old)                             6 893032
## + factor(Civil)                                       1 893038
## <none>                                                  893039
## + factor(cpap_treated):factor(antithrombotic_agents)  1 893039
## + factor(cpap_treated):factor(GFR_high)               1 893040
## + factor(ami_history)                                 1 893041
## - rcs(Raks_AndelEkBisInk)                             4 893115
## - factor(systoliskt_high)                             1 893129
## - factor(GFR_high)                                    1 893203
## - rcs(Raks_AndelSjukInk)                              4 893258
## - rcs(DispInkKEHB04)                                  4 893270
## - factor(rokare)                                      1 893448
## - factor(hba1c_high)                                  1 893500
## - factor(sex)                                         1 893513
## - rcs(time_to_cpap_start)                             4 893554
## - factor(antithrombotic_agents)                       1 894953
## - factor(stroke_history)                              1 897794
## - rcs(alder)                                          4 903451
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892983
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(Raks_AndelArblosInk)                            4 892935
## + rcs(bmi)                                            4 892950
## + factor(kolesterol_high)                             1 892963
## + factor(lipid_modifying_agents)                      1 892969
## + factor(antihypertensive_comb)                       1 892969
## + factor(FodelseLand_EU27_2020)                       1 892977
## + factor(Sun2000niva_old)                             6 892977
## + factor(Civil)                                       1 892982
## <none>                                                  892983
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892983
## + factor(cpap_treated):factor(GFR_high)               1 892983
## + factor(ami_history)                                 1 892985
## - rcs(alder):factor(GFR_high)                         4 893039
## - rcs(Raks_AndelEkBisInk)                             4 893059
## - factor(systoliskt_high)                             1 893073
## - rcs(Raks_AndelSjukInk)                              4 893199
## - rcs(DispInkKEHB04)                                  4 893212
## - factor(rokare)                                      1 893395
## - factor(hba1c_high)                                  1 893445
## - factor(sex)                                         1 893459
## - rcs(time_to_cpap_start)                             4 893498
## - factor(antithrombotic_agents)                       1 894887
## - factor(stroke_history)                              1 897738
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892934.5
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(bmi)                                            4 892902
## + factor(kolesterol_high)                             1 892915
## + factor(antihypertensive_comb)                       1 892920
## + factor(lipid_modifying_agents)                      1 892921
## + factor(FodelseLand_EU27_2020)                       1 892928
## + factor(Sun2000niva_old)                             6 892929
## + factor(Civil)                                       1 892933
## <none>                                                  892935
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892935
## + factor(cpap_treated):factor(GFR_high)               1 892935
## + factor(ami_history)                                 1 892937
## - rcs(Raks_AndelArblosInk)                            4 892983
## - rcs(alder):factor(GFR_high)                         4 892991
## - rcs(Raks_AndelEkBisInk)                             4 892994
## - factor(systoliskt_high)                             1 893025
## - rcs(Raks_AndelSjukInk)                              4 893127
## - rcs(DispInkKEHB04)                                  4 893170
## - factor(rokare)                                      1 893347
## - factor(hba1c_high)                                  1 893397
## - factor(sex)                                         1 893411
## - rcs(time_to_cpap_start)                             4 893445
## - factor(antithrombotic_agents)                       1 894844
## - factor(stroke_history)                              1 897691
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892901.7
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(kolesterol_high)                             1 892882
## + factor(antihypertensive_comb)                       1 892885
## + factor(lipid_modifying_agents)                      1 892889
## + factor(FodelseLand_EU27_2020)                       1 892895
## + factor(Sun2000niva_old)                             6 892896
## + factor(Civil)                                       1 892901
## <none>                                                  892902
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892902
## + factor(cpap_treated):factor(GFR_high)               1 892902
## + factor(ami_history)                                 1 892904
## + rcs(alder):rcs(bmi)                                16 892917
## - rcs(bmi)                                            4 892935
## - rcs(Raks_AndelArblosInk)                            4 892950
## - rcs(alder):factor(GFR_high)                         4 892958
## - rcs(Raks_AndelEkBisInk)                             4 892961
## - factor(systoliskt_high)                             1 892991
## - rcs(Raks_AndelSjukInk)                              4 893096
## - rcs(DispInkKEHB04)                                  4 893143
## - factor(rokare)                                      1 893297
## - factor(sex)                                         1 893357
## - factor(hba1c_high)                                  1 893369
## - rcs(time_to_cpap_start)                             4 893403
## - factor(antithrombotic_agents)                       1 894821
## - factor(stroke_history)                              1 897667
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892881.5
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(antihypertensive_comb)                       1 892863
## + factor(lipid_modifying_agents)                      1 892873
## + factor(FodelseLand_EU27_2020)                       1 892875
## + factor(Sun2000niva_old)                             6 892876
## + factor(Civil)                                       1 892880
## <none>                                                  892882
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892882
## + factor(cpap_treated):factor(GFR_high)               1 892882
## + factor(ami_history)                                 1 892883
## + rcs(alder):rcs(bmi)                                16 892896
## - factor(kolesterol_high)                             1 892902
## - rcs(bmi)                                            4 892915
## - rcs(Raks_AndelArblosInk)                            4 892930
## - rcs(alder):factor(GFR_high)                         4 892938
## - rcs(Raks_AndelEkBisInk)                             4 892941
## - factor(systoliskt_high)                             1 892968
## - rcs(Raks_AndelSjukInk)                              4 893075
## - rcs(DispInkKEHB04)                                  4 893124
## - factor(rokare)                                      1 893277
## - factor(hba1c_high)                                  1 893350
## - factor(sex)                                         1 893352
## - rcs(time_to_cpap_start)                             4 893392
## - factor(antithrombotic_agents)                       1 894822
## - factor(stroke_history)                              1 897632
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892862.7
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(lipid_modifying_agents)                      1 892850
## + factor(FodelseLand_EU27_2020)                       1 892857
## + factor(Sun2000niva_old)                             6 892857
## + factor(Civil)                                       1 892862
## <none>                                                  892863
## + factor(cpap_treated):factor(antithrombotic_agents)  1 892863
## + factor(cpap_treated):factor(GFR_high)               1 892863
## + factor(cpap_treated):factor(antihypertensive_comb)  1 892865
## + factor(ami_history)                                 1 892865
## + rcs(alder):rcs(bmi)                                16 892877
## - factor(antihypertensive_comb)                       1 892882
## - factor(kolesterol_high)                             1 892885
## - rcs(bmi)                                            4 892899
## - rcs(Raks_AndelArblosInk)                            4 892912
## - rcs(alder):factor(GFR_high)                         4 892918
## - rcs(Raks_AndelEkBisInk)                             4 892924
## - factor(systoliskt_high)                             1 892942
## - rcs(Raks_AndelSjukInk)                              4 893056
## - rcs(DispInkKEHB04)                                  4 893107
## - factor(rokare)                                      1 893261
## - factor(sex)                                         1 893329
## - factor(hba1c_high)                                  1 893334
## - rcs(time_to_cpap_start)                             4 893371
## - factor(antithrombotic_agents)                       1 894679
## - factor(stroke_history)                              1 897616
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892849.6
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + factor(lipid_modifying_agents) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(FodelseLand_EU27_2020)                        1 892844
## + factor(Sun2000niva_old)                              6 892844
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 892847
## + factor(Civil)                                        1 892849
## <none>                                                   892850
## + factor(cpap_treated):factor(antithrombotic_agents)   1 892850
## + factor(cpap_treated):factor(GFR_high)                1 892850
## + factor(ami_history)                                  1 892851
## + factor(cpap_treated):factor(antihypertensive_comb)   1 892852
## - factor(lipid_modifying_agents)                       1 892863
## + rcs(alder):rcs(bmi)                                 16 892865
## - factor(kolesterol_high)                              1 892866
## - factor(antihypertensive_comb)                        1 892873
## - rcs(bmi)                                             4 892886
## - rcs(Raks_AndelArblosInk)                             4 892898
## - rcs(alder):factor(GFR_high)                          4 892906
## - rcs(Raks_AndelEkBisInk)                              4 892911
## - factor(systoliskt_high)                              1 892926
## - rcs(Raks_AndelSjukInk)                               4 893042
## - rcs(DispInkKEHB04)                                   4 893092
## - factor(rokare)                                       1 893248
## - factor(sex)                                          1 893315
## - factor(hba1c_high)                                   1 893323
## - rcs(time_to_cpap_start)                              4 893360
## - factor(antithrombotic_agents)                        1 894642
## - factor(stroke_history)                               1 897580
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892843.6
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(Sun2000niva_old)                              6 892839
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 892841
## + factor(Civil)                                        1 892843
## <none>                                                   892844
## + factor(cpap_treated):factor(antithrombotic_agents)   1 892844
## + factor(cpap_treated):factor(GFR_high)                1 892844
## + factor(ami_history)                                  1 892845
## + factor(cpap_treated):factor(antihypertensive_comb)   1 892846
## - factor(FodelseLand_EU27_2020)                        1 892850
## - factor(lipid_modifying_agents)                       1 892857
## + rcs(alder):rcs(bmi)                                 16 892859
## - factor(kolesterol_high)                              1 892859
## - factor(antihypertensive_comb)                        1 892866
## - rcs(bmi)                                             4 892880
## - rcs(Raks_AndelArblosInk)                             4 892892
## - rcs(alder):factor(GFR_high)                          4 892899
## - rcs(Raks_AndelEkBisInk)                              4 892911
## - factor(systoliskt_high)                              1 892920
## - rcs(Raks_AndelSjukInk)                               4 893036
## - rcs(DispInkKEHB04)                                   4 893094
## - factor(rokare)                                       1 893244
## - factor(sex)                                          1 893307
## - factor(hba1c_high)                                   1 893318
## - rcs(time_to_cpap_start)                              4 893346
## - factor(antithrombotic_agents)                        1 894636
## - factor(stroke_history)                               1 897575
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892838.5
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(Sun2000niva_old) + 
##     rcs(alder):factor(GFR_high)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 892836
## + factor(Civil)                                        1 892837
## <none>                                                   892839
## + factor(cpap_treated):factor(antithrombotic_agents)   1 892839
## + factor(cpap_treated):factor(GFR_high)                1 892839
## + factor(ami_history)                                  1 892840
## + factor(cpap_treated):factor(antihypertensive_comb)   1 892840
## - factor(Sun2000niva_old)                              6 892844
## - factor(FodelseLand_EU27_2020)                        1 892844
## - factor(lipid_modifying_agents)                       1 892852
## + rcs(alder):rcs(bmi)                                 16 892854
## - factor(kolesterol_high)                              1 892854
## - factor(antihypertensive_comb)                        1 892861
## - rcs(bmi)                                             4 892875
## - rcs(Raks_AndelArblosInk)                             4 892887
## - rcs(alder):factor(GFR_high)                          4 892894
## - rcs(Raks_AndelEkBisInk)                              4 892905
## - factor(systoliskt_high)                              1 892915
## - rcs(Raks_AndelSjukInk)                               4 893030
## - rcs(DispInkKEHB04)                                   4 893068
## - factor(rokare)                                       1 893235
## - factor(sex)                                          1 893302
## - factor(hba1c_high)                                   1 893314
## - rcs(time_to_cpap_start)                              4 893349
## - factor(antithrombotic_agents)                        1 894630
## - factor(stroke_history)                               1 897570
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892836.3
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(Sun2000niva_old) + 
##     rcs(alder):factor(GFR_high) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## + factor(Civil)                                        1 892835
## <none>                                                   892836
## + factor(cpap_treated):factor(GFR_high)                1 892837
## + factor(cpap_treated):factor(antithrombotic_agents)   1 892838
## + factor(ami_history)                                  1 892838
## + factor(cpap_treated):factor(antihypertensive_comb)   1 892838
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 892839
## - factor(Sun2000niva_old)                              6 892841
## - factor(FodelseLand_EU27_2020)                        1 892842
## + rcs(alder):rcs(bmi)                                 16 892852
## - factor(kolesterol_high)                              1 892852
## - factor(antihypertensive_comb)                        1 892859
## - rcs(bmi)                                             4 892873
## - rcs(Raks_AndelArblosInk)                             4 892885
## - rcs(alder):factor(GFR_high)                          4 892892
## - rcs(Raks_AndelEkBisInk)                              4 892903
## - factor(systoliskt_high)                              1 892912
## - rcs(Raks_AndelSjukInk)                               4 893027
## - rcs(DispInkKEHB04)                                   4 893066
## - factor(rokare)                                       1 893233
## - factor(sex)                                          1 893300
## - factor(hba1c_high)                                   1 893311
## - rcs(time_to_cpap_start)                              4 893346
## - factor(antithrombotic_agents)                        1 894628
## - factor(stroke_history)                               1 897569
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=892835.2
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(Sun2000niva_old) + 
##     factor(Civil) + rcs(alder):factor(GFR_high) + factor(cpap_treated):factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                       Df    AIC
## <none>                                                   892835
## + factor(cpap_treated):factor(GFR_high)                1 892836
## - factor(Civil)                                        1 892836
## + factor(cpap_treated):factor(antithrombotic_agents)   1 892837
## + factor(ami_history)                                  1 892837
## + factor(cpap_treated):factor(antihypertensive_comb)   1 892837
## - factor(cpap_treated):factor(lipid_modifying_agents)  1 892837
## - factor(Sun2000niva_old)                              6 892840
## - factor(FodelseLand_EU27_2020)                        1 892841
## + rcs(alder):rcs(bmi)                                 16 892850
## - factor(kolesterol_high)                              1 892851
## - factor(antihypertensive_comb)                        1 892858
## - rcs(bmi)                                             4 892871
## - rcs(Raks_AndelArblosInk)                             4 892884
## - rcs(alder):factor(GFR_high)                          4 892891
## - rcs(Raks_AndelEkBisInk)                              4 892903
## - factor(systoliskt_high)                              1 892911
## - rcs(Raks_AndelSjukInk)                               4 893026
## - rcs(DispInkKEHB04)                                   4 893062
## - factor(rokare)                                       1 893232
## - factor(sex)                                          1 893291
## - factor(hba1c_high)                                   1 893310
## - rcs(time_to_cpap_start)                              4 893344
## - factor(antithrombotic_agents)                        1 894626
## - factor(stroke_history)                               1 897567
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(time_to_cpap_start) + factor(hba1c_high) + factor(rokare) + 
##     factor(sex) + rcs(DispInkKEHB04) + rcs(Raks_AndelSjukInk) + 
##     factor(GFR_high) + factor(systoliskt_high) + rcs(Raks_AndelEkBisInk) + 
##     rcs(Raks_AndelArblosInk) + rcs(bmi) + factor(kolesterol_high) + 
##     factor(antihypertensive_comb) + factor(lipid_modifying_agents) + 
##     factor(FodelseLand_EU27_2020) + factor(Sun2000niva_old) + 
##     factor(Civil) + rcs(alder):factor(GFR_high) + factor(cpap_treated):factor(lipid_modifying_agents), 
##     data = df_train)
## 
##   n= 562724, number of events= 36038 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                   4.420e-01   1.556e+00
## rcs(alder)alder                                         6.182e-01   1.856e+00
## rcs(alder)alder'                                       -4.556e-01   6.341e-01
## rcs(alder)alder''                                       3.842e+00   4.662e+01
## rcs(alder)alder'''                                     -7.420e+00   5.992e-04
## factor(stroke_history)1                                -1.673e+01   5.407e-08
## factor(antithrombotic_agents)1                          4.949e-01   1.640e+00
## rcs(time_to_cpap_start)time_to_cpap_start               1.769e-01   1.194e+00
## rcs(time_to_cpap_start)time_to_cpap_start'              1.993e-02   1.020e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            -2.653e-02   9.738e-01
## rcs(time_to_cpap_start)time_to_cpap_start'''            1.618e-01   1.176e+00
## factor(hba1c_high)1                                     2.556e-01   1.291e+00
## factor(rokare)1                                         3.018e-01   1.352e+00
## factor(sex)1                                           -2.499e-01   7.789e-01
## rcs(DispInkKEHB04)DispInkKEHB04                         3.411e-02   1.035e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       -1.455e+01   4.821e-07
## rcs(DispInkKEHB04)DispInkKEHB04''                       3.282e+01   1.786e+14
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -1.770e+01   2.048e-08
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 2.699e+00   1.487e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -3.875e+03   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               4.729e+03         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             -8.619e+02   0.000e+00
## factor(GFR_high)1                                      -5.303e-01   5.884e-01
## factor(systoliskt_high)1                                1.110e-01   1.117e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.755e+00   5.785e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -3.911e+02  1.467e-170
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             4.273e+02  3.631e+185
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           -3.655e+01   1.338e-16
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             2.673e+00   1.448e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -1.726e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           2.005e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         -2.830e+02  1.211e-123
## rcs(bmi)bmi                                            -1.173e-01   8.893e-01
## rcs(bmi)bmi'                                            1.063e+00   2.895e+00
## rcs(bmi)bmi''                                          -6.806e+00   1.107e-03
## rcs(bmi)bmi'''                                          9.985e+00   2.170e+04
## factor(kolesterol_high)1                                5.308e-02   1.055e+00
## factor(antihypertensive_comb)1                          6.032e-02   1.062e+00
## factor(lipid_modifying_agents)1                        -4.258e-02   9.583e-01
## factor(FodelseLand_EU27_2020)1                          4.117e-02   1.042e+00
## factor(Sun2000niva_old)2                                7.240e-02   1.075e+00
## factor(Sun2000niva_old)3                                2.996e-02   1.030e+00
## factor(Sun2000niva_old)4                                1.711e-02   1.017e+00
## factor(Sun2000niva_old)5                                3.349e-02   1.034e+00
## factor(Sun2000niva_old)6                               -7.299e-03   9.927e-01
## factor(Sun2000niva_old)7                                5.521e-02   1.057e+00
## factor(Civil)1                                          2.679e-02   1.027e+00
## rcs(alder)alder:factor(GFR_high)1                       1.877e-01   1.206e+00
## rcs(alder)alder':factor(GFR_high)1                      5.984e-01   1.819e+00
## rcs(alder)alder'':factor(GFR_high)1                    -4.224e+00   1.464e-02
## rcs(alder)alder''':factor(GFR_high)1                    6.350e+00   5.725e+02
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  -2.137e-01   8.076e-01
##                                                          se(coef)       z
## factor(cpap_treated)1                                   7.680e-02   5.755
## rcs(alder)alder                                         2.936e-01   2.106
## rcs(alder)alder'                                        7.192e-01  -0.633
## rcs(alder)alder''                                       3.400e+00   1.130
## rcs(alder)alder'''                                      4.742e+00  -1.565
## factor(stroke_history)1                                 8.593e+01  -0.195
## factor(antithrombotic_agents)1                          1.177e-02  42.055
## rcs(time_to_cpap_start)time_to_cpap_start               5.682e-02   3.114
## rcs(time_to_cpap_start)time_to_cpap_start'              1.278e-01   0.156
## rcs(time_to_cpap_start)time_to_cpap_start''             4.659e-01  -0.057
## rcs(time_to_cpap_start)time_to_cpap_start'''            2.073e+00   0.078
## factor(hba1c_high)1                                     1.191e-02  21.452
## factor(rokare)1                                         1.465e-02  20.598
## factor(sex)1                                            1.175e-02 -21.264
## rcs(DispInkKEHB04)DispInkKEHB04                         1.419e-01   0.240
## rcs(DispInkKEHB04)DispInkKEHB04'                        3.351e+00  -4.340
## rcs(DispInkKEHB04)DispInkKEHB04''                       9.961e+00   3.294
## rcs(DispInkKEHB04)DispInkKEHB04'''                      9.336e+00  -1.896
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 4.593e-01   5.877
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                7.800e+02  -4.968
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               9.558e+02   4.948
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              1.781e+02  -4.838
## factor(GFR_high)1                                       3.212e-01  -1.651
## factor(systoliskt_high)1                                1.269e-02   8.747
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               2.433e-01   7.215
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              6.488e+01  -6.027
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             7.132e+01   5.991
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''            6.695e+00  -5.459
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             3.583e-01   7.458
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'            2.496e+02  -6.916
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           2.910e+02   6.888
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          4.258e+01  -6.647
## rcs(bmi)bmi                                             3.285e-02  -3.570
## rcs(bmi)bmi'                                            2.437e-01   4.361
## rcs(bmi)bmi''                                           1.347e+00  -5.053
## rcs(bmi)bmi'''                                          1.861e+00   5.367
## factor(kolesterol_high)1                                1.254e-02   4.234
## factor(antihypertensive_comb)1                          1.221e-02   4.942
## factor(lipid_modifying_agents)1                         1.155e-02  -3.686
## factor(FodelseLand_EU27_2020)1                          1.490e-02   2.763
## factor(Sun2000niva_old)2                                1.983e-02   3.652
## factor(Sun2000niva_old)3                                1.385e-02   2.164
## factor(Sun2000niva_old)4                                1.919e-02   0.892
## factor(Sun2000niva_old)5                                2.162e-02   1.549
## factor(Sun2000niva_old)6                                2.172e-02  -0.336
## factor(Sun2000niva_old)7                                6.915e-02   0.798
## factor(Civil)1                                          1.531e-02   1.750
## rcs(alder)alder:factor(GFR_high)1                       2.980e-01   0.630
## rcs(alder)alder':factor(GFR_high)1                      7.354e-01   0.814
## rcs(alder)alder'':factor(GFR_high)1                     3.516e+00  -1.201
## rcs(alder)alder''':factor(GFR_high)1                    4.994e+00   1.271
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.034e-01  -2.068
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                 8.68e-09 ***
## rcs(alder)alder                                       0.035212 *  
## rcs(alder)alder'                                      0.526433    
## rcs(alder)alder''                                     0.258504    
## rcs(alder)alder'''                                    0.117625    
## factor(stroke_history)1                               0.845606    
## factor(antithrombotic_agents)1                         < 2e-16 ***
## rcs(time_to_cpap_start)time_to_cpap_start             0.001848 ** 
## rcs(time_to_cpap_start)time_to_cpap_start'            0.876029    
## rcs(time_to_cpap_start)time_to_cpap_start''           0.954591    
## rcs(time_to_cpap_start)time_to_cpap_start'''          0.937775    
## factor(hba1c_high)1                                    < 2e-16 ***
## factor(rokare)1                                        < 2e-16 ***
## factor(sex)1                                           < 2e-16 ***
## rcs(DispInkKEHB04)DispInkKEHB04                       0.810099    
## rcs(DispInkKEHB04)DispInkKEHB04'                      1.42e-05 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                     0.000986 ***
## rcs(DispInkKEHB04)DispInkKEHB04'''                    0.057929 .  
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               4.18e-09 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              6.77e-07 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             7.50e-07 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            1.31e-06 ***
## factor(GFR_high)1                                     0.098785 .  
## factor(systoliskt_high)1                               < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             5.38e-13 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            1.67e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           2.09e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''          4.78e-08 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           8.75e-14 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          4.63e-12 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''         5.66e-12 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        2.98e-11 ***
## rcs(bmi)bmi                                           0.000357 ***
## rcs(bmi)bmi'                                          1.30e-05 ***
## rcs(bmi)bmi''                                         4.36e-07 ***
## rcs(bmi)bmi'''                                        8.01e-08 ***
## factor(kolesterol_high)1                              2.30e-05 ***
## factor(antihypertensive_comb)1                        7.74e-07 ***
## factor(lipid_modifying_agents)1                       0.000228 ***
## factor(FodelseLand_EU27_2020)1                        0.005720 ** 
## factor(Sun2000niva_old)2                              0.000260 ***
## factor(Sun2000niva_old)3                              0.030487 *  
## factor(Sun2000niva_old)4                              0.372650    
## factor(Sun2000niva_old)5                              0.121346    
## factor(Sun2000niva_old)6                              0.736812    
## factor(Sun2000niva_old)7                              0.424654    
## factor(Civil)1                                        0.080087 .  
## rcs(alder)alder:factor(GFR_high)1                     0.528734    
## rcs(alder)alder':factor(GFR_high)1                    0.415814    
## rcs(alder)alder'':factor(GFR_high)1                   0.229698    
## rcs(alder)alder''':factor(GFR_high)1                  0.203576    
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.038655 *  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  1.556e+00  6.428e-01
## rcs(alder)alder                                        1.856e+00  5.389e-01
## rcs(alder)alder'                                       6.341e-01  1.577e+00
## rcs(alder)alder''                                      4.662e+01  2.145e-02
## rcs(alder)alder'''                                     5.992e-04  1.669e+03
## factor(stroke_history)1                                5.407e-08  1.850e+07
## factor(antithrombotic_agents)1                         1.640e+00  6.096e-01
## rcs(time_to_cpap_start)time_to_cpap_start              1.194e+00  8.379e-01
## rcs(time_to_cpap_start)time_to_cpap_start'             1.020e+00  9.803e-01
## rcs(time_to_cpap_start)time_to_cpap_start''            9.738e-01  1.027e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           1.176e+00  8.506e-01
## factor(hba1c_high)1                                    1.291e+00  7.745e-01
## factor(rokare)1                                        1.352e+00  7.395e-01
## factor(sex)1                                           7.789e-01  1.284e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        1.035e+00  9.665e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       4.821e-07  2.074e+06
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.786e+14  5.600e-15
## rcs(DispInkKEHB04)DispInkKEHB04'''                     2.048e-08  4.883e+07
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                1.487e+01  6.724e-02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00        Inf
## factor(GFR_high)1                                      5.884e-01  1.699e+00
## factor(systoliskt_high)1                               1.117e+00  8.949e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              5.785e+00  1.728e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            1.467e-170 6.815e+169
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           3.631e+185 2.754e-186
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           1.338e-16  7.474e+15
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            1.448e+01  6.907e-02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        1.211e-123 8.261e+122
## rcs(bmi)bmi                                            8.893e-01  1.124e+00
## rcs(bmi)bmi'                                           2.895e+00  3.455e-01
## rcs(bmi)bmi''                                          1.107e-03  9.031e+02
## rcs(bmi)bmi'''                                         2.170e+04  4.608e-05
## factor(kolesterol_high)1                               1.055e+00  9.483e-01
## factor(antihypertensive_comb)1                         1.062e+00  9.415e-01
## factor(lipid_modifying_agents)1                        9.583e-01  1.044e+00
## factor(FodelseLand_EU27_2020)1                         1.042e+00  9.597e-01
## factor(Sun2000niva_old)2                               1.075e+00  9.302e-01
## factor(Sun2000niva_old)3                               1.030e+00  9.705e-01
## factor(Sun2000niva_old)4                               1.017e+00  9.830e-01
## factor(Sun2000niva_old)5                               1.034e+00  9.671e-01
## factor(Sun2000niva_old)6                               9.927e-01  1.007e+00
## factor(Sun2000niva_old)7                               1.057e+00  9.463e-01
## factor(Civil)1                                         1.027e+00  9.736e-01
## rcs(alder)alder:factor(GFR_high)1                      1.206e+00  8.289e-01
## rcs(alder)alder':factor(GFR_high)1                     1.819e+00  5.497e-01
## rcs(alder)alder'':factor(GFR_high)1                    1.464e-02  6.829e+01
## rcs(alder)alder''':factor(GFR_high)1                   5.725e+02  1.747e-03
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  8.076e-01  1.238e+00
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  1.338e+00  1.809e+00
## rcs(alder)alder                                        1.044e+00  3.299e+00
## rcs(alder)alder'                                       1.548e-01  2.596e+00
## rcs(alder)alder''                                      5.947e-02  3.655e+04
## rcs(alder)alder'''                                     5.513e-08  6.512e+00
## factor(stroke_history)1                                3.880e-81  7.534e+65
## factor(antithrombotic_agents)1                         1.603e+00  1.679e+00
## rcs(time_to_cpap_start)time_to_cpap_start              1.068e+00  1.334e+00
## rcs(time_to_cpap_start)time_to_cpap_start'             7.942e-01  1.310e+00
## rcs(time_to_cpap_start)time_to_cpap_start''            3.907e-01  2.427e+00
## rcs(time_to_cpap_start)time_to_cpap_start'''           2.023e-02  6.831e+01
## factor(hba1c_high)1                                    1.261e+00  1.322e+00
## factor(rokare)1                                        1.314e+00  1.392e+00
## factor(sex)1                                           7.611e-01  7.970e-01
## rcs(DispInkKEHB04)DispInkKEHB04                        7.834e-01  1.367e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       6.768e-10  3.434e-04
## rcs(DispInkKEHB04)DispInkKEHB04''                      5.929e+05  5.379e+22
## rcs(DispInkKEHB04)DispInkKEHB04'''                     2.314e-16  1.813e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                6.045e+00  3.659e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00 2.160e-223
## factor(GFR_high)1                                      3.135e-01  1.104e+00
## factor(systoliskt_high)1                               1.090e+00  1.146e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              3.591e+00  9.320e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            8.680e-226 2.481e-115
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           7.120e+124 1.852e+246
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'''           2.677e-22  6.686e-11
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            7.173e+00  2.922e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        6.935e-160  2.113e-87
## rcs(bmi)bmi                                            8.339e-01  9.485e-01
## rcs(bmi)bmi'                                           1.795e+00  4.667e+00
## rcs(bmi)bmi''                                          7.902e-05  1.552e-02
## rcs(bmi)bmi'''                                         5.660e+02  8.322e+05
## factor(kolesterol_high)1                               1.029e+00  1.081e+00
## factor(antihypertensive_comb)1                         1.037e+00  1.088e+00
## factor(lipid_modifying_agents)1                        9.369e-01  9.803e-01
## factor(FodelseLand_EU27_2020)1                         1.012e+00  1.073e+00
## factor(Sun2000niva_old)2                               1.034e+00  1.118e+00
## factor(Sun2000niva_old)3                               1.003e+00  1.059e+00
## factor(Sun2000niva_old)4                               9.797e-01  1.056e+00
## factor(Sun2000niva_old)5                               9.912e-01  1.079e+00
## factor(Sun2000niva_old)6                               9.514e-01  1.036e+00
## factor(Sun2000niva_old)7                               9.228e-01  1.210e+00
## factor(Civil)1                                         9.968e-01  1.058e+00
## rcs(alder)alder:factor(GFR_high)1                      6.728e-01  2.163e+00
## rcs(alder)alder':factor(GFR_high)1                     4.304e-01  7.689e+00
## rcs(alder)alder'':factor(GFR_high)1                    1.487e-05  1.442e+01
## rcs(alder)alder''':factor(GFR_high)1                   3.210e-02  1.021e+07
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  6.595e-01  9.889e-01
## 
## Concordance= 0.748  (se = 0.001 )
## Likelihood ratio test= 27342  on 52 df,   p=<2e-16
## Wald test            = 21090  on 52 df,   p=<2e-16
## Score (logrank) test = 27691  on 52 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7480958 
## C-index test: 0.7486143

Group 2

run_models(c(list_forms[["form_stroke_tind_spl"]], list_forms[["form_stroke_tind_cat"]]), df_survival_times_sub_train, df_survival_times_sub_test, "time_to_stroke", "stroke", cont_var_sleep, "prof_stroke_ind_g2.html", bigd=F)

## [1] "### FORMULA 1 ###"
## Start:  AIC=7359.64
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 7258.1
## + factor(antithrombotic_agents)   1 7313.3
## + factor(stroke_history)          1 7337.9
## + rcs(DispInkKEHB04)              4 7344.1
## + rcs(systoliskt)                 4 7348.0
## + factor(lipid_modifying_agents)  1 7354.1
## + factor(antihypertensive_comb)   1 7354.1
## + rcs(bmi)                        4 7355.1
## + rcs(GFR)                        4 7355.8
## + rcs(time_to_cpap_start)         4 7356.5
## + factor(rokare)                  1 7357.7
## + factor(ami_history)             1 7358.6
## + rcs(hba1c)                      4 7359.4
## <none>                              7359.6
## + factor(Civil)                   1 7359.9
## + rcs(Raks_AndelArblosInk)        4 7360.1
## + factor(sex)                     1 7360.1
## + factor(FodelseLand_EU27_2020)   1 7360.5
## + factor(Sun2000niva_old)         6 7360.7
## + rcs(kolesterol)                 4 7363.0
## + rcs(Raks_AndelEkBisInk)         3 7363.7
## + rcs(Raks_AndelSjukInk)          4 7364.4
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=7258.13
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(stroke_history)          1 7229.4
## + rcs(DispInkKEHB04)              4 7238.1
## + factor(antithrombotic_agents)   1 7244.4
## + rcs(hba1c)                      4 7246.6
## + factor(rokare)                  1 7248.5
## + rcs(systoliskt)                 4 7252.4
## + rcs(time_to_cpap_start)         4 7256.1
## + rcs(Raks_AndelEkBisInk)         3 7256.9
## + factor(sex)                     1 7257.8
## <none>                              7258.1
## + factor(lipid_modifying_agents)  1 7259.3
## + factor(ami_history)             1 7259.5
## + factor(Civil)                   1 7259.5
## + factor(FodelseLand_EU27_2020)   1 7259.7
## + factor(antihypertensive_comb)   1 7259.8
## + rcs(Raks_AndelArblosInk)        4 7260.5
## + rcs(GFR)                        4 7262.5
## + rcs(kolesterol)                 4 7262.7
## + rcs(Raks_AndelSjukInk)          4 7264.3
## + rcs(bmi)                        4 7264.6
## + factor(Sun2000niva_old)         6 7265.7
## - rcs(alder)                      4 7359.6
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7229.43
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 7209.5
## + rcs(DispInkKEHB04)              4 7209.6
## + rcs(hba1c)                      4 7218.1
## + factor(rokare)                  1 7219.4
## + rcs(systoliskt)                 4 7223.4
## + rcs(time_to_cpap_start)         4 7227.9
## + rcs(Raks_AndelEkBisInk)         3 7228.1
## + factor(sex)                     1 7228.9
## <none>                              7229.4
## + factor(lipid_modifying_agents)  1 7229.8
## + factor(ami_history)             1 7230.6
## + factor(Civil)                   1 7230.7
## + factor(antihypertensive_comb)   1 7231.0
## + factor(FodelseLand_EU27_2020)   1 7231.1
## + rcs(Raks_AndelArblosInk)        4 7231.9
## + rcs(GFR)                        4 7233.7
## + rcs(kolesterol)                 4 7233.8
## + rcs(Raks_AndelSjukInk)          4 7235.3
## + rcs(bmi)                        4 7235.7
## + factor(Sun2000niva_old)         6 7236.8
## - factor(stroke_history)          1 7258.1
## - rcs(alder)                      4 7337.9
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7209.53
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 7190.9
## + rcs(hba1c)                                          4 7198.5
## + factor(rokare)                                      1 7200.5
## + rcs(systoliskt)                                     4 7201.4
## + rcs(time_to_cpap_start)                             4 7208.4
## + rcs(Raks_AndelEkBisInk)                             3 7208.5
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7208.7
## <none>                                                  7209.5
## + factor(sex)                                         1 7210.4
## + factor(Civil)                                       1 7211.0
## + factor(ami_history)                                 1 7211.3
## + factor(FodelseLand_EU27_2020)                       1 7211.3
## + factor(antihypertensive_comb)                       1 7211.5
## + factor(lipid_modifying_agents)                      1 7211.5
## + rcs(Raks_AndelArblosInk)                            4 7212.1
## + rcs(GFR)                                            4 7213.9
## + rcs(kolesterol)                                     4 7214.9
## + rcs(Raks_AndelSjukInk)                              4 7215.7
## + rcs(bmi)                                            4 7215.8
## + factor(Sun2000niva_old)                             6 7217.7
## - factor(antithrombotic_agents)                       1 7229.4
## - factor(stroke_history)                              1 7244.4
## - rcs(alder)                                          4 7280.3
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7190.94
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(hba1c)                                          4 7181.2
## + rcs(systoliskt)                                     4 7182.6
## + factor(rokare)                                      1 7183.3
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7189.9
## + factor(sex)                                         1 7190.5
## <none>                                                  7190.9
## + factor(Civil)                                       1 7192.0
## + rcs(time_to_cpap_start)                             4 7192.2
## + rcs(Raks_AndelEkBisInk)                             3 7192.6
## + factor(ami_history)                                 1 7192.7
## + factor(FodelseLand_EU27_2020)                       1 7192.7
## + factor(lipid_modifying_agents)                      1 7192.9
## + factor(antihypertensive_comb)                       1 7192.9
## + rcs(Raks_AndelArblosInk)                            4 7193.7
## + rcs(GFR)                                            4 7196.0
## + rcs(kolesterol)                                     4 7196.1
## + rcs(bmi)                                            4 7197.0
## + rcs(Raks_AndelSjukInk)                              4 7197.2
## + factor(Sun2000niva_old)                             6 7201.0
## - rcs(DispInkKEHB04)                                  4 7209.5
## - factor(antithrombotic_agents)                       1 7209.6
## - factor(stroke_history)                              1 7225.4
## - rcs(alder)                                          4 7265.4
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7181.2
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(hba1c)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 7173.5
## + rcs(systoliskt)                                     4 7174.0
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7180.4
## <none>                                                  7181.2
## + factor(sex)                                         1 7181.5
## + factor(Civil)                                       1 7182.4
## + rcs(Raks_AndelEkBisInk)                             3 7182.5
## + factor(FodelseLand_EU27_2020)                       1 7183.1
## + factor(ami_history)                                 1 7183.1
## + factor(lipid_modifying_agents)                      1 7183.2
## + factor(antihypertensive_comb)                       1 7183.2
## + rcs(time_to_cpap_start)                             4 7183.4
## + rcs(Raks_AndelArblosInk)                            4 7184.1
## + rcs(bmi)                                            4 7186.9
## + rcs(kolesterol)                                     4 7187.1
## + rcs(Raks_AndelSjukInk)                              4 7187.4
## + rcs(GFR)                                            4 7187.7
## - rcs(hba1c)                                          4 7190.9
## + factor(Sun2000niva_old)                             6 7191.3
## - rcs(DispInkKEHB04)                                  4 7198.5
## - factor(antithrombotic_agents)                       1 7199.8
## - factor(stroke_history)                              1 7215.4
## - rcs(alder)                                          4 7265.4
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7173.49
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(hba1c) + factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(systoliskt)                                     4 7166.5
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7172.2
## <none>                                                  7173.5
## + factor(sex)                                         1 7173.7
## + factor(Civil)                                       1 7174.6
## + factor(FodelseLand_EU27_2020)                       1 7175.3
## + rcs(Raks_AndelEkBisInk)                             3 7175.4
## + factor(ami_history)                                 1 7175.5
## + factor(lipid_modifying_agents)                      1 7175.5
## + factor(antihypertensive_comb)                       1 7175.5
## + rcs(time_to_cpap_start)                             4 7175.7
## + rcs(Raks_AndelArblosInk)                            4 7176.7
## + rcs(kolesterol)                                     4 7179.5
## + rcs(Raks_AndelSjukInk)                              4 7179.6
## + rcs(bmi)                                            4 7179.6
## + rcs(GFR)                                            4 7180.4
## - factor(rokare)                                      1 7181.2
## - rcs(hba1c)                                          4 7183.3
## + factor(Sun2000niva_old)                             6 7183.6
## - rcs(DispInkKEHB04)                                  4 7189.5
## - factor(antithrombotic_agents)                       1 7191.2
## - factor(stroke_history)                              1 7207.9
## - rcs(alder)                                          4 7264.1
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7166.54
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(hba1c) + factor(rokare) + rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7165.2
## <none>                                                  7166.5
## + factor(sex)                                         1 7166.9
## + factor(Civil)                                       1 7167.7
## + factor(antihypertensive_comb)                       1 7168.3
## + rcs(Raks_AndelEkBisInk)                             3 7168.4
## + factor(FodelseLand_EU27_2020)                       1 7168.5
## + factor(ami_history)                                 1 7168.5
## + factor(lipid_modifying_agents)                      1 7168.5
## + rcs(time_to_cpap_start)                             4 7168.8
## + rcs(Raks_AndelArblosInk)                            4 7169.3
## + rcs(bmi)                                            4 7172.5
## + rcs(Raks_AndelSjukInk)                              4 7172.5
## + rcs(kolesterol)                                     4 7172.5
## - rcs(systoliskt)                                     4 7173.5
## + rcs(GFR)                                            4 7173.6
## - factor(rokare)                                      1 7174.0
## - rcs(hba1c)                                          4 7175.3
## + factor(Sun2000niva_old)                             6 7176.6
## - rcs(DispInkKEHB04)                                  4 7183.0
## - factor(antithrombotic_agents)                       1 7186.2
## - factor(stroke_history)                              1 7201.9
## - rcs(alder)                                          4 7249.0
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7165.23
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(hba1c) + factor(rokare) + rcs(systoliskt) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## <none>                                                  7165.2
## + factor(sex)                                         1 7165.5
## + factor(Civil)                                       1 7166.4
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7166.5
## + factor(antihypertensive_comb)                       1 7166.9
## + rcs(Raks_AndelEkBisInk)                             3 7167.0
## + factor(FodelseLand_EU27_2020)                       1 7167.2
## + factor(lipid_modifying_agents)                      1 7167.2
## + factor(ami_history)                                 1 7167.2
## + rcs(time_to_cpap_start)                             4 7167.5
## + rcs(Raks_AndelArblosInk)                            4 7168.1
## + rcs(bmi)                                            4 7171.1
## + rcs(Raks_AndelSjukInk)                              4 7171.1
## + rcs(kolesterol)                                     4 7171.1
## - rcs(systoliskt)                                     4 7172.2
## + rcs(GFR)                                            4 7172.4
## - factor(rokare)                                      1 7173.2
## - rcs(hba1c)                                          4 7173.7
## + factor(Sun2000niva_old)                             6 7175.3
## - rcs(DispInkKEHB04)                                  4 7181.8
## - factor(stroke_history)                              1 7200.8
## - rcs(alder)                                          4 7248.2
## + factor(HushallsType_RTB)                                    
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(hba1c) + factor(rokare) + rcs(systoliskt) + 
##     factor(cpap_treated):factor(antithrombotic_agents), data = df_train)
## 
##   n= 10603, number of events= 425 
## 
##                                                            coef  exp(coef)
## factor(cpap_treated)1                                 4.005e-01  1.493e+00
## rcs(alder)alder                                       5.157e-01  1.675e+00
## rcs(alder)alder'                                      1.899e-01  1.209e+00
## rcs(alder)alder''                                     5.359e-01  1.709e+00
## rcs(alder)alder'''                                   -4.416e+00  1.209e-02
## factor(stroke_history)1                              -1.675e+01  5.310e-08
## factor(antithrombotic_agents)1                        7.028e-01  2.019e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      -2.252e-01  7.983e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                      4.410e+00  8.223e+01
## rcs(DispInkKEHB04)DispInkKEHB04''                    -3.147e+01  2.154e-14
## rcs(DispInkKEHB04)DispInkKEHB04'''                    5.412e+01  3.192e+23
## rcs(hba1c)hba1c                                      -5.163e-01  5.967e-01
## rcs(hba1c)hba1c'                                      6.184e+00  4.849e+02
## rcs(hba1c)hba1c''                                    -5.531e+00  3.962e-03
## rcs(hba1c)hba1c'''                                   -8.977e+00  1.263e-04
## factor(rokare)1                                       4.125e-01  1.511e+00
## rcs(systoliskt)systoliskt                             3.956e-01  1.485e+00
## rcs(systoliskt)systoliskt'                           -7.433e-01  4.756e-01
## rcs(systoliskt)systoliskt''                           3.385e+00  2.952e+01
## rcs(systoliskt)systoliskt'''                         -4.126e+00  1.614e-02
## factor(cpap_treated)1:factor(antithrombotic_agents)1 -3.649e-01  6.943e-01
##                                                        se(coef)      z Pr(>|z|)
## factor(cpap_treated)1                                 1.395e-01  2.872  0.00408
## rcs(alder)alder                                       3.662e-01  1.408  0.15908
## rcs(alder)alder'                                      1.220e+00  0.156  0.87631
## rcs(alder)alder''                                     6.624e+00  0.081  0.93552
## rcs(alder)alder'''                                    1.068e+01 -0.413  0.67934
## factor(stroke_history)1                               9.808e+02 -0.017  0.98637
## factor(antithrombotic_agents)1                        1.598e-01  4.399 1.09e-05
## rcs(DispInkKEHB04)DispInkKEHB04                       4.992e-01 -0.451  0.65181
## rcs(DispInkKEHB04)DispInkKEHB04'                      7.729e+00  0.571  0.56832
## rcs(DispInkKEHB04)DispInkKEHB04''                     2.785e+01 -1.130  0.25843
## rcs(DispInkKEHB04)DispInkKEHB04'''                    3.262e+01  1.659  0.09710
## rcs(hba1c)hba1c                                       5.796e-01 -0.891  0.37309
## rcs(hba1c)hba1c'                                      1.353e+01  0.457  0.64758
## rcs(hba1c)hba1c''                                     4.551e+01 -0.122  0.90326
## rcs(hba1c)hba1c'''                                    4.294e+01 -0.209  0.83440
## factor(rokare)1                                       1.256e-01  3.283  0.00103
## rcs(systoliskt)systoliskt                             3.149e-01  1.256  0.20907
## rcs(systoliskt)systoliskt'                            1.346e+00 -0.552  0.58085
## rcs(systoliskt)systoliskt''                           9.349e+00  0.362  0.71729
## rcs(systoliskt)systoliskt'''                          1.900e+01 -0.217  0.82809
## factor(cpap_treated)1:factor(antithrombotic_agents)1  2.005e-01 -1.820  0.06872
##                                                         
## factor(cpap_treated)1                                ** 
## rcs(alder)alder                                         
## rcs(alder)alder'                                        
## rcs(alder)alder''                                       
## rcs(alder)alder'''                                      
## factor(stroke_history)1                                 
## factor(antithrombotic_agents)1                       ***
## rcs(DispInkKEHB04)DispInkKEHB04                         
## rcs(DispInkKEHB04)DispInkKEHB04'                        
## rcs(DispInkKEHB04)DispInkKEHB04''                       
## rcs(DispInkKEHB04)DispInkKEHB04'''                   .  
## rcs(hba1c)hba1c                                         
## rcs(hba1c)hba1c'                                        
## rcs(hba1c)hba1c''                                       
## rcs(hba1c)hba1c'''                                      
## factor(rokare)1                                      ** 
## rcs(systoliskt)systoliskt                               
## rcs(systoliskt)systoliskt'                              
## rcs(systoliskt)systoliskt''                             
## rcs(systoliskt)systoliskt'''                            
## factor(cpap_treated)1:factor(antithrombotic_agents)1 .  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                      exp(coef) exp(-coef)
## factor(cpap_treated)1                                1.493e+00  6.700e-01
## rcs(alder)alder                                      1.675e+00  5.971e-01
## rcs(alder)alder'                                     1.209e+00  8.270e-01
## rcs(alder)alder''                                    1.709e+00  5.852e-01
## rcs(alder)alder'''                                   1.209e-02  8.274e+01
## factor(stroke_history)1                              5.310e-08  1.883e+07
## factor(antithrombotic_agents)1                       2.019e+00  4.952e-01
## rcs(DispInkKEHB04)DispInkKEHB04                      7.983e-01  1.253e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     8.223e+01  1.216e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                    2.154e-14  4.643e+13
## rcs(DispInkKEHB04)DispInkKEHB04'''                   3.192e+23  3.132e-24
## rcs(hba1c)hba1c                                      5.967e-01  1.676e+00
## rcs(hba1c)hba1c'                                     4.849e+02  2.062e-03
## rcs(hba1c)hba1c''                                    3.962e-03  2.524e+02
## rcs(hba1c)hba1c'''                                   1.263e-04  7.919e+03
## factor(rokare)1                                      1.511e+00  6.620e-01
## rcs(systoliskt)systoliskt                            1.485e+00  6.733e-01
## rcs(systoliskt)systoliskt'                           4.756e-01  2.103e+00
## rcs(systoliskt)systoliskt''                          2.952e+01  3.387e-02
## rcs(systoliskt)systoliskt'''                         1.614e-02  6.195e+01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 6.943e-01  1.440e+00
##                                                      lower .95 upper .95
## factor(cpap_treated)1                                1.136e+00 1.962e+00
## rcs(alder)alder                                      8.170e-01 3.433e+00
## rcs(alder)alder'                                     1.106e-01 1.322e+01
## rcs(alder)alder''                                    3.931e-06 7.430e+05
## rcs(alder)alder'''                                   9.759e-12 1.497e+07
## factor(stroke_history)1                              0.000e+00       Inf
## factor(antithrombotic_agents)1                       1.476e+00 2.762e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      3.001e-01 2.124e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     2.169e-05 3.118e+08
## rcs(DispInkKEHB04)DispInkKEHB04''                    4.269e-38 1.086e+10
## rcs(DispInkKEHB04)DispInkKEHB04'''                   5.465e-05 1.865e+51
## rcs(hba1c)hba1c                                      1.916e-01 1.859e+00
## rcs(hba1c)hba1c'                                     1.482e-09 1.587e+14
## rcs(hba1c)hba1c''                                    7.285e-42 2.155e+36
## rcs(hba1c)hba1c'''                                   3.561e-41 4.478e+32
## factor(rokare)1                                      1.181e+00 1.932e+00
## rcs(systoliskt)systoliskt                            8.012e-01 2.753e+00
## rcs(systoliskt)systoliskt'                           3.399e-02 6.654e+00
## rcs(systoliskt)systoliskt''                          3.251e-07 2.681e+09
## rcs(systoliskt)systoliskt'''                         1.079e-18 2.414e+14
## factor(cpap_treated)1:factor(antithrombotic_agents)1 4.687e-01 1.028e+00
## 
## Concordance= 0.722  (se = 0.012 )
## Likelihood ratio test= 240.7  on 21 df,   p=<2e-16
## Wald test            = 206.9  on 21 df,   p=<2e-16
## Score (logrank) test = 244.8  on 21 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7218482 
## C-index test: 0.7226362[1] "### FORMULA 2 ###"
## Start:  AIC=7359.64
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 7258.1
## + factor(antithrombotic_agents)   1 7313.3
## + factor(stroke_history)          1 7337.9
## + rcs(DispInkKEHB04)              4 7344.1
## + factor(GFR_high)                1 7353.2
## + factor(lipid_modifying_agents)  1 7354.1
## + factor(antihypertensive_comb)   1 7354.1
## + rcs(bmi)                        4 7355.1
## + factor(systoliskt_high)         1 7356.0
## + rcs(time_to_cpap_start)         4 7356.5
## + factor(rokare)                  1 7357.7
## + factor(hba1c_high)              1 7358.5
## + factor(ami_history)             1 7358.6
## <none>                              7359.6
## + factor(Civil)                   1 7359.9
## + rcs(Raks_AndelArblosInk)        4 7360.1
## + factor(sex)                     1 7360.1
## + factor(FodelseLand_EU27_2020)   1 7360.5
## + factor(Sun2000niva_old)         6 7360.7
## + factor(kolesterol_high)         1 7361.6
## + rcs(Raks_AndelEkBisInk)         3 7363.7
## + rcs(Raks_AndelSjukInk)          4 7364.4
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=7258.13
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(stroke_history)          1 7229.4
## + rcs(DispInkKEHB04)              4 7238.1
## + factor(antithrombotic_agents)   1 7244.4
## + factor(rokare)                  1 7248.5
## + factor(hba1c_high)              1 7255.5
## + rcs(time_to_cpap_start)         4 7256.1
## + rcs(Raks_AndelEkBisInk)         3 7256.9
## + factor(systoliskt_high)         1 7257.2
## + factor(sex)                     1 7257.8
## <none>                              7258.1
## + factor(lipid_modifying_agents)  1 7259.3
## + factor(kolesterol_high)         1 7259.4
## + factor(ami_history)             1 7259.5
## + factor(Civil)                   1 7259.5
## + factor(GFR_high)                1 7259.6
## + factor(FodelseLand_EU27_2020)   1 7259.7
## + factor(antihypertensive_comb)   1 7259.8
## + rcs(Raks_AndelArblosInk)        4 7260.5
## + rcs(Raks_AndelSjukInk)          4 7264.3
## + rcs(bmi)                        4 7264.6
## + factor(Sun2000niva_old)         6 7265.7
## - rcs(alder)                      4 7359.6
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7229.43
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 7209.5
## + rcs(DispInkKEHB04)              4 7209.6
## + factor(rokare)                  1 7219.4
## + factor(hba1c_high)              1 7226.9
## + rcs(time_to_cpap_start)         4 7227.9
## + factor(systoliskt_high)         1 7228.1
## + rcs(Raks_AndelEkBisInk)         3 7228.1
## + factor(sex)                     1 7228.9
## <none>                              7229.4
## + factor(lipid_modifying_agents)  1 7229.8
## + factor(GFR_high)                1 7230.6
## + factor(ami_history)             1 7230.6
## + factor(Civil)                   1 7230.7
## + factor(kolesterol_high)         1 7231.0
## + factor(antihypertensive_comb)   1 7231.0
## + factor(FodelseLand_EU27_2020)   1 7231.1
## + rcs(Raks_AndelArblosInk)        4 7231.9
## + rcs(Raks_AndelSjukInk)          4 7235.3
## + rcs(bmi)                        4 7235.7
## + factor(Sun2000niva_old)         6 7236.8
## - factor(stroke_history)          1 7258.1
## - rcs(alder)                      4 7337.9
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7209.53
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents)

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 7190.9
## + factor(rokare)                                      1 7200.5
## + factor(systoliskt_high)                             1 7207.2
## + factor(hba1c_high)                                  1 7207.7
## + rcs(time_to_cpap_start)                             4 7208.4
## + rcs(Raks_AndelEkBisInk)                             3 7208.5
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7208.7
## + factor(kolesterol_high)                             1 7209.4
## <none>                                                  7209.5
## + factor(sex)                                         1 7210.4
## + factor(Civil)                                       1 7211.0
## + factor(GFR_high)                                    1 7211.1
## + factor(ami_history)                                 1 7211.3
## + factor(FodelseLand_EU27_2020)                       1 7211.3
## + factor(antihypertensive_comb)                       1 7211.5
## + factor(lipid_modifying_agents)                      1 7211.5
## + rcs(Raks_AndelArblosInk)                            4 7212.1
## + rcs(Raks_AndelSjukInk)                              4 7215.7
## + rcs(bmi)                                            4 7215.8
## + factor(Sun2000niva_old)                             6 7217.7
## - factor(antithrombotic_agents)                       1 7229.4
## - factor(stroke_history)                              1 7244.4
## - rcs(alder)                                          4 7280.3
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7190.94
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 7183.3
## + factor(systoliskt_high)                             1 7188.3
## + factor(hba1c_high)                                  1 7189.6
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7189.9
## + factor(sex)                                         1 7190.5
## + factor(kolesterol_high)                             1 7190.6
## <none>                                                  7190.9
## + factor(Civil)                                       1 7192.0
## + rcs(time_to_cpap_start)                             4 7192.2
## + rcs(Raks_AndelEkBisInk)                             3 7192.6
## + factor(GFR_high)                                    1 7192.7
## + factor(ami_history)                                 1 7192.7
## + factor(FodelseLand_EU27_2020)                       1 7192.7
## + factor(lipid_modifying_agents)                      1 7192.9
## + factor(antihypertensive_comb)                       1 7192.9
## + rcs(Raks_AndelArblosInk)                            4 7193.7
## + rcs(bmi)                                            4 7197.0
## + rcs(Raks_AndelSjukInk)                              4 7197.2
## + factor(Sun2000niva_old)                             6 7201.0
## - rcs(DispInkKEHB04)                                  4 7209.5
## - factor(antithrombotic_agents)                       1 7209.6
## - factor(stroke_history)                              1 7225.4
## - rcs(alder)                                          4 7265.4
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7183.29
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(systoliskt_high)                             1 7180.6
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7181.7
## + factor(hba1c_high)                                  1 7182.1
## + factor(sex)                                         1 7182.8
## + factor(kolesterol_high)                             1 7183.1
## <none>                                                  7183.3
## + factor(Civil)                                       1 7184.3
## + rcs(time_to_cpap_start)                             4 7184.5
## + factor(GFR_high)                                    1 7184.9
## + factor(FodelseLand_EU27_2020)                       1 7185.0
## + factor(ami_history)                                 1 7185.1
## + factor(lipid_modifying_agents)                      1 7185.3
## + factor(antihypertensive_comb)                       1 7185.3
## + rcs(Raks_AndelEkBisInk)                             3 7185.5
## + rcs(Raks_AndelArblosInk)                            4 7186.2
## + rcs(Raks_AndelSjukInk)                              4 7189.4
## + rcs(bmi)                                            4 7189.6
## - factor(rokare)                                      1 7190.9
## + factor(Sun2000niva_old)                             6 7193.3
## - rcs(DispInkKEHB04)                                  4 7200.5
## - factor(antithrombotic_agents)                       1 7201.1
## - factor(stroke_history)                              1 7218.0
## - rcs(alder)                                          4 7263.9
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7180.6
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare) + factor(systoliskt_high)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7179.1
## + factor(hba1c_high)                                  1 7179.7
## + factor(sex)                                         1 7180.3
## <none>                                                  7180.6
## + factor(kolesterol_high)                             1 7180.6
## + factor(Civil)                                       1 7181.6
## + rcs(time_to_cpap_start)                             4 7182.1
## + factor(GFR_high)                                    1 7182.1
## + factor(FodelseLand_EU27_2020)                       1 7182.4
## + factor(ami_history)                                 1 7182.5
## + factor(antihypertensive_comb)                       1 7182.6
## + factor(lipid_modifying_agents)                      1 7182.6
## + rcs(Raks_AndelEkBisInk)                             3 7182.7
## + rcs(Raks_AndelArblosInk)                            4 7183.2
## - factor(systoliskt_high)                             1 7183.3
## + rcs(Raks_AndelSjukInk)                              4 7186.6
## + rcs(bmi)                                            4 7186.9
## - factor(rokare)                                      1 7188.3
## + factor(Sun2000niva_old)                             6 7190.6
## - rcs(DispInkKEHB04)                                  4 7198.1
## - factor(antithrombotic_agents)                       1 7199.4
## - factor(stroke_history)                              1 7216.1
## - rcs(alder)                                          4 7257.5
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7179.06
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare) + factor(systoliskt_high) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(hba1c_high)                                  1 7178.3
## + factor(sex)                                         1 7178.8
## + factor(kolesterol_high)                             1 7179.0
## <none>                                                  7179.1
## + factor(Civil)                                       1 7180.1
## + rcs(time_to_cpap_start)                             4 7180.6
## + factor(GFR_high)                                    1 7180.6
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7180.6
## + factor(FodelseLand_EU27_2020)                       1 7180.8
## + factor(ami_history)                                 1 7181.0
## + factor(antihypertensive_comb)                       1 7181.0
## + factor(lipid_modifying_agents)                      1 7181.0
## + rcs(Raks_AndelEkBisInk)                             3 7181.2
## + rcs(Raks_AndelArblosInk)                            4 7181.6
## - factor(systoliskt_high)                             1 7181.7
## + rcs(Raks_AndelSjukInk)                              4 7185.1
## + rcs(bmi)                                            4 7185.2
## - factor(rokare)                                      1 7187.3
## + factor(Sun2000niva_old)                             6 7189.1
## - rcs(DispInkKEHB04)                                  4 7196.7
## - factor(stroke_history)                              1 7214.8
## - rcs(alder)                                          4 7256.5
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7178.28
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare) + factor(systoliskt_high) + 
##     factor(hba1c_high) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(kolesterol_high)                             1 7178.2
## + factor(sex)                                         1 7178.2
## <none>                                                  7178.3
## - factor(hba1c_high)                                  1 7179.1
## + factor(Civil)                                       1 7179.4
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7179.7
## + factor(GFR_high)                                    1 7179.8
## + factor(FodelseLand_EU27_2020)                       1 7180.0
## + rcs(time_to_cpap_start)                             4 7180.1
## + factor(antihypertensive_comb)                       1 7180.2
## + factor(ami_history)                                 1 7180.2
## + factor(lipid_modifying_agents)                      1 7180.3
## + rcs(Raks_AndelEkBisInk)                             3 7180.4
## - factor(systoliskt_high)                             1 7180.6
## + rcs(Raks_AndelArblosInk)                            4 7181.0
## + rcs(Raks_AndelSjukInk)                              4 7184.2
## + rcs(bmi)                                            4 7184.2
## - factor(rokare)                                      1 7186.5
## + factor(Sun2000niva_old)                             6 7188.3
## - rcs(DispInkKEHB04)                                  4 7195.5
## - factor(stroke_history)                              1 7213.8
## - rcs(alder)                                          4 7256.9
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7178.17
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare) + factor(systoliskt_high) + 
##     factor(hba1c_high) + factor(kolesterol_high) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## + factor(sex)                                         1 7177.6
## <none>                                                  7178.2
## - factor(kolesterol_high)                             1 7178.3
## - factor(hba1c_high)                                  1 7179.0
## + factor(Civil)                                       1 7179.3
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7179.6
## + factor(GFR_high)                                    1 7179.7
## + rcs(time_to_cpap_start)                             4 7179.9
## + factor(FodelseLand_EU27_2020)                       1 7180.0
## + factor(antihypertensive_comb)                       1 7180.1
## + rcs(Raks_AndelEkBisInk)                             3 7180.1
## + factor(ami_history)                                 1 7180.2
## + factor(lipid_modifying_agents)                      1 7180.2
## - factor(systoliskt_high)                             1 7180.3
## + rcs(Raks_AndelArblosInk)                            4 7180.8
## + rcs(bmi)                                            4 7184.2
## + rcs(Raks_AndelSjukInk)                              4 7184.2
## - factor(rokare)                                      1 7186.1
## + factor(Sun2000niva_old)                             6 7188.0
## - rcs(DispInkKEHB04)                                  4 7195.7
## - factor(stroke_history)                              1 7213.4
## - rcs(alder)                                          4 7257.4
## + factor(HushallsType_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## 
## Step:  AIC=7177.58
## Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare) + factor(systoliskt_high) + 
##     factor(hba1c_high) + factor(kolesterol_high) + factor(sex) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; coefficient may be infinite.

##                                                      Df    AIC
## <none>                                                  7177.6
## - factor(sex)                                         1 7178.2
## - factor(hba1c_high)                                  1 7178.2
## - factor(kolesterol_high)                             1 7178.2
## + factor(GFR_high)                                    1 7179.0
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7179.1
## + factor(Civil)                                       1 7179.1
## + rcs(time_to_cpap_start)                             4 7179.3
## + factor(FodelseLand_EU27_2020)                       1 7179.4
## - factor(systoliskt_high)                             1 7179.5
## + factor(antihypertensive_comb)                       1 7179.5
## + factor(ami_history)                                 1 7179.5
## + factor(lipid_modifying_agents)                      1 7179.6
## + rcs(Raks_AndelEkBisInk)                             3 7179.6
## + rcs(Raks_AndelArblosInk)                            4 7180.1
## + rcs(Raks_AndelSjukInk)                              4 7183.4
## + rcs(bmi)                                            4 7183.5
## - factor(rokare)                                      1 7185.6
## + factor(Sun2000niva_old)                             6 7187.7
## - rcs(DispInkKEHB04)                                  4 7196.4
## - factor(stroke_history)                              1 7212.6
## - rcs(alder)                                          4 7258.5
## + factor(HushallsType_RTB)                                    
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(time_to_stroke, stroke) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + factor(rokare) + factor(systoliskt_high) + 
##     factor(hba1c_high) + factor(kolesterol_high) + factor(sex) + 
##     factor(cpap_treated):factor(antithrombotic_agents), data = df_train)
## 
##   n= 10603, number of events= 425 
## 
##                                                            coef  exp(coef)
## factor(cpap_treated)1                                 4.020e-01  1.495e+00
## rcs(alder)alder                                       5.068e-01  1.660e+00
## rcs(alder)alder'                                      2.420e-01  1.274e+00
## rcs(alder)alder''                                     5.043e-02  1.052e+00
## rcs(alder)alder'''                                   -3.483e+00  3.072e-02
## factor(stroke_history)1                              -1.674e+01  5.359e-08
## factor(antithrombotic_agents)1                        6.984e-01  2.011e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      -2.612e-01  7.701e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                      2.695e+00  1.481e+01
## rcs(DispInkKEHB04)DispInkKEHB04''                    -2.500e+01  1.383e-11
## rcs(DispInkKEHB04)DispInkKEHB04'''                    4.679e+01  2.085e+20
## factor(rokare)1                                       4.140e-01  1.513e+00
## factor(systoliskt_high)1                              2.207e-01  1.247e+00
## factor(hba1c_high)1                                   1.700e-01  1.185e+00
## factor(kolesterol_high)1                              1.751e-01  1.191e+00
## factor(sex)1                                         -1.722e-01  8.418e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 -3.737e-01  6.881e-01
##                                                        se(coef)      z Pr(>|z|)
## factor(cpap_treated)1                                 1.394e-01  2.884 0.003928
## rcs(alder)alder                                       3.676e-01  1.379 0.167995
## rcs(alder)alder'                                      1.224e+00  0.198 0.843273
## rcs(alder)alder''                                     6.637e+00  0.008 0.993937
## rcs(alder)alder'''                                    1.069e+01 -0.326 0.744597
## factor(stroke_history)1                               9.832e+02 -0.017 0.986414
## factor(antithrombotic_agents)1                        1.612e-01  4.332 1.48e-05
## rcs(DispInkKEHB04)DispInkKEHB04                       4.935e-01 -0.529 0.596651
## rcs(DispInkKEHB04)DispInkKEHB04'                      7.732e+00  0.349 0.727387
## rcs(DispInkKEHB04)DispInkKEHB04''                     2.786e+01 -0.897 0.369519
## rcs(DispInkKEHB04)DispInkKEHB04'''                    3.262e+01  1.434 0.151549
## factor(rokare)1                                       1.256e-01  3.297 0.000976
## factor(systoliskt_high)1                              1.136e-01  1.942 0.052107
## factor(hba1c_high)1                                   1.064e-01  1.598 0.110045
## factor(kolesterol_high)1                              1.072e-01  1.632 0.102592
## factor(sex)1                                          1.079e-01 -1.596 0.110546
## factor(cpap_treated)1:factor(antithrombotic_agents)1  2.005e-01 -1.864 0.062306
##                                                         
## factor(cpap_treated)1                                ** 
## rcs(alder)alder                                         
## rcs(alder)alder'                                        
## rcs(alder)alder''                                       
## rcs(alder)alder'''                                      
## factor(stroke_history)1                                 
## factor(antithrombotic_agents)1                       ***
## rcs(DispInkKEHB04)DispInkKEHB04                         
## rcs(DispInkKEHB04)DispInkKEHB04'                        
## rcs(DispInkKEHB04)DispInkKEHB04''                       
## rcs(DispInkKEHB04)DispInkKEHB04'''                      
## factor(rokare)1                                      ***
## factor(systoliskt_high)1                             .  
## factor(hba1c_high)1                                     
## factor(kolesterol_high)1                                
## factor(sex)1                                            
## factor(cpap_treated)1:factor(antithrombotic_agents)1 .  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                      exp(coef) exp(-coef)
## factor(cpap_treated)1                                1.495e+00  6.690e-01
## rcs(alder)alder                                      1.660e+00  6.024e-01
## rcs(alder)alder'                                     1.274e+00  7.850e-01
## rcs(alder)alder''                                    1.052e+00  9.508e-01
## rcs(alder)alder'''                                   3.072e-02  3.255e+01
## factor(stroke_history)1                              5.359e-08  1.866e+07
## factor(antithrombotic_agents)1                       2.011e+00  4.974e-01
## rcs(DispInkKEHB04)DispInkKEHB04                      7.701e-01  1.298e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     1.481e+01  6.752e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                    1.383e-11  7.229e+10
## rcs(DispInkKEHB04)DispInkKEHB04'''                   2.085e+20  4.797e-21
## factor(rokare)1                                      1.513e+00  6.610e-01
## factor(systoliskt_high)1                             1.247e+00  8.020e-01
## factor(hba1c_high)1                                  1.185e+00  8.437e-01
## factor(kolesterol_high)1                             1.191e+00  8.394e-01
## factor(sex)1                                         8.418e-01  1.188e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 6.881e-01  1.453e+00
##                                                      lower .95 upper .95
## factor(cpap_treated)1                                1.137e+00 1.964e+00
## rcs(alder)alder                                      8.076e-01 3.412e+00
## rcs(alder)alder'                                     1.157e-01 1.403e+01
## rcs(alder)alder''                                    2.357e-06 4.693e+05
## rcs(alder)alder'''                                   2.439e-11 3.869e+07
## factor(stroke_history)1                              0.000e+00       Inf
## factor(antithrombotic_agents)1                       1.466e+00 2.758e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      2.927e-01 2.026e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     3.883e-06 5.649e+07
## rcs(DispInkKEHB04)DispInkKEHB04''                    2.652e-35 7.216e+12
## rcs(DispInkKEHB04)DispInkKEHB04'''                   3.539e-08 1.228e+48
## factor(rokare)1                                      1.183e+00 1.935e+00
## factor(systoliskt_high)1                             9.980e-01 1.558e+00
## factor(hba1c_high)1                                  9.622e-01 1.460e+00
## factor(kolesterol_high)1                             9.655e-01 1.470e+00
## factor(sex)1                                         6.813e-01 1.040e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 4.645e-01 1.019e+00
## 
## Concordance= 0.715  (se = 0.012 )
## Likelihood ratio test= 220.4  on 17 df,   p=<2e-16
## Wald test            = 185.4  on 17 df,   p=<2e-16
## Score (logrank) test = 222.4  on 17 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7147762 
## C-index test: 0.716021